发布求助
文献互助 智能选刊 最新文献

Current Opinion in Systems Biology最新文献

筛选
英文 中文
Editorial Board Page 编辑委员会页面
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-12-01 DOI: 10.1016/S2452-3100(23)00052-5
{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2452-3100(23)00052-5","DOIUrl":"https://doi.org/10.1016/S2452-3100(23)00052-5","url":null,"abstract":"","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"36 ","pages":"Article 100495"},"PeriodicalIF":3.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452310023000525/pdfft?md5=796aff2b175ba2c293085564fefc486e&pid=1-s2.0-S2452310023000525-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138489626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A pan-metazoan view of germline-soma distinction challenges our understanding of how the metazoan germline evolves 泛后生动物对生殖细胞-体细胞区分的观点挑战了我们对后生动物生殖细胞如何进化的理解
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-12-01 DOI: 10.1016/j.coisb.2023.100486
Dominic K. Devlin , Austen R.D. Ganley , Nobuto Takeuchi
{"title":"A pan-metazoan view of germline-soma distinction challenges our understanding of how the metazoan germline evolves","authors":"Dominic K. Devlin ,&nbsp;Austen R.D. Ganley ,&nbsp;Nobuto Takeuchi","doi":"10.1016/j.coisb.2023.100486","DOIUrl":"10.1016/j.coisb.2023.100486","url":null,"abstract":"<div><p>A germline-soma distinction — irreversible differentiation from reproductive germline cells to sterile somatic cells — is a landmark of cellular cooperation in metazoans. Traditionally, this distinction was considered a property of only some metazoan taxa, such as vertebrates and insects. However, recent studies on a number of other metazoan taxa are challenging this traditional perspective, suggesting that a germline-soma distinction is widespread among metazoans. Here, we review recent molecular and cellular evidence supporting this suggestion and emphasise the difference between germline-soma distinction and germline segregation. We also outline the considerable diversity among metazoans in germline specification, segregation and regeneration. We finish by discussing how evolutionary explanations for this diversity can be investigated by harnessing theoretical modelling approaches.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"36 ","pages":"Article 100486"},"PeriodicalIF":3.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452310023000434/pdfft?md5=06baf838b4701fd9a8bb16f2bc11278d&pid=1-s2.0-S2452310023000434-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135668926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering live bacterial therapeutics to treat human diseases 利用活细菌疗法治疗人类疾病
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-11-30 DOI: 10.1016/j.coisb.2023.100492
In Young Hwang
{"title":"Engineering live bacterial therapeutics to treat human diseases","authors":"In Young Hwang","doi":"10.1016/j.coisb.2023.100492","DOIUrl":"https://doi.org/10.1016/j.coisb.2023.100492","url":null,"abstract":"<div><p>In recent years, synthetic biology has provided many engineering approaches to reprogram and engineer cells in diverse applications including the development of novel therapeutics. Engineered cells provide advantages over small molecules<span> or biologics, as these cells can be reprogrammed to have spatial and temporal control over the delivery of therapeutics in response to disease biomarkers. Herein, some of the recent applications of engineered live bacterial therapeutics against human diseases such as cancer, metabolic disorders<span>, gastrointestinal diseases, and infections are reviewed. Furthermore, this review highlights active clinical trials on engineered cells with promising results.</span></span></p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"37 ","pages":"Article 100492"},"PeriodicalIF":3.7,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138769941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction of microbial platform chassis for CO2 utilisation 构建二氧化碳利用微生物平台底盘
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-11-25 DOI: 10.1016/j.coisb.2023.100489
Simona Della Valle, Weiming Tu, Wei E. Huang
{"title":"Construction of microbial platform chassis for CO2 utilisation","authors":"Simona Della Valle,&nbsp;Weiming Tu,&nbsp;Wei E. Huang","doi":"10.1016/j.coisb.2023.100489","DOIUrl":"https://doi.org/10.1016/j.coisb.2023.100489","url":null,"abstract":"<div><p>To achieve a circular bioeconomy, carbon streams can be utilised through microbial conversion to produce value-added compounds. Although some microorganisms are naturally able to grow on these renewable carbon sources and generate desirable molecules, significant engineering is required to develop platform chassis exhibiting attractive performance parameters for industrial-scale processes. Here, we provide a brief overview of the core considerations in chassis engineering for autotrophic bioproduction, including carbon and energy supply, in addition to emerging standards for rewiring metabolic pathways to enhance growth and biosynthetic capabilities. We highlight examples of successful strategies, placing emphasis on recent advances in engineering autotrophic capabilities in both native autotrophs and heterotrophs.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"37 ","pages":"Article 100489"},"PeriodicalIF":3.7,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S245231002300046X/pdfft?md5=7a85534cbab719644d59ae9349c85905&pid=1-s2.0-S245231002300046X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138582140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systems metabolic engineering for the production of pharmaceutical natural products 生产药用天然产品的系统代谢工程
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-11-25 DOI: 10.1016/j.coisb.2023.100491
Hengrui Zhou , Hyunmin Eun , Sang Yup Lee
{"title":"Systems metabolic engineering for the production of pharmaceutical natural products","authors":"Hengrui Zhou ,&nbsp;Hyunmin Eun ,&nbsp;Sang Yup Lee","doi":"10.1016/j.coisb.2023.100491","DOIUrl":"https://doi.org/10.1016/j.coisb.2023.100491","url":null,"abstract":"<div><p>The increased awareness of the pharmaceutical supply chain<span><span> issues after the recent pandemic crisis has emphasized the need for innovative drug discovery. Natural products (NPs) have emerged as promising candidates to address pandemics due to their diverse structures and medicinal properties. However, development of novel NP-drugs in pharmaceutical supply chains has faced many challenges, including the absence of an efficient large-scale production platform to meet market demands. The advent of systems metabolic engineering has facilitated the efficient production of NPs in microorganisms compared with traditional plant-based and chemical-based production. In this article, we review recent strategies in systems metabolic engineering that have opened up new avenues for NP-drug discovery and production. In addition, we suggest viewpoints on how </span>combinatorial approaches of systems metabolic engineering and synthetic chemistry will further enhance the diversity of NP-drugs and provide prospects for the development of NP-drugs in the pharmaceutical supply chain.</span></p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"37 ","pages":"Article 100491"},"PeriodicalIF":3.7,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138582331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The critical role of co-translational folding: An evolutionary and biophysical perspective 共翻译折叠的关键作用：进化与生物物理视角
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-11-23 DOI: 10.1016/j.coisb.2023.100485
Amir Bitran , William M. Jacobs , Eugene Shakhnovich
{"title":"The critical role of co-translational folding: An evolutionary and biophysical perspective","authors":"Amir Bitran ,&nbsp;William M. Jacobs ,&nbsp;Eugene Shakhnovich","doi":"10.1016/j.coisb.2023.100485","DOIUrl":"https://doi.org/10.1016/j.coisb.2023.100485","url":null,"abstract":"<div><p><span>Many proteins begin to fold as they are being synthesized by the ribosome. Growing experimental evidence, supported by new theory, simulation and bioinformatics studies, suggests that many proteins rely on co-translational folding in order to fold efficiently and to avoid misfolded intermediates that arise posttranslationally. Consistent with these findings, complementary bioinformatics analyses have revealed widespread evolutionary selection for efficient co-translational folding kinetics. This perspective summarizes recent theoretical and experimental advances that have uncovered specific molecular mechanisms underlying the benefits of co-translational folding </span><em>in vivo</em>. We highlight studies involving single-domain proteins that begin adopting nativelike structure on the ribosome, which can help commit misfolding-prone domains to their native state. We emphasize the need for new experimental techniques to probe the molecular details underlying this process systematically.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"37 ","pages":"Article 100485"},"PeriodicalIF":3.7,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138570230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent development on DNA & genome synthesis DNA 和基因组合成的最新发展
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-11-23 DOI: 10.1016/j.coisb.2023.100490
Wenfei Yu , Junbiao Dai , Yingxin Ma
{"title":"Recent development on DNA & genome synthesis","authors":"Wenfei Yu ,&nbsp;Junbiao Dai ,&nbsp;Yingxin Ma","doi":"10.1016/j.coisb.2023.100490","DOIUrl":"https://doi.org/10.1016/j.coisb.2023.100490","url":null,"abstract":"<div><p><span>After decades of development, DNA synthesis, assembly, and sequencing technologies have reached a high level, allowing faster and cheaper acquirements of synthetic genes or even </span><em>de novo</em><span> synthesis of an entire genome. Meanwhile, the value of synthetic genomes keeps increasing, and the target organisms have covered viruses, bacteria, and yeast and moved toward higher eukaryotes. However, as the length of genomes moves from kilobase to gigabase, the cost of synthetic genome projects increases sharply and requires years of effort to complete. Therefore, new DNA synthesis technology and a next-generation DNA synthesizer are urgently needed. In this review, we focus mainly on the advances in DNA and genome synthesis and discuss difficulties that need to be addressed in both areas.</span></p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"37 ","pages":"Article 100490"},"PeriodicalIF":3.7,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138570495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing high-throughput screening systems for synthetic biology and biofoundry 推进合成生物学和生物铸造的高通量筛选系统
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-11-21 DOI: 10.1016/j.coisb.2023.100487
Kil Koang Kwon , Jinju Lee , Haseong Kim , Dae-Hee Lee , Seung-Goo Lee
{"title":"Advancing high-throughput screening systems for synthetic biology and biofoundry","authors":"Kil Koang Kwon ,&nbsp;Jinju Lee ,&nbsp;Haseong Kim ,&nbsp;Dae-Hee Lee ,&nbsp;Seung-Goo Lee","doi":"10.1016/j.coisb.2023.100487","DOIUrl":"https://doi.org/10.1016/j.coisb.2023.100487","url":null,"abstract":"<div><p>High-throughput (HT) methodologies are extensively applied in synthetic biology for the rapid enrichment and selection of desired properties from a wide range of genetic diversity. In order to effectively analyze these vast variants, HT tools must offer parallel experiments and compact reaction capabilities to enhance overall throughput. Here, we discuss about various aspects of three representative high-throughput screening (HTS) systems: microwell-, droplet-, and single-cell-based screening. These systems can be categorized based on their reaction volume, which in turn determines the associated technology, machinery, and supporting applications. Furthermore, HT techniques that rapidly connect numerous genotypes and phenotypes have evolved to enhance the precision of predictions through the integration of digital technologies like machine learning and artificial intelligence. The use of advanced HT techniques within biofoundry will enable rapid selection and analysis from extensive genetic diversity, making it a driving force for the advancement of synthetic biology.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"37 ","pages":"Article 100487"},"PeriodicalIF":3.7,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452310023000446/pdfft?md5=c79f76a94a5c0e68e948902ca3894d28&pid=1-s2.0-S2452310023000446-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138549932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell-free synthetic biology: Navigating the new frontiers of biomanufacturing and biological engineering 无细胞合成生物学：开拓生物制造和生物工程的新领域
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-11-21 DOI: 10.1016/j.coisb.2023.100488
So Jeong Lee, Dong-Myung Kim
{"title":"Cell-free synthetic biology: Navigating the new frontiers of biomanufacturing and biological engineering","authors":"So Jeong Lee,&nbsp;Dong-Myung Kim","doi":"10.1016/j.coisb.2023.100488","DOIUrl":"https://doi.org/10.1016/j.coisb.2023.100488","url":null,"abstract":"<div><p>Cell-free synthetic biology is swiftly progressing and is poised to revolutionize multiple domains within synthetic biology. By departing from the constraints of living cells, it dramatically expands potential applications, surmounting the intrinsic limitations associated with cellular systems<span>, especially where access to cytosolic conditions poses challenges. The open nature of cell-free systems means their potential applications are vast, limited only by creative imagination. A burgeoning number of studies underline its versatility across a broad spectrum of fields. This review article offers an insight into the recent advancements in this vibrant area, pinpointing key achievements and challenges in arenas such as biomanufacturing, pathway prototyping, and material sciences.</span></p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"37 ","pages":"Article 100488"},"PeriodicalIF":3.7,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138570597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering living therapeutics and diagnostics: A new frontier in human health 活体治疗和诊断工程：人类健康的新领域
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-11-13 DOI: 10.1016/j.coisb.2023.100484
Raja Selvakumar, Ishita Kumar, Glory J. Onajobi, Yongjoon Yu, Corey J. Wilson
{"title":"Engineering living therapeutics and diagnostics: A new frontier in human health","authors":"Raja Selvakumar,&nbsp;Ishita Kumar,&nbsp;Glory J. Onajobi,&nbsp;Yongjoon Yu,&nbsp;Corey J. Wilson","doi":"10.1016/j.coisb.2023.100484","DOIUrl":"10.1016/j.coisb.2023.100484","url":null,"abstract":"<div><p>Traditional therapeutics aim to diagnose, treat, and cure diseases through various synthetic and natural approaches. The emerging field of engineered living therapeutics (ELTs) genetically functionalizes living cells to alter the paradigm of designed solutions. In this review, we focus on ELTs derived from microbial cell scaffolds. We propose three synergistic modalities for the rational design of ELTs: first, use of regulatory operations to regulate genetic expression; second, integration of alternative biosensing inputs for directed application; third, choice of microbial chassis to deliver solutions. We highlight the challenges and future opportunities within each group and conclude by providing a prospective outlook for ELTs.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"37 ","pages":"Article 100484"},"PeriodicalIF":3.7,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135715588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信