Journal of Molecular Liquids最新文献

{"title":"Exploring the interaction between JQ1 and IgG: An integrative multispectroscopic and in-silico approach","authors":"Swathy Ravindran ,&nbsp;Bobby Paul ,&nbsp;Padmanaban S. Suresh","doi":"10.1016/j.molliq.2026.129344","DOIUrl":"10.1016/j.molliq.2026.129344","url":null,"abstract":"<div><div>JQ1, a potent bromodomain inhibitor of BET proteins, has gained significant interest for its anticancer potential. However, its clinical use is limited by its very short half-life in circulation. Investigating the interaction of JQ1 with serum proteins provides an alternative method to enhance its stability and prolong the circulation time. Our previous reports revealed the potential binding of JQ1 with human serum albumin (HSA). In this study, we explored the interactions of JQ1 with Immunoglobulin G (IgG), another major serum protein, using spectroscopic and <em>in-silico</em> methods. UV–visible and fluorescence techniques showed static quenching and stable JQ1–IgG complex formation. Stern-Volmer analysis yielded a binding constant of 8.36 × 10⁴ L mol⁻¹ at 298 K, and n ≈ 1 from the double-logarithmic plot indicating single-site binding. Thermodynamic parameters (ΔH⁰ = − 48.35 kJ mol⁻¹ and ΔS⁰ = −182.1 mol⁻¹ K⁻¹) suggest spontaneous binding dominated by hydrogen bonding and Van der Waals forces. Circular dichroism revealed a slight increase in IgG β-sheet content from 45.1% to 49.9%, indicating conformational stabilization. Molecular docking and molecular dynamics simulations further supported the experimental findings, showing that JQ1 occupies binding pockets in the Fab and Fc regions, stabilized primarily by hydrogen bonding and π–π stacking interactions. MM-GBSA binding energy calculations also highlighted Van der Waals-dominated interactions, particularly in the Fc region. Collectively, this study provides spectroscopic and computational evidence of the IgG-JQ1 interaction, suggesting that IgG can influence the pharmacokinetics of JQ1 under physiological conditions.</div></div>","PeriodicalId":371,"journal":{"name":"Journal of Molecular Liquids","volume":"448 ","pages":"Article 129344"},"PeriodicalIF":5.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing nanoscale molecular organization in Liquid Crystals via cryogenic Atom Probe Tomography","authors":"Kuan Meng ,&nbsp;Kang'an Wang ,&nbsp;Sebastian Eich ,&nbsp;Pierre Nacke ,&nbsp;Johanna R. Bruckner ,&nbsp;Patrick Stender ,&nbsp;Frank Giesselmann ,&nbsp;Guido Schmitz","doi":"10.1016/j.molliq.2026.129358","DOIUrl":"10.1016/j.molliq.2026.129358","url":null,"abstract":"<div><div>While liquid crystals (LCs) have been extensively studied, obtaining a comprehensive nanoscale picture of their molecular organization remains challenging, as conventional techniques face an intrinsic trade-off between spatial and chemical resolution. Here, cryogenic atom probe tomography (cryo-APT) is introduced as a new analytical approach for LC materials, using 4′-pentyl-4-cyanobiphenyl (5CB) and 4′-octyl-4-cyanobiphenyl (8CB) as representative model compounds. This was enabled by a tailored cryogenic focused ion beam (cryo-FIB) protocol optimized for small organic molecules. The method enables controlled field evaporation of both intact molecules and diagnostic fragments, achieving over 90% molecular retention while preserving four characteristic dissociation patterns. By spatially correlating these fragmentation profiles with the local electric field derived from the tip geometry, we reveal field-directed dissociation pathways of the <em>n</em>CB molecules. In parallel, the distribution of intact molecular ions enables nanoscale visualization of material structure. The observed structures correspond to frozen configurations that kinetically preserve molecular arrangements inherited from the parent LC state, rather than equilibrium LC phases. We resolve homogeneous mixing of 5CB and 8CB in the nematic phase and directly observe the sub-nanometer crystalline layering in a supercooled 8CB sample, with contrast to the surrounding amorphous matrix suggesting the presence of a solid-liquid interfacial configuration. This work establishes cryo-APT as a new powerful analytical platform for LC research and reveals its broad potential for application in soft matter systems, as it enables 3D atomic-scale compositional mapping of LC systems which conventional microscopy techniques struggle to analyze.</div></div>","PeriodicalId":371,"journal":{"name":"Journal of Molecular Liquids","volume":"448 ","pages":"Article 129358"},"PeriodicalIF":5.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surfactant-induced modulation of collagen dynamics and rheological behaviour","authors":"Anjali C. Venkitesan ,&nbsp;Nitin P. Lobo ,&nbsp;N. Nishad Fathima","doi":"10.1016/j.molliq.2026.129354","DOIUrl":"10.1016/j.molliq.2026.129354","url":null,"abstract":"<div><div>Analysing and understanding the dynamics and structural changes associated with protein–surfactant interactions is important in protein chemistry and physical biochemistry. This study examines the impact of various surfactants (anionic – sodium dodecyl sulfate (SDS), cationic – cetyltrimethylammonium bromide (CTAB), and non-ionic – Triton X-100 (TX-100) on the hydration dynamics and rheological properties of collagen solutions. Using a combination of spectroscopic techniques, such as Nuclear Magnetic Resonance (NMR) and Raman spectroscopy, the changes in the coordination and mobility of the water network surrounding collagen are studied. The rotational rheometer is equipped to study the viscoelastic properties of collagen-surfactant solutions. It is observed that the type and concentration of surfactant affect the dynamics of the hydration network and the resulting mechanical behaviour of collagen-surfactant mixtures. Ionic surfactants, especially SDS, improve the stability of hydration layers and, hence, the viscosity and elastic modulus increase. In contrast, the non-ionic surfactant (TX-100) slightly enhances the mobility of the hydration shell, resulting in decreased viscosity and a lower elastic modulus. These findings highlight the significance of water surfactant interactions in determining the macroscopic rheological behaviour of collagen-based systems, providing new insights for the development of functional biopolymer materials for biomedical and cosmetic applications.</div></div>","PeriodicalId":371,"journal":{"name":"Journal of Molecular Liquids","volume":"448 ","pages":"Article 129354"},"PeriodicalIF":5.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural, dielectric, thermal, antioxidant activity, and antibacterial efficiency of electrospun PVA/PVP/TiO2-GO nanocomposites","authors":"İbrahim Erol ,&nbsp;İbrahim İsmail ,&nbsp;Ömer Hazman ,&nbsp;Gofur Khamidov ,&nbsp;Esra Efe ,&nbsp;Sedat Yurdakal","doi":"10.1016/j.molliq.2026.129360","DOIUrl":"10.1016/j.molliq.2026.129360","url":null,"abstract":"<div><div>Electrospun nanofiber composites based on PVA/PVP incorporating TiO₂ nanowires and graphene oxide (GO) were fabricated, and the effects of GO loadings (0.5%, 1%, and 2%) on their structural, surface/interface, thermal, dielectric, and biological properties were systematically investigated. FTIR analysis confirmed hydrogen bonding and coordination interactions between GO/TiO₂ and polymer chains, while XRD verified the anatase phase of TiO₂ and revealed changes in polymer crystallinity. SEM images showed a marked reduction in average fiber diameter, from 396 to 122 nm, with increasing GO, and improved morphological uniformity. Surface characterization by contact angle and surface free energy analyses revealed a gradual increase in hydrophobicity, with the water contact angle rising from 38.9° for the PVA–PVP/TiO₂ nanocomposite to 43.1° for the sample containing 2 wt% GO, accompanied by a reduction in surface free energy from 60.25 to 58.97 mN/m. These changes indicate the formation of more stable, low-energy interfaces, which are highly desirable for durable coating applications. Thermal analysis revealed enhanced stability, with the temperature corresponding to 50% weight loss (T₅₀) increasing from 315 to 342 °C, and the glass transition temperature rising from 118 to 131 °C at a 2 wt% GO loading. Dielectric measurements revealed an increase in dielectric constant (from 1.9 to 2.7 at 1 kHz) and AC conductivity (up to 7.5 × 10⁻⁶ S/cm at 1 MHz), confirming the role of GO in enhancing charge transport. Biological assays further demonstrated improved antioxidant activity through enhanced DPPH radical scavenging and increased antibacterial efficiency, particularly against Gram-negative strains. Overall, the incorporation of GO led to systematic improvements in the structural uniformity, dielectric response, thermal stability, antioxidant activity, and antibacterial efficiency of the PVA–PVP/TiO₂ nanocomposites. These results demonstrate that controlled GO loading is an effective strategy for tailoring the functional properties of electrospun polymer-based nanocomposites.</div></div>","PeriodicalId":371,"journal":{"name":"Journal of Molecular Liquids","volume":"448 ","pages":"Article 129360"},"PeriodicalIF":5.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlating chemico-physical features of thymol-based deep eutectic solvents with astaxanthin extraction performances","authors":"Vanessa Spadavecchia ,&nbsp;Matteo Ballottari ,&nbsp;Nico Betterle ,&nbsp;Edoardo Ceschi ,&nbsp;Paola Galletti ,&nbsp;Lorenzo Montalbetti ,&nbsp;Laura Pezzolesi ,&nbsp;Diego Romano Perinelli ,&nbsp;Chiara Samorì ,&nbsp;Matteo Tiecco","doi":"10.1016/j.molliq.2026.129357","DOIUrl":"10.1016/j.molliq.2026.129357","url":null,"abstract":"<div><div>Hydrophobic/water-insoluble Deep Eutectic Solvents (DESs), such as the thymol-based ones, are widely used and studied for the extraction and pre-concentration of valuable compounds from various matrices. In this paper, a structure-activity approach was used to determine the factors that influence the efficacy of a series of thymol-based hydrophobic DESs applied for the extraction of astaxanthin from genetically-modified <em>Picosynechococcus</em> sp. PCC 11901, a recently discovered cyanobacterium. As expected, the polarity of the media plays a significant role, but surprisingly, the intimacy of the molecules forming the DESs has a relevant role in the process as well, showing this parameter to be crucial for their performances. This parameter is also linked to the viscosity, which is also playing a key role in the processes. Moreover, the comparison of the results with an ideal non-DES mixture showed a non-correlation of this liquid with the set of DESs used, underlining the importance of the liquid's identity determination in this field.</div></div>","PeriodicalId":371,"journal":{"name":"Journal of Molecular Liquids","volume":"448 ","pages":"Article 129357"},"PeriodicalIF":5.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental and computational insights into nitrogen retention and controlled release in glauconite-based nanocomposites","authors":"Evgeny Tararushkin ,&nbsp;Alexey Ruban ,&nbsp;Hongling Bu ,&nbsp;Wei Yanfu ,&nbsp;Maxim Rudmin","doi":"10.1016/j.molliq.2026.129359","DOIUrl":"10.1016/j.molliq.2026.129359","url":null,"abstract":"<div><div>This study investigates the molecular mechanisms governing ammonium interactions with glauconite, a potassium- and iron-rich phyllosilicate, focusing on the structure and dynamics of aqueous NH₄NO₃ solutions confined at mineral interfaces. Glauconite-ammonium nanocomposites (GANs) were prepared with varying ammonium concentrations and characterized by X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, scanning electron microscopy, Brunauer-Emmett-Teller method, and differential thermogravimetric analysis. Molecular dynamics simulations were performed to resolve ion coordination modes, hydrogen-bonding environments, and interfacial organization within the confined aqueous phase. Controlled-release behavior was evaluated through leaching experiments, and molecular simulations elucidated the adsorption mechanisms. Oat growth experiments assessed the agricultural efficacy of GANs.</div><div>Ammonium incorporation into glauconite basal planes was confirmed, with basal reflection shifts to 17.0 Å indicating effective adsorption. The combined structural and spectroscopic evidence confirms that NH₄⁺ retention is controlled by inner- and outer-sphere complexation and by the stability of the interfacial hydrogen-bond network. Simulations further reveal concentration-dependent reorganization of the interfacial layers and variations in ion mobility that govern ammonium release. Leaching experiments demonstrated controlled release of ammonium, nitrate, and potassium, highlighting the potential of GANs to reduce nutrient losses. Oat growth tests showed a yield increase of up to 15.9%, demonstrating the efficacy of GANs in enhancing agricultural productivity.</div><div>The multiscale integration of experimental data and molecular simulations provides a molecular-level framework describing ion coordination, interfacial hydration, and transport processes in confined NH₄NO₃ solutions. These findings are relevant for understanding ion behavior in layered mineral systems and for designing mineral-based matrices with tunable release properties.</div></div>","PeriodicalId":371,"journal":{"name":"Journal of Molecular Liquids","volume":"448 ","pages":"Article 129359"},"PeriodicalIF":5.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defective dicubane cobalt clusters as selective anticancer agents: dual DNA/BSA targeting and structural-biological correlations","authors":"Mahtab Gheytasi Zarouny ,&nbsp;Shayan Golpar Kavishahi ,&nbsp;Zahra Asadi ,&nbsp;Michal Dusek ,&nbsp;Monika Kucerakova ,&nbsp;Banafsheh Rastegari","doi":"10.1016/j.molliq.2026.129330","DOIUrl":"10.1016/j.molliq.2026.129330","url":null,"abstract":"<div><div>Two novel tetranuclear mixed-valence cobalt (II/III) clusters (<strong>C1</strong> and <strong>C2</strong>), featuring defective dicubane architectures, were synthesized and structurally characterized <em>via</em> single-crystal X-ray diffraction and complementary spectroscopic techniques. Both clusters crystallize in a triclinic system (space group P-1), exhibiting two missing vertices in the dicubane core. Comprehensive <em>in-vitro</em> interaction studies were conducted with fish sperm DNA (FS-DNA) and bovine serum albumin (BSA) for the free ligand (<strong>H</strong>_{<strong>3</strong>}<strong>L</strong>) and both clusters. DNA-binding assays including, UV–Vis spectroscopy titration, fluorescence quenching, cyclic voltammetry, viscosity measurements, circular dichroism, and molecular docking, revealed intercalation as the dominant binding mode. Binding affinities followed the order <strong>C2</strong> &gt; <strong>C1</strong> &gt; <strong>H</strong>_{<strong>3</strong>}<strong>L</strong>, underscoring the role of structural features in nucleic acid interaction. Protein-binding studies using fluorescence quenching, UV–Vis spectroscopy, synchronous spectroscopy, site-marker analysis, circular dichroism, and docking simulations indicated preferential binding at site (I) of BSA. The affinity trend (<strong>C1</strong> &gt; <strong>C2</strong> &gt; <strong>H</strong>_{<strong>3</strong>}<strong>L</strong>) again highlighted the influence of cluster geometry. Hirshfeld surface analysis provided further insight into intermolecular interactions. Biological evaluation against leukemia cell lines demonstrated selective cytotoxicity, with both clusters inducing DNA fragmentation, elevated ROS generation, and S-phase cell cycle arrest, ultimately triggering apoptosis in Jurkat cells.</div></div>","PeriodicalId":371,"journal":{"name":"Journal of Molecular Liquids","volume":"448 ","pages":"Article 129330"},"PeriodicalIF":5.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroelectric and dielectric studies of a ferroelectric liquid crystal (FLC) dispersed ferroelectric nanoparticles (NPs): Impact of NP dispersions on the rotational viscoelastic properties of the FLC","authors":"Alejandro Segovia Mera ,&nbsp;Yahia Boussoualem ,&nbsp;Benoıt Duponchel ,&nbsp;Yaochen Lin ,&nbsp;Jean-François Blach ,&nbsp;Sébastien Saitzek ,&nbsp;Carine Davoisne ,&nbsp;Redouane Douali ,&nbsp;Abdelylah Daoudi","doi":"10.1016/j.molliq.2026.129363","DOIUrl":"10.1016/j.molliq.2026.129363","url":null,"abstract":"<div><div>This study focuses on the effects of dispersing tin thiohypodiphosphate ferroelectric nanoparticles (Sn₂P₂S₆) on the structural, ferroelectric, and dielectric properties of a ferroelectric liquid crystal (SmC*) phase. Our findings show that nanoparticle dispersion leads to modifications in phase transition temperatures, spontaneous polarization, and dielectric relaxation modes associated with ferroelectricity. These effects are attributed to changes in the viscoelastic parameters of the SmC* phase. Two concentration regimes were identified: at low concentrations, nanoparticles are well-dispersed, introducing local defects in the smectic layers and distortions in the helical structure, thereby enhancing the viscoelastic properties of the FLC. At higher concentrations, aggregation of nanoparticles reduces the dispersion effects, and the nanocomposite behavior tends to resemble that of the pure liquid crystal.</div></div>","PeriodicalId":371,"journal":{"name":"Journal of Molecular Liquids","volume":"448 ","pages":"Article 129363"},"PeriodicalIF":5.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, and theoretical investigation of picolinaldehyde-derived liquid crystals with cinnamate and chalcone functionalities","authors":"Jaimin Panchal ,&nbsp;Priyanka Yadav ,&nbsp;Vinay S. Sharma ,&nbsp;Hitendra Mali ,&nbsp;Parth Parmar ,&nbsp;Hemant R. Prajapati","doi":"10.1016/j.molliq.2026.129365","DOIUrl":"10.1016/j.molliq.2026.129365","url":null,"abstract":"<div><div>A newly picolinaldehyde embedded chalcone-cinnamate linked heterocyclic compounds <strong>(d</strong>_{<strong>1</strong>}<strong>-d</strong>_{<strong>4</strong>}<strong>)</strong> were obtained and fully characterized by spectroscopic techniques. All four pyridine-based derivatives were examined for their thermal and liquid crystalline behavior. One terminal end of the phenyl ring has been replaced by variable alkoxy side chain whereas the other terminal end was fixed with chalcone substituted with pyridine core. All four calamitic LCs displayed nematic type mesomorphic properties confirmed by POM study. For better understanding about the correlation between mesophase with respect to molecular structure, structure property relationship has been carried out with the comparison of structurally related similar series. The phase transition behavior and thermal stability of all four compounds were examined using DSC. The TGA analysis revealed thermal stability of molecules up to 400 °C. All compounds displayed an enantiotropic nematic phase with narrow mesophase range up to 35 °C (cooling) and broad thermal stability. The DFT calculations were performed for all four compounds to investigate the electronic properties and reactivity. Relatively high bandgap values of 3.7 eV were calculated which was consistent with all compounds in series. The relationship between the mesophase behavior of the heterocyclic framework and its electronic properties (dipole moment, HOMO-LUMO levels, bandgap, polarizability) was systematically analyzed. The findings highlight the influence of molecular architecture on phase stability, mesophase range, and transition temperatures, offering insights into structure-property correlations.</div></div>","PeriodicalId":371,"journal":{"name":"Journal of Molecular Liquids","volume":"448 ","pages":"Article 129365"},"PeriodicalIF":5.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into spectrofluorimetric analysis in deep eutectic solvents","authors":"Zeliha Akçin,&nbsp;Tuğçe Emre,&nbsp;Orhan Gezici","doi":"10.1016/j.molliq.2026.129325","DOIUrl":"10.1016/j.molliq.2026.129325","url":null,"abstract":"<div><div>Deep eutectic solvents (DESs) have recently attracted considerable attention as tunable liquid media capable of modulating the photophysical behavior of dissolved species. In this study, the fluorescence characteristics of Rhodamine B were systematically investigated in two model DESs—choline chloride/urea (DES-U) and choline chloride/ethylene glycol (DES-E)—and their aqueous mixtures. The results demonstrate that DES composition and water content exert a pronounced influence on fluorescence intensity, emission wavelength, detection limits, and dynamic linear ranges. Compared to water, DES-based systems generally enhance fluorescence response, induce bathochromic shifts, and provide lower limit of detection, albeit with narrower linear dynamic ranges. These effects are attributed primarily to solvent-controlled protonation–deprotonation equilibria and aggregate formation arising from the unique microenvironments of DESs. The findings highlight the potential of DESs as designable media for fluorescence-based analytical applications.</div></div>","PeriodicalId":371,"journal":{"name":"Journal of Molecular Liquids","volume":"447 ","pages":"Article 129325"},"PeriodicalIF":5.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}