Sleep Medicine: X最新文献

{"title":"Impact and efficacy of sound machine on sleep in hospitalized adults: A systematic review","authors":"Kanika Khandelwal , Alecia Anyim , Sara Shu , Dana Gerberi , Mohammed Yousufuddin , Sandeep Pagali","doi":"10.1016/j.sleepx.2025.100154","DOIUrl":"10.1016/j.sleepx.2025.100154","url":null,"abstract":"<div><h3>Background</h3><div>Sleep in hospitalized adults is impaired due to several reasons. Non-pharmacological approaches should be attempted first before considering medications to treat insomnia. Environmental noise levels in the hospital are also a major culprit that might result in disturbed sleep. While limiting any disturbance or sound during sleeping hours is crucial, it might not be completely feasible in the acute care setting. Sound machines that deliver a masking noise such as white noise are reported to mask these environmental noises and promote sleep. We aim to analyze the efficacy and safety of sound machines on sleep efficiency in hospitalized adults.</div></div><div><h3>Methods</h3><div>A systematic review of all published literature was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We searched MEDLINE, Embase, Cochrane Cochrane Central Register of Controlled Trials, EBSCO CINAHL, Google scholar, APA PsycINFO, Web of Science, and Scopus from inception to August 13, 2024. All studies that reported sound machine-based interventions on sleep efficiency in hospitalized adults were included. Sleep efficiency and other sleep related outcomes as total sleep time, latency, awakenings, and total sleep score were noted. Cochrane Risk of Bias 2 for RCTs was used to evaluate study quality. This study was registered with PROSPERO (CRD42024595293).</div></div><div><h3>Results</h3><div>A total of 1920 studies were screened, of which 74 were selected for full text review. Seven RCT studies (<em>n</em> = 496 participants) met the inclusion criteria and were included. Two studies were from USA, and India each, while one study was reported each from Iran, China, and South Korea. Six of the seven studies used white noise, while one study reported using Uncorrelated Signal and Ambient noise in Space Integration (USASI) masking noise. Two studies reported using Pittsburgh Sleep Quality Index (PSQI), and Richards Campbell Sleep Questionnaire (RCSQ) each to measure sleep outcomes. White noise was well tolerated with no major adverse effects reported, and only 8 participants discontinued the study due to discomfort or found it less acceptable. Collectively, these studies provide evidence of improved sleep efficiency with white noise use in hospitalized adults. Given the heterogeneity in the duration of white noise use, inclusion criteria, and the outcome measurement scales in this small sample of RCT studies, meta-analysis was not feasible.</div></div><div><h3>Conclusions</h3><div>White-noise and other similar masking noises seem to improve sleep efficiency in hospitalized adults, with good tolerability. Only limited studies report the efficacy and demonstrate wide heterogeneity in the duration of masking noise use, varied inclusion criteria, and outcome measurement scales. Larger studies analyzing the hospitalized patient population type, across different units, to identify the best patien","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100154"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rest assured: Promoting sleep health in undergraduate education","authors":"Haley Nowlin,&nbsp;Emily Badin,&nbsp;Jess P. Shatkin","doi":"10.1016/j.sleepx.2025.100159","DOIUrl":"10.1016/j.sleepx.2025.100159","url":null,"abstract":"<div><h3>Background</h3><div>Sleep deprivation among young adults is a pervasive problem driven by high levels of stress, excessive screen time, disruptive school and living environments, irregular sleep habits, high academic demands, early school start times, and low rates of physical activity. Difficulties with emotion regulation, high rates of anxiety and depression, and poor academic performance are only a few of the struggles faced by sleep deprived young adults. Although sleep apps and wearables are increasingly popular, knowledge of positive sleep health without the proper tools to motivate and instill behavior change can contribute to anxiety and negative cognitions about sleep, which only further fuel the problem.</div></div><div><h3>Methods</h3><div>In this report we describe a series of undergraduate university curricula, housed within a unique undergraduate department, designed to enhance not only knowledge of sleep, but also associated behavior changes that have been demonstrated to improve sleep, mood, and anxiety among university students.</div></div><div><h3>Results</h3><div>Numerous courses within the Child and Adolescent Mental Health Studies (CAMS) department at New York University address sleep directly, teaching students about the science of sleep and how they can improve their own sleep to enhance overall wellbeing. Our work to date demonstrates that students find these courses desirable and impactful.</div></div><div><h3>Conclusion</h3><div>College courses present a unique opportunity to improve the health and wellbeing of young adults by teaching about sleep health. Undergraduate campuses may represent an underutilized locale from which to address population health.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100159"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delivering sleep: Bed kit distributions to children living in poverty in Tanzania","authors":"Debbie Will-Dryden ,&nbsp;Wandoa Mwambu ,&nbsp;Teegan Nordstrom ,&nbsp;Reut Gruber","doi":"10.1016/j.sleepx.2025.100155","DOIUrl":"10.1016/j.sleepx.2025.100155","url":null,"abstract":"<div><h3>Background</h3><div>Overcrowded housing, insufficient beds, and poor mosquito protection are major barriers to healthy sleep for children living in poverty in developing countries. This study aimed to address these barriers by providing children living in poverty in Tanzania with climate-appropriate items essential for creating a safe and comfortable micro-sleep environment.</div></div><div><h3>Methods</h3><div>From 2000 to 2024, Sleeping Children Around the World (SCAW) delivered 135,500 bed kits to children aged 7–11 years living in poverty in Tanzania. Since 2019, culturally adapted sleep education information was delivered orally to parents of bed kit recipients.</div></div><div><h3>Results</h3><div>Twenty-four distributions reached an average of 5646 children per cohort years. Mattresses and mosquito nets were consistently included; other items varied.</div></div><div><h3>Conclusions</h3><div>This study demonstrates a community-driven approach to improving the sleep environments of children living in poverty in a developing country, offering a scalable model for promoting sleep health in low-resource settings.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100155"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Playing sports in higher education as a protective factor against social jetlag: An exploratory study","authors":"Guilherme Agra Costa ,&nbsp;Michael A. Grandner ,&nbsp;Daniel Ruivo Marques","doi":"10.1016/j.sleepx.2025.100152","DOIUrl":"10.1016/j.sleepx.2025.100152","url":null,"abstract":"<div><h3>Background</h3><div>Student-athletes face challenges balancing academic and athletic commitments, often leading to dysfunctional sleep patterns. Social jetlag - a misalignment between biological and social clocks - has emerged as a potential contributor to mental and physical strain. The current study is aimed at determining the social jetlag frequency and its associations with other sleep and health variables among student-athletes in higher education.</div></div><div><h3>Methods</h3><div>Sixty-seven European Portuguese student-athletes (mean age = 21.4 years) were evaluated for chronotype, social jetlag, sleep effort, daytime sleepiness, psychological distress, and perceived academic and athletic performance.</div></div><div><h3>Results</h3><div>Social jetlag was computed using a corrected midpoint of sleep approach (SJLsc). Most participants (62.7 %) reported moderate social jetlag (1–2 h), and only 6 % of the sample presented high social jetlag (&gt;2 h). Higher social jetlag was negatively correlated with academic performance and positively associated with evening chronotypes. Although group differences across social jetlag levels and chronotypes were not statistically significant, there is a trend suggesting morning types experience lower misalignment. Compared to normative data derived from Portuguese samples, participants showed higher sleep effort and lower perceived daytime sleepiness.</div></div><div><h3>Conclusions</h3><div>The prevalence of significant social jetlag among student-athletes was low, suggesting that participation in sports may serve as a protective factor, possibly due to greater health awareness and monitoring. However, further studies with larger samples are needed.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100152"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a saffron extract on sleep quality in adults with moderate insomnia: A decentralized, randomized, double-blind, placebo-controlled trial","authors":"Julius Schuster ,&nbsp;Christin Mundhenke ,&nbsp;Hannah Nordsieck ,&nbsp;Camille Pouchieu ,&nbsp;Line Pourtau ,&nbsp;Andreas Hahn","doi":"10.1016/j.sleepx.2025.100147","DOIUrl":"10.1016/j.sleepx.2025.100147","url":null,"abstract":"<div><h3>Aim</h3><div>Natural interventions for sleep disturbances, such as saffron extract, are gaining scientific and clinical interest. This 3-arm, randomized, double-blind, placebo-controlled trial examined the effect of a standardized saffron extract (Safr’Inside™) on sleep, stress, and other associated psychological outcomes in 165 adults reporting moderate insomnia.</div></div><div><h3>Methods</h3><div>Participants received 30 mg, 20 mg saffron extract, or placebo for 4 weeks. The primary endpoint was the change in insomnia symptoms (Athens Insomnia Scale, AIS). Secondary outcomes were the Single-Item Sleep Quality Scale (SQS), Perceived Stress Scale (PSS), Patient Health Questionnaire-4 (PHQ-4), Positive and Negative Affect Schedule (PANAS), Epworth Sleepiness Scale (ESS), and World Health Organization Quality of Life (WHOQOL). Analyses followed an intention-to-treat (ITT) approach, with per-protocol (PP) confirmation.</div></div><div><h3>Results</h3><div>Among 150 completers, saffron extract led to a greater reduction in insomnia symptoms (AIS) than the placebo (between-group adjusted mean difference <em>β</em> = −0.95 [95 % CI: −1.79, −0.11], <em>P</em> &lt; .05). In secondary analyses, sleep quality (SQS) improved significantly after 3 weeks and was sustained at week 4 in both saffron groups compared to placebo (30 mg vs placebo: <em>β</em> = 0.82 [95 % CI: 0.22, 1.41], <em>P</em> = .004; 20 mg vs placebo: <em>β</em> = 1.02 [0.43, 1.62], <em>P</em> &lt; .001). Perceived stress (PSS) was significantly reduced with 30 mg or 20 mg saffron extract compared to placebo (30 mg vs placebo: <em>β</em> = −1.87 [95 % CI: −3.23, −0.53], <em>P</em> = .01; 20 mg vs placebo: <em>β</em> = −1.89 [95 % CI: −3.22, −0.52], <em>P</em> = .04). Some improvement in psychological symptoms (PHQ-4) was also observed with 30 mg saffron extract compared to placebo (<em>β</em> = −0.79 [−1.40, −0.18], <em>P</em> = .03). All other measures showed no significant differences. No serious adverse events occurred.</div></div><div><h3>Conclusions</h3><div>Four weeks of 20 or 30 mg saffron extract may reduce insomnia and stress in middle-aged adults. Future research should assess longer interventions and explore which subgroups benefit most from saffron extract.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of acupressure at different ear acupoints on Insomnia: A secondary analysis of a randomized controlled trial","authors":"Jingyu Zhang ,&nbsp;Giulia Castelli ,&nbsp;Aomei Shen ,&nbsp;Junxin Li ,&nbsp;Jennifer Kawi ,&nbsp;Hulin Wu ,&nbsp;Paul Christo ,&nbsp;Claudia M. Campbell ,&nbsp;Johannes Thrul ,&nbsp;Constance M. Johnson ,&nbsp;Nada Lukkahatai","doi":"10.1016/j.sleepx.2025.100158","DOIUrl":"10.1016/j.sleepx.2025.100158","url":null,"abstract":"<div><h3>Introduction</h3><div>Insomnia is highly prevalent among older adults with chronic low back pain (cLBP), contributing to a cycle of heightened pain sensitivity, impaired physical function, and reduced quality of life. Auricular Point Acupressure (APA), a nonpharmacologic intervention for pain, has shown emerging evidence of improving sleep. We compared the effectiveness of targeted APA (T-APA) versus non-targeted APA (NT-APA) on insomnia in older adults with cLBP.</div></div><div><h3>Methods</h3><div>This secondary analysis used data from a parent RCT, including 99 adults aged 60 or older with cLBP and clinical insomnia (Insomnia Severity Index [ISI]&gt;7). Participants received four weeks of T-APA or NT-APA. Sleep outcomes (ISI, PROMIS-29 sleep disturbance) and pain outcomes (intensity, interference) were assessed at baseline and post-intervention, with pain examined as a mediator of sleep change.</div></div><div><h3>Results</h3><div>The T-APA (n = 45) and NT-APA (n = 54) groups had similar baseline characteristics. Both groups showed significant reductions in sleep disturbance, pain interference, and pain intensity (p &lt; 0.05). However, only the NT-APA group demonstrated significant improvement in ISI scores (p &lt; 0.001, d = 0.50). No significant mediation effect of pain on sleep outcomes was found.</div></div><div><h3>Conclusions</h3><div>APA may be an effective nonpharmacologic approach for improving sleep among older adults with cLBP. Unexpectedly, NT-APA showed greater improvements in insomnia compared to T-APA, suggesting mechanisms beyond traditional somatotopic theory. Further research is warranted to confirm these findings and explore the potential of point-specific versus non-specific APA protocols in treating insomnia.</div></div><div><h3>Trial ID</h3><div>NCT03589703 (registration date: May 22, 2018).</div></div><div><h3>URL</h3><div><span><span>https://clinicaltrials.gov/ct2/show/record/NCT03589703</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145320049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased mortality in people with chronic multisite pain and insomnia: the HUNT study","authors":"Jonas Bloch Thorlund ,&nbsp;Tom Ivar Lund Nilsen ,&nbsp;Eivind Schjelderup Skarpsno","doi":"10.1016/j.sleepx.2025.100163","DOIUrl":"10.1016/j.sleepx.2025.100163","url":null,"abstract":"<div><h3>Objective</h3><div>Insomnia is common among individuals with chronic musculoskeletal pain, and both conditions have been linked to mortality. However, the joint association of chronic multisite pain and insomnia with all-cause mortality is unknown, which we aimed to investigate in this study.</div></div><div><h3>Methods</h3><div>We used data from 39,545 persons participating in the third wave of the Norwegian HUNT Study (2006–08) with complete information on both musculoskeletal pain and insomnia symptoms, linked to the national Cause of Death Registry. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated to assess the risk of death associated with the joint association of insomnia and chronic multisite pain.</div></div><div><h3>Results</h3><div>Compared to individuals without chronic musculoskeletal pain and no insomnia, individuals with multisite chronic pain had a HR for all-cause mortality of 1.21 (95 % CI 1.01 to 1.43) if they reported insomnia and a HR of 1.00 (0.91–1.11) if they did not suffer from insomnia. Compared to the same reference category, pain-free individuals with insomnia had a HR of 1.05 (95 % 0.83 to 1.34). Our data showed no evidence of a synergistic effect between chronic multisite pain and insomnia on all-cause mortality.</div></div><div><h3>Conclusion</h3><div>Individuals with chronic multisite pain and insomnia appeared to have higher all-cause mortality compared to pain-free persons without insomnia. Although speculative, these findings suggest that improving sleep quality in individuals with chronic multisite pain and insomnia may contribute to better overall health and potentially lower the risk of death from all causes.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100163"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metacognitive therapy for insomnia: An open cohort study on clinical outcomes and the role of cognitive-attentional syndrome factors in insomnia","authors":"Osame Salim ,&nbsp;Serena Bauducco ,&nbsp;Annika Norell ,&nbsp;Pia Callesen","doi":"10.1016/j.sleepx.2025.100153","DOIUrl":"10.1016/j.sleepx.2025.100153","url":null,"abstract":"<div><h3>Background</h3><div>Insomnia is a common and distressing disorder. Evidence suggests that metacognitive beliefs and maladaptive strategies, such as worry and rumination, may maintain insomnia.</div></div><div><h3>Objectives</h3><div>This study is the first trial of metacognitive therapy (MCT) for insomnia. It aimed to evaluate the effects of MCT on insomnia severity and examine how cognitive-attentional syndrome (CAS) components predict these changes.</div></div><div><h3>Methods</h3><div>An uncontrolled open cohort trial was conducted with 31 participants in a clinic setting. Participants received up to ten MCT sessions and completed weekly measures of insomnia severity, anxiety, depressive symptoms, and metacognitive beliefs, including maladaptive strategies. The primary outcome was remission status from pre-to post-treatment. Associations between components of the cognitive-attentional syndrome (CAS) and insomnia severity were examined using a mixed model. Follow-up data were collected at 3, 6, and 12 months.</div></div><div><h3>Results</h3><div>At post-treatment, 57 % of participants met remission criteria and 67 % scored below the clinical cut-off. Within-group effect sizes were large for the Insomnia Severity Index (Hedges’ g = 1.64) and moderate for anxiety (HADS-A, g = 0.67) and depression (HADS-D, g = 0.72). Among those providing follow-up data, 87.5 % remained at or further improved their insomnia symptoms by their last assessment. Moreover, both between-person averages and within-person changes in maladaptive CAS strategies significantly predicted ISI scores, whereas only within-person changes in CAS-negative metacognitions reached significance.</div></div><div><h3>Conclusions</h3><div>These preliminary findings indicate that metacognitive therapy (MCT) shows promise as an intervention for insomnia. However, large-scale, controlled trials are necessary to further evaluate its clinical utility for this condition.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100153"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-reported sleep variables, sleep quality, and quality of life assessment in transition to lemborexant in patients with Insomnia: the multicenter, open-label SOMNUS study","authors":"Motohiro Ozone ,&nbsp;Susumu Hirota ,&nbsp;Yu Ariyoshi ,&nbsp;Kenichi Hayashida ,&nbsp;Azusa Ikegami ,&nbsp;Mitsunari Habukawa ,&nbsp;Hayato Ohshima ,&nbsp;Daisuke Harada ,&nbsp;Hiroshi Hiejima ,&nbsp;Nozomu Kotorii ,&nbsp;Kenta Murotani ,&nbsp;Yurie Nishi ,&nbsp;Michinori Koebis ,&nbsp;Takehiro Taninaga ,&nbsp;Naohisa Uchimura","doi":"10.1016/j.sleepx.2025.100149","DOIUrl":"10.1016/j.sleepx.2025.100149","url":null,"abstract":"<div><h3>Aims</h3><div>Lemborexant, a dual orexin receptor antagonist, is approved for treating adults with insomnia. We present diary-based sleep parameters, self-reported sleep quality, insomnia severity, and health-related quality of life following direct transition to lemborexant from previous treatment in Japanese patients with insomnia using data from the SOMNUS Study.</div></div><div><h3>Methods</h3><div>The prospective, nonrandomized, open-label, multicenter SOMNUS Study analyzed data from 90 patients across four cohorts of direct switching to lemborexant from Z-drugs (monotherapy cohort: n = 25), suvorexant (monotherapy cohort: n = 25, combination cohort: n = 21), and ramelteon (combination cohort: n = 19) up to 14 weeks.</div></div><div><h3>Results</h3><div>Diary-based sleep parameters (subjective sleep onset latency, subjective wake time after sleep onset, subjective total sleep time, and subjective sleep efficiency) significantly improved after transitioning to lemborexant in the 90 patients. At 2, 6, and 14 weeks, significant reductions in Insomnia Severity Index total scores were observed (−2.6 ± 3.81, −4.4 ± 5.13, and −5.3 ± 4.80, respectively; all p &lt; 0.0001). Self-reported sleep quality and morning alertness also showed consistent, significant improvements across all time points. Short Form-8 physical component summary and mental component summary scores demonstrated positive trends, with notable improvements observed in the overall population by the end of the study. Treatment-emergent adverse events (TEAEs) occurred in 47.8 % of patients; most were mild or moderate in severity. No serious TEAEs occurred; somnolence was the most common TEAE.</div></div><div><h3>Conclusions</h3><div>These findings indicate that transitioning to lemborexant from previous insomnia treatment is efficacious in improving sleep parameters, insomnia severity, and health-related quality of life, with a favorable safety profile.</div></div><div><h3>Trial registration</h3><div>NCT04742699.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of digital media use with sleep habits in school children: A cross-sectional study - Author reply","authors":"Doreswamy Chandranaik,&nbsp;Prawin Kumar","doi":"10.1016/j.sleepx.2025.100143","DOIUrl":"10.1016/j.sleepx.2025.100143","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100143"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}