Sleep Medicine: X最新文献

{"title":"Erratum to “Association of food intake with sleep disorders in children and adolescents with obesity” [Sleep Med: X 4 (2022) 100053]","authors":"Raquel S.M. Zarpellon , Dra Regina M. Vilela , Fernando Mazzilli Louzada , Dra Rosana B. Radominski , Dra Ana Chrystina de Souza Crippa","doi":"10.1016/j.sleepx.2024.100132","DOIUrl":"10.1016/j.sleepx.2024.100132","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insomnia, cardiorespiratory function and quality of life in individuals with post-COVID-19 fatigue","authors":"Nathalea Spode de Arruda ,&nbsp;Alessandra Hofstadler Deiques Fleig ,&nbsp;Charles Rech ,&nbsp;Carine Cristina Callegaro","doi":"10.1016/j.sleepx.2024.100135","DOIUrl":"10.1016/j.sleepx.2024.100135","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to compare the prevalence of insomnia, lung function, inspiratory muscle function, functional capacity, and quality of life in individuals with and without post-COVID-19 fatigue.</div></div><div><h3>Methods</h3><div>Thirty-four post-COVID-19 individuals participated in the study, 20 with fatigue (32 ± 12 years old, 15% male) and 14 without fatigue (31 ± 12 years old, 42.9% male). The Chalder Fatigue Scale (CFS) was employed to categorize the volunteers into two groups: those with fatigue (score ≥4) and those without fatigue (score &lt;4). The Insomnia Severity Index (ISI) and the Epworth Sleepiness Scale (ESS) were used to assess insomnia and excessive daytime sleepiness, respectively. Pulmonary function was evaluated by spirometry, inspiratory muscle strength was assessed by the maximum inspiratory pressure (MIP), and inspiratory endurance was evaluated by maintaining an inspiratory load of 60% of MIP until fatigue. The 6-min walk test (6MWT) was used to evaluated functional capacity, while the WHOQOL-BREF questionnaire assessed quality of life.</div></div><div><h3>Results</h3><div>Individuals with post-COVID-19 fatigue demonstrated a higher prevalence of insomnia (80% vs. 49%) and excessive daytime sleepiness (45% vs. 7%), as well as lower MIP, shorter distance covered in the 6MWT, and lower FEV₁/FVC (forced expired volume in the first second divided by forced vital capacity), and FEV₁/FVC% of predicted. Additionally, they exhibited poorer quality of life in the physical and environmental domains. CFS demonstrated a direct correlation with ISI (r=0.436, p=0.01) and ESS (r=0.593, p=0.001), as well as an inverse correlation with the distance covered in the 6MWT (r=-0.398, p=0.022) and FEV₁ (r=-0.412, p=0.01). ISI was an independent predictor of CFS, with 62% of CFS variance explained by ISI variance.</div></div><div><h3>Conclusion</h3><div>Individuals with symptoms of post-COVID-19 fatigue may have a higher prevalence of insomnia, reduced inspiratory muscle strength, functional capacity, and Tiffeneau index, along with impaired quality of life. ISI is an independent predictor of post-COVID-19 fatigue.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"9 ","pages":"Article 100135"},"PeriodicalIF":0.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality and associated factors in adults living in the southern Brazil: A population-based study","authors":"Ernani Tiaraju de Santa Helena ,&nbsp;Nicolas Boeira Machado ,&nbsp;Rafael Tadao Sakae ,&nbsp;Clovis Arlindo de Sousa ,&nbsp;Carlos Roberto de Oliveira Nunes ,&nbsp;Henry Völzke ,&nbsp;Ralf Ewert ,&nbsp;Marcello Ricardo Paulista Markus","doi":"10.1016/j.sleepx.2024.100133","DOIUrl":"10.1016/j.sleepx.2024.100133","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze sleep quality and associated socio-demographic and lifestyle factors in participants from a city originally colonised by Germans in southern Brazil.</div></div><div><h3>Methods</h3><div>A cross-sectional population-based study of 2333 individuals aged 20 to 79 years. Data was collected by interview using a structured questionnaire. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The prevalence of poor sleep quality (PSQI score five or more) was estimated and the associations with study variables were measured by crude and adjusted prevalence ratios using Poisson regression.</div></div><div><h3>Results</h3><div>participants were mostly women (50.9 %), with an average age of 43.3 years. The median total PSQI score was 4 (IQ = 3-7). The frequency of poor sleep quality was 32.7 % (95 % CI 30.7-34.4), higher in older adults (44.0 % vs 30.7 %; p&lt;0.001) and women (40.0 % vs 25.2 %; p&lt;0.001). Multivariate analysis showed that women (PR = 1.3; 95%CI 1.1- 1.5; p&lt;0.001), former smokers (PR = 1.2; 95%CI 1.0-1.4; p = 0.014), current smokers (PR = 1.3; 95%CI 1.1-1.5; p = 0.006), depression (PR = 1.5; 95%CI 1.3-1.7; p&lt;0.001), taking 5 or more medications (PR = 1.2; 95%CI 1.1-1.4; p = 0.001), self-perceived fair health (PR = 2.1; 95%CI 1.8-2.4; p&lt;0.001) or poor/very poor health (PR = 2.6; 95%CI 2.1-3.1; p&lt;0.001) were risk factors for poor sleep quality. Germanic culture (PR = 0.8; 95%CI 0.7-0.9; p&lt;0.001), high school (PR = 0.8; 95%CI 0.6–1.0; p = 0.046) or elementary school (PR = 0.7; 95%CI 0.6-1.0; p = 0.025) or being at work (RP = 0.8; 95%CI 0.7-0.9; p = 0.002) were inversely associated with poor sleep quality.</div></div><div><h3>Conclusions</h3><div>Women, older adults and some clinical, social, cultural and behavioural conditions are associated with poor sleep quality.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100133"},"PeriodicalIF":0.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and acceptability of switching from a previous-generation to a new-generation mask for positive airway pressure therapy of sleep apnea using remote care","authors":"Xueling Zhu ,&nbsp;Adam Benjafield ,&nbsp;Ross Deas ,&nbsp;Leslee Willes ,&nbsp;Jeff Armitstead","doi":"10.1016/j.sleepx.2024.100128","DOIUrl":"10.1016/j.sleepx.2024.100128","url":null,"abstract":"<div><h3>Purpose</h3><div>Mask selection could affect an individual's experience with positive airway pressure (PAP) treatment for obstructive sleep apnea, but there is very limited data on the impact of switching to a different mask once established on PAP therapy. This study investigated the patient's experience when switching from a previous-generation PAP mask to a new-generation mask via remote care.</div></div><div><h3>Methods</h3><div>A new-generation mask (AirFit F30i or AirFit N30i) was successfully fitted to 215 participants during video conferencing sessions. Participants completed online questionnaires on day 1, day 3, day 7, day 30 and day 90 after mask switch to collect subjective feedback and quality of life data; objective PAP device data were also downloaded.</div></div><div><h3>Results</h3><div>Residual apnea-hypopnea index showed statistically significant difference from baseline at day 30 (+0.2 ± 0.9/h [p = 0.026]) and day 90 (+0.2 ± 0.8/h [p = 0.006]), however unlikely to be clinically relevant. Average daily usage was significantly increased from baseline at day 30 (+0.2 ± 1.2 h/day [p = 0.010]) but not day 90 (+0.1 ± 1.0 h/day [p = 0.126]). Functional Outcomes of Sleep Questionnaire (FOSQ-10) score was significantly higher at day 90 (change from baseline to day 90: +0.48 ± 2.29 [p = 0.015]). Subjective ratings for comfort, seal, and usability of the new-generation mask were significantly better than the predefined acceptability level. Rates of PAP-related side effects were generally acceptable.</div></div><div><h3>Conclusion</h3><div>Remote management of mask change was associated with good outcomes in terms of objective device data and patient acceptability. This approach could be used to improve the overall therapy experience for individuals requiring a PAP therapy mask change for any reason.</div></div><div><h3>Clinical trial registration</h3><div><span><span>http://clinicaltrials.gov</span><svg><path></path></svg></span> (NCT05262439).</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central sleep apnea (CSA) in a treated brainstem chordoma","authors":"Bibi Aneesah Jaumally ,&nbsp;Diwakar D. Balachandran ,&nbsp;Ahmed M. Salem ,&nbsp;Lara Bashoura ,&nbsp;Saadia A. Faiz","doi":"10.1016/j.sleepx.2024.100127","DOIUrl":"10.1016/j.sleepx.2024.100127","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100127"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidity of obstructive sleep apnea and narcolepsy: A challenging diagnosis and complex management","authors":"Silvia Miano ,&nbsp;Leila Kheirandish-Gozal ,&nbsp;Marco De Pieri","doi":"10.1016/j.sleepx.2024.100126","DOIUrl":"10.1016/j.sleepx.2024.100126","url":null,"abstract":"<div><h3>Introduction</h3><div>Narcolepsy and obstructive sleep apnea syndrome (OSA) are relevant causes of excessive daytime sleepiness (EDS); although different for etiopathogenesis and symptoms, differential diagnosis is sometimes difficult, and guidelines are lacking concerning their management when coexisting in a same patient.</div></div><div><h3>Methods</h3><div>A narrative review of the literature was realized including PubMed, Scopus and Embase, aimed to regroup studies and case reports evaluating epidemiology, clinical and instrumental features and treatment of patients presenting comorbid NT1 and OSA. Moreover, a snowball search on the pathophysiology underpinnings of the association of the two disorder was realized.</div></div><div><h3>Results</h3><div>For adults, the prevalence of OSA in NT1 ranged from 24.8 % to 51.4 %. No studies were found concerning the treatment of EDS in double-diagnosis patients, but only case reports; these latter and the experience on patients with either NT or OSA suggest that modafinil, methylphenidate, pitolisant and solriamfetol are effective.</div></div><div><h3>Discussion</h3><div>Adults with NT1 showed a higher prevalence of OSA compared to the general population, but the reach of the results reviewed here is limited by the retrospective design of most of the studies and by the inhomogeneous utilization of diagnostic criteria. The association with OSA is likely to be explained by the involvement of orexin in hypercapnic-hypoxic responses: a deficit of orexin may promote obstructive events during sleep. Open questions warrant further investigation, especially orexin's involvement in other sleep disorders associated with EDS, and the more appropriate treatment for the OSA-narcolepsy comorbidity.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142724000247/pdfft?md5=6de7d81d052f90264f12650f306bf7ee&pid=1-s2.0-S2590142724000247-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142316174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective and objective sleep quality assessment in adolescent patients with inflammatory bowel disease","authors":"Holly Breeden ,&nbsp;Elizabeth McDonough ,&nbsp;Amanda Glinky ,&nbsp;Rebecca Wallace ,&nbsp;Robbie Beyl ,&nbsp;Colleen LeBlanc","doi":"10.1016/j.sleepx.2024.100125","DOIUrl":"10.1016/j.sleepx.2024.100125","url":null,"abstract":"<div><h3>Objectives</h3><p>There is a link between inflammatory bowel disease (IBD) and poor sleep quality that is presumed to be multifactorial. The purpose of this study was to identify factors that impact sleep quality in this group including clinical disease activity, depression, anxiety, quality of life, and disordered social media use through questionnaires.</p></div><div><h3>Methods</h3><p>This prospective study analyzed sleep quality in adolescent patients ages 13 to 18 with a diagnosis of IBD using objective data from wrist actigraphy and subjective report from the Pittsburgh Sleep Quality Index (PSQI). Additional screeners including the Short Pediatric Crohn's Disease Activity Index or Pediatric Ulcerative Colitis Activity Index, Pediatric Quality of Life Inventory Gastrointestinal Symptoms Module, Generalized Anxiety Disorder 7-item screener, Patient Health Questionnaire depression screener, and Social Media Disorder scale were also collected.</p></div><div><h3>Results</h3><p>Twenty-three subjects enrolled and 16 completed questionnaires. 62.5 % of participants were in clinical remission and the remaining 37.5 % had mild to severe clinical IBD activity. Poor subjective sleep quality was associated with a shorter duration of sleep time and an increased clinical disease activity score. Patients in clinical remission slept for a longer duration than those with mild IBD activity.</p></div><div><h3>Conclusions</h3><p>This study did not identify a significant relationship between sleep quality and psychosocial factors in the adolescent population with IBD, though their influence cannot be discounted. There was a connection between the presence of disease activity and shorter sleep duration. Similarly, PSQI scores correlated with sleep time but not sleep quality.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142724000235/pdfft?md5=8932590a994a63029c74287f14eabf12&pid=1-s2.0-S2590142724000235-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between Japanese calligraphy practice and sleep quality in community-dwelling older adults: A cross-sectional Study","authors":"Georg von Fingerhut ,&nbsp;Keitaro Makino ,&nbsp;Osamu Katayama ,&nbsp;Ryo Yamaguchi ,&nbsp;Daiki Yamagiwa ,&nbsp;Jessica K. Bone ,&nbsp;Hiroyuki Shimada","doi":"10.1016/j.sleepx.2024.100124","DOIUrl":"10.1016/j.sleepx.2024.100124","url":null,"abstract":"<div><h3>Background</h3><p>Sleep disturbances, such as insomnia, are common among the elderly population and have been associated with negative health outcomes. Japanese calligraphy is a traditional art practice previously associated with various health benefits, such as stress reduction and improved cognitive function; however, its association with sleep quality has not been fully explored.</p></div><div><h3>Methods</h3><p>This cross-sectional study included 21,207 subjects with basic attributes, health status, depressive symptoms, artistic practices, and sleep habits. Individuals who satisfied the chronic insomnia criteria were categorized into the following subtypes: sleep onset latency (SOL) insomnia, early morning awakening (EMA) insomnia, and wake after sleep offset (WASF) insomnia. The <em>t</em>-test, chi-square test, and logistic regression analysis were used to determine the association between Japanese calligraphy practice and sleep quality.</p></div><div><h3>Results</h3><p>In this study, 17,597 elderly Japanese individuals were included, among whom 13.7 % practiced Japanese calligraphy. Regarding sleep characteristics, 32.0 % had chronic insomnia, 13.1 % had SOL insomnia, 9.1 % had EMA insomnia, and 14.2 % had WASF insomnia. Japanese calligraphy practice was associated with lower rates of chronic insomnia (odds ratio [OR] = 0.85, 95 % confidence interval (CI) = 0.76–0.95), including SOL insomnia (OR = 0.84, 95 % CI = 0.71–0.98), and EMA insomnia (OR = 0.80, 95 % CI = 0.66–0.97) but had no significant association with WASF insomnia.</p></div><div><h3>Conclusions</h3><p>This study suggests that Japanese calligraphy practice is associated with lower odds of insomnia, particularly SOL and EMA insomnia. Calligraphy may be an effective nonpharmacological intervention for insomnia and poor sleep quality among elderly Japanese individuals.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142724000223/pdfft?md5=84ea5440c11f90ccd4129d5258462969&pid=1-s2.0-S2590142724000223-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial","authors":"Heather A. Hausenblas ,&nbsp;Tarah Lynch ,&nbsp;Stephanie Hooper ,&nbsp;Aahana Shrestha ,&nbsp;Doug Rosendale ,&nbsp;Jennifer Gu","doi":"10.1016/j.sleepx.2024.100121","DOIUrl":"10.1016/j.sleepx.2024.100121","url":null,"abstract":"<div><h3>Objective/Background</h3><p>Sleep problems challenge overall wellbeing. Magnesium has been implicated to benefit sleep, although the clinical evidences varied based on the magnesium source used. Magnesium L-threonate (MgT) is a promising intervention due to its brain bioavailability and effects on cognition, memory and mood. We investigated MgT supplementation on sleep quality and daily function.</p></div><div><h3>Patients/methods</h3><p>Eighty 35–55-year-olds with self-assessed sleep problems participated in a randomized, double-blind, placebo-controlled, parallel-arm study, taking 1 g/day of MgT or placebo for 21 days. Sleep and daily behaviors were measured subjectively using standardized questionnaires including the Insomnia Severity Index, Leeds Sleep Evaluation Questionnaire, and Restorative Sleep Questionnaire, and objectively using an Oura ring. The Profile of Mood States questionnaire and a daily diary were used to evaluate mood, energy and productivity, and record any safety concerns.</p></div><div><h3>Results</h3><p>The MgT group maintained good sleep quality and daytime functioning, while placebo declined. From objective Oura ring measurements, MgT significantly (p &lt; 0.05) improved <em>vs</em> placebo deep sleep score, REM sleep score, light sleep time, and activity and readiness parameters activity score, activity daily movement score, readiness score, readiness activity balance, and readiness sleep balance. From subjective questionnaires, MgT significantly (p &lt; 0.05) improved <em>vs</em> placebo behavior upon awakening, energy and daytime productivity, grouchiness, mood and mental alertness. MgT was safe and well tolerated.</p></div><div><h3>Conclusions</h3><p>This showed MgT improved sleep quality, especially deep/REM sleep stages, improved mood, energy, alertness, and daily activity and productivity. These are consistent with how MgT works in neuron cells and animal models, suggesting broader positive impacts on overall brain health.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142724000193/pdfft?md5=ca2c05f6b86f85b46bcdd8282887e714&pid=1-s2.0-S2590142724000193-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep duration in middle-aged years of life predicts the age of diagnosis of Parkinson's disease","authors":"Cayla E. Clark,&nbsp;Joshua Gold,&nbsp;B. Rhett Rigby","doi":"10.1016/j.sleepx.2024.100123","DOIUrl":"10.1016/j.sleepx.2024.100123","url":null,"abstract":"<div><h3>Introduction</h3><p>Chronic short sleep duration (i.e., &lt;7 h sleep daily) could reduce the brain's ability to attenuate toxin and protein accumulation, which may contribute to Parkinson's disease (PD). The purpose of this study was to characterize the relationship between self-reported sleep duration from adolescence to adulthood and the age of diagnosis in people with PD. A secondary purpose was to characterize the interaction between sleep duration and physical activity through the lifespan on the age of PD diagnosis.</p></div><div><h3>Methods</h3><p>A secondary data analysis was performed using the Fox Insight data set. Multiple regression analysis was used to determine the age range that sleep duration best predicted the age of diagnosis of PD. Hierarchical linear multiple regression was performed to assess if self-reported sleep duration, physical activity, and their interaction predicted the age of diagnosis for PD, after accounting for sociodemographic factors.</p></div><div><h3>Results</h3><p>Both sleep (p &lt; 0.001) and physical activity time (p = 0.013) significantly predicted the of age of onset of PD. In contrast, there was no evidence to support an interaction of sleep by physical activity on the age of diagnosis of PD. Sleep duration at 46–55 years maintained significance after controlling for education, income, race, ethnicity, and sex (p &lt; 0.001). Weekly duration of time spent performing moderate-intensity physical activity was added as an input variable.</p></div><div><h3>Conclusion</h3><p>Sleep duration significantly predicts the age of diagnosis of PD, with shorter sleep duration associated with a younger age of diagnosis of PD.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142724000211/pdfft?md5=4f6742e9da7aaedc78a6f5644e4ed6b8&pid=1-s2.0-S2590142724000211-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142040395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}