Engineering live bacterial therapeutics to treat human diseases

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Systems Biology Pub Date : 2023-11-30 DOI:10.1016/j.coisb.2023.100492

In Young Hwang

引用次数: 0

Abstract

In recent years, synthetic biology has provided many engineering approaches to reprogram and engineer cells in diverse applications including the development of novel therapeutics. Engineered cells provide advantages over small molecules or biologics, as these cells can be reprogrammed to have spatial and temporal control over the delivery of therapeutics in response to disease biomarkers. Herein, some of the recent applications of engineered live bacterial therapeutics against human diseases such as cancer, metabolic disorders, gastrointestinal diseases, and infections are reviewed. Furthermore, this review highlights active clinical trials on engineered cells with promising results.

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利用活细菌疗法治疗人类疾病

近年来，合成生物学提供了许多工程方法，用于对细胞进行重编程和工程化，以实现各种应用，包括开发新型疗法。与小分子药物或生物制剂相比，工程细胞具有优势，因为这些细胞可以进行重编程，以便在空间和时间上控制治疗药物的输送，从而对疾病生物标志物做出反应。本文回顾了工程活菌疗法最近在癌症、代谢紊乱、胃肠道疾病和感染等人类疾病方面的一些应用。此外，本综述还重点介绍了目前正在进行的、结果令人鼓舞的工程细胞临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Systems Biology Mathematics-Applied Mathematics

CiteScore

7.10

自引率

2.70%

发文量

期刊介绍： Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution