Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine最新文献

{"title":"Magnesium - The Silent Partner or the Next Vitamin D? Shifting Paradigm in Mineral Metabolism in Health and Disease.","authors":"Sibtain Ahmed, Afrah Abdul Sattar, Imran Siddiqui","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 1","pages":"5-8"},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case-Based Analysis of Pre-analytical and Analytical Non-Conformities in Urinary Protein Testing.","authors":"Sajjad Bakhtiari, Majid Sirati-Sabet, Anisha Mathew, Vivek Pant","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Accurate quantification of urinary protein is fundamental for the diagnosis, monitoring, and management of kidney disease. Despite technological advances, both pre-analytical and analytical non-conformities in laboratory testing remain significant sources of misinterpretation that can adversely affect clinical decision-making. This report analyzes two such cases to highlight common but critical pitfalls in proteinuria assessment. We present two illustrative cases: the first involves a pediatric patient, where a pre-analytical non-conformity led to a significant overestimation of proteinuria severity. The second case describes an elderly diabetic patient where an analytical non-conformity resulted in a profound underestimation of albuminuria. In both instances, discrepancies between semi-quantitative and quantitative results were the critical clues that prompted investigation. These cases underscore that urinary protein results, while quantitative, are not infallible. Vigilant attention to pre-analytical procedures, strict adherence to analytical limits, and the integration of semi-quantitative results as a plausibility check are essential to prevent diagnostic non-conformities. Effective communication between clinicians and laboratory professionals is paramount to ensure that laboratory results accurately inform, rather than misdirect, clinical decision-making.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 1","pages":"181-190"},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations of Parathormone and Biochemical Parameters in Chronic Kidney Disease.","authors":"Hamide Shllaku-Sefa, Ndok Marku","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Hyperparathyroidism due to chronic kidney disease (CKD) is a common complication characterized by elevated parathyroid hormone (PTH) levels secondary to derangements in the homeostasis of calcium and phosphorus. The aim of our study was to figure out PTH, calcium, phosphorus, and magnesium levels in CKD and the possible correlations between them and the stages of CKD.</p><p><strong>Materials and methods: </strong>We performed a prospective study including 217 outpatients with levels of serum creatinine out of reference range from February 2023 to July 2024. We calculated the glomerular filtration rate (eGFR) with the 2021 CKD-Epi equation using serum creatinine. We used Jamovi Statistical Software version 2.3.28. A \"p\" value equal to or less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>We had 105 females (48%) and 112 males (52%), median age 72 years (35-94yrs). We found differences in PTH and phosphorus levels between distinct stages of CKD. For PTH the differences were found between stages IIIa and IV (p<0.001), IIIb and IV (p=0.001), while for phosphorus between stages IIIa and IIIb (p=0.003), IIIa and IV (p<0.001), IIIb and IV (p=0.01). We found correlation between eGFR and PTH (r= -0.360, p=0.001), eGFR and calcium (r=0.169, p=0.015), eGFR and magnesium (r= -0.153, p=0.028), eGFR and phosphorus (r= -0.336, p<0.001).</p><p><strong>Conclusions: </strong>We concluded that there is a statistically significant correlation between PTH and stages of CKD, but the strength of correlation is low, it cannot be generalized, therefore each patient with CKD must be assessed individually.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 1","pages":"51-62"},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synovial Fluid Cell Counts Remain Stable for 72 Hours Regardless of Storage Temperature: Implications for PJI Diagnosis.","authors":"Balato Giovanni, Balboni Fiamma, Ascione Tiziana, Pezzati Paola, Festa Enrico, Terreni Alessandro, Andrea Baldini, Lippi Giuseppe","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Synovial fluid analysis plays a crucial role in the diagnosis of periprosthetic joint infection (PJI). However, the stability of leukocyte counts and the percentage of polymorphonuclear neutrophils (PMN%) under different storage conditions remains uncertain, and many institutions lack immediate access to on-site laboratories. We investigated whether storage temperature (room temperature (RT) vs 4 °C) influences synovial fluid white blood cell (WBC) count and PMN%, and if these parameters are stable for up to 72 hours after aspiration.</p><p><strong>Methods: </strong>We prospectively analysed 106 synovial fluid samples obtained during revision arthroplasty for suspected PJI. Assuming that the population was homogenous according to the inclusion criteria, patient's samples were randomly allocated either to be stored at RT or at 4°C, in order to obtain two different set of samples. In both set of samples WBC count and PMN% were measured at baseline, 6, 12, 24, 48, and 72 hours using an automated haematology analyser after pre-treatment with hyaluronidase. Changes over time in the same patient synovial fluid and between different storage temperature groups were assessed with independent T test.</p><p><strong>Results: </strong>Both WBC count and PMN% remained stable for up to 72 hours in samples stored at either RT or 4 °C. Mean WBC counts were slightly higher in refrigerated samples, but differences were minimal and not statistically significant. No variation led to reclassification of samples across the ICM 2018 diagnostic thresholds for PJI.</p><p><strong>Conclusion: </strong>Synovial fluid WBC and PMN% remain stable for up to 72 hours regardless of storage temperature. These findings challenge the assumption that immediate analysis is required and support greater flexibility in clinical workflows, particularly in institutions without immediate on-site laboratory availability.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 1","pages":"78-83"},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Urinary Albumin/Creatinine Ratio Strip Assay: A Reliable Screening Alternative to Replacing the Quantitative Biochemical Methods.","authors":"Antonio Sierra-Rivera, Manuela María Morales-Garcés, Pedro José Villafruela-Rodríguez-Manzaneque, Judit Méndez-Izquierdo, Diego Carmona-Talavera, Laura Sahuquillo-Frías","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Clinical laboratories play a crucial role in the diagnosis and monitoring of chronic kidney disease. Quantitative measurement of urinary albumin, expressed as the albumin/creatinine ratio (ACR), is the most commonly used biomarker for this purpose. This study evaluates the feasibility of using urinary strips as a screening tool for ACR, compared with conventional biochemical methods. Specifically, we assessed the diagnostic performance of the urinary strip and the potential economic impact of implementing this screening approach.</p><p><strong>Materials and methods: </strong>This study included 1,257 samples obtained in primary care, with systematic assessment of requests for urinary strip tests and biochemical quantification of urinary albumin and creatinine. Semiquantitative measurements were performed using Unamax autoanalyzer and quantitative determinations were conducted using AU5800 autoanalyzer. Diagnostic indicators for ACR were calculated for different albumin and creatinine levels. Economic effects were analyzed based on the costs of both testing methods.</p><p><strong>Results: </strong>Results at different cut-off values for albumin and creatinine showed optimal performance at 10 mg/L and above 100 mg/dL, respectively. 666 biochemical quantification tests (53.85% screening) for urinary albumin and creatinine could have been avoided during the study period, resulting in total savings of 522.81€.</p><p><strong>Conclusions: </strong>The present study supports the use of Unamax autoanalyzer for ACR measurement as a screening tool, avoiding unnecessary quantitative measurement, as well as allowing early identification of patients with pathological albuminuria levels. The economic impact was significant, demonstrating effective optimisation of financial resources and workflow efficiency in clinical laboratories.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 1","pages":"72-77"},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Ethical Aspects of AI in Scientific Publishing.","authors":"Joris R Delanghe","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Printing allowed the scientific revolution. Scientific journals established peer review. AI is driving the next wave of scientific progress. Ethical aspects of AI in publishing are an emerging area of concern.</p><p><strong>Key issues: </strong>AI tools are used in generating papers. This raises questions about authorship and accountability: who is responsible? If AI contributes, should they be credited as authors? Are researchers accountable for AI-generated content? If AI is involved in writing, this should be disclosed to maintain transparency. Otherwise, there could be concerns about misrepresentation or lack of rigor.</p><p><strong>Another consequence is intellectual property: </strong>if AI generates portions of a paper, who owns the rights to that work? Frameworks for intellectual property were designed for human creators, so these might be rethought. Many journals require a written statement regarding AI use. AI use in publishing could exacerbate inequality in research access, leading to a divide between well-funded and less-funded institutions. Global inequality in science sharpens: AI might skew research toward countries with more technological resources.</p><p><strong>Ai can be used to assist peer review this challenges peer review integrity: </strong>relying on AI could undermine the integrity of human oversight. AI does not replace but complements reviewers' expertise. AI-driven tools might lack the nuanced human understanding. Over-reliance on AI could compromise publishing quality.</p><p><strong>Conclusion: </strong>AI offers possibilities to speed up and to improve scientific publishing, but it is essential to judge and to address the ethical implications. This requires guidelines and rules warranting an honest, transparent and integer approach of publishing.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 1","pages":"177-180"},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking Glomerular Endothelial Dysfunction with Urinary KIM-1, sFlt-1, Serum IL-10, and Regulatory T Cells in Preeclampsia.","authors":"Kasala Farzia, Prakruti Dash, Gautom Kumar Saharia, Saubhagya Kumar Jena, Saurav Nayak","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia (PE) usually presents after 20 weeks of pregnancy with high blood pressure and protein levels in the urine. An imbalance between the body's proinflammatory and anti-inflammatory responses has been suggested to be a key issue in the pathophysiology of the disease. Some important factors, such as soluble fms like tyrosine kinase -1 (sFlt-1), T regulatory cells (Tregs), and Interleukin-10 (IL-10) molecules are thought to be involved as mediators in a systematic response affecting the blood vessel lining. Proteinuria is an essential feature of preeclampsia suggesting the involvement of the kidneys in the disease.</p><p><strong>Objective: </strong>Our study aimed to explore how Tregs, IL-10 and sFlt-1 correlate with Kidney Injury Molecule-1(KIM-1) protein levels in urine to better understand preeclampsia-induced renal endothelial dysfunction in better way.</p><p><strong>Methodology: </strong>36 normal pregnant women and 29 women with preeclampsia were enrolled in this cross-sectional study. Tregs, IL-10, sFlt-1 and KIM-1 levels were analysed and correlated between both the groups.</p><p><strong>Results: </strong>Our findings revealed that the levels of CD4+FOXP3+ Treg cells and serum IL-10 were much higher and the levels of serum sFlt-1 and urinary KIM-1 were lower in normal pregnant women than in those with preeclampsia. ROC curve showed that serum sFlt-1 was a strong marker for diagnosing preeclampsia with a sensitivity of 93% and specificity of 92%, followed by urinary KIM-1 with a sensitivity of 76% and specificity of 58%, implying at ongoing kidney injury in preeclampsia.</p><p><strong>Conclusion: </strong>Our study elucidates preeclampsia and supports better biomarker use and treatments, aiming to improve health outcomes for mothers and babies.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 1","pages":"127-138"},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Dysfunction - Associated Fatty Liver Disease (MAFLD), and Lipid-Based Insulin Resistance Markers in Hepatitis C Virus Infection (HCV).","authors":"Jagadish Ramasamy, Geerthana Balasubramaniam, Aarathy Dhanapalan, Viveka Murugiah, Malathi Murugesan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>Hepatitis C Virus (HCV) infection promotes insulin resistance, and metabolic dysfunction-associated fatty liver disease (MAFLD). HCV per se leads to impairment in host lipid metabolism and causes a deranged lipid profile. This study aims to analyze the prevalence of MAFLD and determine the levels of lipid profile parameters, surrogate markers of insulin resistance, liver fibrosis, and steatosis in patients with HCV infection.</p><p><strong>Methods: </strong>This study used data from the Centers for Disease Control - National Health and Nutritional Examination Survey (CDC-NHANES) 2017-2020. Those who tested positive on HCV RNA PCR were included in HCV group (n=89). Propensity score-based age- and gender-matching was done among those tested negative for HCV to select controls (n=89). Homeostatic Model Assessment of Insulin Resistance (HOMAIR), Homeostatic Model Assessment of Beta-cell Function (HOMAB), and the lipid-based insulin resistance markers such as Visceral Adiposity Index (VAI), Lipid Accumulation Product (LAP), Triglyceride-Glucose Index (TyG) were calculated using the standard formulae.</p><p><strong>Results: </strong>Serum triglycerides, total cholesterol and low-density lipoprotein cholesterol were significantly lower in HCV. HOMAIR, HOMAB were similar, and the lipid-based insulin resistance markers such as VAI, LAP and TyG index were significantly lower in HCV. FibroScan showed less steatosis, but increased fibrosis in the HCV patients. The surrogate markers of insulin resistance showed a significant association with the presence of MAFLD.</p><p><strong>Conclusion: </strong>HCV patients showed hypocholesterolemia, hypotriglyceridemia and the levels of lipid-based insulin resistance markers were significantly lower. TyG index showed a strong positive association with the presence of MAFLD. These observations could be due to association between HCV replication and host lipid metabolism.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 1","pages":"63-71"},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher Levels of Monocyte Distribution Width as a Potential Flagging Parameter of HIV Progression: Results of a Monocentric Observational Study.","authors":"Ennio Polilli, Federica Sozio, Giovanni Annoni, Fabrizio Carinci, Giustino Parruti","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Monocyte Distribution Width (MDW) is the standard deviation of the mean volume of monocytes and may indicate innate immune activation. We investigated the possible association between MDW values and late HIV diagnosis in consecutive patients.</p><p><strong>Methods: </strong>We retrospectively enrolled newly diagnosed HIV patients admitted to our clinical center. Demographic and clinical characteristics were analyzed.</p><p><strong>Results: </strong>A total of 97 patients were enrolled. Of these, 63% were late presenters and 43% fulfilled the criteria for advanced HIV disease. Continuous measures showed a significant inverse correlation between CD4 T-cell count and MDW. Multivariate analysis showed that MDW≥21.1 (OR:7.45, 2.13-30.54), HIV viral load >5 log (10) c/mL (OR:3.62, 1.04-13.30), blood lymphocytes<2 x103/μL (OR:14.82, 3.19-111.8) and HIV testing without symptoms (OR:0.21, 0.05-0.82) were independently associated with late presentation. Similarly, adjusted ORs for MDW≥22.5 (OR:4.03, 1.28-13.17), blood lymphocytes<1 x103/μL (OR:9.67, 2.19-57.57), age (OR:1.05, 1.00-1.10) and HIV testing without symptoms (OR:0.16, 0.04-0.52) were significantly associated with advanced HIV disease.</p><p><strong>Conclusions: </strong>Our results suggest that MDW may be a potential flagging parameter of innate immune activation in HIV infection. Continuous measurements of MDW showed a significant inverse correlation with CD4 T-cell count.Patients with increased MDW values were more likely to be diagnosed late.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 1","pages":"42-50"},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting the Platelet-β-Cell Axis: Insights into How Platelet-Derived Mediators, Lipid Signaling, and DOC2B Pathways Converge to Drive β-Cell Dysfunction in Type 2 Diabetes.","authors":"Mustakin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Type 2 diabetes mellitus (T2DM) is a multifactorial disorder where platelet-derived mediators, lipid metabolic pathways, and exocytotic proteins intersect to drive β-cell dysfunction. Activated platelets release serotonin, platelet factor 4 (PF4), sphingosine-1-phosphate (S1P), and microvesicles that trigger oxidative and endoplasmic reticulum (ER) stress in pancreatic islets. CD36-mediated lipid uptake and sphingolipid imbalance intensify ceramide-driven mitochondrial damage. These insults converge on exocytotic failure through disruption of DOC2B, a Ca²⁺-sensitive mediator of insulin vesicle fusion. Revisiting this axis clarifies how thromboinflammation and lipotoxicity orchestrate β-cell failure and highlights emerging therapeutic targets for T2DM. This review introduces a novel integrative perspective linking platelet-derived mediators, lipid dysregulation, and DOC2B-mediated exocytotic failure as a unified model of β-cell dysfunction in T2DM.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}