Immunological Medicine最新文献

Comprehensive management of immune-related adverse events: predictive strategies, mechanistic insights, and therapeutic approaches. 免疫相关不良事件的综合管理：预测策略，机制见解和治疗方法。

IF 2.9

Immunological Medicine Pub Date : 2026-04-29 DOI: 10.1080/25785826.2026.2664951

Kosaku Murakami

{"title":"Comprehensive management of immune-related adverse events: predictive strategies, mechanistic insights, and therapeutic approaches.","authors":"Kosaku Murakami","doi":"10.1080/25785826.2026.2664951","DOIUrl":"https://doi.org/10.1080/25785826.2026.2664951","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) have been game changer in cancer therapy but can trigger diverse immune-related adverse events (irAEs) that impact multiple organs. This review offers a unified perspective on irAE risk assessment, underlying mechanisms, and therapeutic strategies aimed at maintaining anticancer efficacy while safeguarding patient well-being. We explore predictive tools-including baseline profiles of several cytokines, HLA genotype, and markers such as interleukin-6-for identifying high-risk individuals. Key drivers of irAEs were dysregulated T- and B-cell responses, antigenic cross-reactivity, and gut microbiome imbalances. Management follows a graduated approach: initial glucocorticoid intervention, followed by biologics (anti-TNF agents, IL-6 receptor blockers) or small-molecule inhibitors (JAK inhibitors) in refractory cases. Real-world data support cautious ICI use in pre-existing autoimmune disorders under stringent monitoring. We also discuss the emerging notion of \"inverse irAEs,\" where immunosuppression may predispose to secondary malignancies, underscoring the importance of long-term surveillance. Finally, we highlight the urgent need for expansive, multicenter studies to refine irAE management to enhance therapeutic outcomes.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":" ","pages":"1-15"},"PeriodicalIF":2.9,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of MS4A4A on synovial infiltrating macrophages is a hallmark of rheumatoid arthritis and reflects disease severity. MS4A4A在滑膜浸润性巨噬细胞上的表达是类风湿关节炎的标志，反映了疾病的严重程度。

IF 2.9

Immunological Medicine Pub Date : 2026-04-09 DOI: 10.1080/25785826.2026.2647497

Hirotomo Asakura, Yu Matsueda, Keisuke Ikeda, Shunsuke Kyoda, Eri Shishido, Risa Shindo, Kazuma Ino, Yasuhiro Hasegawa, Tomoki Tanaka, Tatsuhiko Wada, Sumiaki Tanaka, Kenji Oku, Kengo Harigane, Yuichi Mochida, Akito Nishimura, Kunihiro Yamaoka

{"title":"Expression of MS4A4A on synovial infiltrating macrophages is a hallmark of rheumatoid arthritis and reflects disease severity.","authors":"Hirotomo Asakura, Yu Matsueda, Keisuke Ikeda, Shunsuke Kyoda, Eri Shishido, Risa Shindo, Kazuma Ino, Yasuhiro Hasegawa, Tomoki Tanaka, Tatsuhiko Wada, Sumiaki Tanaka, Kenji Oku, Kengo Harigane, Yuichi Mochida, Akito Nishimura, Kunihiro Yamaoka","doi":"10.1080/25785826.2026.2647497","DOIUrl":"https://doi.org/10.1080/25785826.2026.2647497","url":null,"abstract":"Macrophages play a pivotal role in the progression of synovitis and joint destruction in rheumatoid arthritis (RA). MS4A4A, a transmembrane protein, has been linked to RA disease activity, but its role in synovitis remains unclear. The present cross-sectional study analyzed MS4A4A and CX3CR1 expression on monocytes and macrophages from peripheral blood and synovial tissue from 15 RA and 14 osteoarthritis (OA) patients. MS4A4A+ cells were increased in RA compared to OA across all monocyte subsets (p < 0.001). In the synovium, MS4A4A was selectively elevated on infiltrating (CD206-MerTK-) macrophages in RA (p = 0.008), but not on resident macrophages. In RA, MS4A4A+ non-classical monocytes correlated with MS4A4A+ infiltrating macrophages (r = 0.44, p = 0.016), and these infiltrating macrophages correlated with the Clinical Disease Activity Index (CDAI) (r = 0.58, p = 0.024). Across all subsets, MS4A4A+ monocytes expressed higher CX3CR1 than MS4A4A- monocytes (p < 0.001); only MS4A4A+CX3CR1+ non-classical monocytes correlated with MS4A4A+ infiltrating macrophages (r = 0.57, p = 0.026). MS4A4A may therefore link systemic monocyte upregulation to local infiltrating macrophage accumulation and disease activity. Given MS4A4A's reported role in promoting M2 macrophage polarization, its selective upregulation on infiltrating macrophages may indicate a plastic macrophage population and a potential biomarker for predicting therapeutic response in RA.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":" ","pages":"1-11"},"PeriodicalIF":2.9,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of oral Janus kinase inhibitors for the treatment of severe alopecia areata: narrative review and real-world experience. 使用口服Janus激酶抑制剂治疗严重斑秃：叙述回顾和现实世界的经验。

IF 2.9

Immunological Medicine Pub Date : 2026-03-27 DOI: 10.1080/25785826.2026.2647503

Manabu Ohyama, Masahiro Fukuyama, Reina Hayakawa, Misaki Kinoshita-Ise

{"title":"Use of oral Janus kinase inhibitors for the treatment of severe alopecia areata: narrative review and real-world experience.","authors":"Manabu Ohyama, Masahiro Fukuyama, Reina Hayakawa, Misaki Kinoshita-Ise","doi":"10.1080/25785826.2026.2647503","DOIUrl":"https://doi.org/10.1080/25785826.2026.2647503","url":null,"abstract":"Alopecia areata (AA) is a common autoimmune, non-scarring hair loss disease in which anagen hair follicles are predominantly affected. Typically, from a single to multiple and round to oval patchy hair loss is observed in AA with a tendency for spontaneous regression; however, total scalp or whole-body hair loss can be seen in severe cases. 'IFN-γ-IL-15 cytokine loop' existing between autoreactive cytotoxic T cells and hair follicle epithelial cells underlies AA intractability, leading to the development of Janus kinase inhibitors (JAKis) inhibiting the downstream signaling pathways as remedies for severe AA. JAKis were shown to be effective and tolerable in clinical studies and now, baricitinib and ritlecitinib have been used for severe AA in Japan. Despite the fact that these medications can achieve clinically meaningful hair regrowth in around 30%-40% of treated patients, nearly 30% of patients have been found to be non-responders both in post-hoc analyses and real-world experience including ours. In addition, relapse can be seen not only in those who are downtitrated or discontinued medication but also in patients under treatment, leaving room for further improvement/development. New medications and/or dosing regimens tested in currently ongoing/planned clinical trials have potential to address JAKi-associated unmet needs in severe AA.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":" ","pages":"1-12"},"PeriodicalIF":2.9,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147533365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eosinophilic cholangitis mimicking IgG4-related sclerosing cholangitis in an older female patient. 1例老年女性患者嗜酸性胆管炎模拟igg4相关硬化性胆管炎。

IF 2.9

Immunological Medicine Pub Date : 2026-03-27 DOI: 10.1080/25785826.2026.2650902

Misa Kasahara, Keisuke Ojiro, Makoto Ueno, Yukie Nakadai, Takaya Tabuchi, Ryosuke Kasuga, Nobuhito Taniki, Shingo Usui, Nobuhiro Nakamoto, Takanori Kanai

引用次数: 0

A case of refractory Mooren's ulcer successfully treated with systemic immunosuppressive therapy. 全身免疫抑制治疗难治性摩尔氏溃疡1例。

IF 2.9

Immunological Medicine Pub Date : 2026-03-26 DOI: 10.1080/25785826.2026.2647494

Erika Yumori-Matsunaka, Kaoru Araki-Sasaki, Atsuko Ishimoto, Yoshio Ozaki, Hisanori Imai

{"title":"A case of refractory Mooren's ulcer successfully treated with systemic immunosuppressive therapy.","authors":"Erika Yumori-Matsunaka, Kaoru Araki-Sasaki, Atsuko Ishimoto, Yoshio Ozaki, Hisanori Imai","doi":"10.1080/25785826.2026.2647494","DOIUrl":"https://doi.org/10.1080/25785826.2026.2647494","url":null,"abstract":"We will report the efficacy and precautions for the systemic administration of immunosuppressants in refractory Mooren's ulcer. A 65-year-old woman with refractory Mooren's ulcer was referred to our hospital. Initial visual acuity was 0.01 (logMAR 2.0) in the right eye and hand motion vision in the left eye. The right eye showed anterior chamber hemorrhage and a circumscribed peripheral ulcer with corneal perforation. The patient underwent conjunctival excision and lamellar keratoplasty in the right eye. Systemic methylprednisolone and oral cyclosporine (CsA) were initiated, along with topical betamethasone and tacrolimus. Systemic medications were continued with gradual tapering. At 8.5 months, the patient developed varicella-zoster virus (VZV)-associated keratouveitis in the right eye. Systemic steroid administration was promptly discontinued, but CsA was continued at a reduced dose. Antiviral treatment led to prompt improvement. Oral CsA was discontinued after 16 months of treatment. The total cumulative dose of PSL was 1,803 mg, and CsA was 64,730 mg. No relapses occurred during 36 months of follow-up. Multidisciplinary care was required to manage systemic complications. The long-term systemic administration of steroids and immunosuppressants may be associated with sustained remission in a patient with refractory Mooren's ulcer with appropriate monitoring for various systemic conditions caused by immunosuppression.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":" ","pages":"1-6"},"PeriodicalIF":2.9,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recovery trajectories of TAFRO syndrome: a single-center case series highlighting prolonged thrombocytopenia and anasarca. TAFRO综合征的恢复轨迹：一个单中心病例系列，突出了延长的血小板减少和贫血。

IF 2.9

Immunological Medicine Pub Date : 2026-03-23 DOI: 10.1080/25785826.2026.2647499

Chiharu Miyamoto, Yo Ueda, Hirotaka Yamada, Naoe Jimbo, Takaichi Okano, Keisuke Nishimura, Sho Sendo, Tomoo Itoh, Jun Saegusa

{"title":"Recovery trajectories of TAFRO syndrome: a single-center case series highlighting prolonged thrombocytopenia and anasarca.","authors":"Chiharu Miyamoto, Yo Ueda, Hirotaka Yamada, Naoe Jimbo, Takaichi Okano, Keisuke Nishimura, Sho Sendo, Tomoo Itoh, Jun Saegusa","doi":"10.1080/25785826.2026.2647499","DOIUrl":"https://doi.org/10.1080/25785826.2026.2647499","url":null,"abstract":"TAFRO syndrome is a rare systemic inflammatory disorder characterized by thrombocytopenia, anasarca, fever or inflammation, reticulin fibrosis or renal dysfunction, and organomegaly. Despite increasing recognition, its natural history, particularly the timeline of organ-specific recovery, remains poorly understood. We retrospectively analyzed seven patients, encompassing nine treatment courses, diagnosed with TAFRO syndrome at our institution. Time to recovery was assessed across four clinical domains-renal dysfunction, systemic inflammation, anasarca, and thrombocytopenia-using predefined objective criteria. The median time to recovery was 7.0 days for renal dysfunction, 21.0 days for systemic inflammation, 24.0 days for anasarca, and 46.0 days for thrombocytopenia. Recovery of thrombocytopenia and anasarca tended to be delayed compared with that of renal dysfunction and systemic inflammation, with thrombocytopenia showing the longest median time to recovery. These findings indicate substantial heterogeneity in organ-specific recovery trajectories in TAFRO syndrome, with hematologic and fluid-related manifestations resolving more slowly than inflammatory or renal abnormalities. Recognition of domain-specific recovery timelines may aid interpretation of treatment responses and support more balanced, individualized management strategies.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":" ","pages":"1-11"},"PeriodicalIF":2.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Psoriasis Area and Severity Index Score and atherosclerotic risk in psoriasis patients using the Hisayama Score: a single-center retrospective study. 使用Hisayama评分的银屑病患者的银屑病面积和严重指数评分与动脉粥样硬化风险的关系：一项单中心回顾性研究

IF 2.9

Immunological Medicine Pub Date : 2026-03-17 DOI: 10.1080/25785826.2026.2641279

Airi Kobayashi, Hitoshi Terui, Ryoko Shimada-Omori, Toshiki Okazaki, Mana Sekine, Miyu Yano, Takehiro Takahashi, Yoshihide Asano

{"title":"Association between Psoriasis Area and Severity Index Score and atherosclerotic risk in psoriasis patients using the Hisayama Score: a single-center retrospective study.","authors":"Airi Kobayashi, Hitoshi Terui, Ryoko Shimada-Omori, Toshiki Okazaki, Mana Sekine, Miyu Yano, Takehiro Takahashi, Yoshihide Asano","doi":"10.1080/25785826.2026.2641279","DOIUrl":"https://doi.org/10.1080/25785826.2026.2641279","url":null,"abstract":"Psoriasis is a chronic immune-mediated skin disorder causing systemic inflammation, which significantly increases the risk of cardiovascular disease (CVD). In Japan, the Hisayama Score was recently introduced as a comprehensive tool to assess coronary artery disease and stroke risk. This retrospective study represents the first investigation applying the Hisayama Score to psoriasis patients to determine the association between the Psoriasis Area and Severity Index (PASI) and cardiovascular risk. We analyzed data from 119 patients aged 40-79 visiting Tohoku University Hospital between 2010 and 2022. After excluding 48 patients with pre-existing comorbidities like diabetes and chronic kidney disease, 71 participants remained. Patients were stratified into low, moderate, and high-risk groups based on blood pressure, lipid profiles, and smoking history. Results showed that higher PASI scores were significantly associated with increased cardiovascular risk (p = 0.003). Notably, male patients with PASI scores exceeding 10 were frequently categorized into moderate or high-risk groups (p = 0.049). Additionally, systolic blood pressure was identified as an independent predictor. These findings suggest that psoriasis severity correlates with elevated cardiovascular risk, validating the Hisayama Score's utility in this population and highlighting the critical need for dermatologists to implement proactive, interdisciplinary risk management strategies.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":" ","pages":"1-10"},"PeriodicalIF":2.9,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A patient with WHIM syndrome presenting relatively low TREC, KREC, and housekeeping gene levels by newborn screening -a case report and the literature review^. 新生儿筛查显示1例WHIM综合征患者TREC、KREC和管家基因水平相对较低- 1例报告及文献综述

IF 2.9

Immunological Medicine Pub Date : 2026-03-07 DOI: 10.1080/25785826.2026.2640306

Yuta Azuma, Shinsuke Hirabayashi, Masahiro Ueki, Ayako Ishikura, Jyunji Hanai, Mika Nakajima, Atushi Manabe

{"title":"A patient with WHIM syndrome presenting relatively low TREC, KREC, and housekeeping gene levels by newborn screening -a case report and the literature review.","authors":"Yuta Azuma, Shinsuke Hirabayashi, Masahiro Ueki, Ayako Ishikura, Jyunji Hanai, Mika Nakajima, Atushi Manabe","doi":"10.1080/25785826.2026.2640306","DOIUrl":"https://doi.org/10.1080/25785826.2026.2640306","url":null,"abstract":"WHIM syndrome is the inborn errors of immunity characterized by warts, hypogammaglobulinemia, infections, and myelokathexis, by the pathogenic variant in CXCR4. Patients with WHIM syndrome demonstrate neutropenia and lymphopenia due to the impaired migration of neutrophils and lymphocytes from the bone marrow. Diagnosis of patients with WHIM syndrome is often challenging, because some patients with WHIM syndrome do not show all characteristic four manifestations. T-cell receptor excision circle (TREC) and kappa-deleting recombination excision circle (KREC) assay is used for the screening of disease, such as severe combined immunodeficiencies and X-linked agammaglobulinemia. Several reports have shown that patients with WHIM syndrome show relatively low TREC or KREC levels, sometimes below the cut-off value. We present a patient with WHIM syndrome who developed recurrent viral and bacterial infections with myelokathexis. We assessed TREC, KREC, and a housekeeping gene marker levels at 5 days after birth and 3 years of age; although all values were relatively low, they remained above the established cut-off thresholds. We reviewed reports on TREC, KREC, and housekeeping gene levels in patients with WHIM syndrome and found that these patients generally showed relatively low levels of all three markers, with some values falling below the established cut-off thresholds.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":" ","pages":"1-6"},"PeriodicalIF":2.9,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical improvement of salt-and-pepper skin changes in juvenile systemic sclerosis using mycophenolate mofetil after intravenous methylprednisolone: a 3-year follow-up. 静脉注射甲基强的松龙后使用霉酚酸酯改善青少年系统性硬化症盐和胡椒皮肤变化的临床疗效：3年随访

IF 2.9

Immunological Medicine Pub Date : 2026-03-01 Epub Date: 2025-10-07 DOI: 10.1080/25785826.2025.2570899

Daisuke Hironaka, Hiroyuki Wakiguchi, Fumiko Okazaki, Yuno Korenaga, Yoshihiro Azuma, Akira Tanaka, Reiji Hirano, Yutaka Shimomura, Shunji Hasegawa

{"title":"Clinical improvement of salt-and-pepper skin changes in juvenile systemic sclerosis using mycophenolate mofetil after intravenous methylprednisolone: a 3-year follow-up.","authors":"Daisuke Hironaka, Hiroyuki Wakiguchi, Fumiko Okazaki, Yuno Korenaga, Yoshihiro Azuma, Akira Tanaka, Reiji Hirano, Yutaka Shimomura, Shunji Hasegawa","doi":"10.1080/25785826.2025.2570899","DOIUrl":"10.1080/25785826.2025.2570899","url":null,"abstract":"In adult systemic sclerosis (SSc), salt-and-pepper skin changes can be used to diagnose diffuse cutaneous SSc during the early stages. However, reports of juvenile SSc (JSSc) with salt-and-pepper skin changes are unavailable. A 12-year-old Japanese girl presented with JSSc, showing scleroderma, Raynaud's phenomenon, digital ulcers, and telangiectasia. She developed scleroderma at 10 years of age and later experienced salt-and-pepper skin changes. Laboratory findings revealed positive antinuclear and anti-U3-RNP antibodies. After being diagnosed with JSSc based on established criteria, she received two courses of intravenous methylprednisolone (IVMP) followed by mycophenolate mofetil (MMF). Her modified Rodnan skin score improved from 25 to 0, and the salt-and-pepper changes resolved. This case represents the first report of the presence and subsequent improvement of salt-and-pepper skin changes in JSSc treated with MMF following IVMP. Recognition of salt-and-pepper changes may serve as an early clinical clue, prompting further diagnostic evaluation for JSSc and supporting early diagnosis of adult SSc. Moreover, MMF after IVMP may exert beneficial anti-fibrotic effects, potentially improving pigment changes by controlling scleroderma.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":" ","pages":"125-129"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of T cell-mediated immune evasion in cervical cancer: a comprehensive bibliometric analysis and future research directions. 宫颈癌中T细胞介导的免疫逃避机制：综合文献计量学分析及未来研究方向

IF 2.9

Immunological Medicine Pub Date : 2026-03-01 Epub Date: 2025-09-19 DOI: 10.1080/25785826.2025.2560214

Xue Bai, Hongxia Wang, Qianyu Guo

引用次数: 0