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Current Opinion in Systems Biology最新文献

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From regulation of cell fate decisions towards patient-specific treatments, insights from mechanistic models of signalling pathways 从细胞命运决定的调控到针对患者的治疗，信号通路机理模型的启示
IF 3.4
Current Opinion in Systems Biology Pub Date : 2024-08-28 DOI: 10.1016/j.coisb.2024.100533
{"title":"From regulation of cell fate decisions towards patient-specific treatments, insights from mechanistic models of signalling pathways","authors":"","doi":"10.1016/j.coisb.2024.100533","DOIUrl":"10.1016/j.coisb.2024.100533","url":null,"abstract":"<div><p>Cell fate decisions are tightly regulated by complex signalling networks. Disturbed signalling through these networks is prominent in disease development. To elucidate pathway contributions and effects of alterations to the regulation of proliferation, quiescence, senescence, and apoptosis, computational modelling has been essential. Modelling heterogeneity on different scales was shown to be important for cell fate prediction. In recent years, personalised models capturing signalling and cell fate decisions have been developed. Of special interest is the application of these models to predict the response to drugs. In this review, we highlight examples of mathematical models of signalling pathways that regulate disease-relevant cell fate decisions on the path to develop individualised patient models for optimal treatment prediction.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452310024000295/pdfft?md5=a7902f0bcf991e2a2e087d02b9cf0b9d&pid=1-s2.0-S2452310024000295-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Systems biology of ecological interactions across scales 编辑综述：跨尺度生态相互作用的系统生物学
IF 3.4
Current Opinion in Systems Biology Pub Date : 2024-08-02 DOI: 10.1016/j.coisb.2024.100532
{"title":"Editorial overview: Systems biology of ecological interactions across scales","authors":"","doi":"10.1016/j.coisb.2024.100532","DOIUrl":"10.1016/j.coisb.2024.100532","url":null,"abstract":"","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A critical review of multiscale modeling for predictive understanding of cancer cell metabolism 多尺度建模用于预测性了解癌细胞代谢的重要综述
IF 3.4
Current Opinion in Systems Biology Pub Date : 2024-07-20 DOI: 10.1016/j.coisb.2024.100531
{"title":"A critical review of multiscale modeling for predictive understanding of cancer cell metabolism","authors":"","doi":"10.1016/j.coisb.2024.100531","DOIUrl":"10.1016/j.coisb.2024.100531","url":null,"abstract":"<div><p>Metabolism, whose reprogramming is an established cancer hallmark, promotes growth and proliferation in cancer cells. Genome-wide metabolic models are becoming increasingly capable of describing cancer growth. Multiscale models may allow the capture of other relevant features of cancer cells and their relationship with the tumor microenvironment. The merging of multiscale metabolic modeling and artificial intelligence can lead to a paradigm shift in oncology, possibly leading to patient-specific personalized digital twins.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network modeling approaches for metabolic diseases and diabetes 代谢性疾病和糖尿病的网络建模方法
IF 3.4
Current Opinion in Systems Biology Pub Date : 2024-06-21 DOI: 10.1016/j.coisb.2024.100530
Apurva Badkas , Maria Pires Pacheco , Thomas Sauter
{"title":"Network modeling approaches for metabolic diseases and diabetes","authors":"Apurva Badkas ,&nbsp;Maria Pires Pacheco ,&nbsp;Thomas Sauter","doi":"10.1016/j.coisb.2024.100530","DOIUrl":"https://doi.org/10.1016/j.coisb.2024.100530","url":null,"abstract":"<div><p>Metabolic diseases (MD) are amenable to network-based modeling frameworks, given the systemic perturbations induced by disrupted molecular mechanisms. We present here a brief overview of network modeling methods applied to inborn errors of metabolism (IEM), systemic metabolic conditions (mainly diabetes), and metabolism-related inflammation and autoimmune disorders. Clinical diagnosis and identification of causal agents in IEMs and uncovering the multifactorial mechanisms underlying the development of diabetes and other systemic metabolic diseases are the main challenges being addressed. The review also highlights some of the studies undertaken to investigate the role of the gut microbiome in MD, especially in diabetes. While the network frameworks employed in different modeling approaches have provided novel insights, some technique-specific limitations and overall gaps in general research trends need further attention.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S245231002400026X/pdfft?md5=3af7589f4c37de8917481422dc190763&pid=1-s2.0-S245231002400026X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Board Page 编辑委员会页面
IF 3.7
Current Opinion in Systems Biology Pub Date : 2024-06-01 DOI: 10.1016/S2452-3100(24)00022-2
{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2452-3100(24)00022-2","DOIUrl":"https://doi.org/10.1016/S2452-3100(24)00022-2","url":null,"abstract":"","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452310024000222/pdfft?md5=716e77e36be5ebe62ada61f5a261ff2e&pid=1-s2.0-S2452310024000222-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141264011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational systems biology of cellular processes in the human lymph node 人体淋巴结细胞过程的计算系统生物学
IF 3.7
Current Opinion in Systems Biology Pub Date : 2024-06-01 DOI: 10.1016/j.coisb.2024.100518
Sonja Scharf , Jörg Ackermann , Patrick Wurzel , Martin-Leo Hansmann , Ina Koch
{"title":"Computational systems biology of cellular processes in the human lymph node","authors":"Sonja Scharf ,&nbsp;Jörg Ackermann ,&nbsp;Patrick Wurzel ,&nbsp;Martin-Leo Hansmann ,&nbsp;Ina Koch","doi":"10.1016/j.coisb.2024.100518","DOIUrl":"10.1016/j.coisb.2024.100518","url":null,"abstract":"<div><p>The human immune system is determined by the functionality of the human lymph node. With the use of high-throughput techniques in clinical diagnostics, a large number of data is currently collected. The new data on the spatiotemporal organization of cells offer new possibilities to build a mathematical model of the human lymph node - a <em>virtual lymph node</em>. The virtual lymph node can be applied to simulate drug responses and may be used in clinical diagnosis. Here, we review mathematical models of the human lymph node from the viewpoint of cellular processes. Starting with classical methods, such as systems of differential equations, we discuss the values of different levels of abstraction and methods in the range of artificial intelligence techniques formalism.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452310024000143/pdfft?md5=66c9fec4f5325a388d754ce533b52cf6&pid=1-s2.0-S2452310024000143-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141031573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ODE-based models of signaling networks in autophagy 基于 ODE 的自噬信号网络模型
IF 3.4
Current Opinion in Systems Biology Pub Date : 2024-05-31 DOI: 10.1016/j.coisb.2024.100519
Markus Galhuber , Kathrin Thedieck
{"title":"ODE-based models of signaling networks in autophagy","authors":"Markus Galhuber ,&nbsp;Kathrin Thedieck","doi":"10.1016/j.coisb.2024.100519","DOIUrl":"https://doi.org/10.1016/j.coisb.2024.100519","url":null,"abstract":"<div><p>Aberrant metabolism and nutrient processing are hallmarks of cancer. Autophagy is a catabolic process, clearing macromolecules and providing metabolite intermediates for anabolism. Autophagy safeguards healthy cells from tumorigenesis while mobilizing metabolites promoting tumor growth. Autophagy is controlled by the mTOR signaling network in conjunction with AMPK and ULK1. This kinase triad features highly intertwined feedback and feedforward mechanisms, complicating predictions on nutrient and drug response. ODE-based models offer a deterministic approach frequently used for the exploration of signaling dynamics. Recent ODE models of the mTOR-AMPK-ULK1 network revealed non-linear behaviors, bistable switches, and oscillatory patterns, shedding light on the robustness and adaptability of autophagy control. We highlight emerging perspectives on AMPK in mTORC1-ULK1 crosstalk and mechanisms for integration into future models.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452310024000155/pdfft?md5=532f93bc6d4222d42ab440c05bdddad3&pid=1-s2.0-S2452310024000155-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From signalling oscillations to somite formation 从信号振荡到体节形成
IF 3.7
Current Opinion in Systems Biology Pub Date : 2024-05-25 DOI: 10.1016/j.coisb.2024.100520
Wilke H.M. Meijer, Katharina F. Sonnen
{"title":"From signalling oscillations to somite formation","authors":"Wilke H.M. Meijer,&nbsp;Katharina F. Sonnen","doi":"10.1016/j.coisb.2024.100520","DOIUrl":"https://doi.org/10.1016/j.coisb.2024.100520","url":null,"abstract":"<div><p>Periodic segmentation of vertebrate embryos or somitogenesis is regulated by a dynamic network of signalling pathways. Signalling gradients determine the spacing of the forming segments, while signalling oscillations, collectively termed the segmentation clock, ensure their regular timing. Since the segmentation clock is a paradigm of signalling dynamics at tissue level, its mechanism and function have been the topic of many studies. Recently, researchers have been able to analyse and quantify these signalling dynamics with unprecedented precision, revealing the complexity of interlinked oscillations and tissue-wide dynamics throughout development. Initial studies have shown how the interplay between signalling dynamics and cellular mechanics drive the periodic formation of segments. Looking ahead, new techniques such as <em>in vitro</em> stem cell-based models of (human) embryonic development will enable detailed investigations into the mechanisms of somitogenesis.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452310024000167/pdfft?md5=420768ab4b5e9d9250762433dd41de5a&pid=1-s2.0-S2452310024000167-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large-scale knowledge graph representations of disease processes 疾病过程的大规模知识图谱表示
IF 3.7
Current Opinion in Systems Biology Pub Date : 2024-04-30 DOI: 10.1016/j.coisb.2024.100517
Matti Hoch , Shailendra Gupta , Olaf Wolkenhauer
{"title":"Large-scale knowledge graph representations of disease processes","authors":"Matti Hoch ,&nbsp;Shailendra Gupta ,&nbsp;Olaf Wolkenhauer","doi":"10.1016/j.coisb.2024.100517","DOIUrl":"https://doi.org/10.1016/j.coisb.2024.100517","url":null,"abstract":"<div><p>Today, a wide range of technologies and data types are available when studying disease-relevant processes. Therefore, a major challenge is integrating data from different technologies covering different levels of functional cellular organization. This motivates approaches that start with a bird's-eye perspective, initially considering as many molecules, cell types, and cellular functions as possible. Knowledge graphs (KGs) provide such a perspective through graphically structured representations of the functional connections between biological entities. However, linking KGs of disease processes with experimental or clinical data requires their curation in a large-scale, multi-level layout. The resulting heterogeneity leads to new challenges in KG curation, data integration, and analysis. Existing approaches for small-scale applications must be adapted or combined into multi-scale tools to analyze multi-omics data in KGs. This short review reflects upon the large-scale KG approach to studying disease processes. We do not review all modeling approaches but focus on a personal perspective on.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452310024000131/pdfft?md5=612c0970fb95e722075e70945bafea7f&pid=1-s2.0-S2452310024000131-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140817028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitatively mapping immune control during influenza 定量绘制流感期间的免疫控制图
IF 3.7
Current Opinion in Systems Biology Pub Date : 2024-03-20 DOI: 10.1016/j.coisb.2024.100516
Jordan J.A. Weaver, Amber M. Smith
{"title":"Quantitatively mapping immune control during influenza","authors":"Jordan J.A. Weaver,&nbsp;Amber M. Smith","doi":"10.1016/j.coisb.2024.100516","DOIUrl":"https://doi.org/10.1016/j.coisb.2024.100516","url":null,"abstract":"<div><p>Host immune responses play a pivotal role in defending against influenza viruses. The activation of various immune components, such as interferon, macrophages, and CD8<sup>+</sup> T cells, works to limit viral spread while maintaining lung integrity. Recent mathematical modeling studies have investigated these responses, describing their regulation, efficacy, and movement within the lung. Here, we discuss these studies and their emphasis on identifying nonlinearities and multifaceted roles of different cell phenotypes that could be responsible for spatially heterogeneous infection patterns.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S245231002400012X/pdfft?md5=32f7c5e3112251b43a5b24b1786085b1&pid=1-s2.0-S245231002400012X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140543536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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