Nutrition and Healthy Aging最新文献_第8页

The immune-nutrition interplay in aging – facts and controversies 免疫与营养在衰老中的相互作用——事实与争议

Nutrition and Healthy Aging Pub Date : 2019-01-01 DOI: 10.3233/NHA-170034

I. Alam, A. Almajwal, Wajid Alam, Ibrar Alam, N. Ullah, Mahmoud Abulmeaaty, S. Razak, Saleem Khan, G. Pawelec, P. Paracha

引用次数: 13

Reply to critique of "A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity". 回复对 "无卡拉胶饮食对溃疡性结肠炎疾病活动影响的随机试验 "的评论。

Nutrition and Healthy Aging Pub Date : 2019-01-01 Epub Date: 2019-09-23 DOI: 10.3233/NHA-190068

Sumit Bhattacharyya, Hui Xie, Amar Dodda, Krista A Varady, Leo Feferman, Allan G Halline, Stephen B Hanauer, Joanne K Tobacman

引用次数: 0

A Critical Review of “A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity (Nutr. Healthy Aging. 2017; 4(2): 181–192).” 一项关于无卡拉胶饮食对溃疡性结肠炎疾病活动性影响的随机试验(nur。健康老龄化;2017;4(2): 181 - 192)。”

Nutrition and Healthy Aging Pub Date : 2019-01-01 DOI: 10.3233/NHA-180051

J. Mckim, J. Willoughby, W. Blakemore, M. Weiner

{"title":"A Critical Review of “A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity (Nutr. Healthy Aging. 2017; 4(2): 181–192).”","authors":"J. Mckim, J. Willoughby, W. Blakemore, M. Weiner","doi":"10.3233/NHA-180051","DOIUrl":"https://doi.org/10.3233/NHA-180051","url":null,"abstract":"Carrageenan (CGN) is a widely used food additive commonly found in dairy products, dairy substitutes (such as almond milk and soy milk), deli meats, nutritional supplements, beverages, and infant formula. It is typically used as a gelling, thickening, emulsifying and stabilizing agent and to improve the mouthfeel of the product. Decades of research on CGN safety has been reviewed by numerous regulatory bodies across the world. These regulatory bodies have all agreed on the safety status of CGN used as a food additive. Despite this, a few groups have continually published reports using misinformation and misinterpretation of results to suggest that CGN is harmful. The study reviewed here, “A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity (Bhattacharyya et al. Nutr. Healthy Aging. 2017; 4(2): 181–192)” from Joanne Tobacman’s group, is an example of this. In this study, Bhattacharyya et al. set out to assess the impact of CGN in the diet on the interval to relapse in patients with ulcerative colitis (UC) who were currently in remission. For the study, UC patients in remission were instructed to participate in a “no carrageenan” diet. Some of the participants also received placebo capsules while others received CGN capsules. CGN, being a food additive, is mostly ingested as part of the diet, and typically bound to food protein. It is never ingested as a bolus in capsule form. The study contains errors in the interpretation of CGN literature and has cited studies that used degraded CGN, not food grade CGN. There are also issues with the use of statistical tests and data interpretation. In one instance, the authors seemed to ignore their own study results, suggested that CGN in the diet had no effect. Here we will review these issues as well as discuss how this study could have been approached to eliminate obvious bias.","PeriodicalId":37419,"journal":{"name":"Nutrition and Healthy Aging","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NHA-180051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70143858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Vitamin D level predicts all-cause dementia 维生素D水平预测全因痴呆

Nutrition and Healthy Aging Pub Date : 2019-01-01 DOI: 10.3233/NHA-190065

H. Karl Greenblatt, C. Adler, M. Aslam, J. Welge, R. Krikorian

{"title":"Vitamin D level predicts all-cause dementia","authors":"H. Karl Greenblatt, C. Adler, M. Aslam, J. Welge, R. Krikorian","doi":"10.3233/NHA-190065","DOIUrl":"https://doi.org/10.3233/NHA-190065","url":null,"abstract":"BACKGROUND: Vitamin D deficiency is common in Western societies and has been implicated in a number of health conditions including late-life dementia. OBJECTIVE: To assess whether vitamin D level is associated with all-cause dementia in late life. METHODS: This was a retrospective case control study using the electronic medical record of an urban medical center to obtain information on age, sex, body mass index, 25-hydroxy vitamin D (25-(OH)D) values, and presence of dementia diagnosis in patients 65 to 90 years old. We classified patients to quartiles according to vitamin D values and performed logistic regression analysis to determine associations between vitamin D quartiles and incidence of dementia diagnosis. RESULTS: Rates of all-cause dementia decreased with increasing levels of 25-(OH)D independent of age, sex, and BMI, factors that also predicted dementia. Vitamin D levels above 38 ng/mL were associated with the lowest rate of all-cause dementia. CONCLUSIONS: We observed dose-dependent, inverse associations of 25-hydroxy vitamin D levels with all-cause, late life dementia independent of age, sex, and BMI. There may be greater protection for supra-sufficient levels, a notion that warrants evaluation in controlled trials.","PeriodicalId":37419,"journal":{"name":"Nutrition and Healthy Aging","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NHA-190065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70143541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthy eating index-2010 and physical activity and disabilities of old age 健康饮食指数-2010与老年身体活动和残疾

Nutrition and Healthy Aging Pub Date : 2019-01-01 DOI: 10.3233/NHA-170040

M. Root, M. T. Nielsen, Timothy Smith, Katelyn M. Meaux

{"title":"Healthy eating index-2010 and physical activity and disabilities of old age","authors":"M. Root, M. T. Nielsen, Timothy Smith, Katelyn M. Meaux","doi":"10.3233/NHA-170040","DOIUrl":"https://doi.org/10.3233/NHA-170040","url":null,"abstract":"BACKGROUND: Consuming a poor diet and being physically inactive may increase the risk of developing disabilities of old age. OBJECTIVE: To investigate correlations between Healthy Eating Index-2010 (HEI-2010) scores, physical activity levels, and disabilities of old age in a large biracial cohort. METHODS: The ARIC Study is a prospective cohort aged 45–64 years at baseline. Overall diet quality was assessed using the HEI-2010. A physical activity score was the sum of work, sports, and leisure. Activities of daily living (ADL), instrumental activities of daily living (IADL), and functional abilities were compared with HEI-2010 and physical activity by logistic regression 9 years after the baseline examination. RESULTS: Compared with the lowest quartile, quartile 4 healthier HEI-2010 scores showed an odds ratios of 0.76 (95% confidence interval 0.67–0.87) for functional disability, 0.89 (95% CI 0.75–1.07) for ADL disabilities, and 0.88 (95% CI 0.76–0.1.03) for IADL disabilities.Compared with the lowest tertile, tertile 3 of physical activity showed an odds ratios of 0.60 (95% CI 0.54– 0.67) for functional disability, 0.68 (95% CI 0.60–0.78) for ADL disabilities, and 0.53 (95% CI 0.47–0.60) for IADL disabilities. CONCLUSIONS: Healthier diet and higher physical activity were associated with lower levels of the disabilities of aging, particularly functional disability, at follow up.","PeriodicalId":37419,"journal":{"name":"Nutrition and Healthy Aging","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NHA-170040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70143658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mediterranean diet and metabolic status in post-menopausal women living in a mediterranean area 地中海地区绝经后妇女的地中海饮食和代谢状况

Nutrition and Healthy Aging Pub Date : 2019-01-01 DOI: 10.3233/NHA-190062

V. Fiore, M. Capraro, R. Ragusa, J. Godos, A. Mistretta, M. Marranzano

{"title":"Mediterranean diet and metabolic status in post-menopausal women living in a mediterranean area","authors":"V. Fiore, M. Capraro, R. Ragusa, J. Godos, A. Mistretta, M. Marranzano","doi":"10.3233/NHA-190062","DOIUrl":"https://doi.org/10.3233/NHA-190062","url":null,"abstract":"BACKGROUND: Limited data are available regarding the association between dietary habits and metabolic outcomes in post-menopausal women living in Italy. OBJECTIVE: To investigate the relation between adherence to the Mediterranean diet and prevalence of overweight/obesity, type-2 diabetes, hypertension and dyslipidemias in a sample of post-menopausal women. METHODS: Data on 499 women were extracted from a population-based representative sample collected in Sicily, southern Italy. High adherence to the Mediterranean diet was defined as being in the highest quartile of a score used to calculate the level of adherence in the entire cohort. RESULTS: Only 15.8% (n = 83) of the study sample was found to have high adherence to the Mediterranean diet; these individuals were less likely to be overweight [odds ratio (OR) = 0.52, 95% confidence interval (CI): 0.31–0.86] and obese (OR = 0.38, 95% CI: 0.18–0.78) as well as having dyslipidemias (OR = 0.50, 95% CI: 0.30–0.84). Among individual components of the Mediterranean diet adherence score used, obesity was inversely associated with fruit component, type-2 diabetes with cereals and olive oil, hypertension with fruit and dairy products, dyslipidemias with legumes and dairy products. CONCLUSIONS: Higher adherence to the Mediterranean diet was associated with better metabolic status in post-menopausal women.","PeriodicalId":37419,"journal":{"name":"Nutrition and Healthy Aging","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NHA-190062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70143494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Smart devices and healthy aging 智能设备和健康老龄化

Nutrition and Healthy Aging Pub Date : 2019-01-01 DOI: 10.3233/NHA-170039

S. Vinciguerra, M. Vinciguerra

引用次数: 4

Clinical Trials Corner. 临床试验角。

Nutrition and Healthy Aging Pub Date : 2018-06-15 DOI: 10.3233/NHA-180001

Leonie K Heilbronn

引用次数: 0

Skin aging as a mechanical phenomenon: The main weak links. 皮肤老化作为一种机械现象：主要薄弱环节。

Nutrition and Healthy Aging Pub Date : 2018-06-15 DOI: 10.3233/NHA-170037

Ilja L Kruglikov, Philipp E Scherer

{"title":"Skin aging as a mechanical phenomenon: The main weak links.","authors":"Ilja L Kruglikov, Philipp E Scherer","doi":"10.3233/NHA-170037","DOIUrl":"10.3233/NHA-170037","url":null,"abstract":"From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below the much more compliant adjacent layer of subcutaneous white adipose tissue (sWAT). Upon exposure to a strain, such a multi-layer system demonstrates structural instabilities in its stiffer layers, which in its simplest form is the wrinkling. These instabilities appear hierarchically when the mechanical strain in the skin exceeds some critical values. Their appearance is mainly dependent on the mismatch in mechanical properties between adjacent skin layers or between the skin and sWAT, on the adhesive strength and thickness ratios between the layers, on their bending and tensile stiffness as well as on the value of the stress existing in single layers. Gradual reduction of elastic fibers in aging significantly reduces the skin's ability to bend, prompting an up to 4-fold reduction of its stability against wrinkling, thereby explaining the role of these fibers in skin aging. While chronological and extrinsic aging differently modify these parameters, they lead to the same end result, reducing the critical strain required for the onset of instabilities. Comparing of mechanical properties of the skin presented as a bi-, tri- or tetra-layer structure demonstrates the particular importance of the papillary dermis in skin aging and provides the arguments to consider the undulations on the dermal-epidermal and dermal-sWAT interfaces as the result of mechanical bifurcation, leading to structural instabilities inside of the skin. According to this model, anti-aging strategies should focus not as much on the reinforcement of the dermis, but rather aim to treat the elastic mismatch between different adjacent layers in the skin and sWAT as well as the adhesion between these layers.","PeriodicalId":37419,"journal":{"name":"Nutrition and Healthy Aging","volume":"4 4","pages":"291-307"},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/37/36/nha-4-nha170037.PMC6004930.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36264912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationships between the inflammatory potential of the diet, aging and anthropometric measurements in a cross-sectional study in Pakistan. 巴基斯坦一项横断面研究中饮食、衰老和人体测量的炎症潜能之间的关系。

Nutrition and Healthy Aging Pub Date : 2018-06-15 DOI: 10.3233/NHA-180042

Iftikhar Alam, Nitin Shivappa, James R Hebert, Graham Pawelec, Anis Larbi

{"title":"Relationships between the inflammatory potential of the diet, aging and anthropometric measurements in a cross-sectional study in Pakistan.","authors":"Iftikhar Alam, Nitin Shivappa, James R Hebert, Graham Pawelec, Anis Larbi","doi":"10.3233/NHA-180042","DOIUrl":"10.3233/NHA-180042","url":null,"abstract":"Background: Little is known about associations between dietary inflammation, age and anthropometric measurements.Objective: In this regard, we examine how DII is related to age, anthropometrics [weight, Body mass index (BMI), waist to hip ratio (WHR)] and other parameters of nutrition (energy, protein, fats and cholesterol intake, Net Endogenous Acid Production (NEAP) and Phytochemical Index (PI)) in a cross-sectional study in Pakistan.Design: Only men (n = 651, age 54-95 years) participated in the study. Anthropometric data were collected using standard methods. DII was calculated from nutrients derived from 24-hr Dietary Recall questionnaires. NEAP and PI were calculated by established algorithms using information on nutrient intake.Results: The results show that with increasing age, there was a significant increase in the DII score (p < 0.05). Similarly significant positive correlations were found between DII score and weight, BMI, WHR and % BF (p, for all trends < 0.05). DII score significantly positively correlated with the dietary factors studied i.e. energy, protein, and fats (p, for all trends < 0.0001) but non-significantly with cholesterol (p > 0.05). Similarly, a significant positive correlation with NEAP (p < 0.0001) was found, but negative with PI (p < 0.0001).Conclusion: In conclusion, the present study shows direct positive correlations between the DII, age and indices of obesity, and thus supports the hypothesis that diet may have a role in the development of obesity through inflammatory modulation mechanisms in elderly.","PeriodicalId":37419,"journal":{"name":"Nutrition and Healthy Aging","volume":"4 4","pages":"335-343"},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NHA-180042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36264313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20