The platelet-to-lymphocyte ratio versus neutrophil-to-lymphocyte ratio in prediction of COVID-19 outcome

Q4 Medicine

Pulmonologiya Pub Date : 2022-12-12 DOI:10.18093/0869-0189-2022-32-6-849-853

L. Suliman, M. Elwasefy, Nesrine S Farrag, H. A. Tawab, H. Abdelwahab

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引用次数: 0

Abstract

Clinical presentation is an undependable prognostic indicator of COVID-19 (COronaVIrus Disease 2019). So, a more objective predictor is needed to precisely evaluate and classify the prognosis. Immune dysregulation to lymphocytes, mainly T-lymphocytes, have been noticed between COVID-19 patients. The aim. This study was planned to determine the role of platelet-to-lymphocyte count ratio and neutrophil-to-lymphocyte ratio in assessment of COVID-19 prognosis. Methods. 70 hospitalized patients with confirmed COVID-19 were included in this study. All included patients underwent a consistent clinical, radiological and blood examination. Laboratory analysis was made by means of a commercially accessible kit. Blood cells ratios were computed by dividing their absolute counts. Results. Non-significant association was found between laboratory data and COVID-19 clinical severity. A significant association between CT classification and platelet-to-lymphocyte count ratio (higher value in L type; p = 0.001) was detected. Platelet-to-lymphocyte count ratio was significantly higher among intubated cases. However, Non-significant association was found between neutrophil-to-lymphocyte ratio and need of endotracheal intubation. Conclusion. Routine blood values are abnormal in patients with COVID-19. Platelet-to-lymphocyte count ratio ratios could be used as more meaningful biomarker than other values in predicting the prognosis of COVID-19. LMR helpful in COVID-19 severity.

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血小板与淋巴细胞比值与中性粒细胞与淋巴细胞比值在预测COVID-19预后中的作用

临床表现是COVID-19(冠状病毒病2019)的一个不可靠的预后指标。因此，需要一种更客观的预测因子来准确评估和分类预后。新冠肺炎患者之间存在以t淋巴细胞为主的免疫失调。的目标。本研究旨在确定血小板-淋巴细胞计数比和中性粒细胞-淋巴细胞计数比在评估COVID-19预后中的作用。方法:70例住院确诊COVID-19患者纳入本研究。所有纳入的患者均接受了一致的临床、放射学和血液检查。实验室分析是通过市售试剂盒进行的。血细胞比率通过除以它们的绝对数量来计算。结果。实验室数据与COVID-19临床严重程度无显著相关性。CT分型与血小板/淋巴细胞计数比有显著相关性(L型较高;P = 0.001)。血小板/淋巴细胞计数比插管组明显增高。然而，中性粒细胞与淋巴细胞的比例与气管插管的需要之间没有显著的关联。结论。COVID-19患者血常规值异常。血小板/淋巴细胞计数比比值可作为预测COVID-19预后的更有意义的生物标志物。LMR对COVID-19严重程度有帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pulmonologiya Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The aim of this journal is to state a scientific position of the Russian Respiratory Society (RRS) on diagnosis and treatment of respiratory diseases based on recent evidence-based clinical trial publications and international consensuses. The most important tasks of the journal are: -improvement proficiency qualifications of respiratory specialists; -education in pulmonology; -prompt publication of original studies on diagnosis and treatment of respiratory diseases; -sharing clinical experience and information about pulmonology service organization in different regions of Russia; -information on current protocols, standards and recommendations of international respiratory societies; -discussion and consequent publication Russian consensus documents and announcement of RRS activities; -publication and comments of regulatory documents of Russian Ministry of Health; -historical review of Russian pulmonology development. The scientific concept of the journal includes publication of current evidence-based studies on respiratory medicine and their discussion with the participation of Russian and foreign experts and development of national consensus documents on respiratory medicine. Russian and foreign respiratory specialists including pneumologists, TB specialists, thoracic surgeons, allergists, clinical immunologists, pediatricians, oncologists, physiologists, and therapeutists are invited to publish article in the journal.