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Mechanisms of pulmonary hypertension development in COVID-19 新冠肺炎患者肺动脉高压的发病机制
Pulmonologiya Pub Date : 2023-06-27 DOI: 10.18093/0869-0189-2023-33-4-525-532
Н.А.Царева, N. Tsareva
{"title":"Mechanisms of pulmonary hypertension development in COVID-19","authors":"Н.А.Царева, N. Tsareva","doi":"10.18093/0869-0189-2023-33-4-525-532","DOIUrl":"https://doi.org/10.18093/0869-0189-2023-33-4-525-532","url":null,"abstract":"The novel coronavirus infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome-relate CoronaVirus 2) is a serious disease often associated with cardiovascular complications. The combination of acute respiratory distress syndrome, invasive ventilation, thromboembolic complications, and direct myocardial injury creates conditions that increase likelihood of right ventricular (RV) dysfunction due to pulmonary hypertension (PH). The aim of the work was to search for literature sources in the PubMed, Google Scholar and eLibrary databases and analyze these sources to elucidate the main pathophysiological mechanisms that underly the onset and progression of PH in COVID-19 (COronaVIrus Disease 2019). Viral damage to the myocardium and pulmonary vascular endothelium in hospitalized patients with COVID-19 may contribute to the development of PH, which is associated with signs of a more severe course of the disease and the development of RV failure in the future. Results. It was concluded that the routine echocardiography protocol should be expanded with additional indicators of the right ventricular function, since these data can be used can be used to predict course of the disease. Conclusion. Based on the literature data, COVID-19 can lead to the development of clinically significant PH in some cases.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"116 1-2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84527795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using colistimethate sodium in complex therapy of cystic fibrosis in children under 6 years of age 粘菌酸钠在6岁以下儿童囊性纤维化综合治疗中的应用
Pulmonologiya Pub Date : 2023-06-22 DOI: 10.18093/0869-0189-2023-33-4-510-516
Н.В.Петрова, О.И.Симонова, Л.С.Гордеев, Ч.Г.Анай-оол, Е.А.Самойлова, N. V. Petrova, O. Simonova, Leonid S. Gordeev, Ch.G. Anai-ool, Ekaterina A. Samoilova
{"title":"Using colistimethate sodium in complex therapy of cystic fibrosis in children under 6 years of age","authors":"Н.В.Петрова, О.И.Симонова, Л.С.Гордеев, Ч.Г.Анай-оол, Е.А.Самойлова, N. V. Petrova, O. Simonova, Leonid S. Gordeev, Ch.G. Anai-ool, Ekaterina A. Samoilova","doi":"10.18093/0869-0189-2023-33-4-510-516","DOIUrl":"https://doi.org/10.18093/0869-0189-2023-33-4-510-516","url":null,"abstract":"Early and adequate antibacterial therapy of airway infections in patients with cystic fibrosis (CF) may lead to decrease in chronic inflammation, delay the worsening of pulmonary function, and prevent the selection of resistant bacteria. Inhaled forms of antibiotics, which can help to achieve high concentrations of drug in airways and minimize systemic adverse reactions, are particularly important when treating children under 6 years of age. Purpose. To evaluate effectiveness of combined therapy and tolerability of therapy with inhaled colistimethate sodium when treating exacerbations of infectious process in children with cystic fibrosis under 6 years of age. Methods. A retrospective analysis of medical records of patients with CF and infections caused by Pseudomonas aeruginosa who were admitted to pulmonology department of Federal State Autonomous Institution “National Medical Research Center for Children’s Health” of the Ministry of Health of the Russian Federation from June of 2021 to March of 2023 and who were treated with inhaled colistimethate sodium. Results. 20 courses of therapy in 17 patients with cystic fibrosis under 6 years of age were recorded. Mean duration of treatment was 10.4 days (4 – 19 days). There were no adverse reactions that led to discontinuation of the treatment. Clinical and microbiological effectiveness of the combined therapy was 60%. Conclusion. Therapy of exacerbations of airway infections caused by P. aeruginosa with inhaled colistimethate sodium was well tolerated by patients under 6 years of age. No adverse drug reactions were reported.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80599426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Status, problems and directions of improvement of pulmonological care for patients with chronic obstructive pulmonary disease according to the results of multicenter medical and sociological study 根据多中心医学和社会学研究结果探讨慢性阻塞性肺疾病患者肺部护理的现状、问题及改善方向
Pulmonologiya Pub Date : 2023-06-10 DOI: 10.18093/0869-0189-2023-33-4-517-524
О.А.Ризаханова, М.В.Авдеева, Л.Ю.Никитина, С.Н.Авдеев, O. Rizakhanova, M. Avdeeva, L. Nikitina, S. Avdeev
{"title":"Status, problems and directions of improvement of pulmonological care for patients with chronic obstructive pulmonary disease according to the results of multicenter medical and sociological study","authors":"О.А.Ризаханова, М.В.Авдеева, Л.Ю.Никитина, С.Н.Авдеев, O. Rizakhanova, M. Avdeeva, L. Nikitina, S. Avdeev","doi":"10.18093/0869-0189-2023-33-4-517-524","DOIUrl":"https://doi.org/10.18093/0869-0189-2023-33-4-517-524","url":null,"abstract":"An expert analysis of existing organizational approaches at different levels of pulmonological medical care is needed to develop measures to improve pulmonological care for patients with chronic obstructive pulmonary disease. Aims: To conduct a multicenter medical and sociological study among pulmonologists to find priority areas and optimal ways to improve the organization of medical care for patients with chronic obstructive pulmonary disease (COPD). Methods. 181 pulmonologists from 23 regions of the Russian Federation were surveyed. Results. Pulmonologists believe that the actual prevalence (59.7%), disability rate (49.7%) and mortality rate (39.2%) associated with COPD are higher than official statistics in Russia. The most significant problems of the organization of pulmonological care are: defects in the organization of medical care at different levels, including insufficient quality of medical care (95.6%); lower quality of outpatient medical care compared to the inpatient care (p < 0.001); insufficient subsidized drug provision (69.6%); lack of dispensary follow-up (58.1%); insufficient rehabilitation measures (56.4%); diagnostic errors (53.4%); insufficient preventive measures (52.3%); long distance between specialized medical institution and the patient’s place of residence (41.4%); lack of continuum between the pre-hospital and hospital care (39.2%); lack of effective patient routing (37.1%); the high need of the regions in the medical and social programs to reduce morbidity and mortality from COPD (92.8%); insufficient contribution of the medical community to the adherence of COPD patients to prevention, treatment and rehabilitation; inadequate legal framework governing pulmonary care for COPD patients (29.3%). According to 97.7% of pulmonologists, COPD should be classified as a socially significant disease. This will allow for upscaling the programs aimed at prevention of COPD and reduction of the mortality rate and disability rate associated with COPD. Conclusion. The priority direction in the development of pulmonological care in Russia is improvement of regulatory and legal support with the development of more effective approaches to the provision of medical care to patients with COPD at all levels.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78176593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posthypercapnic syndrome Posthypercapnic综合症
Pulmonologiya Pub Date : 2023-06-09 DOI: 10.18093/0869-0189-2023-33-3-420-426
H. C. Nguyen, I. Baranova, A. Chuchalin
{"title":"Posthypercapnic syndrome","authors":"H. C. Nguyen, I. Baranova, A. Chuchalin","doi":"10.18093/0869-0189-2023-33-3-420-426","DOIUrl":"https://doi.org/10.18093/0869-0189-2023-33-3-420-426","url":null,"abstract":"Hypercapnic respiratory failure is a common cause of hospitalization and death in patients with chronic obstructive pulmonary disease (COPD).The aim of this work was to analyze the pathophysiological mechanisms and clinical picture of hypercapnic respiratory failure and to discuss the tactics of managing a patient with COPD and posthypercapnic alkalosis that developed during treatment using a clinical case as an example.Conclusion. To date, the search for new treatments for posthypercapnic alkalosis is still relevant, but there are few published studies on this topic. Acute problems in mixed metabolic disorders can be solved with an integrated therapeutic approach that includes the use of medical gases.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76447806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphangioleiomyomatosis: diagnosis of a rare cystic lung disease in a clinical case 淋巴管平滑肌瘤病:罕见囊性肺疾病临床诊断1例
Pulmonologiya Pub Date : 2023-06-09 DOI: 10.18093/0869-0189-2023-33-3-427-433
M. Makarova, A. Chernyak
{"title":"Lymphangioleiomyomatosis: diagnosis of a rare cystic lung disease in a clinical case","authors":"M. Makarova, A. Chernyak","doi":"10.18093/0869-0189-2023-33-3-427-433","DOIUrl":"https://doi.org/10.18093/0869-0189-2023-33-3-427-433","url":null,"abstract":"Sporadic lymphangioleiomyomatosis (LAM) is an orphan disease that primarily affects women of childbearing age. Increasing awareness of this disease among physicians can contribute to its timely diagnosis and treatment.The aim of this work was to present a case of a young woman with a rare cystic lung disease. At the first visit to the clinic, the patient showed pronounced clinical, radiological and functional changes in the bronchopulmonary system, and a rare pathology was suspected. Establishing the definitive diagnosis in the shortest possible time was essential because pathogenetic therapy with an mTOR inhibitor had to be initiated as soon as the diagnosis of LAM had been clarified. Until 2010, a definitive diagnosis of LAM was made only by surgical lung biopsy. However, there is currently a shift in practice toward less invasive diagnostic methods that eliminate the need for surgical intervention in most patients.Conclusion. An algorithm for making a definitive diagnosis (sporadic LAM) without morphologic examination of the lung is demonstrated.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81540764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapy of gram-negative infection in the complex treatment of cystic fibrosis 革兰氏阴性感染在囊性纤维化综合治疗中的应用
Pulmonologiya Pub Date : 2023-06-09 DOI: 10.18093/0869-0189-2023-33-4-498-508
А.Ю.Воронкова, Е.К.Жекайте, В.Д.Шерман, Е.Л.Амелина, А.В.Орлов, О.В.Усачева, В.П.Тараканова, Л.В.Смирнова, Е.В.Паснова, Н.Д.Одинаева, Е.И.Кондратьева, A. Voronkova, E. Zhekaite, V. Sherman, E. Amelina, Alexander V. Orlov, O. V. Usacheva, V. Tarakanova, Larisa V. Smirnova, E. Pasnova, N. D. Odinaeva, E. Kondratyeva
{"title":"Therapy of gram-negative infection in the complex treatment of cystic fibrosis","authors":"А.Ю.Воронкова, Е.К.Жекайте, В.Д.Шерман, Е.Л.Амелина, А.В.Орлов, О.В.Усачева, В.П.Тараканова, Л.В.Смирнова, Е.В.Паснова, Н.Д.Одинаева, Е.И.Кондратьева, A. Voronkova, E. Zhekaite, V. Sherman, E. Amelina, Alexander V. Orlov, O. V. Usacheva, V. Tarakanova, Larisa V. Smirnova, E. Pasnova, N. D. Odinaeva, E. Kondratyeva","doi":"10.18093/0869-0189-2023-33-4-498-508","DOIUrl":"https://doi.org/10.18093/0869-0189-2023-33-4-498-508","url":null,"abstract":"Chronic lung infections are a consequence of the disturbance of mucociliary clearance process in cystic fibrosis. For most patients with cystic fibrosis, chronic lung infection is associated with a poor prognosis. The impact of chronic Pseudomonas aeruginosa infection on progressive deterioration of lung function and nutritional status has been established. Timely and effective antibiotic therapy aimed at eradication or control of gram-negative flora affects the duration and quality of life. The purpose of the study. To investigate the safety and efficacy of inhaled administration of sodium colistimethate (Colimistin®). Methods. The study enrolled 42 patients (27 patients aged 5 to 17 years and 15 patients over 18 years) with an established diagnosis of cystic fibrosis, 38 with monoculture of P. aeruginosa or various associations, 4 with Achromobacter spp. culture. Microbial status, external respiratory function, nutritional status, assessment of well-being, adverse reactions, exacerbations, and use of antibiotic therapy during colimistin inhalations were recorded in all patients at baseline and at 3 months. Results. A significant improvement in nutritional status in terms of weight (p < 0.007) and height (p < 0.001) was shown in the general patient group and the children’s group. In the group of children, there was a significant increase in weight (p < 0.034) and height (p < 0.0001). In the group of patients older than 18 years, there was a significant increase in weight (p < 0.045) and BMI three months after therapy (p < 0.013). There were no significant improvements in FVC and FEV1. The treatment efficacy was shown by the assessment of well-being in the general patient group (p < 0.001) and in the children’s group (p < 0.002). No significant difference was found in the adult patient group (p < 0.067). Two patients dropped out of the study due to ADR at the start of therapy. Conclusion. Sodium colistimethate showed efficacy and safety in bronchopulmonary infections caused by P. aeruginosa in monoculture and in association with Achromobacter spp. and may be recommended for use in children and adults with cystic fibrosis.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80449379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of clinical and morphological manifestations of pneumonia complicated by exudative pleuritis in senile patients 老年肺炎并发渗出性胸膜炎的临床及形态学特点
Pulmonologiya Pub Date : 2023-06-08 DOI: 10.18093/0869-0189-2023-33-3-350-356
N. Stogova
{"title":"Features of clinical and morphological manifestations of pneumonia complicated by exudative pleuritis in senile patients","authors":"N. Stogova","doi":"10.18093/0869-0189-2023-33-3-350-356","DOIUrl":"https://doi.org/10.18093/0869-0189-2023-33-3-350-356","url":null,"abstract":"Globally, pneumonia complicated by exudative pleurisy is often recognised too late and inadequately treated in senile patients.Purpose. To study the clinical manifestations, diagnosis, and treatment of community-acquired pneumonia complicated by exudative pleurisy in the senile.Methods. Archived case histories from the period 2006 – 2022 were used to conduct a comparative study of these clinical manifestations and the outcomes of treatment of community-acquired pneumonia complicated by pleurisy was carried out in 33 patients aged 75 – 88 years and 50 patients aged   18 – 34 years.Results. Acute onset of pneumonia complicated by pleurisy was less common in senile age than in young people (60.6% vs 82.0%; p < 0.05), pneumonia proceeded without an increase in body temperature more often than in young people (24.2% vs 4.0%; p < 0.01), chest pain was less common (60.6% vs 90.0%; p < 0.01), rales in the lungs were heard more often on auscultation (48.5% vs 22.0%; p < 0.05). In the analysis of peripheral blood in senile age, leukocytosis (33.3% vs 66.0%; p < 0.05) and a leftward shift in the leukocyte formula (6.1% vs 24.0%; p < 0.05) occurred less frequently in senile patients. Pneumonia occurred against diseases of cardiovascular system(84.9% vs 8.0%; p < 0.01), gastrointestinal tract (42.4% vs 18.0%; p < 0.05) and urinary system(27.3% vs 4.0%; p < 0.01), and lingered more often in senile people (36.4% vs 10.0%; p < 0.05) than in young ones. In senile age, pneumonia was combined with pericarditis in 6.06% of cases, and in 21.2% it occurred against a background of residual changes after previous respiratory tuberculosis, which was not observed in young age.Conclusion. Antibacterial therapy, taking into account the sensitivity of sputum microflora to drugs, combined with regular aspiration of pleural exudate, made it possible to cure all senile patients without surgical intervention. The severity of residual pleural changes was similar to that in young people.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77886215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of the genotype and respiratory tract microflora on lung function and nutritional status in adult cystic fibrosis patients in long-term follow-up 基因型及呼吸道菌群对成人囊性纤维化患者肺功能及营养状况的影响
Pulmonologiya Pub Date : 2023-06-08 DOI: 10.18093/0869-0189-2023-33-3-366-373
O. Titova, V. Makhmutova, T. Gembitskaya, A. G. Chermensky, T. Stepanenko, N. A. Shklyarevich
{"title":"The influence of the genotype and respiratory tract microflora on lung function and nutritional status in adult cystic fibrosis patients in long-term follow-up","authors":"O. Titova, V. Makhmutova, T. Gembitskaya, A. G. Chermensky, T. Stepanenko, N. A. Shklyarevich","doi":"10.18093/0869-0189-2023-33-3-366-373","DOIUrl":"https://doi.org/10.18093/0869-0189-2023-33-3-366-373","url":null,"abstract":"In recent years, an increase in the number of patients with chronic infection with nonfermenting gram-negative bacteria (NFGNB) in adult patients with cystic fibrosis (CF) has increased. The genotype and phenotype characteristics, NFGNB structure, changes in sensitivity and the development of antibiotic resistance in adult patients have not been adequately studied.Aim. To determine the impact of genotype severity and Achromobacter xylosoxidans sensitivity to carbapenems on the functional and nutritional status of adult cystic fibrosis patients over a period 2016 – 2021.Materials. Retrospective analysis of genotypic and microbiological data from 54 adult CF patients and their effects on FEV1 and BMI over a period 2016 – 2021. Sputum cultures were confirmed by MALDI-TOF mass spectrometer. Depending on the severity of the mutation, the patients were divided into 2 groups: group 1 (“severe” genotype) – patients who had 2 mutations of class I – III; group 2 (“soft” genotype) – at least 1 class IV – VI mutation.Results. The group of patients with “mild” mutations had a higher BMI (kg / m2) than the group with severe mutations for a longer period of follow-up from 2018 – 2021 than in the group with severe mutations: BMI (2016) – 21.14 ± 3.55 / 19.28 ± 3.13 (p = 0.163); BMI (2017) – 21.27 ± 3.43 / 18.31 ± 2.05 (p = 0.123); BMI (2018) – 21.17 ± 4.00 / 18.80 ± 2.12 (p = 0.025); BMI (2019) – 21.01 ± 4.20 / 18.55 ± 2.53 (p = 0.049); BMI (2020) – 20.94 ± 4.12 / 18.41 ± 2.15 (p = 0.050). Age at diagnosis was 20.36 ± 2.18 years for “mild” genotypes and was higher (p = 0.042) than for “severe” genotypes (6.27 ± 1.53 years). All 7 patients who died (100%) were in the “severe” genotype group (23.3%). Functional status assessment showed no differences in FEV1 over 6 years between the “severe” and “mild” genotype groups: FEV1 (2016) – p = 0.51; FEV1 (2017) – p = 0.39; FEV1 (2018) – p = 0.51; FEV1 (2019) – p = 0.35; FEV1 (2020) – p = 0.48. Nonfermenting Gram-negative bacteria accounted for 49.9% of the isolated microorganisms. The group of carbapenem-resistant Achromobacter xylosoxidans lost the FEV1 level faster every year for 6 years (p < 0.05) compared to the group of the sensitive variant.Conclusion. In general, patients with the “mild” genotype have higher nutritional status and do not differ from patients with the “severe” genotype in terms of FEV1. The survival rate of patients with the “mild” genotype patients survival rate is higher, despite the later diagnosis and start of treatment. Development of carbаpenem resistance in Achromobacter xylosoxidans is associated with an unfavorable prognosis of the functional status decline.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79223174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urgent intraoperative cytological diagnosis of spherical mass lesions in the lungs 术中肺球形肿块的紧急细胞学诊断
Pulmonologiya Pub Date : 2023-06-08 DOI: 10.18093/0869-0189-2023-33-3-357-365
I. Kruglova, T. V. Paranina, S. Zinoviev, O. Utkin, A. Denisenko
{"title":"Urgent intraoperative cytological diagnosis of spherical mass lesions in the lungs","authors":"I. Kruglova, T. V. Paranina, S. Zinoviev, O. Utkin, A. Denisenko","doi":"10.18093/0869-0189-2023-33-3-357-365","DOIUrl":"https://doi.org/10.18093/0869-0189-2023-33-3-357-365","url":null,"abstract":"Differential diagnosis of pulmonary mass lesions is one of the most difficult tasks not only in pulmonology but also in phthisiology, because clinical manifestations, data from visual and laboratory examinations are undifferentiated in the early stages. In the case of an unclear diagnosis, morphological verification of the process played a crucial role. Urgent intraoperative examination is the most difficult option for morphologic verification of lung lesions, which requires a quick, detailed, and accurate answer.The aim of this study was to evaluate the clinical significance and efficacy of urgent intraoperative cytologic examination in the differential diagnosis between granulomatous (tuberculosis, sarcoidosis), tumor and tumor-like lesions of the lung.Methods. The results of urgent intraoperative cytologic examination of 173 tissue specimens from lung masses were retrospectively analyzed. Cytologic specimens were stained by the May – Grunwald – Giemse and Ziehl – Neelsen methods and then visualized on a Zeiss Lab A1 microscope (Carl Zeiss, Germany). The obtained data are compared with the results of histological examination. To evaluate the effectiveness of intraoperative cytologic examination, the accuracy, sensitivity, and specificity were calculated.Results. Analysis of the results of urgent cytological examinations (n = 173) shows that granulomatosis (tuberculosis/sarcoidosis) was established in 64.7% of cases, malignancy – in 31 cases (cancer – 9.2%, carcinoid tumor – 2.9%, malignant neoplasm of unclear etiology – 4%, suspected malignant lesion – 1.7%); benign process – in 9.2% of cases (hamartoma + chondroma – 5.2%, chronic inflammation – 4%). 1.2% of the cases had no diagnostic material. When comparing the obtained results, there was a discrepancy between the histological picture (2.9% of cases) and the primary clinical diagnosis (5.7% of cases). Sensitivity, specificity, and accuracy of cytologic examination of intraoperative material amounted to 95.9, 71, and 98%, respectively.Conclusion. The high sensitivity and accuracy (> 90%) of urgent cytologic diagnosis of pathologic processes in the lung under intraoperative conditions were demonstrated by the correct assessment of morphologic signs of a given lesion and by their comparison with the clinical picture and the results of additional examinations. Analysis of cytological specimens showed that urgent cytological examination significantly complements the morphological picture of lung lesions and can be considered as the first stage of phenotypic diagnosis.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81528419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spirometry: national guidelines for the testing and interpretation of results Interregional Public Organization “Russian Respiratory Society” All-Russian Public Organization “Russian Association of Specialists in Functional Diagnostics” All-Russian Public Organization “Russian Scientific Medical Soc 肺活量测定法:国家测试和结果解释指南区域间公共组织“俄罗斯呼吸学会”全俄公共组织“俄罗斯功能诊断专家协会”全俄公共组织“俄罗斯科学医学协会”
Pulmonologiya Pub Date : 2023-06-08 DOI: 10.18093/08690189-2023-33-3-307-340
M. Kameneva, A. Cherniak, Z. Aisanov, S. Avdeev, S. L. Babak, А. S. Belevskiy, N. F. Beresten, Е. N. Kalmanova, A. Malyavin, J. Perelman, A. Prikhodko, P. Struchkov, S. Chikina, M. Chushkin
{"title":"Spirometry: national guidelines for the testing and interpretation of results Interregional Public Organization “Russian Respiratory Society” All-Russian Public Organization “Russian Association of Specialists in Functional Diagnostics” All-Russian Public Organization “Russian Scientific Medical Soc","authors":"M. Kameneva, A. Cherniak, Z. Aisanov, S. Avdeev, S. L. Babak, А. S. Belevskiy, N. F. Beresten, Е. N. Kalmanova, A. Malyavin, J. Perelman, A. Prikhodko, P. Struchkov, S. Chikina, M. Chushkin","doi":"10.18093/08690189-2023-33-3-307-340","DOIUrl":"https://doi.org/10.18093/08690189-2023-33-3-307-340","url":null,"abstract":"Spirometry is the most common method to assess respiratory function. It is widely used to obtain objective information for the diagnosis of respiratory diseases and monitoring the functional state of the respiratory system. In 2014, the Russian Respiratory Society approved the technical standards for performing spirometry. Improvements in measuring devices have necessitated updating technical standards and standardizing the result interpretation algorithm.Methods. This document on spirometry was prepared by a joint group of experts from the Russian Respiratory Society and the Russian Association of Specialists in Functional Diagnostics, who have experience in performing spirometry in accordance with quality criteria, analyzing the results of the study, and developing national standards.Results. The 2014 Spirometry Technical Standards were revised, including the addition of quality criteria for measurements and test quality assessment. Where necessary, evidence was provided to support the change. The experience and knowledge of the expert group members were used to develop these recommendations.Conclusion. Standards for spirometry and bronchodilator test and the result interpretation algorithm are presented to improve the measurement quality and consistency of data interpretation.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75902015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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