Current Womens Health Reviews最新文献

{"title":"Current Status of Pharmacokinetic Research of Clinical Trial Records in the Female Population in India: A systematic review","authors":"P. Thangaraju, Hemasri Velmurugan","doi":"10.2174/1573404820666230420113904","DOIUrl":"https://doi.org/10.2174/1573404820666230420113904","url":null,"abstract":"\u0000\u0000Pharmacological treatment influence men and women in distinct ways. Over\u0000the last decade, pharmacological research has significantly enhanced our understanding of many elements determining medicine prescription. The objective of this study is to carefully assess the clinical\u0000pharmacokinetic studies involved female subjects in India.\u0000\u0000\u0000\u0000We conducted a systematic review to assess clinical trial records' pharmacokinetic data in\u0000the female population of all age groups. The keywords 'pharmacokinetics’ or 'pharmacokinetic parameters’ or ‘bioavailability’ was used in the clinicaltrials.gov website and clinical trial registry of India\u0000[CTRI] website to find eligible clinical trials or records carried out between January 1, 2000 and June\u000030, 2022. Interventional studies, pharmacokinetics, pharmacokinetic parameters, bioavailability, female participants, India were all included in an advanced search filter on the two websites.\u0000\u0000\u0000\u0000In a total of 714 records, 17 (2.4%) records of interventional clinical trials with pharmacokinetic data involving the female population were assessed. All 17 trials were conducted in 15 research\u0000settings, with 27.3% of studies conducted in Maharashtra, followed by Karnataka (12.7%) and New\u0000Delhi (9.1%). A total of 30 pharmacokinetic parameters were studied in trials with peak concentration\u0000(C max) and area under the curve (AUC) of plasma or tissue concentration, accounting for 23.3% of\u0000the trials. The majority of drug trials focused on treating neoplasms accounted for 14 trials (76.4%).\u0000\u0000\u0000\u0000This review provides an overview of the current status and gaps in pharmacokinetic research in female populations. More studies should be conducted to properly examine the often limited\u0000data available on pharmacokinetic studies to guide trial design to make future clinical trials feasible\u0000and economical\u0000","PeriodicalId":371340,"journal":{"name":"Current Womens Health Reviews","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133757288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Comparison of Periostin Levels in Gingival Crevicular Fluid among Patients with Endometrial Cancer and Chronic Periodontitis","authors":"Afrooz Nakhostin, Azade Khalajian, M. Bayani, Fateme Abdolalian, Ashraf Zamani","doi":"10.2174/1573404820666230224114559","DOIUrl":"https://doi.org/10.2174/1573404820666230224114559","url":null,"abstract":"\u0000\u0000Serum periostin in cancer patients and chronic periodontitis (CP) is the lowest and could be linked to the association between CP and endometrial cancer (EC). Periostin is a matricellular protein secreted by fibroblasts associated with cancer and is also secreted in chronic inflammatory conditions such as CP.\u0000\u0000\u0000\u0000Serum periostin in cancer patients and chronic periodontitis (CP) is the lowest and could be linked to the association between CP and endometrial cancer (EC). Periostin is a matricellular protein secreted by fibroblasts associated with cancer and is also secreted in chronic inflammatory conditions such as CP.\u0000\u0000\u0000\u0000The aim of this study is to compare the GCF periostin level among CP, EC, and healthy people and the evaluation of the plausible role of periostin in this association.\u0000\u0000\u0000\u0000This case-control study was conducted on 80 participants including 20 people with both EC and CP (EC-CP), 20 only CP cases (H-CP), 20 only EC cases (EC-H), and 20 healthy people (H-H). Then, the gingival crevicular fluid (GCF) periostin levels for all the participants were measured through enzyme-linked immunosorbent assay (ELISA). Finally, the data were analyzed using Stata software version 11.\u0000\u0000\u0000\u0000This matched case-control study was conducted on 80 participants (40 cases and 40 controls). The participants were divided into four groups : 1) 20 patients with EC and severe CP (EC-CP), 2) 20 patients with EC and without CP (EC-H), 3) 20 patients without EC and with severe CP (H-CP), and 4) 20 healthy participants (H-H). Then, the GCF periostin levels for all the participants were measured through enzyme-linked immunosorbent assay (ELISA). Finally, the data were analyzed using Stata 11.\u0000\u0000\u0000\u0000The mean value of periostin levels was significantly different between groups (p<0.001) and the lowest and highest mean was observed in EC-CP and H-H groups, respectively. The mean of GCF periostin before treatment in the EC-CP group was 2.14 which was lower than that after treatment; however, this difference was not significant (P=0.086). Also, the mean of GCF periostin in the H-CP group was 3.96 before non-surgical treatment and after treatment it significantly raised to 6.79 (P=0.049).\u0000\u0000\u0000\u0000Periostin is a potential biomarker for CP diagnosis in EC patients and also can be used to prevent CP. However, further studies are required to confirm this role.\u0000\u0000\u0000\u0000Periostin is a potential biomarker for the CP diagnosis in EC patients and also can be used to prevent CP. However, more studies are required to confirm this role.\u0000","PeriodicalId":371340,"journal":{"name":"Current Womens Health Reviews","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125913779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Salvia Officinalis on the Prevention of Recurrent Vulvovaginal Candidiasis: A Randomized, Controlled Clinical Trial","authors":"A. Farshbaf‐Khalili, F. Ahangari, B. S. Oskouei, Y. Javadzadeh, M. Adibpour","doi":"10.2174/1573404819666221208095337","DOIUrl":"https://doi.org/10.2174/1573404819666221208095337","url":null,"abstract":"\u0000\u0000In addition to physical discomfort, recurrent vulvovaginal candidiasis imposes a significant financial and psychosocial burden, such as lower levels of self-esteem, a higher level of stress, clinical depression, and less satisfaction with their life. Recurrent vulvovaginal candidiasis interferes with emotional and sexual relationships.\u0000\u0000\u0000\u0000This study aimed to compare the effect of vaginal Salvia officinalis, clotrimazole, and their combination on the prevention of recurrent vulvovaginal candidiasis.\u0000\u0000\u0000\u0000This randomized triple-blinded trial was conducted on 111 women aged 18-49 years with vulvovaginal candidiasis. Participants were randomly assigned into one of the three groups of vaginal tablets of Salvia officinalis-400mg and placebo of clotrimazole-100mg, clotrimazole-100mg and placebo of Salvia Officinalis-400mg, or Salvia officinalis and clotrimazole that were applied every night for 7 consecutive days. A recurrence rate of vulvovaginal candidiasis was evaluated by WET test and vaginitis symptoms examination after 12 weeks. In the case of positive evaluation, the culture of vaginal discharge was performed.\u0000\u0000\u0000\u0000Totally, 29 patients (80.6%) in group clotrimazole, 33 patients (94.3%) in group Salvia Officinalis and 35 patients (97.2%) in group Salvia officinalis-clotrimazole were treated (P=0.43). Out of cured patients, 4 (13.8%) patients in the group clotrimazole, 1 patient (3%) in group Salvia Officinalis, and no case in group Salvia officinalis-clotrimazole experienced the recurrence of infection. There was a significant difference among the 3 groups in terms of recurrence (P=0.023). Moreover, no adverse event during the 12 weeks after treatment was observed.\u0000\u0000\u0000\u0000Adjuvant therapy of Salvia Officinalis alongside routine vaginal clotrimazole could successfully prevent recurrent vulvovaginal candidiasis after three months.\u0000","PeriodicalId":371340,"journal":{"name":"Current Womens Health Reviews","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127743313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact Of Health Education Intervention On Nutritional Status Among Adolescent Girls In Government Secondary Schools Maiduguri: A Randomised Control Trial","authors":"S. Ismail, Ruth Charles Shapu, Lim Poh Ying, Norliza Ahmad, H. Garba, I. A. Njodi","doi":"10.2174/1573404819666221207123433","DOIUrl":"https://doi.org/10.2174/1573404819666221207123433","url":null,"abstract":"\u0000\u0000The study aimed to evaluate the impact of a health education intervention on nutritional status among adolescent girls in government secondary schools in Maiduguri Metropolitan Council.\u0000\u0000\u0000\u0000The study was a randomized control trial among 417 adolescent girls aged 10-19 years old. Data were collected from October 2019 to March 2020 using KoBo collect toolbox. Chi-square and Fisher exact were used to compare baseline differences between the intervention and control group, a generalized estimating equation was used to evaluate the impact of health education intervention.\u0000\u0000\u0000\u0000There was no significant difference in nutritional status (body mass index for age percentile and mid-upper arm circumference) between the intervention and control group at baseline. There was a statistically significant difference at three and six-months post-intervention for body mass index for age percentile p = 0.005; p < 0.001, while the mid-upper arm circumference was statistically significant at three months post-intervention p < 0.001, but not statistically significant at six months post-intervention.\u0000\u0000\u0000\u0000It is clear that health education intervention has an important role in improving the nutritional status of adolescents.\u0000","PeriodicalId":371340,"journal":{"name":"Current Womens Health Reviews","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130793913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise to Combat the Effect of Insulin Resistance in PCOS.. A Narrative Review","authors":"Safa Anwar, Nigar Shikalgar, N. Ashraf, Rizwan Khan","doi":"10.2174/1573404819666221128121141","DOIUrl":"https://doi.org/10.2174/1573404819666221128121141","url":null,"abstract":"\u0000\u0000PCOS is a complex multigenic condition influenced by significant epigenetic and environmental variables, including nutrition and lifestyle. IR is found in roughly 80% of obese women with PCOS and 30–40% of lean women. IR is an impairment of insulin to mediate metabolism in skeletal muscle, adipocytes and liver. Following weight gain, the severity of IR in women with PCOS increases. IR affects many PCOS women who are not overweight, and minor weight loss improves clinical results in those with near-normal body weight. The effect of exercise on IS is optimized through glucose transport and metabolism. Exercise is the first-line treatment for PCOS. Moderate intensity (60–70% VO2max; comparable to 75–80% HRmax) and high-intensity aerobic exercise (heart rate >80%) improves IR in women with PCOS. These exercises are performed for at least 30 minutes per session and 3–5 days per week. A single bout of exercise (2–72 hours postexercise) can improve IS immediately. Exercise improves IS and glycemic management as well as helps in lowering the abdominal fat. Therefore, exercise performed on a regular basis can help improve insulin resistance in women with PCOS.\u0000","PeriodicalId":371340,"journal":{"name":"Current Womens Health Reviews","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123863757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterotopic Triplet Pregnancy after Double Frozen Embryo Transfer Resulting in Delivery of Healthy Twins at Term: A Case Report","authors":"F. Al-Rshoud, Tamara Darwish, Rami Kilani, Lina Almahmoud, Emad Aldeen AL-Sharua","doi":"10.2174/1573404819666221125145304","DOIUrl":"https://doi.org/10.2174/1573404819666221125145304","url":null,"abstract":"\u0000\u0000Sonographic visualization of intrauterine pregnancy after multiple embryo transfers does not preclude the coexistence of an ectopic pregnancy, which should be excluded routinely. Heterotopic pregnancy carries high morbidity and mortality. Therefore, it needs high index of suspicion to diagnose and manage accordingly.\u0000\u0000\u0000\u0000Our case reports a 39-year-old woman who presented with heterotopic triplet pregnancy at 5 weeks and 5 days of gestation. It resulted in a successful delivery of intrauterine monozygotic twins at 37 weeks. This pregnancy is an outcome of ICSI treatment due to low ovarian reserve. Only two embryos were obtained through the protocol and double frozen embryo transfer was done afterwards. Tubal pregnancy was successfully managed expectantly.\u0000\u0000\u0000\u0000Our case highlights the importance of early surveillance and close monitoring of patients undergoing multiple embryo transfers. Thus, keeping the possibility of heterotopic pregnancy in mind after ART cannot be over-emphasized.\u0000","PeriodicalId":371340,"journal":{"name":"Current Womens Health Reviews","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122051901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study of postpartum depression in a tertiary care hospital in South India","authors":"Krishnapriya L, Poorani Devi A, Chippy Tess Mathew, Anuja S. Panicker, K. S.","doi":"10.2174/1573404819666221108123556","DOIUrl":"https://doi.org/10.2174/1573404819666221108123556","url":null,"abstract":"\u0000\u0000South India has a high prevalence of postpartum depression (PPD) compared to other regions. With declining maternal mortality, physicians need to focus on decreasing maternal morbidities, including postpartum mental health disorders.\u0000\u0000\u0000\u0000To evaluate the incidence of PPD and the influence of demographic and pregnancy related factors on PPD, and to identify major symptom subsets manifested postnatally.\u0000\u0000\u0000\u0000This cross-sectional study, conducted on 435 women between 2 weeks to 6 months postpartum, in a tertiary care centre in South India, was administered with questionnaires including Edinburgh Postnatal Depression Scale (EPDS) and patient demographics and pregnancy related factors. Chi squared test was used to evaluate the association between EPDS scores and demographic and pregnancy variables. Subset analysis was carried out to identify the predominant symptoms in the patients.\u0000\u0000\u0000\u0000Completed questionnaires were obtained from 427 postpartum women, among which 26.2% (n=112) had EPDS score >12. Among demographic variables, EPDS scores showed a significant association with relationship problems (p=.000) only, while among pregnancy factors, preterm birth (p=.019), neonatal intensive care admission (p=.005), pregnancy complications (p=.009), and history of depression (p=.043) were significantly associated with EPDS scores. Subset analysis revealed a high mean EPDS score for anxiety (1.91), followed by depressive (1.38) and anhedonia (0.91) symptoms.\u0000\u0000\u0000\u0000Several clinical factors and adverse events during pregnancy, including socio-demographic factors and pregnancy-related complications itself, can set the stage for PPD and other mental health conditions. Simple assessments like EPDS can be considered part of routine postnatal check-up examinations for early recognition and treatment of PPD.\u0000","PeriodicalId":371340,"journal":{"name":"Current Womens Health Reviews","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115219225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Vitamin D supplementation on menstrual cycle irregularities among women with polycystic ovary syndrome who were treated with metformin: A systematic review with meta-analysis","authors":"E. Alenzi","doi":"10.2174/1573404819666221103142456","DOIUrl":"https://doi.org/10.2174/1573404819666221103142456","url":null,"abstract":"\u0000\u0000There is inconsistency in the evidence about the effect of adding vitamin D supplements to metformin therapy among women with polycystic ovary syndrome (PCOS).\u0000\u0000\u0000\u0000In this systematic review, we described the differences in menstrual cycle irregularities between women who received vitamin D supplementation and those who didn’t receive vitamin D among women diagnosed with PCOS and metformin.\u0000\u0000\u0000\u0000We reviewed previous literature to identify all relevant studies. The included studies' quality and risk of bias were assessed using the Consolidated Standards of Reporting Trials (CONSORT) and the Reporting of Observational Studies in Epidemiology (STROBE) instrument. Cochrane's Q-test and I2 statistic were used to assess the heterogeneity across included studies. The fixed-effect model was used to calculate the total effect size.\u0000\u0000\u0000\u0000Six studies were included, involving 633 women diagnosed with PCOS. Supplementation of vitamin D with metformin could significantly impact the improvement of menstrual cycles compared to receiving metformin alone (OR = 2.11, 95% CI, 1.40- 3.19). There was no evidence of heterogeneity across included studies. Subgroup analysis showed that the magnitude of the association increased when only infertile women with PCOS were included (OR = 2.37, 95% CI, 1.52-3.72).\u0000\u0000\u0000\u0000This evidence suggests the possible benefit of adding vitamin D to metformin in regulating the menstrual cycle among women with PCOS, especially infertile women.\u0000","PeriodicalId":371340,"journal":{"name":"Current Womens Health Reviews","volume":"238 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133457896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Haptonomy Intervention on Fear of Childbirth and Maternal-Fetal Attachment among Primigravid Women","authors":"Roghaiyeh Nourizadeh, Elham Dorosti, E. Mehrabi, S. Herizchi","doi":"10.2174/1573404819666221031154700","DOIUrl":"https://doi.org/10.2174/1573404819666221031154700","url":null,"abstract":"\u0000\u0000Fear of childbirth (FOC) is considered as one of the factors influencing the increase of elective cesarean section. The appropriate solution to reduce the FOC has not yet been identified.\u0000\u0000\u0000\u0000The present study aimed to evaluate the effect of haptonomy intervention on FOC and maternal-fetal attachment (MFA) among primigravid women‎.\u0000\u0000\u0000\u0000This quasi-experimental study was conducted on 68 primigravid women with a gestational age of 24-28 weeks who referred to health centers in Tabriz, Iran with a FOC score above 65. Participants were randomly assigned into the intervention and control groups. The intervention group (n=34) received haptonomy in 5 sessions, once a week for 45-60 minutes, and control group received an information pamphlet about pain management options in labor and fetal development during pregnancy. The data were collected using Wijma Delivery Expectancy/Experience Questionnaire-version A, Cranley’s MFA Scale, and Revised Pregnancy Related Anxiety Questionnaire, before the intervention and at gestational age of 35-37 weeks. The data were analyzed using Chi-square, independent t-test, and ANCOVA.\u0000\u0000\u0000\u0000After intervention and controlling the effect of baseline score, the mean score of FOC in the intervention group was significantly lower than that in the control group [Adjusted mean difference (AMD): -23.67, 95% CI: - 28.12 to -19.23, P =0.001]. Further, the mean score of MFA indicated a significant difference between the two groups [AMD: 10.12, 95% CI: 6.44 to 13.8, p <0.001].\u0000\u0000\u0000\u0000The results of the present study revealed the effectiveness of the haptonomy intervention in reducing FOC and increasing MFA. Therefore, the use of haptonomy intervention is recommended among mothers with high and severe FOC and low MFA.\u0000","PeriodicalId":371340,"journal":{"name":"Current Womens Health Reviews","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126868671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontline Management of Advanced Epithelial Ovarian Cancer: A Comprehensive Statement by an Expert Group from Middle East and North Africa Region","authors":"H. Azim, O. Ozyılkan, Mudieddine Seoud, Amal Ladjeroud, H. Jaafar, M. Mokhtar, S. Alkhayyat, S. Dawood, Zafir Arik","doi":"10.2174/1573404819666221021091708","DOIUrl":"https://doi.org/10.2174/1573404819666221021091708","url":null,"abstract":"\u0000\u0000Worldwide, ovarian cancer (OC) is one of the leading causes of cancer-related death among women. Despite the recent progress in the treatment of advanced OC, oncologists in many parts of the world still face several difficulties and constraints in their daily management of their patients. In addition to the shortage of resources and expertise, non-adherence to the up to date international guidelines has been identified as a major obstacle towards the improvement of treatment outcomes in the majority of developing countries, including the Middle East and North African (MENA) countries. A multidisciplinary gynecological oncology panel from the MENA region met virtually in December 2020 to discuss the challenges and hurdles faced by the community oncologists in the management of advanced OC. This manuscript reviews the key molecular and clinical studies that shaped the current international guidelines and suggests several modifications to make them more adaptable to the health status of developing countries of this region\u0000","PeriodicalId":371340,"journal":{"name":"Current Womens Health Reviews","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128403093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}