Hyaluronic acid as a predictor of exacerbation of occupational chronic obstructive pulmonary disease

Q4 Medicine

Pulmonologiya Pub Date : 2022-12-12 DOI:10.18093/0869-0189-2022-32-6-862-868

V. Fedotov, A. Khlystov, T. Blinova, L. Strakhova, N. Lavrenyuk, I. Dobrotina

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引用次数: 0

Abstract

The frequency of exacerbations of chronic obstructive pulmonary disease (COPD) is one of the main factors determining the outcome. The search for biomarkers which reflect the risk of exacerbations is one of the urgent scientific and practical objectives. Aim. The study aimed to analyze the relationship between the serum concentration of hyaluronic acid (HA) and the frequency of exacerbations of occupational COPD caused by exposure to silica dust and to substantiate the use of HA as a predictor of exacerbations of COPD. Methods. 78 individuals with a diagnosis of occupational COPD were examined. Respiratory function was assessed based on forced vital capacity of the lungs (FVC, %), the forced expiratory volume in 1 second (FEV1, %) and the calculated ratio of these parameters (FEV1/FVC, %), i.e., modified Tiffno index. The serum concentration of hyaluronic acid (ng/ml) was determined in all individuals using solid-phase enzyme-linked immunosorbent assay (ELISA). The absolute blood level of eosinophils (cell/μl) was determined by a unified method of morphological study of hemocytes with white blood cell differential count. Results. Serum HA concentration in patients with occupational COPD with frequent exacerbations was 25% higher than in the patients with rare exacerbations (the difference was statistically significant; р = 0,004). The analysis of the obtained data showed that the most significant moderate correlation was found between the level of HA and the frequency of COPD exacerbations (direct relationship, r = 0.32; p < 0.05), and FEV1 and the frequency of COPD exacerbations (feedback, r = -0.32;p < 0.05). A weak relationship was found between the relative number of eosinophils and the frequency of COPD exacerbations (direct relationship, r = 0.2; p < 0.05). Weak correlations were also found between the level of HA and FEV1 (feedback, r = -0.23; p < 0.05), between the level of HA and the relative number of eosinophils (direct relationship, r = 0.18; p < 0.05). Conclusion. Quantitative analysis of serum HA in patients with occupational COPD can be used in clinical practice as a biochemical marker for assessing the risk of exacerbations and progression of bronchopulmonary pathology.

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透明质酸作为职业性慢性阻塞性肺疾病恶化的预测因子

慢性阻塞性肺疾病(COPD)的发作频率是决定预后的主要因素之一。寻找反映病情恶化风险的生物标志物是迫切的科学和实际目标之一。的目标。本研究旨在分析血清透明质酸(HA)浓度与暴露于二氧化硅粉尘引起的职业性COPD加重频率之间的关系，并证实HA可作为COPD加重的预测因子。方法:对诊断为职业性慢性阻塞性肺病的78例患者进行检查。根据肺用力肺活量(FVC， %)、1秒用力呼气量(FEV1， %)和计算出的这些参数的比值(FEV1/FVC， %)即修正的Tiffno指数来评估呼吸功能。采用固相酶联免疫吸附试验(ELISA)测定所有个体血清透明质酸浓度(ng/ml)。血嗜酸性粒细胞绝对水平(细胞/μl)采用白细胞差异计数统一的血细胞形态学研究方法测定。结果。职业性慢性阻塞性肺病频繁发作患者血清HA浓度比罕见发作患者高25%(差异有统计学意义;= 0.004)。对获得的数据进行分析，发现HA水平与COPD加重频率之间存在最显著的中度相关性(直接相关，r = 0.32;p < 0.05)， FEV1与COPD加重次数(反馈，r = -0.32;p < 0.05)。嗜酸性粒细胞的相对数量与慢性阻塞性肺病发作频率呈弱相关(直接相关，r = 0.2;P < 0.05)。HA水平与FEV1之间也存在弱相关性(反馈，r = -0.23;p < 0.05)，血凝素水平与嗜酸性粒细胞相对数量之间存在直接关系(r = 0.18;P < 0.05)。结论。职业性COPD患者血清HA定量分析可作为评估支气管肺病理恶化风险和进展的生化指标用于临床实践。

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来源期刊

Pulmonologiya Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The aim of this journal is to state a scientific position of the Russian Respiratory Society (RRS) on diagnosis and treatment of respiratory diseases based on recent evidence-based clinical trial publications and international consensuses. The most important tasks of the journal are: -improvement proficiency qualifications of respiratory specialists; -education in pulmonology; -prompt publication of original studies on diagnosis and treatment of respiratory diseases; -sharing clinical experience and information about pulmonology service organization in different regions of Russia; -information on current protocols, standards and recommendations of international respiratory societies; -discussion and consequent publication Russian consensus documents and announcement of RRS activities; -publication and comments of regulatory documents of Russian Ministry of Health; -historical review of Russian pulmonology development. The scientific concept of the journal includes publication of current evidence-based studies on respiratory medicine and their discussion with the participation of Russian and foreign experts and development of national consensus documents on respiratory medicine. Russian and foreign respiratory specialists including pneumologists, TB specialists, thoracic surgeons, allergists, clinical immunologists, pediatricians, oncologists, physiologists, and therapeutists are invited to publish article in the journal.