特发性炎性肌病小鼠模型。

IF 2.7 Q3 IMMUNOLOGY
Risa Konishi, Yuki Ichimura, Naoko Okiyama
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引用次数: 0

摘要

特发性炎症性肌病(IIMs)的特征是肌肉和其他器官的炎症。在IIMs中发现了几种肌炎特异性自身抗体(msa),并发现它们与不同的临床特征相关。尽管msa对IIMs的诊断有价值,但这些抗体的致病作用尚不清楚。为了研究IIMs的发病机制,我们建立了几种实验性肌炎动物模型。经典的自身免疫性肌炎、实验性自身免疫性肌炎和C蛋白诱导的肌炎小鼠模型分别通过肌肉特异性抗原、肌球蛋白和骨骼C蛋白免疫建立。此外,通过小鼠重组组氨酸- trna合成酶Jo-1免疫建立小鼠实验性肌炎模型,通过获得性免疫诱导反映抗合成酶综合征的肌肉和肺部炎症。最近,来自免疫介导的坏死性肌病患者的人igg的转移,包括抗信号识别颗粒和抗3-羟基-3-甲基戊二酰辅酶A还原酶抗体,被发现在受体小鼠中诱导补体介导的肌炎。CD8+ T细胞介导的肌炎可通过对转录中介因子1γ (TIF1γ)的自身免疫而建立,TIF1γ是重组人TIF1γ免疫诱导的msa的自身抗原。这些反映msa相关IIMs的新小鼠模型是准确理解IIMs病理机制的有用工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Murine models of idiopathic inflammatory myopathy.
Abstract Idiopathic inflammatory myopathies (IIMs) are characterized by inflammation of muscles and other organs. Several myositis-specific autoantibodies (MSAs) have been identified in IIMs and were found to be associated with distinct clinical features. Although MSAs are valuable for the diagnosis of IIMs, the pathogenic roles of these antibodies remain unknown. To investigate the pathogenesis of IIMs, several animal models of experimental myositis have been established. Classical murine models of autoimmune myositis, experimental autoimmune myositis, and C protein-induced myositis are established by immunization with muscle-specific antigens, myosin, and skeletal C protein, respectively. Furthermore, a murine model of experimental myositis was generated by immunization with a murine recombinant histidyl-tRNA synthetase, Jo-1, in which muscle and lung inflammation reflecting anti-synthetase syndrome are induced depending on acquired immunity. Recently, the transfer of human IgGs from patients with immune-mediated necrotizing myopathy, comprising anti-signal recognition particles and anti-3-hydroxy-3-methylglutaryl coenzyme A reductase antibodies, was found to induce complement-mediated myositis in recipient mice. CD8+ T cell-mediated myositis can be established depending on autoimmunity against transcriptional intermediary factor 1γ (TIF1γ), an autoantigen for MSAs induced by recombinant human TIF1γ immunization. These new murine models reflecting MSA-related IIMs are useful tools for accurately understanding the pathological mechanisms underlying IIMs.
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来源期刊
Immunological Medicine
Immunological Medicine Medicine-Immunology and Allergy
CiteScore
7.10
自引率
2.30%
发文量
19
审稿时长
19 weeks
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