Pulmonologiya最新文献

{"title":"Microflora of the lungs in health and disease, the impact of vaccination","authors":"M. Zolotov, A. V. Zhestkov, A. Lyamin, V. Fedotov","doi":"10.18093/0869-0189-2022-4144","DOIUrl":"https://doi.org/10.18093/0869-0189-2022-4144","url":null,"abstract":"The development of new methods for diagnosing infectious diseases, such as polymerase chain reaction, sequencing, and mass spectrometry, has made it possible to expand our understanding of the microflora of the human body in general and of the respiratory tract in particular. The most common microorganisms in lungs include Proteobacteria (Pseudomonas spp., Haemophilus spp.), Bacteriodetes (Prevotella spp., Porphyromonas spp.) and Firmicutes (Veillonella spp., Streptococcus spp.). Pathological processes in the lower respiratory tract change the microbiome. Consequently, Moraxella, Haemophilus, and Acinetobacter microorganisms are found in patients with chronic obstructive pulmonary disease. The main causative agents of community-acquired pneumonia include Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Klebsiella pneumoniae and other enterobacteria. Atypical causative agents of pneumonia include Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila. The wide prevalence of S. pneumoniae in the population confirms the need for vaccines to prevent the development of invasive and noninvasive forms of infection. The aim of the study was to analyze literature data on the structure of the normal microflora of the lung and to investigate its role in the development of pathological conditions. Conclusion. A growing body of research confirms the important role of the normal microflora of the respiratory tract. Vaccination against diseases of the bronchopulmonary system may reduce the incidence and mortality of pneumonia. However, the problem of community-acquired pneumonia is still relevant. In particular, the changes in the structure of the pathogens of this disease is of great interest. Vaccination against respiratory pathogens in combination with uncontrolled use of antibiotics during the pandemic of the new coronavirus infection could contribute to a change in the structure of both the lower respiratory microflora in general and the pathogens of bacterial community-acquired pneumonia in particular. The detection of a change in the predominant pathogen calls for revising etiotropic treatment and organizing planned prophylaxis if the appropriate vaccines are available.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"84 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83566787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic granulomatosis with polyangiitis: etiopathogenesis, classification and clinical phenotypes","authors":"С. Белевский, Н. П. Княжеская, E. K. Anaev, Andrey S. Belevskiy, N. P. Kniajeskaia","doi":"10.18093/0869-0189-2022-4101","DOIUrl":"https://doi.org/10.18093/0869-0189-2022-4101","url":null,"abstract":"Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic disease that can be classified as both a hypereosinophilic condition and an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis and is characterized by granulomatous inflammation. The pathogenesis of EGPA is not completely understood. It is likely that this disease is Th2-mediated, and blood and tissue eosinophilia serves as the main diagnostic criterion. The hallmarks and main effectors of organ damage in EGPA include asthma-associated necrotizing vasculitis of small-to-medium vessels and eosinophilic proliferation. Endothelial injury and vascular inflammation in EGPA is caused by ANCA via activation of circulating neutrophils. Two clinical phenotypes of the disease have been described based on the detection of ANCA: ANCA-negative with manifestations of hypereosinophilia (for example, pulmonary infiltrates and cardiomyopathy) and ANCA-positive with clinical signs of vasculitis (for example, glomerulonephritis, purpura, and mononeuritis multiplex). Both phenotypes were confirmed by histological and genomic research. However, these two coexisting mechanisms cannot be separated in clinical practice. The aim of the article is to present current knowledge of eosinophilic and ANCA-mediated aspects of the pathogenesis, classification and clinical phenotypes of EGPA, and consider prospects for future research. Conclusion. The development of EGPA is based on eosinophilic dysfunction. This dysfunction means that patients with a genetically determined predisposition to recognize the ANCA antigen and with HLA-DQ (human leukocyte antigen DQ) alleles produce anti-myeloperoxidase autoantibodies and later develop an aberrant autoimmune process. Further comprehensive post-genomic studies are needed to identify the pathogenetic mechanisms and characterize molecular features of EGPA clinical phenotypes. The elaboration of molecular endotypes will lead to the identification of new activity biomarkers and therapeutic targets that can improve the diagnosis of EGPA and the treatment outcomes.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82082557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyaluronic acid as a predictor of exacerbation of occupational chronic obstructive pulmonary disease","authors":"V. Fedotov, A. Khlystov, T. Blinova, L. Strakhova, N. Lavrenyuk, I. Dobrotina","doi":"10.18093/0869-0189-2022-32-6-862-868","DOIUrl":"https://doi.org/10.18093/0869-0189-2022-32-6-862-868","url":null,"abstract":"The frequency of exacerbations of chronic obstructive pulmonary disease (COPD) is one of the main factors determining the outcome. The search for biomarkers which reflect the risk of exacerbations is one of the urgent scientific and practical objectives. Aim. The study aimed to analyze the relationship between the serum concentration of hyaluronic acid (HA) and the frequency of exacerbations of occupational COPD caused by exposure to silica dust and to substantiate the use of HA as a predictor of exacerbations of COPD. Methods. 78 individuals with a diagnosis of occupational COPD were examined. Respiratory function was assessed based on forced vital capacity of the lungs (FVC, %), the forced expiratory volume in 1 second (FEV1, %) and the calculated ratio of these parameters (FEV1/FVC, %), i.e., modified Tiffno index. The serum concentration of hyaluronic acid (ng/ml) was determined in all individuals using solid-phase enzyme-linked immunosorbent assay (ELISA). The absolute blood level of eosinophils (cell/μl) was determined by a unified method of morphological study of hemocytes with white blood cell differential count. Results. Serum HA concentration in patients with occupational COPD with frequent exacerbations was 25% higher than in the patients with rare exacerbations (the difference was statistically significant; р = 0,004). The analysis of the obtained data showed that the most significant moderate correlation was found between the level of HA and the frequency of COPD exacerbations (direct relationship, r = 0.32; p < 0.05), and FEV1 and the frequency of COPD exacerbations (feedback, r = -0.32;p < 0.05). A weak relationship was found between the relative number of eosinophils and the frequency of COPD exacerbations (direct relationship, r = 0.2; p < 0.05). Weak correlations were also found between the level of HA and FEV1 (feedback, r = -0.23; p < 0.05), between the level of HA and the relative number of eosinophils (direct relationship, r = 0.18; p < 0.05). Conclusion. Quantitative analysis of serum HA in patients with occupational COPD can be used in clinical practice as a biochemical marker for assessing the risk of exacerbations and progression of bronchopulmonary pathology.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82278045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic obstructive pulmonary disease and miocardial revascularisation outcomes: relationship with self-reported quality of life","authors":"O. Kamenskaya, I. Loginova, A. Klinkova, S. S. Porotnikova, V. Lomivorotov, V. V. Lomivorotov, A. Cherniavsky","doi":"10.18093/0869-0189-2022-32-6-854-861","DOIUrl":"https://doi.org/10.18093/0869-0189-2022-32-6-854-861","url":null,"abstract":"Aim. To assess the impact of chronic obstructive pulmonary disease (COPD) on the outcomes of myocardial revascularisation and the self-reported quality of life (QoL) during long-term follow-up. Methods. This prospective cohort study included 454 consecutive patients who underwent scheduled myocardial revascularisation. The follow-up continued for 3 years after the surgery. All patients underwent pulmonary functional tests before the surgery. The diagnosis of COPD was verified according to the Global Initiative for Obstructive Lung Disease criteria. QoL assessment was performed before and 3 years after the surgery using the 36-Item Short-Form Health Survey (SF-36). Results. In the study group, the diagnosis of COPD was verified in 14.5% of cases. The mortality rate was 5%, and was significantly higher in patients with COPD. The baseline QoL level was reduced in all patients, regardless of the presence of COPD, with an average of 50 points both in the physical and mental health scores of the SF-36 questionnaire. COPD had a significant negative impact on the QoL physical health score after myocardial revascularisation (odds ratio (OR) 0.95 (0.91 - 0.99), p = 0.043). The forced expiratory volume in the first second (OR 1.02 (1.00 - 1.07), p = 0.048) and new-onset atrial fibrillation in the early postoperative period (OR 0.54 (0.33 - 0.88), p = 0,036) were predictors of lack of QoL improvement. COPD did not correlate with the changes in the psychoemotional component of QoL. Conclusion. COPD has an independent negative impact on the clinical outcomes of myocardial revascularisation, including survival and health-related QoL (physical health score). Thereby, preoperative assessment of the respiratory function is important in these patients.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85396186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The platelet-to-lymphocyte ratio versus neutrophil-to-lymphocyte ratio in prediction of COVID-19 outcome","authors":"L. Suliman, M. Elwasefy, Nesrine S Farrag, H. A. Tawab, H. Abdelwahab","doi":"10.18093/0869-0189-2022-32-6-849-853","DOIUrl":"https://doi.org/10.18093/0869-0189-2022-32-6-849-853","url":null,"abstract":"Clinical presentation is an undependable prognostic indicator of COVID-19 (COronaVIrus Disease 2019). So, a more objective predictor is needed to precisely evaluate and classify the prognosis. Immune dysregulation to lymphocytes, mainly T-lymphocytes, have been noticed between COVID-19 patients. The aim. This study was planned to determine the role of platelet-to-lymphocyte count ratio and neutrophil-to-lymphocyte ratio in assessment of COVID-19 prognosis. Methods. 70 hospitalized patients with confirmed COVID-19 were included in this study. All included patients underwent a consistent clinical, radiological and blood examination. Laboratory analysis was made by means of a commercially accessible kit. Blood cells ratios were computed by dividing their absolute counts. Results. Non-significant association was found between laboratory data and COVID-19 clinical severity. A significant association between CT classification and platelet-to-lymphocyte count ratio (higher value in L type; p = 0.001) was detected. Platelet-to-lymphocyte count ratio was significantly higher among intubated cases. However, Non-significant association was found between neutrophil-to-lymphocyte ratio and need of endotracheal intubation. Conclusion. Routine blood values are abnormal in patients with COVID-19. Platelet-to-lymphocyte count ratio ratios could be used as more meaningful biomarker than other values in predicting the prognosis of COVID-19. LMR helpful in COVID-19 severity.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84974938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the effectiveness of smoking cessation in patients with pulmonary tuberculosis in a hospital setting","authors":"N. Chumovatov, N. Antonov, G. Sakharova, N. Chernyh, V. Romanov, A. Ergeshov, L. Rusakova","doi":"10.18093/0869-0189-2022-32-6-869-875","DOIUrl":"https://doi.org/10.18093/0869-0189-2022-32-6-869-875","url":null,"abstract":"According to the WHO, tobacco use is currently the leading cause (16%) of all adult deaths. Studies conducted in many countries and in the Russian Federation have revealed the association between smoking and pulmonary tuberculosis (PT). Due to the negative impact of tobacco smoking on the course of tuberculosis and the effectiveness of treatment, there is a need to develop approaches to smoking cessation in patients with PT. Aim. To evaluate the effectiveness of the treatment of PT in smoking patients in combination with nicotine replacement therapy in an inpatient setting. Methods. The study included 27 patients with a confirmed diagnosis of PT. The inclusion criteria for the study were: age 18 years and older, patients who are currently active smokers, and a confirmed diagnosis of PT. The exclusion criteria were the presence of asthma and oncological diseases, unconfirmed diagnosis of PT, and earlier history of tobacco use. In the study group, an analysis of the smoking status was carried out. This status was based on the length of smoking period, number of cigarettes per day, and calculation of the smoking patient index. The degree of nicotine addiction, the presence of withdrawal symptoms, and the motivation of patients to quit smoking were assessed. The principle of nicotine dependence treatment was to prescribe nicotine-containing drugs in a dose depending on the degree of nicotine addiction. The duration of treatment was 12 weeks. Results. After 4 months of PT treatment, the cessation of bacterial excretion was detected 2 times more often, the closure of decay cavities in the lung tissue - 2.5 times more often, the relief of systemic inflammatory reactions - 2 times more often in patients who quit smoking than in patients who continue to smoke. Conclusion. This study showed that the treatment of PT in smokers was more effective in combination with nicotine replacement therapy for smoking cessation than when the patients continued to smoke.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89429313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectral analysis of cough sounds of patients with COVID-19","authors":"A. Budnevsky, S. Avdeev, E. S. Ovsyannikov, S. N. Feygelman, O. N. Choporov, A. V. Maximov, A. V. Pertsev","doi":"10.18093/0869-0189-2022-32-6-834-841","DOIUrl":"https://doi.org/10.18093/0869-0189-2022-32-6-834-841","url":null,"abstract":"Cough is a frequent manifestation  of COVID-19  (COronaVIrus Disease 2019), therefore,  it has an important  diagnostic value. There is little information  about the characteristics  of cough of COVID-19  patients in the literature.  To perform a spectral analysis of cough sounds in COVID-19 patients in comparison  with induced cough of healthy individuals. Methods. The main group consisted of 218 COVID-19  patients (48.56% – men, 51.44% – women, average age 40.2 (32.4; 50.1) years). The comparison group consisted of 60 healthy individuals (50.0% men, 50.0% women, average age 41.7 (31.2; 53.0) years) who were induced to cough. Each subject had a cough sound recorded,  followed by digital processing using a fast Fourier transform algorithm. The temporal-frequency parameters of cough sounds were evaluated: duration (ms), the ratio of the energy of low and medium frequencies (60 – 600 Hz) to the energy of high frequencies (600 – 6 000 Hz), the frequency of the maximum sound energy (Hz). These parameters  were determined  in relation  to both the entire cough and individual phases of the cough sound. Results. Significant differences were found between some cough parameters  in the main group and in the comparison  group. The total duration  of the coughing act was significantly shorter in patients with COVID-19, in contrast to the induced cough of healthy individuals (T = 342.5 (277.0; 394.0) – in the main group; T (c) = 400.5 (359.0; 457.0) – in the comparison  group; p = 0.0000). In addition,  it was found that the cough sounds of COVID-19  patients are dominated by the energy of higher frequencies as compared  to the healthy controls (Q = 0.3095 (0.223; 0.454) – in the main group; Q (c) = 0.4535 (0.3725; 0.619) – in the comparison  group; p = 0.0000). The maximum frequency of cough sound energy in the main group was significantly higher than in the comparison  group (Fmax = 463.0 (274.0; 761.0) – in the main group; Fmax = 347 (253.0; 488.0) – in the comparison  group; p = 0.0013). At the same time, there were no differences between the frequencies of the maximum energy of cough sound of the individual phases of cough act and the duration of the first phase. Conclusion. The cough of patients with COVID-19 is characterized  by a shorter duration and a predominance of high-frequency energy compared to the induced cough of healthy individuals.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72499750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and functional characteristics of the post-COVID period (6-month follow-up)","authors":"I. Leshchenko, T. V. Glushkova","doi":"10.18093/0869-0189-2022-32-6-795-805","DOIUrl":"https://doi.org/10.18093/0869-0189-2022-32-6-795-805","url":null,"abstract":"Respiratory symptoms and functional disorders are registered in patients who suffered from COVID-19 (COronaVIrus Disease 2019). Aim. Clinical and functional evaluation of the respiratory system during 6-month follow-up in patients who had moderate and severe COVID-19. Methods. 80 patients were included in the cohort observational prospective study. Patients were examined in 46 (36 - 60) days from the onset of symptoms of COVID-19 and in 93 (89 - 103) and 180 (135 - 196) days at the 2nd and 3rd stages respectively. At all stages, symptoms, dyspnea level, and quality of life were analyzed using validated questionnaires, and a 6-minute step test was performed. At the 2nd and 3rd stages, we assessed spirometric parameters, total lung capacity, carbon monoxide diffusing capacity (DLCO), and high resolution computed tomography scans of chest organs. Results. At the 1st stage of the study, 62% of patients complained of fatigue, muscle weakness, 61% of patients had dyspnea of variable severity. At the 3rd stage of the study, 43% and 42% of patients had the same complaints respectively. The prevalence of moderate COVID-19 form in patients with 35 (25 - 45)% lung damage and severe COVID-19 form with 75 (62 - 75)% of lung damage was established. At the 2nd stage, a DLCO < 80% level was recorded in 46% of patients with 35 (25 - 45)% lung damage and in 54% of patients with 75 (62 - 75)%. At the 3rd stage, DLCO < 80% was diagnosed in 51.9% and 48.1% of patients with of 35 (25 - 45)% and 75 (62 - 75)% lung damage respectively. The level of DLCO < 60% was found in 38,5% and 35,5% of patients with moderate and severe lung damage at the 2nd and 3rd stages of the study respectively. Conclusion. The symptoms were reported less frequently during the 6-month follow-up after COVID-19. 77% and 87% of patients had DLCO < 80% in 93 (89 - 103) and 180 (135 - 196) days after the disease onset, respectively. 38.5% and 35.5% of those patients, predominantly having suffered COVID-19 in severe form, had DLCO < 60% at 93 (89 - 103) and 180 (135 - 196) days, respectively. This calls for a continuous observation and regular examinations after COVID-19.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84910643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenge No.2. Differential diagnosis of bronchiectasis","authors":"O. Brodskaya, I. Butyugina, O. Y. Gracheva","doi":"10.18093/0869-0189-2022-32-6-921-922-928-930","DOIUrl":"https://doi.org/10.18093/0869-0189-2022-32-6-921-922-928-930","url":null,"abstract":"Ответ на клиническую задачу № 2 см. на с. 928.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84548784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidities in patients with chronic obstructive lung disease and COVID-19 in Almaty (Kazakhstan Republic)","authors":"G. Esetova, L. R. Idrisova, S. S. Salimova, B. Konysbay, D. Batyrbay, T. Muminov","doi":"10.18093/0869-0189-2022-32-6-923-926","DOIUrl":"https://doi.org/10.18093/0869-0189-2022-32-6-923-926","url":null,"abstract":"SARS-CoV-2 (Severe Acute Respiratory Syndrome-related CoronaVirus 2) infection is characterized by multi-comorbidity, which increases the severity of the disease. The aim of the study was to identify the relationship between the length of stay in the hospital and the comorbidity and the severity of lung damage. Methods. 72 patients with COVID-19 (COronaVIrus Disease 2019) infection were studied, including 33 women and 39 men who were treated in the city hospitals. The average age was 67.4 ± 12.02 years. The SARS-CoV-2 RNA virus was identified by PCR in 46 (63.8%) patients. Results. The most common comorbidities in chronic obstructive pulmonary disease (COPD) patients with COVID-19 included arterial hypertension (in 32%), coronary artery disease (17%), and type 2 diabetes (10%). The majority of patients (48.7%) had the CT II stage. The total proportion of patients with an advanced damage (corresponding to CT III - IV) was 36.2%. Mean hospitalization length was 13.8 ± 7.9 days. Conclusion. COPD patients with COVID-19 infection included a significant percentage of patients with arterial hypertension, which required additional treatment.","PeriodicalId":37383,"journal":{"name":"Pulmonologiya","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84759229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}