Immunological Medicine最新文献_第8页

Homeostasis and immunological function of self-driven memory-phenotype CD4⁺ T lymphocytes. 自我驱动记忆表型CD4+ T淋巴细胞的稳态和免疫功能。

IF 4.4

Immunological Medicine Pub Date : 2023-03-01 DOI: 10.1080/25785826.2022.2129370

Takeshi Kawabe

{"title":"Homeostasis and immunological function of self-driven memory-phenotype CD4+ T lymphocytes.","authors":"Takeshi Kawabe","doi":"10.1080/25785826.2022.2129370","DOIUrl":"https://doi.org/10.1080/25785826.2022.2129370","url":null,"abstract":"CD4+ T lymphocytes play an essential role in adaptive immune responses. In pathogen infection, naïve CD4+ T cells that strongly respond to foreign antigens robustly proliferate to differentiate into effector/memory cells, contributing to elimination of the pathogen concerned. In addition to this conventional T cell activation pathway, naïve T cells can also weakly respond to self antigens in the periphery to spontaneously acquire a memory phenotype through homeostatic proliferation in steady state. Such 'memory-phenotype' (MP) CD4+ T lymphocytes are distinguishable from foreign antigen-specific memory cells in terms of marker expression. Once generated, MP cells are maintained by rapid proliferation while differentiating into the T-bet+ 'MP1' subset, with the latter response promoted by IL-12 homeostatically produced by type 1 dendritic cells. Importantly, MP1 cells possess innate immune function; they can produce IFN-γ in response to IL-12 and IL-18 to contribute to host defense against pathogens. Similarly, the presence of RORγt+ 'MP17' and Gata3hi 'MP2' cells as well as their potential immune functions have been proposed. In this review, I will discuss our current understanding on the unique mechanisms of generation, maintenance, and differentiation of MP CD4+ T lymphocytes as well as their functional significance in various disease conditions.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":"46 1","pages":"1-8"},"PeriodicalIF":4.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10687004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 4.4

Immunological Medicine Pub Date : 2023-03-01 DOI: 10.1080/25785826.2023.2152540

引用次数: 1

Signaling via dopamine and adenosine receptors modulate viral peptide-specific and T-cell IL-8 response in COVID-19. 在COVID-19中，通过多巴胺和腺苷受体的信号传导调节病毒肽特异性和t细胞IL-8反应。

IF 4.4

Immunological Medicine Pub Date : 2022-09-01 DOI: 10.1080/25785826.2022.2079369

Mieko Tokano, Rie Takagi, Masaaki Kawano, Shigefumi Maesaki, Norihito Tarumoto, Sho Matsushita

{"title":"Signaling via dopamine and adenosine receptors modulate viral peptide-specific and T-cell IL-8 response in COVID-19.","authors":"Mieko Tokano, Rie Takagi, Masaaki Kawano, Shigefumi Maesaki, Norihito Tarumoto, Sho Matsushita","doi":"10.1080/25785826.2022.2079369","DOIUrl":"https://doi.org/10.1080/25785826.2022.2079369","url":null,"abstract":"B-cell but not T-cell responses have been extensively studied using peripheral blood mononuclear cells (PBMCs) obtained from patients with coronavirus disease 2019 (COVID-19). Our recent study showed that not only T-helper (Th) 17 but also Th1 cells directly produce interleukin (IL)-8, a major source of neutrophilic inflammation, which is also known to induce disseminated intravascular coagulation (DIC) in COVID-19 patients. Neutrophilic inflammation caused by IL-17A or IL-8 can be fatal; thus, therapeutic intervention is highly expected. The present study aimed to investigate the T-cell responses in the Japanese patients. We synthesized spike protein-derived 15-mer peptides that are expected to bind to HLA class II allelic products frequently observed in the Japanese population, and checked the T-cell responses in Japanese patients with COVID-19. We have found that (i) patients show marked IL-8 but not IL-17A responses; (ii) these responses are restricted by HLA-DR; and (iii) IL-8 responses are abrogated by a dopamine D2 like receptor (D2R) agonist, ropinirole, and an adenosine A2a receptor (A2aR) antagonist, istradefylline. Compounds used for the treatment of Parkinson's disease may ease DIC in COVID-19. (183 words).","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":"45 3","pages":"162-167"},"PeriodicalIF":4.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9630616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

B-cell depletion therapy for multiple sclerosis. b细胞消耗疗法治疗多发性硬化症。

IF 4.4

Immunological Medicine Pub Date : 2022-06-01 Epub Date: 2021-07-21 DOI: 10.1080/25785826.2021.1952543

Yusei Miyazaki, Masaaki Niino

{"title":"B-cell depletion therapy for multiple sclerosis.","authors":"Yusei Miyazaki, Masaaki Niino","doi":"10.1080/25785826.2021.1952543","DOIUrl":"https://doi.org/10.1080/25785826.2021.1952543","url":null,"abstract":"Since the initial observation of increased immunoglobulin concentrations in the cerebrospinal fluid of multiple sclerosis (MS) patients in the 1940s, B cells have been considered to participate in the pathology of MS through the production of autoantibodies reactive against central nervous system antigens. However, it is now recognized that B cells contribute to MS relapses via antibody-independent activities, including the presentation of antigens to T cells and the release of pro-inflammatory cytokines. In addition, the recent identification of B cell-rich follicle-like structures in the meninges of progressive MS patients suggests that the pathogenic roles of B cells also exist at the progressive phase of this disease. Recently, large-scale clinical trials have demonstrated the efficacy of B-cell depletion therapy using anti-CD20 antibodies in relapsing as well as primary progressive MS. B-cell depletion therapy has become an essential treatment option for MS based on its unique benefit to risk balance in relapsing MS, and because it is the only drug that has been shown to be effective in primary progressive MS to date.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":"45 2","pages":"54-62"},"PeriodicalIF":4.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/25785826.2021.1952543","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39209598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The role of toll-like receptors in peptic ulcer disease. toll样受体在消化性溃疡疾病中的作用。

IF 4.4

Immunological Medicine Pub Date : 2022-06-01 Epub Date: 2021-10-16 DOI: 10.1080/25785826.2021.1963190

Shizhu Jin, Narayan Nepal, Yang Gao

{"title":"The role of toll-like receptors in peptic ulcer disease.","authors":"Shizhu Jin, Narayan Nepal, Yang Gao","doi":"10.1080/25785826.2021.1963190","DOIUrl":"https://doi.org/10.1080/25785826.2021.1963190","url":null,"abstract":"Helicobacter pylori (HP) is the primary etiologic factor that induces events in the immune system that lead to peptic ulcers. Toll-like receptors (TLRs) are an important part of the innate immune system, as they play pivotal roles in pathogen-associated molecular pattern (PAMP) recognition of HP as well host-associated damage-associated molecular patterns (DAMPs). Recent advancements such as COX-2 production, LPS recognition through TLR2, CagL, and CagY protein of HP activating TLR5, TLR9 activation via type IV secretion system (T4SS) using DNA transfer, TLR polymorphisms, their adaptor molecules, cytokines, and other factors play a significant role in PUD. Thus, some novel PUD treatments including Chuyou Yuyang granules, function by TLR4/NF-κB signaling pathway suppression and TNF-α and IL-18 inhibition also rely on TLR signaling. Similarly glycyrrhetinic acid (GA) treatment activates TLR-4 in Ana-1 cells not via TRIF, but via MYD88 expression, which is significantly upregulated to cure PUD. Therefore, understanding TLR signaling complexity and its resultant immune modulation after host-pathogen interactions is pivotal to drug and vaccine development for other diseases as well including cancer and recent pandemic COVID-19. In this review, we summarize the TLRs and HP interaction; its pathophysiology-related signaling pathways, polymorphisms, and pharmaceutical approaches toward PUD.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":"45 2","pages":"69-78"},"PeriodicalIF":4.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39525896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Role of CD4⁺CD25⁺FOXP3⁺ T_Reg cells on tumor immunity. CD4+CD25+FOXP3+ TReg细胞在肿瘤免疫中的作用。

IF 4.4

Immunological Medicine Pub Date : 2022-06-01 Epub Date: 2021-09-08 DOI: 10.1080/25785826.2021.1975228

Agustinus Darmadi Hariyanto, Tiara Bunga Mayang Permata, Soehartati Argadikoesoema Gondhowiardjo

{"title":"Role of CD4+CD25+FOXP3+ TReg cells on tumor immunity.","authors":"Agustinus Darmadi Hariyanto, Tiara Bunga Mayang Permata, Soehartati Argadikoesoema Gondhowiardjo","doi":"10.1080/25785826.2021.1975228","DOIUrl":"https://doi.org/10.1080/25785826.2021.1975228","url":null,"abstract":"Not all T cells are effector cells of the anti-tumor immune system. One of the subpopulations of CD4+ T cells that express CD25+ and the transcription factor FOXP3, known as Regulator T cells (TReg), plays an essential role in maintaining tolerance and immune homeostasis preventing autoimmune diseases, minimalize chronic inflammatory diseases by enlisting various immunoregulatory mechanisms. The balance between effector T cells (Teff) and regulator T cells is crucial in determining the outcome of an immune response. Regarding tumors, activation or expansion of TReg cells reduces anti-tumor immunity. TReg cells inhibit the activation of CD4+ and CD8+ T cells and suppress anti-tumor activity in the tumor microenvironment. In addition, TReg cells also promote tumor angiogenesis both directly and indirectly to ensure oxygen and nutrient transport to the tumor. There is accumulating evidence showing a positive result that removing or suppressing TReg cells increases anti-tumor immune response. However, depletion of TReg cells will cause autoimmunity. One strategy to improve or restore tumor immunity is targeted therapy on the dominant effector TReg cells in tumor tissue. Various molecules such as CTLA-4, CD4, CD25, GITR, PD-1, OX40, ICOS are in clinical trials to assess their role in attenuating TReg cells' function.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":"45 2","pages":"94-107"},"PeriodicalIF":4.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39413323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Immunopathological basis of immune-related adverse events induced by immune checkpoint blockade therapy. 免疫检查点阻断治疗引起的免疫相关不良事件的免疫病理学基础。

IF 4.4

Immunological Medicine Pub Date : 2022-06-01 Epub Date: 2021-09-19 DOI: 10.1080/25785826.2021.1976942

Terufumi Kubo, Yoshihiko Hirohashi, Tomohide Tsukahara, Takayuki Kanaseki, Kenji Murata, Rena Morita, Toshihiko Torigoe

引用次数: 5

Obstetric anti-phospholipid syndrome: from pathogenesis to treatment. 产科抗磷脂综合征:从发病机理到治疗。

IF 4.4

Immunological Medicine Pub Date : 2022-06-01 Epub Date: 2021-09-01 DOI: 10.1080/25785826.2021.1969116

Kayoko Kaneko, Nobuaki Ozawa, Atsuko Murashima

引用次数: 6

Interactomic inhibition of Eomes in the nucleus alleviates EAE via blocking the conversion of Th17 cells into non-classic Th1 cells. 通过阻断Th17细胞向非经典Th1细胞的转化，细胞核中Eomes的相互作用抑制减轻了EAE。

IF 4.4

Immunological Medicine Pub Date : 2022-06-01 Epub Date: 2022-02-07 DOI: 10.1080/25785826.2022.2031812

Bo-Young Shin, Su-Hyeon Lee, Yuna Kim, Jaekyeung An, Tae-Yoon Park, Sang-Kyou Lee

{"title":"Interactomic inhibition of Eomes in the nucleus alleviates EAE via blocking the conversion of Th17 cells into non-classic Th1 cells.","authors":"Bo-Young Shin, Su-Hyeon Lee, Yuna Kim, Jaekyeung An, Tae-Yoon Park, Sang-Kyou Lee","doi":"10.1080/25785826.2022.2031812","DOIUrl":"https://doi.org/10.1080/25785826.2022.2031812","url":null,"abstract":"Th17 cells are implicated in the pathogenesis of several autoimmune diseases. During the inflammation, Th17 cells exposed to IL-12 can shift towards the Th1 phenotype. These shifted cells are defined as 'non-classic Th1 cells'. Th17-derived non-classic Th1 cells play a critical role in late-onset chronic inflammatory diseases and are more pathogenic than the unshifted Th17 cells. Eomes is a transcription factor highly expressed in non-classic Th1 cells. To study the functional role of Eomes without genetic alteration, novel recombinant protein, ntEomes-TMD, was generated by fusing TMD of Eomes and Hph-1-PTD that facilitate intracellular delivery of its cargo molecule. ntEomes-TMD was delivered into the nucleus of the cells without influencing the T cell activation and cytotoxicity. ntEomes-TMD specifically inhibited the Eomes- and ROR-γt-mediated transcription and suppressed the Th1 and Th17 differentiation. Interestingly, ntEomes-TMD blocked the generation of non-classic Th1 cells from Th17 cells, leading to the inhibition of IFN-γ and GM-CSF secretion. In EAE, ntEomes-TMD alleviated the symptoms of EAE, and the combination treatment using ntEomes-TMD and anti-IL-17 mAb together showed better therapeutic efficacy than anti-IL-17 mAb treatment. The results suggest that ntEomes-TMD can be a new therapeutic reagent for treating chronic inflammatory diseases associated with non-classic Th1 cells.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":"45 2","pages":"119-127"},"PeriodicalIF":4.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39600508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The impact of maternal exposure to antibiotics on the development of child gut microbiome. 母体接触抗生素对儿童肠道微生物群发育的影响。

IF 4.4

Immunological Medicine Pub Date : 2022-06-01 Epub Date: 2021-08-15 DOI: 10.1080/25785826.2021.1963189

Jun Miyoshi, Tadakazu Hisamatsu

{"title":"The impact of maternal exposure to antibiotics on the development of child gut microbiome.","authors":"Jun Miyoshi, Tadakazu Hisamatsu","doi":"10.1080/25785826.2021.1963189","DOIUrl":"https://doi.org/10.1080/25785826.2021.1963189","url":null,"abstract":"Antibiotics are widely prescribed for mothers in the peripartum period today. Approximately 40% of pregnant women at term are exposed to antibiotics. Antibiotics are useful against infectious conditions such as chorioamnionitis; however, they alter the maternal microbiome. The maternal microbiome, particularly the gut microbiome, is transmitted to their neonates and is one of the major sources that shape the child's gut microbiome. The gut microbiome early in life plays a crucial role in the development of the gut microbiome itself as well as the host health over the entire life. Microbes structure the commensal ecosystem in the host. Simultaneously, microbial components and metabolites influence the host organ functions including the immune system, and vice versa, the various factors of the host impact the microbiome. The alterations of the gut microbiome induced by antibiotics in mothers can lead to gut dysbiosis in children eventually resulting in chronic disease conditions including immune disorders. Knowledge of the lasting impacts of maternal peripartum exposure to antibiotics on the gut microbiome and health in offspring and reconsideration of the adequate use of antibiotics in clinical practice are needed. Avoiding and restoring neonatal dysbiosis following maternal antibiotics-induced dysbiosis could be a new preventive strategy for various diseases.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":"45 2","pages":"63-68"},"PeriodicalIF":4.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39322977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3