Sleep Medicine: X最新文献

{"title":"The effect and safety of sleep interventions on suicidal thoughts and behavior – A systematic review and meta-analyses","authors":"Paula von Spreckelsen ,&nbsp;Daan Schouten ,&nbsp;Natasha G. Waslam ,&nbsp;Patricia Katuin ,&nbsp;Henriette D. Heering ,&nbsp;Caroline Planting ,&nbsp;Niki Antypa ,&nbsp;Liia Kivelä ,&nbsp;Marike Lancel ,&nbsp;Lizanne J.S. Schweren","doi":"10.1016/j.sleepx.2025.100145","DOIUrl":"10.1016/j.sleepx.2025.100145","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbances are a risk factor for suicidal ideation, suicide attempts and suicide. While recent findings suggest that improving sleep by psychotherapeutic sleep interventions exerts a positive effect on suicidality, there are also indications that certain sleep medications are associated with an increased risk for suicidality. Given these discrepancies, the current study systematically reviewed the effect of non-pharmacological and pharmacological sleep interventions on suicidality.</div></div><div><h3>Methods</h3><div>A systematic literature search of various scientific databases was conducted (March 2025). Randomized controlled trials that examined the effect of sleep interventions on suicidality were searched for.</div></div><div><h3>Results</h3><div>The search strategy resulted in 5037 unique articles. A total of <em>k</em> = 44 articles (<em>N</em> = 14965 participants) were included in the systematic review. The results indicate that sleep interventions, particularly psychotherapeutic sleep treatments (<em>g</em> = −0.17, [-0.26 to −0.08]), result in a small significant reduction of suicidal ideation. No conclusive evidence was found for the effect or safety of pharmacotherapy or light therapy targeting sleep disturbance on suicidality. The findings should be interpreted in light of the limited number of studies with often small sample sizes, methodological inconsistencies in monitoring suicidality as an adverse event, restrictions on the inclusion of people with suicidality, and reliance on suicidal ideation as an outcome measure of suicidality.</div></div><div><h3>Conclusion</h3><div>Health care professionals are recommended to apply psychotherapeutic sleep interventions, such as cognitive behavioral therapy for insomnia, to reduce suicidal ideation in clients with disturbed sleep. When prescribing medications for disturbed sleep, we recommend professionals to closely monitor clients for potential adverse effects on suicidality.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144569956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the relationship between sleep quality and reproductive health issues in fertile and infertile men and women: A cross-sectional study","authors":"Farangis habibi ,&nbsp;Marzieh Azizi ,&nbsp;Sepideh Peyvandi ,&nbsp;Roya Nikbakht ,&nbsp;Javad Setareh ,&nbsp;Mohammad Ahmadi ,&nbsp;Zohreh Shahhosseini","doi":"10.1016/j.sleepx.2025.100151","DOIUrl":"10.1016/j.sleepx.2025.100151","url":null,"abstract":"<div><h3>Background and objective</h3><div>Reproductive health is an integral part of overall health. Sleep disorders and infertility may be reciprocally related. Therefore, the present study aims to investigate the association between sleep quality and reproductive health in fertile and infertile men and women.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, the population consists of 736 men and women who visited health centers in Behshahr County and the infertility center at Imam Khomeini Hospital in Sari in 2024. Four questionnaires were utilized in this study: Socio-Demographic-Medical Questionnaire, Pittsburgh Sleep Quality Index, Sexual Quality of Life Questionnaire, and the Depression Anxiety Stress Scale. After data collection, the data were entered into SPSS version 22. If the data distribution was normal, independent two-sample t-tests and one-way analysis of variance were used, and if the data distribution was not normal, nonparametric equivalents, Mann-Whitney U and Kruskal-Wallis tests, were used.</div></div><div><h3>Result</h3><div>The results showed a considerable difference in sleep quality between fertile and infertile individuals, particularly among females. Among infertile females, 65.9 % reported poor sleep quality (PSQI ≥6), compared to 49.6 % of fertile females, which showed a statistically significant difference (p = 0.007). In contrast, although a higher proportion of infertile males (36.8 %) reported poor sleep quality compared to fertile males (29.1 %), this difference was not statistically significant (p = 0.077).</div></div><div><h3>Conclusion</h3><div>We found that sleep disturbance and reproductive health are linked. Therefore, it is essential to manage sleep quality in infertile individuals by reproductive health professionals.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial light exposure at night: A hidden risk factor for type 2 diabetes","authors":"Izere Salomon ,&nbsp;Shema Sam ,&nbsp;Yahya Ur Rehman ,&nbsp;Intwari Munyaneza Hope","doi":"10.1016/j.sleepx.2025.100146","DOIUrl":"10.1016/j.sleepx.2025.100146","url":null,"abstract":"<div><div>This study examines the effect of nighttime light exposure on the risk of developing type 2 diabetes Mellitus (T2DM), highlighting an often-overlooked environmental factor. While lifestyle choices such as diet and physical activity have long been recognized as critical risk factors for T2DM, emerging evidence suggests that artificial light at night (LAN) may also play a significant role. LAN disrupts circadian rhythms, which regulate sleep cycles and glucose metabolism, leading to metabolic dysfunction. Using data from the UK Biobank, researchers assessed the relationship between personal light exposure patterns and T2DM risk. Findings revealed that for every 10-lux increase in LAN, the risk of developing T2DM rises by 30 %. The study underscores the importance of circadian alignment in metabolic health and suggests that mitigating nighttime light exposure, especially in urban environments, could be a practical strategy for reducing T2DM risk. Raising awareness about the health risks of light pollution and advocating for healthier lighting solutions in public spaces could play a crucial role in T2DM prevention. Further research is needed to confirm these findings and explore interventions that reduce nighttime light exposure and its impact on diabetes risk.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100146"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new telemonitoring feature for detection of long-term CPAP adherence","authors":"Benedetta Giachetti ,&nbsp;Clément Blanloeil ,&nbsp;Elena Mugellini ,&nbsp;Marco Ghislieri ,&nbsp;Dany Jaffuel ,&nbsp;Frédéric Gagnadoux ,&nbsp;Arnaud Prigent","doi":"10.1016/j.sleepx.2025.100164","DOIUrl":"10.1016/j.sleepx.2025.100164","url":null,"abstract":"<div><h3>Rationale</h3><div>Suboptimal adherence limits the efficacy of Continuous Positive Airway Pressure (CPAP) in Obstructive Sleep Apnea (OSA).</div></div><div><h3>Objective</h3><div>To determine whether the Monthly Adherence Standard Deviation (MASD), that quantifies the variability in CPAP use during the baseline month (January 2021, at least the fourth month of treatment) provides predictive information about adherence, 6 and 12 months after baseline that would not be captured by the Monthly Adherence Mean (MAM) value alone.</div></div><div><h3>Methods</h3><div>This retrospective analysis includes CPAP telemonitoring data from a population of 1612 patients. The overall population was randomly assigned to a construction (80 %) and test cohort (20 %) for internal validation. A threshold on baseline MASD was defined using a Receiver Operating Characteristic (ROC) curve.</div></div><div><h3>Results</h3><div>A MASD threshold of 1.76 h was identified. Based on this threshold and the standard 4 h/day criterion applied to the MAM, patients were classified into four groups: high MAM/low MASD, high MAM/high MASD, low MAM/low MASD, and low MAM/high MASD. Significant differences were observed among the groups 6 and 12 months after baseline data. Six months after baseline, average MAM for each patient group in the test population were 6.84 ± 1.58, 5.66 ± 1.97, 1.27 ± 2.09, and 3.04 ± 1.90 h/day, respectively (<em>p</em> &lt; 0.001); percentages of adherent patients were 91.4 %, 69.9 %, 6.25 %, and 13.9 % (<em>p</em> &lt; 0.001). Similar patterns were found 12 months after baseline.</div></div><div><h3>Conclusions</h3><div>MASD in CPAP adherence can distinguish between patients with different adherence behaviors 6 and 12 months after, capturing patterns not evident from MAM alone.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The benefit of KidsO2 ring as a pre-screening device in pediatric obstructive sleep apnea","authors":"Sarisa Thawongit ,&nbsp;Phirawan Benchachart ,&nbsp;Vorasith Siripornpanich ,&nbsp;Anchana Thongyam ,&nbsp;Cholatid Ratanatharathorn ,&nbsp;Aroonwan Preutthipan ,&nbsp;Teeradej Kuptanon","doi":"10.1016/j.sleepx.2025.100150","DOIUrl":"10.1016/j.sleepx.2025.100150","url":null,"abstract":"<div><h3>Background</h3><div>Several consumer-grade Wearable Wireless Continuous Pulse Oximeters (WWCPO) have been developed both for comfort and offering reasonable cost and advanced oximetric data to help clinicians detect significant Obstructive Sleep Apnea (OSA) in children.</div></div><div><h3>Objectives</h3><div>To evaluate the diagnostic performance of various parameters from consumer-grade WWCPO (KidsO2 ring) compared to the gold-standard polysomnography (PSG).</div></div><div><h3>Study design</h3><div>A cross-sectional study.</div></div><div><h3>Research tool</h3><div>The Wellue KidsO2™ ring as hardware, and the Vi Health App as software.</div></div><div><h3>Methods</h3><div>Children aged 3–10 years, meeting the eligibility criteria, underwent simultaneous measurement with both PSG and the KidsO2 ring. Data from both devices were collected and analyzed statistically.</div></div><div><h3>Results</h3><div>Eighty-three patients were enrolled, of whom 37 were female (44.6 %), with a mean age of 5.6 ± 1.8 years and a mean BMI of 17.8 ± 4.1 kg/m². The oxygen trend graphs, interpreted using the McGill Oximetry Score, showed high specificity (100 %) and positive predictive value (100 %) for moderate to severe OSA, although sensitivity was low (17.2 %). The recommended cut-off values for ODI&gt;3 (Drops per hour&gt;3) and ODI&gt;4 (Drops per hour&gt;4) to differentiate severe OSA from non-severe OSA are ≥4.6 and ≥ 2.8 events per hour, with specificity at 98.7 %.</div></div><div><h3>Conclusion</h3><div>The KidsO2 ring has shown benefits in evaluating children with suspected OSA. The use of oxygen trend graphs and ODI (Drops per hour) values from the KidsO2 ring effectively detected significant OSA, potentially expediting further investigations and treatment such as adenotonsillectomy.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving children's sleep habits using an interactive smartphone app: Effect on children's sleep and caregivers' stress","authors":"Sanae Tanaka ,&nbsp;Arika Yoshizaki ,&nbsp;Takashi X. Fujisawa ,&nbsp;Emi Murata ,&nbsp;Takuya Kosaka ,&nbsp;Hiroki Shinkawa ,&nbsp;Yuko Yoshimura ,&nbsp;Ikuko Mohri ,&nbsp;Akemi Tomoda ,&nbsp;Manabu Saito ,&nbsp;Mitsuru Kikuchi ,&nbsp;Masako Taniike","doi":"10.1016/j.sleepx.2025.100156","DOIUrl":"10.1016/j.sleepx.2025.100156","url":null,"abstract":"<div><h3>Background</h3><div>Sleep problems in children are strongly influenced by household lifestyle habits. Detailed advice to each family is needed to improve sleep habits. Previously, we developed an interactive sleep education app for smartphones named ‘Nenne Navi^Ⓡ’ and confirmed its effectiveness in improving young children's sleep habits in one region in Japan. We aimed to verify its effectiveness in four regions in Japan where children's sleep habits may differ.</div></div><div><h3>Methods</h3><div>This study included 52 infants (mean: 20.58 months) and their caregivers recruited from one urban city and three regional cities in Japan. The effectiveness of 6-month usage of Nenne Navi^Ⓡ on children's sleep and caregivers' stress of caregiving was assessed.</div></div><div><h3>Results</h3><div>The app had a 100 % adherence rate at 6 months of intervention. Improvement in wake-up times, sleep onset latency, and social jet lag was observed as previously reported. In addition, there was a reduction in awakenings during the night, and caregivers' mood regarding parenting improved. There were regional differences at baseline in children's age, percentage attending nursery school, mothers' employment status, and nuclear family structure. A main effect of areas was observed only for wake-up time standard deviation of children.</div></div><div><h3>Conclusions</h3><div>The app shows promise for improving children's and caregivers' sleep habits in a wider area of Japan, even after 6 months of use. Furthermore, its use might reduce caregivers' parenting stress. It could be expected that Nenne Navi^Ⓡ will be used as a parenting support tool to assist caregivers.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100156"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It takes a village, not questionnaires, to improve children's sleep health: A commentary on community-driven sleep health","authors":"Reut Gruber","doi":"10.1016/j.sleepx.2025.100161","DOIUrl":"10.1016/j.sleepx.2025.100161","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100161"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing a nurturing micro-sleep environment may positively influence children's overall development","authors":"Oliviero Bruni","doi":"10.1016/j.sleepx.2025.100162","DOIUrl":"10.1016/j.sleepx.2025.100162","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100162"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of obstructive sleep apnea, neurofilaments and early CPAP intervention in post-stroke cognitive recovery","authors":"Petra Levicka ,&nbsp;Miriam Slavkovska ,&nbsp;Dominik Koren ,&nbsp;Joaquim Ventosa ,&nbsp;Ján Hlodak ,&nbsp;Jana Papikova ,&nbsp;Zuzana Gdovinova ,&nbsp;Eva Feketeova","doi":"10.1016/j.sleepx.2025.100142","DOIUrl":"10.1016/j.sleepx.2025.100142","url":null,"abstract":"<div><div>Stroke is a leading cause of disability worldwide, with cognitive impairment following stroke influenced by a complex interplay of modifiable and non-modifiable risk factors.</div><div>This study investigated the impact of obstructive sleep apnea (OSA) on cognitive outcomes after ischemic stroke (IS) and the predictive value of plasma neurofilament light chain (pNFL) levels. Seventy-three acute IS patients were analyzed, with 59 completing a three-month follow-up. Cognitive function (Montreal Cognitive Assessment, MoCA) was assessed. Patients underwent polygraphic screening for OSA in the acute phase, with treatment recommended when indicated, and pNFL levels measured at baseline and follow-up.</div><div>Results showed that 93.2 % of IS patients had OSA. Forty (72.7 %) of OSA patients (moderate, severe OSA) were recommended continuous positive airway pressure (CPAP). CPAP-treated patients in the acute phase demonstrated cognitive improvement at three-month follow-up (CPAP-treated: MoCA 23 vs 25 points, CPAP indicated untreated, MoCA 22 vs 22 points, p = 0.05). However, long-term adherence to CPAP was poor - only 25 % remained on therapy at three months. While pNFL levels correlated with infarct volume and significantly decreased over time, no correlation was found between OSA severity and CPAP treatment. Regression analysis identified age, prior stroke history, and anxiety as key predictors of cognitive and functional post-stroke outcome.</div><div>Early CPAP therapy could contribute to improved post-stroke cognitive performance. Decline in pNFL levels shows ongoing neuronal recovery; a direct relationship with OSA is inconclusive. Furthermore, advanced age, history of prior stroke, and anxiety symptoms emerged as significant contributors to poorer cognitive outcomes.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100142"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internet-delivered cognitive behavioral therapy for insomnia: The future of insomnia treatment with large language models","authors":"Chenxing Lin ,&nbsp;Chen Cheng ,&nbsp;Yu Xia ,&nbsp;Ruoyun Wang ,&nbsp;Luying Zhang ,&nbsp;Lintong Han ,&nbsp;Darong Hai ,&nbsp;Chenyue Dai ,&nbsp;Tianen Dai ,&nbsp;Luhuan Cao ,&nbsp;Xingyu Zhu ,&nbsp;Hao Chen ,&nbsp;Li Zeng ,&nbsp;Chufan Ren ,&nbsp;Dongren Yang ,&nbsp;Yijun Wang ,&nbsp;Meijia Zhang ,&nbsp;Zefei Mo ,&nbsp;Yinda Chen ,&nbsp;Jianwei Shuai ,&nbsp;Yuming Peng","doi":"10.1016/j.sleepx.2025.100157","DOIUrl":"10.1016/j.sleepx.2025.100157","url":null,"abstract":"<div><div>With the rise in the prevalence of insomnia, cognitive behavioral therapy for insomnia (CBT-I) has become an important non-pharmacological approach to the treatment of insomnia patients. Traditional CBT-I faces challenges such as low patient acceptance and long treatment cycles. To address these issues, Internet-delivered Cognitive Behavioral Therapy for Insomnia (eCBT-I) emerged as a digital treatment modality with greater flexibility, accessibility and cost-effectiveness. However, eCBT-I still faces issues such as digital literacy and patient engagement. With the development of artificial intelligence (AI) technology, especially the application of large language models (LLM), AI-driven CBT-I is becoming an important direction for future therapy. The LLM is able to provide personalized treatment recommendations based on patient feedback, improving treatment outcomes and patient engagement. This paper reviews the application status and challenges of CBT-I and eCBT-I, focuses on the potential and prospect of LLM in CBT-I therapy, and proposes future research directions, including multi-source data fusion and privacy protection issues, to promote the innovation and development of CBT-I.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100157"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}