Annals of Medicine & Surgery最新文献

{"title":"Targeting MDSCs by inhibiting HIF-1α could improve tumor progression","authors":"Qiying Xu, Huifang Liu, Xiaoyan Song, Tana Wuren, Ri-li Ge","doi":"10.1097/ms9.0000000000002126","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002126","url":null,"abstract":"Myeloid-derived suppressor cells (MDSCs) are a subset of immature myeloid cells that inhibit anti-tumor immunity and contribute to poor cancer outcomes. In this study, we used multi-color flow cytometry to detect changes in MDSCs in patients with cancer and tumor-bearing mice. Then we studied changes in MDSCs ratio and mouse tumors after administration of HIF-1α inhibitor. The results showed that the ratio of MDSCs, specifically polymorphonuclear MDSCs (PMN-MDSCs), was higher in patients with cancer, and both PMN-MDSCs and monocytic MDSCs (M-MDSCs) ratio were higher in tumor-bearing mice. When provided with the HIF-1α inhibitor LW6, the ratio of MDSCs decreased in tumor-bearing mice, particularly PMN-MDSCs, and the volume of liver metastases also decreased. Our findings suggest that reducing MDSCs by inhibiting hypoxia-inducible factor 1α may slow tumor progression.","PeriodicalId":373451,"journal":{"name":"Annals of Medicine & Surgery","volume":"59 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140964904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coexistence of severe peripheral ulcerative keratitis and lichen planus. Case Report","authors":"Hamza Lazaar, T. Boutaj, M. Sefrioui, Najoua ElMoubarik, B. Azarkan, Saad Benchekroun, Abdellah Amazouzi, Noureddine Boutimzine, Lalla Cherkaoui Ouafa","doi":"10.1097/ms9.0000000000002179","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002179","url":null,"abstract":"\u0000 \u0000 Ocular involvement in lichen planus is highly uncommon, primarily affecting the eyelids, conjunctiva, and less frequently, the cornea. Peripheral Ulcerative Keratitis (PUK), a rare subtype form of corneal lichen planus, has been reported only once in the literature.\u0000 \u0000 \u0000 \u0000 We report details of a 34-year-old man with confirmed cutaneous lichen planus who developed severe peripheral ulcerative keratitis (PUK), a rare ocular manifestation of lichen planus. Despite initial worsening with corticosteroids, successful resolution of PUK was achieved with topical Cyclosporin and azathioprine over two months but with a final visual acuity limited to light perception.\u0000 \u0000 \u0000 \u0000 To the best of our knowledge, very rare cases have been reported of the Coexistence of Severe Peripheral Ulcerative Keratitis and Lichen Planus. Lichen planus should be considered in any case of peripheral ulcerative keratitis associated with cutaneous-mucosal manifestations Cyclosporin and azathioprine are crucial for effective management and favorable outcomes in such cases.\u0000 \u0000 \u0000 \u0000 This case aims to show the importance of dermatological examination in the presence of any peripheral ulcerative keratitis. it also sheds light on the therapeutic difficulties and the prognosis of this rare form of ocular lichen planus.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine & Surgery","volume":"12 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140962181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tele-stroke: a strategy to improve acute stroke care in low- and middle-income countries","authors":"Hafiza Qurat Ul Ain, Muhammad Junaid Tahir, Khabab Abbasher Hussien Mohamed Ahmed, Faizan Ahmed, Mustafa Mohamed Ibrahim Ali, Esraa Hassan Salih Elhaj, Ghassan E. Mustafa, Areeba Ahsan, Zohaib Yousaf","doi":"10.1097/ms9.0000000000002187","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002187","url":null,"abstract":"","PeriodicalId":373451,"journal":{"name":"Annals of Medicine & Surgery","volume":"113 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141126633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic determinants influencing adherence to secondary prophylaxis in patients with rheumatic heart disease- a systematic review","authors":"Manish Yadav, Newton Ashish Shah, Kritick Bhandari, Aksharaa G. Iyer, Ashish Mishra, Pratik Lamichhane, Amir Joshi, Digraj Yadav, Aanand K. Singh, Nischal Shah, Samridhi Yadav","doi":"10.1097/ms9.0000000000002164","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002164","url":null,"abstract":"\u0000 \u0000 Rheumatic Heart Disease (RHD) poses a substantial global health challenge, especially impacting resource-limited nations, with over 40.5 million cases reported in 2019. The crucial role of Benzathine penicillin G in both primary and secondary prevention, particularly the latter, emphasizes its significance.\u0000 \u0000 \u0000 \u0000 Following PRISMA guidelines, our systematic review explored Medline, Scopus, Google Scholar, and Embase databases from 1990 to 2022. Registered with PROSPERO ), the review utilized quality appraisal tools, including the PRISMA checklist, Cochrane bias tool and Newcastle-Ottawa scale. The objective was to identify and stratify the impact of socioeconomic factors on adherence to secondary prophylaxis in RHD.\u0000 \u0000 \u0000 \u0000 The impact of education on adherence has been found to be significant. Socially disadvantaged environments significantly influenced adherence, shaped by education, socioeconomic status, and geographical location and access to healthcare. Surprisingly, lower education levels were associated with better adherence in certain cases. Factors contributing to decreased adherence included forgetfulness, injection-related fears, and healthcare provider-related issues. Conversely, higher adherence correlated with younger age, latent disease onset, increased healthcare resources, and easy access.\u0000 \u0000 \u0000 \u0000 Patient education and awareness were crucial for improving adherence. Structured frameworks, community initiatives, and outreach healthcare programs were identified as essential in overcoming barriers to secondary prophylaxis. Taking active steps to address obstacles like long-distance commute, waiting time, injection fears, and financial issues has the potential to greatly improve adherence. This, in turn, can lead to a more effective prevention of complications associated with RHD.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine & Surgery","volume":"59 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140965139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple brain abscesses in a neonate:a rare case report along with review of literature","authors":"Aanand Mehta, Manish Yadav, Bishal Kumar Gupta, Bikash Thapa, Junu Rai, Surya Bahadur Thapa, Sudip Kumar Yadav, Digraj Yadav, Mohan Raj Sharma","doi":"10.1097/ms9.0000000000002155","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002155","url":null,"abstract":"\u0000 \u0000 Brain abscess is a pyogenic infection of the brain parenchyma caused by various organisms. Multiple brain abscesses are uncommon in neonates, and Candida albicans as a causative agent is very rare. If left untreated, brain abscesses are invariably fatal. Early diagnosis, prompt surgical intervention, simultaneous eradication of the primary source, and high-dose intravenous antibiotics decrease the incidence of morbidity and mortality.\u0000 \u0000 \u0000 \u0000 A 20-day-old newborn, delivered normally at term with a full APGAR score, presented with a 5-day history of fever, decreased activity, jaundice, and seizures. Imaging identified multiple cerebral cysts, diagnosed as multiple cerebral abscesses. Treatment involved intraoperative USG-guided burr hole drainage, followed by a 6-week antifungal therapy course. Candida albicans was found to be the causative organism following microscopic examination and culture of the pus.\u0000 \u0000 \u0000 \u0000 This literature highlights the rarity of fungal involvement in multiple cerebral abscesses in neonates. Managing such cases is very challenging, as the presentation may mimic bacterial infections. The importance of considering fungi as a causative agent in treatment decisions is crucial.\u0000 \u0000 \u0000 \u0000 Multiple brain abscesses of fungal origin are extremely rare. Early detection and management of cases can reduce mortality among neonates.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine & Surgery","volume":"40 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140966238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unruptured tubal ectopic pregnancy concurrent with trophoblastic tissue spread to the rectum: A case report","authors":"Kareem Zabad, Massa Tarakji, Raghad Arafat, Yeser Al-Douni, Merry Nakhleh, Bashar Kurdi","doi":"10.1097/ms9.0000000000002141","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002141","url":null,"abstract":"\u0000 \u0000 Ectopic pregnancy is a term used to describe pregnancies outside of the uterus. If ruptured, persistent trophoblastic tissue can be present at the site of an ectopic pregnancy, which is an unusual complication. In rare cases, the patients may present with primary implants.\u0000 \u0000 \u0000 \u0000 A 23-year-old woman who was pregnant for the first time complained of abdominal pain and was diagnosed with a ten-week tubal ectopic pregnancy. During laparotomy, trophoblastic implants were discovered in the rectum; however, the pregnancy did not rupture.\u0000 \u0000 \u0000 \u0000 The presented case report highlights a rare and late diagnosis of ectopic pregnancy in a 23-year-old primigravida woman with no known risk factors. The patient experienced sudden abdominal pain in the tenth week of gestation, leading to the surgical approach of salpingectomy. Notably, trophoblastic tissue was found in the rectum, indicating local invasion. It was then treated with methotrexate therapy. However, the low-resource setting in Syria limited the use of laparoscopy and resulted in the use of laparotomy.\u0000 \u0000 \u0000 \u0000 This case emphasizes the importance of considering trophoblastic implantation in the management plan for ectopic pregnancies, even in cases in which the pregnancy has not ruptured. It is crucial to evaluate all possible complications of this disease to ensure proper treatment and care of the patient.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine & Surgery","volume":"26 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of vitamin D treatment on pregnancy rate among endometriosis patients: A Systematic Review and Meta-Analysis","authors":"Oadi N. Shrateh, Haneen A. Siam, Yasmeen S. Ashhab, R. R. Sweity, M. Naasan","doi":"10.1097/ms9.0000000000002174","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002174","url":null,"abstract":"\u0000 \u0000 Vitamin D supplementation is supposed to have an important role in the management of several endometriosis-related aspects, offering potential relief to affected individuals. Herein, we aim to evaluate the impact of vitamin D on the pregnancy rates and clinical symptoms in women with endometriosis.\u0000 \u0000 \u0000 \u0000 We extensively searched PubMed, Cochrane Library, EMBASE, Ovid MEDLINE, and CINAHL from their inception to July 20, 2023.\u0000 \u0000 \u0000 \u0000 Three randomized controlled trials involving 167 patients were included in this meta-analysis. The findings demonstrated that vitamin D supplementation exhibits efficacy in alleviating dysmenorrhea associated with endometriosis, as evidenced by a meta-analysis showing a significant reduction in dysmenorrhea (mean difference -1.41, 95% CI -2.61 to -0.22, P = 0.02). However, the impact on dyspareunia was inconclusive, with a non-significant mean difference of -0.2 (95% CI -1.62 to 1.22, P = 0.78). In contrast, dyschezia significantly decreased with vitamin D supplementation (mean difference -1.10, 95% CI -2.22 to 0.02, P = 0.05 However, the meta-analysis did not show a significant effect of vitamin D on chronic pelvic pain associated with endometriosis.\u0000 \u0000 \u0000 \u0000 While antioxidant Vitamin D supplementation demonstrates general effectiveness in alleviating endometriosis symptoms, such as dysmenorrhea, dyspareunia, and dyschezia, the existing literature lacks direct investigations into the specific impact of Vitamin D on enhancing pregnancy rates among endometriosis patients. This observation prompts various hypotheses, suggesting that the positive effects of Vitamin D supplementation on endometriosis-related symptoms may indirectly contribute to improved pregnancy outcomes and enhanced fertility.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine & Surgery","volume":"39 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of hepatic injury in chronic hepatitis B and C Using APRI and FIB-4 indices compared to fibroscan results","authors":"Narges Najafi, Alireza Razavi, Hamed Jafarpour, Maedeh Raei, Zahra Azizi, L. Davoodi, A. Abdollahi, Mehran Frouzanian","doi":"10.1097/ms9.0000000000002095","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002095","url":null,"abstract":"\u0000 \u0000 Hepatitis B (HBV) and hepatitis C viruses (HCV) are significant causes of liver disease worldwide. Liver fibrosis (LF) is a complication of chronic liver damage caused by HBV and HCV due to our limited knowledge comparing the diagnostic performance of platelet to aspartate aminotransferase ratio index (APRI) and fibrosis-4 (FIB-4) index with fibroscan.\u0000 \u0000 \u0000 \u0000 This study evaluated liver damage in HBV and HCV using APRI, FIB4, and fibroscan indices. This retrospective cohort descriptive-analytical study was conducted on patients with HBV and HCV. This study uses laboratory results and imaging to investigate liver damage in chronic HBV and HCV patients. APRI and FIB-4 were computed based on laboratory results.\u0000 \u0000 \u0000 \u0000 A total of 185 patients (82 hepatitis B and 103 hepatitis C) were included in the study. Thirteen patients had liver cirrhosis. There was no statistically significant difference between the fibroscan results in the two groups (P=0.99). The HBV group’s mean APRI and FIB-4 were lower than HCV, but no significant difference was observed (P>0.05). Our results in HBV and HCV patients showed that APRI and FIB-4 accomplished well anticipating cirrhosis with an AUC of 0.771-0.845 and 0.871-0.910, respectively.\u0000 \u0000 \u0000 \u0000 Fibroscan is a powerful tool superior to APRI and FIB-4 in predicting LF and cirrhosis. Nevertheless, APRI and FIB-4 are inexpensive and non-invasive indicators with acceptable efficacy in predicting advanced fibrosis or cirrhosis. However, these two measures are not reliable in low-grade fibrosis.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine & Surgery","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140969108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual spread of cervical adenocarcinoma to the endometrium and left fallopian tube: a case report and literature review","authors":"Zahraa M. M. Zeer, Duha Jawaada, Sami Bannoura, Saadah Jaber","doi":"10.1097/ms9.0000000000002153","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002153","url":null,"abstract":"\u0000 \u0000 The incidence of cervical adenocarcinoma and adenocarcinoma in situ are gradually increasing especially in younger women. However, unusual spread of cervical adenocarcinoma has rarely been reported.\u0000 \u0000 \u0000 \u0000 We report a case of a 60-year-old woman who presented with postmenopausal bleeding. She was misdiagnosed to have endometrial adenocarcinoma on the lower uterine segment depending on curettage specimen. After hysterectomy, it was revealed depending on morphological features in histology accompanied with immunohistochemistry that the patient had cervical adenocarcinoma with endometrial and left fallopian tube extension.\u0000 \u0000 \u0000 \u0000 Distinguishing endocervical adenocarcinoma from endometroid adenocarcinoma poses many challenges especially when evaluating endometrial curettage specimens. Histological diagnosis based on morphological features combined with a panel of immunohistochemistry stains is crucial for accurate diagnosis and identifying the primary origin of the tumor.\u0000 \u0000 \u0000 \u0000 Accurate distinction between cervical adenocarcinoma versus endometrial adenocarcinoma is important because of its significant effects on choosing the appropriate treatment option.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine & Surgery","volume":"15 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140973270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bibliometric study of the top 100 most-cited papers in high tibial osteotomy","authors":"Ling-Chen Ye, Jing-Yu Zhang, Ying-Ying Jiang, Ren-Jie Xu","doi":"10.1097/ms9.0000000000002115","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002115","url":null,"abstract":"\u0000 \u0000 High tibial osteotomy (HTO) is a well-established surgical procedure, employed to treat medial compartment knee osteoarthritis by modifying the mechanical axis of the lower limb, thereby reducing the load on the affected joint. It has gained increased attention in recent years, resulting in numerous research advancements in this field.\u0000 \u0000 \u0000 \u0000 The top 100 most-cited papers on HTO, published between 1970 and 2023, were identified by searching the Web of Science Core Collection database. Data, including the title, author, keywords, journal, publication year, country, and institution, were extracted. Subsequently, a bibliometric analysis was performed.\u0000 \u0000 \u0000 \u0000 The 100 papers collectively garnered a total of 15,833 citations, with a median of 122 and an average of 158.33 citations per article. Since the onset of the 21st century, there has been a significant increase in the number of publications and citations. Lobenhoffer authored the most published papers. The majority of papers originated from the USA. Hannover Medical School produced the most papers. Analysis of keywords in the articles revealed several research hotspots, including open-wedge osteotomy, biomechanical study, tibial slope, patellar height, Puddu plate, TomoFix plate, stability, complications, and accuracy.\u0000 \u0000 \u0000 \u0000 This study offers bibliometric insights into HTO, underscoring that the USA is a prominent leader in this field. HTO has garnered increasing attention since the onset of the 21st century and is expected to remain a significant research area in the future. Concurrently, we advise focusing on potential research hotspots, such as the navigation system, to augment the accuracy of the correction.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine & Surgery","volume":"57 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140973903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}