Immunological Medicine最新文献_第10页

Comparison of complications during 1-year follow-up between remitting seronegative symmetrical synovitis with pitting edema syndrome and elderly-onset rheumatoid arthritis 缓解血清阴性对称性滑膜炎伴点状水肿综合征与老年性类风湿关节炎1年随访期间并发症的比较

IF 4.4

Immunological Medicine Pub Date : 2022-04-02 DOI: 10.1080/25785826.2022.2046307

T. Origuchi, M. Umeda, T. Koga, S. Kawashiri, N. Iwamoto, K. Ichinose, M. Tamai, T. Tsukada, T. Miyashita, N. Iwanaga, Y. Horai, K. Arima, T. Aramaki, Y. Ueki, K. Eguchi, A. Kawakami

{"title":"Comparison of complications during 1-year follow-up between remitting seronegative symmetrical synovitis with pitting edema syndrome and elderly-onset rheumatoid arthritis","authors":"T. Origuchi, M. Umeda, T. Koga, S. Kawashiri, N. Iwamoto, K. Ichinose, M. Tamai, T. Tsukada, T. Miyashita, N. Iwanaga, Y. Horai, K. Arima, T. Aramaki, Y. Ueki, K. Eguchi, A. Kawakami","doi":"10.1080/25785826.2022.2046307","DOIUrl":"https://doi.org/10.1080/25785826.2022.2046307","url":null,"abstract":"Abstract Remitting seronegative symmetrical synovitis with pitting edema syndrome (RS3PE), a rheumatic disease affecting the elderly, responds well to corticosteroids; however, our RS3PE patients' corticosteroid therapy is longer than expected. Elderly-onset rheumatoid arthritis (EORA) patients are reported to be at a significantly increased risk for steroid-related side effects including cardiovascular diseases (CVDs). To clarify the complications during a 1-year follow-up in corticosteroid-treated RS3PE patients compared to EORA patients. We retrospectively analyzed the records of 47 RS3PE patients (28 men, 19 women, age 78.4 ± 7.5 years) and 46 EORA patients (10 men, 36 women; 77.0 ± 6.8 yrs) to compare the complications over a 1-year follow-up. The RS3PE and EORA groups' average initial PSL doses were 16.5 ± 7.2 mg/day and 7.3 ± 4.6 mg/day, respectively. During the 1-year follow-up after treatment, there was no significant increase in CVDs in both groups. However, infections occurred in nine RS3PE patients, which is a significantly higher incidence compared to the EORA patients with infections (n = 3). The initial PSL dose was the independent variable associated with the incidence of infection. Infections were significantly increased during elderly RS3PE patients' steroid therapy. The initial corticosteroid dose was an infection-risk factor. Key messages Infections are increased during steroid therapy in elderly patients with RS3PE syndrome. The initial dose of corticosteroids was one of the risk factors for infections.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44717873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Prevalence and predictive factors of difficult-to-treat rheumatoid arthritis: the KURAMA cohort. 难治性类风湿关节炎的患病率和预测因素:KURAMA队列。

IF 4.4

Immunological Medicine Pub Date : 2022-03-01 Epub Date: 2021-05-25 DOI: 10.1080/25785826.2021.1928383

Ryu Watanabe, Motomu Hashimoto, Koichi Murata, Kosaku Murakami, Masao Tanaka, Koichiro Ohmura, Hiromu Ito, Shuichi Matsuda

{"title":"Prevalence and predictive factors of difficult-to-treat rheumatoid arthritis: the KURAMA cohort.","authors":"Ryu Watanabe, Motomu Hashimoto, Koichi Murata, Kosaku Murakami, Masao Tanaka, Koichiro Ohmura, Hiromu Ito, Shuichi Matsuda","doi":"10.1080/25785826.2021.1928383","DOIUrl":"https://doi.org/10.1080/25785826.2021.1928383","url":null,"abstract":"Difficult-to-treat rheumatoid arthritis (D2T RA) is a multifactorial condition in which disease activity of RA persists despite consecutive treatment with biological or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs). To evaluate the prevalence and predictive risk factors of D2T RA in our institution, a single-center, retrospective study was conducted. Medical records of RA patients, who visited our hospital from 2011 to 2020 and had a follow-up of more than 6 months, were retrospectively reviewed. D2T RA was defined as RA with a disease activity score of 28 - erythrocyte sedimentation rate (DAS28-ESR) of 3.2 or higher at the last visit, despite the use of at least two b/tsDMARDs. A logistic regression model was used to identify risk factors. A total of 672 patients were enrolled. The mean age at disease onset was 52.1 years and females were dominant (76.3%). After a mean follow-up of 46.6 months, patients with D2T RA accounted for 7.9% of overall patients. Multivariate analysis identified high rheumatoid factor (RF) levels (≥156.4 IU/mL, odds ratio [OR]: 1.95), DAS28-ESR (OR: 1.24), and coexisting pulmonary disease (OR: 2.03) as predictive risk factors of D2T RA. In conclusion, high RF levels, high DAS28-ESR, and coexisting pulmonary disease at baseline can predict the development of D2T RA.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/25785826.2021.1928383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39017230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Emerging role of leptin in joint inflammation and destruction. 瘦素在关节炎症和破坏中的新作用。

IF 4.4

Immunological Medicine Pub Date : 2022-03-01 Epub Date: 2021-08-06 DOI: 10.1080/25785826.2021.1948689

Haruka Tsuchiya, Keishi Fujio

引用次数: 4

Adaptive immunity in the joint of rheumatoid arthritis. 类风湿关节炎关节的适应性免疫。

IF 4.4

Immunological Medicine Pub Date : 2022-03-01 Epub Date: 2021-05-30 DOI: 10.1080/25785826.2021.1930371

Hisakata Yamada

{"title":"Adaptive immunity in the joint of rheumatoid arthritis.","authors":"Hisakata Yamada","doi":"10.1080/25785826.2021.1930371","DOIUrl":"https://doi.org/10.1080/25785826.2021.1930371","url":null,"abstract":"Adaptive immunity plays central roles in the pathogenesis of rheumatoid arthritis (RA), as it is regarded as an autoimmune disease. Clinical investigations revealed infiltrations of B cells in the synovium, especially those with ectopic lymphoid neogenesis, associate with disease severity. While some B cells in the synovium differentiate into plasma cells producing autoantibodies such as anti-citrullinated protein antibody, others differentiate into effector B cells producing proinflammatory cytokines and expressing RANKL. Synovial B cells might also be important as antigen-presenting cells. Synovial T cells are implicated in the induction of antibody production as well as local inflammation. In the former, a recently identified CD4 T cell subset, peripheral helper T (Tph), which is characterized by the expression of PD-1 and production of CXCL13 and IL-21, is implicated, while the latter might be mediated by Th1-like CD4 T cell subsets that can produce multiple proinflammatory cytokines, including IFN-γ, TNF-α, and GM-CSF, and express cytotoxic molecules, such as perforin, granzymes and granulysin. CD8 T cells in the synovium are able to produce large amount of IFN-γ. However, the involvement of those lymphocytes in the pathogenesis of RA still awaits verification. Their antigen-specificity also needs to be clarified.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/25785826.2021.1930371","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39032518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Characteristics and management of ocular sarcoidosis. 眼结节病的特点及治疗。

IF 4.4

Immunological Medicine Pub Date : 2022-03-01 Epub Date: 2021-07-02 DOI: 10.1080/25785826.2021.1940740

Hiroshi Takase

引用次数: 6

New mimic of relapse or regional lymph node metastasis in a cancer survivor: a case of mRNA COVID-19 vaccine-induced lymphadenitis with high FDG uptake. 癌症幸存者复发或局部淋巴结转移的新模拟物:mRNA - COVID-19疫苗诱导的淋巴结炎伴高FDG摄取病例

IF 4.4

Immunological Medicine Pub Date : 2022-03-01 Epub Date: 2021-12-16 DOI: 10.1080/25785826.2021.1999786

Yusuke Tsumura, Koiku Asakura, Ikuko Takahashi, Mitsuko Akaihata, Yoshiyuki Takahashi, Yuji Ishida

引用次数: 4

Anti-interferon-gamma autoantibody related disseminated nontuberculous mycobacteriosis with pathological features of immunoglobulin G4-related disease. 具有免疫球蛋白g4相关疾病病理特征的抗干扰素γ自身抗体相关弥散性非结核分枝杆菌病

IF 4.4

Immunological Medicine Pub Date : 2022-03-01 Epub Date: 2021-05-25 DOI: 10.1080/25785826.2021.1914962

Norihiro Nagamura, Toshihiro Imada

{"title":"Anti-interferon-gamma autoantibody related disseminated nontuberculous mycobacteriosis with pathological features of immunoglobulin G4-related disease.","authors":"Norihiro Nagamura, Toshihiro Imada","doi":"10.1080/25785826.2021.1914962","DOIUrl":"https://doi.org/10.1080/25785826.2021.1914962","url":null,"abstract":"A 72-year-old man who was diagnosed as pulmonary mycobacterium avium complex (MAC) disease had suffered from antibiotics resistant fever with left renal enlargement surrounded by inflammatory change and multiple osteolytic lesions on computed tomography (CT). The renal biopsied samples pathologically showed immunoglobulin G4 (IgG4) positive plasma cell infiltration and many acid-fast bacilli without granuloma formation. Nucleic acid identification test for MAC from the samples of vertebral osteolytic lesion was positive. In the autopsy samples from left kidney, epithelioid cell granuloma and Langhans giant cell with many acid-fast bacilli were shown pathologically. In addition to osteolytic lesions on CT study, these pathological findings were not consistent with IgG4-related disease (IgG4-RD). The diagnosis of disseminated nontuberculous mycobacteriosis was made, and plasma anti-interferon-gamma (IFN-γ) autoantibody was found as the cause of underlying immunodeficiency. Disturbed function of IFN-γ resulted in impaired ability of phagocytic cells against pathogens and leading to spread of infection. T-helper type 2 dominant immune response was induced by prolonged antigenic stimulation of mycobacteria, which might have contributed to form the pathological features of IgG4-RD.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/25785826.2021.1914962","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39017232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Arthritis-associated osteoclastogenic macrophages (AtoMs) participate in pathological bone erosion in rheumatoid arthritis. 关节炎相关的破骨细胞巨噬细胞(原子)参与类风湿关节炎的病理性骨侵蚀。

IF 4.4

Immunological Medicine Pub Date : 2022-03-01 Epub Date: 2021-06-30 DOI: 10.1080/25785826.2021.1944547

Tomoya Agemura, Tetsuo Hasegawa, Shinya Yari, Junichi Kikuta, Masaru Ishii

{"title":"Arthritis-associated osteoclastogenic macrophages (AtoMs) participate in pathological bone erosion in rheumatoid arthritis.","authors":"Tomoya Agemura, Tetsuo Hasegawa, Shinya Yari, Junichi Kikuta, Masaru Ishii","doi":"10.1080/25785826.2021.1944547","DOIUrl":"https://doi.org/10.1080/25785826.2021.1944547","url":null,"abstract":"Rheumatoid arthritis is a chronic form of arthritis that causes bone destruction in joints such as the knees and fingers. Over the past two decades, the clinical outcomes of rheumatoid arthritis have improved substantially with the development of biological agents and Janus kinase inhibitors. Osteoclasts are myeloid lineage cells with a unique bone-destroying ability that can lead to joint destruction. On the other hand, osteoclasts play an important role in skeletal homeostasis by supporting bone remodeling together with osteoblasts in the bone marrow under steady-state conditions. However, the same osteoclasts are considered to participate in physiological bone remodeling and joint destruction. We found that pathological osteoclasts have different differentiation pathways and regulatory transcription factors compared to physiological osteoclasts. We also identified arthritis-associated osteoclastogenic macrophages (AtoMs), which are common progenitors of pathological osteoclasts in mice and humans that develop specifically in inflamed synovial tissue. This review presents details of the newly identified AtoMs and the original intravital imaging systems that can visualize synovial tissue and pathological osteoclasts at the pannus-bone interface.","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/25785826.2021.1944547","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39141753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

B cell targeted therapy for immunoglobulin G4-related disease. 免疫球蛋白g4相关疾病的B细胞靶向治疗。

IF 4.4

Immunological Medicine Pub Date : 2021-12-01 Epub Date: 2021-02-14 DOI: 10.1080/25785826.2021.1886630

Motohisa Yamamoto

引用次数: 10

Black-blood magnetic resonance imaging suggesting central nervous system vasculitis in moyamoya syndrome associated with systemic lupus erythematosus. 黑血磁共振成像提示烟雾综合征与系统性红斑狼疮相关的中枢神经系统血管炎。

IF 4.4

Immunological Medicine Pub Date : 2021-12-01 Epub Date: 2021-02-17 DOI: 10.1080/25785826.2021.1878728

Keiichiro Kadoba, Keisuke Nishimura, Daisuke Waki, Tsutomu Okada, Takao Kumazawa, Rintaro Saito, Hiroyuki Murabe, Toshihiko Yokota

引用次数: 0