Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine最新文献

{"title":"The Influence of COVID-19 Disease on Pre-Analytical Blood Sample Haemolysis Rates in Three Acute Medical Units: An Interrupted Time Series Analysis.","authors":"Nellie Makhumula-Nkhoma,&nbsp;Andrew K Teggert,&nbsp;John S Young","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The COVID-19 pandemic impacted delivery of health services. The aim of our study was to determine the impact of COVID-19 disease on pre-analytical blood sample haemolysis by modelling the daily haemolysis rates variations pre and post COVID-19 infections. Ethics approval was obtained prior to study commencing. Interrupted Time Series data analysis was conducted on UK National Health Service Acute Admissions Unit 25-month (1 February 2019 to 28 February 2021) biochemistry (total and haemolysed) blood sample dataset. Interruption was set on 23 March 2021, the start of the first UK lockdown. Daily haemolysis rate (% samples haemolysed) data were fitted with a spline curve to determine influence of haemolysis rates on short or medium-term temporal trends. Linear regression was performed so as to determine long-term temporal trends pre- and post-intervention. There were 32,316 biochemistry blood sample results: 19,058 pre and 13,258 (342 days) from the post-intervention period. Overall median daily haemolysis rate was 7.3% (range: 0-30.6%), 7.7% pre-intervention versus 6.5% post-intervention (p<0.0001). The proportion of haemolysis cases negatively correlated with the number of samples processed (<i>rho</i>=0.09; p=0.01). The pre-intervention slope was -1.70 %.y^-1, y intercept 9.04%; post-intervention slope was -1.88%.y^-1, y intercept was 10.2%; with no difference in either the slope (p=0.87) or intercept (p=0.16). There was no association between short-term variation in haemolysis rates with changes in practice due to COVID-19 disease and the disease itself. The negative correlation between haemolysis rate and the number of samples processed highlights the importance of continued venepuncture practice to facilitate haemolysis rate reduction.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"34 1","pages":"10-26"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a1/46/ejifcc-34-010.PMC10131240.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9392961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific Journals Should Encourage, Not Hinder, Debates About Their Published Papers.","authors":"Eleftherios P Diamandis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The revolution in electronic publishing now allows for papers to be continuously critiqued through letters to the editor, online comments, tweets and other means. However, established top-ranked journals still pose serious barriers regarding cultivation, documentation and dissemination of post publication critiques (1). To improve on this situation, Hardwicke et al. published a set of rules, one being for journals to actively encourage and highlight post publication critique to their readership. In this commentary, I present a case whereby the editors of a top ranked journal hindered the discussion/debate between authors and expert readers. Highlighting and publishing such cases will likely put pressure on journals to modify their current policies and actively encourage post publication review. Like Hardwicke et al., we believe that post publication review is a major vehicle for advancing and accelerating science, by encouraging debates, resolving disagreements and revealing flaws in already published (and in many cases seemingly high-impact) papers.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"34 1","pages":"81-84"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/f7/ejifcc-34-081.PMC10131242.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9399058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Combination of Inflammatory and Hematological Markers is Strongly Associated with the Risk of Death in Both Mild and Severe Initial Disease in Unvaccinated Individuals with COVID-19 Infection.","authors":"Parul Chopra,&nbsp;Tushar Sehgal,&nbsp;Ranjan Yadav,&nbsp;Suneeta Meena,&nbsp;Souvik Maitra,&nbsp;Kapil Dev Soni,&nbsp;Arulselvi Subramanian,&nbsp;Shyam Prakash,&nbsp;Purva Mathur,&nbsp;Sandeep Mittan,&nbsp;Sooyun Tavolacci,&nbsp;Ajeet Kaushik,&nbsp;Kiran Gulia,&nbsp;Ebrahim Mostafavi,&nbsp;Abhishek Gupta,&nbsp;Anjan Trikha,&nbsp;Ritu Gupta,&nbsp;Kunzang Chosdol,&nbsp;Anant Mohan,&nbsp;Kalaivani Mani,&nbsp;Subrata Sinha,&nbsp;Sudip Kumar Datta","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory and hematological markers are used extensively for early prognostication and monitoring in COVID-19.We aimed to determine whether routinely prescribed laboratory markers can predict adverse outcome at presentation in COVID-19.</p><p><strong>Methods: </strong>This retrospective observational study was performed on 401 samples collected between July to December 2020 from COVID-19 positive subjects, admitted at All India Institute of Medical Sciences, Delhi, India. Clinical details and laboratory investigations within 3 days of COVID-19 positivity were obtained. Clinical outcomes were noted from patient medical records, till discharge or death. Laboratory parameters, with individually defined cut-offs, were used, either singly or in combination to distinguish survival and death for those having severe and non-severe disease at initial presentation.</p><p><strong>Findings: </strong>Total Leukocyte count, Absolute neutrophil count, Neutrophil to Lymphocyte ratio, C-Reactive Protein (CRP), Interleukin-6 (IL-6), Lactate Dehydrogenase, Ferritin and Lymphocyte to CRP ratio (LCR) were significantly altered at presentation in severe COVID-19 as compared to non-severe cases; and, also in those who died due to COVID-19 compared to those who survived. A combination of four markers, CRP (≥3.9mg/dL); IL-6 (≥45.37pg/ml); Ferritin (≥373ng/mL); 1/LCR ≥0.405 was found to strongly predict mortality in cases with non-severe presentation as also in severe cases.</p><p><strong>Conclusion and interpretation: </strong>The combination of routinely used markers, CRP, IL-6, Ferritin and 1/LCR can be used to predict adverse outcomes, even in those presenting with mild to moderate disease. This would identify subset of patients who would benefit from closer monitoring than usual for non-severe disease.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"34 1","pages":"42-56"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/03/fc/ejifcc-34-042.PMC10131235.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9399059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose Interference in Serum and Urine Samples with Various Creatinine Concentrations Measured by the Jaffe Kinetic Method.","authors":"Pensiri Choosongsang,&nbsp;Naphatohn Bhornsrivathanyou,&nbsp;Peechana Aiadsakun,&nbsp;Phattanapong Choosongsang,&nbsp;Anucha Bodhikul,&nbsp;Yupawadee Yamsuwan,&nbsp;Wilaiwan Sriwimol,&nbsp;Supamai Soonthornpun","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The effect of glucose interference on creatinine measurement by Jaffe kinetic method differs between serum and urine specimens. We investigated the effects of creatinine concentration and specimen dilution on glucose interference with urine creatinine measurement.</p><p><strong>Methods: </strong>Leftover serum and urine specimens were collected and stored at -20°C until study. Serum specimens were mixed to make 5 glucose concentrations ranging from <5.6 to 27.8 mmol/L, each group consisting of 5 levels of creatinine concentration ranging from <45 to 354 μmol/L. Urine specimens were divided into 5 groups of creatinine concentration ranging from <1,769 to >7956 μmol/L, each sample was spiked with glucose powder to produce 5 aliquots with glucose concentrations ranging from 0 to 666 mmol/L. Urine samples were automatically diluted 1:20 before analysis. Percent interference of creatinine measurement by Jaffe kinetic method was calculated using enzymatic method as the reference.</p><p><strong>Results: </strong>A total of 148 serum samples and 335 urine samples were analyzed. In serum, glucose interference with Jaffe creatinine measurement was found if creatinine concentrations were 177 μmol/L or less, corresponding to 3,540 μmol/L or less in urine specimens prior to 1:20 dilution. The degree of interference was greater when glucose concentration was higher or creatinine concentration was lower.</p><p><strong>Conclusions: </strong>When creatinine concentration and specimen dilution were considered, the effects of glucose interference on Jaffe creatinine measurement were similar in serum and urine specimens, and was found when creatinine concentrations in serum or diluted urine were 177 μmol/L or less.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"34 1","pages":"57-65"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/6a/ejifcc-34-057.PMC10131238.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9392958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of Anti-Mullerian Hormone: Preliminary Evaluation of an ABEI-Based Fully Automated Immunoassay.","authors":"Damien Gruson,&nbsp;Akdim Siham,&nbsp;Catherine Fillée","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The added value of Anti-Müllerian hormone (AMH) measurement is recognized for several clinical applications such as assessment of the ovarian reserve, monitoring of <i>in vitro</i> fertilization protocol or in the field of oncofertility. Our study objective was to determine the performances of a novel fully automated chemiluminescent assay for AMH testing.</p><p><strong>Methods: </strong>We evaluated the performances of the Maglumi^® 800 AMH chemiluminescent immunoassay that applies N-(4-Aminobutyl)-N-ethylisoluminol (ABEI) labels. Assay imprecision was assessed with two levels of control materials. Method comparison was performed with an ultrasensitive AMH ELISA assay (Ansh Laboratories, Inc, Webster, TX, USA) with 88 patients' samples.</p><p><strong>Results: </strong>The within-run and between-run coefficients of variation (CVs) were below <i>3%</i> for both low and high internal quality controls. The automated and ELISA methods were significantly correlated. Bland-Altman plot evidenced a bias between the methods with a mean bias of 0.6 ng/mL.</p><p><strong>Conclusions: </strong>Our preliminary evaluation showed overall good analytical performances for the Maglumi^® AMH fully automated immunoassay and good concordance with a routinely used assay.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"34 1","pages":"4-9"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/74/a1/ejifcc-34-004.PMC10131241.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9399060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinical Laboratory Study of a Non-Classical Case of Celiac Disease: How to Anticipate the Diagnosis.","authors":"Ana Comes Raga,&nbsp;Irene Millá Tamarit,&nbsp;Marta Fandos Sánchez,&nbsp;Pilar Teresa Timoneda Timoneda,&nbsp;Clara Marti Macia,&nbsp;Ana Belén Durá Ayet,&nbsp;Goitzane Marcaida Benito","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Celiac disease (CD) is a systemic autoimmune pathological condition caused by the intake of gluten in genetically predisposed individuals. Despite its wide prevalence, it remains an underdiagnosed disease since a large percentage of individuals who suffer from the condition do not have the classic symptoms described for the disease. We present the case of a 43-year-old man with severe iron deficiency and asthenia. We found high levels of anti-transglutaminase and anti-endomysium antibodies, a severe intraepithelial lymphocytosis, 3A Marsh-Oberhuber classification upon gastroscopy and the presence of HLA-DQ2 and HLA-DQ8 heterodimers. The patient was diagnosed with CD and was placed on a gluten-free diet. After 19 months, an improvement in biomarkers of CD and other biochemical parameters was observed. A delay in the diagnosis of CD can produce nutritional deficiencies, such as iron deficiency which may not improve even with oral iron treatment. In similar clinical presentation, the laboratory can advance a diagnosis of CD.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"34 1","pages":"66-71"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/ea/ejifcc-34-066.PMC10131243.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9392959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In <i>Silico</i> Copy Number Variation (CNVs) Bioinformatics Estimation: Dream or Nightmare?","authors":"Leandro Gutiérrez,&nbsp;Lara Parada-Fennen,&nbsp;Angela Rosaria Solano","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"34 1","pages":"72-75"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/87/ejifcc-34-072.PMC10131236.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9399061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepancies in Lipemia Interference Between Endogenous Lipemic Samples and Smoflipid^®-Supplemented Samples.","authors":"Carla Fernández-Prendes,&nbsp;Maria-José Castro-Castro,&nbsp;Laura Jiménez-Añón,&nbsp;Cristian Morales-Indiano,&nbsp;María Martínez-Bujidos","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Manufacturers evaluate lipemia-induced interference using Intralipid^®, but it does not contain all lipoprotein types. The aim of this study was to evaluate lipemiainduced interference in biochemical parameters from endogenous lipemic samples and SMOFlipid^® supplemented samples, in order to assess if SMOFlipid^® can be used in lipemic interference studies.</p><p><strong>Methods: </strong>Serum pools were supplemented with SMOFlipid^® to achieve 800 mg/dL and 1500 mg/dL triglyceride concentration, and analyzed for 25 biochemical parameters both before and after the supplementation. In another independent phase, lipemic serum pools were prepared choosing patient samples of 800 mg/dL and 1500 mg/dL triglyceride concentration. These lipemic serum pools were ultracentrifugated in order to remove lipids. Biochemical parameters were analyzed before and after ultracentrifugation. The bias between SMOFlipid^®-supplemented samples and endogenous lipemic samples were compared. The bias between the lipemic and non-lipemic samples were compared with the reference change value.</p><p><strong>Results: </strong>At 800 mg/dL triglyceride concentration, we found that total protein and transferrin had been affected only in endogenous lipemic serum samples. Magnesium and creatinine had been affected only in SMOFlipid^®-supplemented samples. At 1500 mg/dL triglyceride concentration, we found that total protein, amylase, ferritin and glucose had lipemic interference only in endogenous lipemic samples, and chloride only in SMOFlipid^®-supplemented samples.</p><p><strong>Conclusions: </strong>The use of SMOFlipid^®-supplemented samples does not provide suitable data to estimate lipemia-induced interference. Thus, interference studies should be performed using a wide variety of lipemic patient samples that represent the heterogeneity of the lipoprotein particles size.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"34 1","pages":"27-41"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/73/ca/ejifcc-34-027.PMC10131237.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9399062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-HMGCR Myopathy without Exposure to Statins: A Case Report.","authors":"Jorge Ferriz Vivancos,&nbsp;Marta Fandos Sánchez,&nbsp;Pilar Teresa Timoneda Timoneda,&nbsp;Goitzane Marcaida Benito","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Anti-HMGCR, which was first identified in 2010, has emerged as an important mechanism of myopathogenesis in patients with exposure to statins. The availability of new detection methods has expanded the phenotypic spectrum with a subtype of population that hasn't been exposed to the drug and whose clinical, analytical, and pathological manifestations are similar. The observation by immunofluorescence of a highly specific pattern known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern) can be useful in the detection of these antibodies.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"33 4","pages":"342-349"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1b/ea/ejifcc-33-342.PMC9768615.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10857003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Time to Positive Result of SARS-CoV-2 Rapid Antigen Self-Test and Viral Antigen Concentration.","authors":"Gian Luca Salvagno,&nbsp;Brandon M Henry,&nbsp;Simone De Nitto,&nbsp;Laura Pighi,&nbsp;Giuseppe Lippi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>This study was planned to investigate how the positivization time of a SARS-CoV-2 rapid antigen self-test may correlate with SARS-CoV-2 nucleocapsid (N) antigen concentration measured with a quantitative laboratory-based immunoassay.</p><p><strong>Methods: </strong>Paired nasopharyngeal (healthcare-collected) and nasal (self-collected) samples were taken from patients undergoing routine SARS-CoV-2 testing. The concentration of SARS-CoV-2 antigen nucleocapsid (N) was assayed with Liaison SARS-CoV-2 Antigen test, whilst the time of positivization of COVID-VIRO ALL rapid diagnostic test (RDT) was concomitantly measured and then compared SARS-CoV-2 viral load measured with Liaison SARS-CoV-2 Antigen test and expressed as Median Tissue Culture Infectious Dose (TCID50)/mL.</p><p><strong>Results: </strong>The study sample consisted of 32 paired specimens which tested positive with COVID-VIRO ALL IN RDT and had SARS-CoV-2 N protein concentration measured with Liaison SARS-CoV-2 Antigen test. A highly significant correlation was found between SARS-CoV-2 viral antigen concentration and RDT positivization time (r=-0.64; 95%CI, -0.81 to -0.38; p<0.001). At the >1500 TCID50/mL threshold of the Liaison SARS-CoV-2 Antigen test, the positivization time of the COVID-VIRO ALL IN RDT displayed high accuracy (93.7%). A positivization time <42 sec enabled to identify patients with high SARS-CoV-2 antigen concentration (i.e., >1500 TCID50/mL) with 91.3% negative and 100% positive predictive values.</p><p><strong>Conclusion: </strong>Self-testing using COVID-VIRO ALL IN RDT could be reliably used for garnering valuable information on the actual SARS-CoV-2 viral antigen concentration in respiratory samples.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"33 4","pages":"309-316"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/84/ejifcc-33-309.PMC9768622.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10857004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}