新冠肺炎患者肺动脉高压的发病机制

Q4 Medicine

Pulmonologiya Pub Date : 2023-06-27 DOI:10.18093/0869-0189-2023-33-4-525-532

Н.А.Царева, N. Tsareva

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引用次数: 0

摘要

由SARS-CoV-2(严重急性呼吸综合征相关冠状病毒2)引起的新型冠状病毒感染是一种常伴有心血管并发症的严重疾病。急性呼吸窘迫综合征、有创通气、血栓栓塞并发症和直接心肌损伤的结合会增加肺动脉高压(PH)引起右心室功能障碍的可能性。这项工作的目的是在PubMed、Google Scholar和图书馆数据库中检索文献来源，并对这些文献来源进行分析，以阐明COVID-19(冠状病毒病2019)PH发生和进展的主要病理生理机制。COVID-19住院患者心肌和肺血管内皮的病毒损伤可能促进PH的发展，这与未来更严重病程的迹象和RV衰竭的发展有关。结果。由此得出结论，常规超声心动图方案应扩大与其他指标的右心室功能，因为这些数据可以用来预测疾病的进程。结论。根据文献资料，在某些病例中，COVID-19可导致临床显著的PH发展。

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Mechanisms of pulmonary hypertension development in COVID-19

The novel coronavirus infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome-relate CoronaVirus 2) is a serious disease often associated with cardiovascular complications. The combination of acute respiratory distress syndrome, invasive ventilation, thromboembolic complications, and direct myocardial injury creates conditions that increase likelihood of right ventricular (RV) dysfunction due to pulmonary hypertension (PH). The aim of the work was to search for literature sources in the PubMed, Google Scholar and eLibrary databases and analyze these sources to elucidate the main pathophysiological mechanisms that underly the onset and progression of PH in COVID-19 (COronaVIrus Disease 2019). Viral damage to the myocardium and pulmonary vascular endothelium in hospitalized patients with COVID-19 may contribute to the development of PH, which is associated with signs of a more severe course of the disease and the development of RV failure in the future. Results. It was concluded that the routine echocardiography protocol should be expanded with additional indicators of the right ventricular function, since these data can be used can be used to predict course of the disease. Conclusion. Based on the literature data, COVID-19 can lead to the development of clinically significant PH in some cases.

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来源期刊

Pulmonologiya Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The aim of this journal is to state a scientific position of the Russian Respiratory Society (RRS) on diagnosis and treatment of respiratory diseases based on recent evidence-based clinical trial publications and international consensuses. The most important tasks of the journal are: -improvement proficiency qualifications of respiratory specialists; -education in pulmonology; -prompt publication of original studies on diagnosis and treatment of respiratory diseases; -sharing clinical experience and information about pulmonology service organization in different regions of Russia; -information on current protocols, standards and recommendations of international respiratory societies; -discussion and consequent publication Russian consensus documents and announcement of RRS activities; -publication and comments of regulatory documents of Russian Ministry of Health; -historical review of Russian pulmonology development. The scientific concept of the journal includes publication of current evidence-based studies on respiratory medicine and their discussion with the participation of Russian and foreign experts and development of national consensus documents on respiratory medicine. Russian and foreign respiratory specialists including pneumologists, TB specialists, thoracic surgeons, allergists, clinical immunologists, pediatricians, oncologists, physiologists, and therapeutists are invited to publish article in the journal.