Sleep Medicine: XPub Date : 2025-06-14DOI: 10.1016/j.sleepx.2025.100143
Doreswamy Chandranaik, Prawin Kumar
{"title":"Association of digital media use with sleep habits in school children: A cross-sectional study - Author reply","authors":"Doreswamy Chandranaik, Prawin Kumar","doi":"10.1016/j.sleepx.2025.100143","DOIUrl":"10.1016/j.sleepx.2025.100143","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100143"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine: XPub Date : 2025-06-14DOI: 10.1016/j.sleepx.2025.100146
Izere Salomon , Shema Sam , Yahya Ur Rehman , Intwari Munyaneza Hope
{"title":"Artificial light exposure at night: A hidden risk factor for type 2 diabetes","authors":"Izere Salomon , Shema Sam , Yahya Ur Rehman , Intwari Munyaneza Hope","doi":"10.1016/j.sleepx.2025.100146","DOIUrl":"10.1016/j.sleepx.2025.100146","url":null,"abstract":"<div><div>This study examines the effect of nighttime light exposure on the risk of developing type 2 diabetes Mellitus (T2DM), highlighting an often-overlooked environmental factor. While lifestyle choices such as diet and physical activity have long been recognized as critical risk factors for T2DM, emerging evidence suggests that artificial light at night (LAN) may also play a significant role. LAN disrupts circadian rhythms, which regulate sleep cycles and glucose metabolism, leading to metabolic dysfunction. Using data from the UK Biobank, researchers assessed the relationship between personal light exposure patterns and T2DM risk. Findings revealed that for every 10-lux increase in LAN, the risk of developing T2DM rises by 30 %. The study underscores the importance of circadian alignment in metabolic health and suggests that mitigating nighttime light exposure, especially in urban environments, could be a practical strategy for reducing T2DM risk. Raising awareness about the health risks of light pollution and advocating for healthier lighting solutions in public spaces could play a crucial role in T2DM prevention. Further research is needed to confirm these findings and explore interventions that reduce nighttime light exposure and its impact on diabetes risk.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100146"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine: XPub Date : 2025-05-31DOI: 10.1016/j.sleepx.2025.100142
Petra Levicka , Miriam Slavkovska , Dominik Koren , Joaquim Ventosa , Ján Hlodak , Jana Papikova , Zuzana Gdovinova , Eva Feketeova
{"title":"The role of obstructive sleep apnea, neurofilaments and early CPAP intervention in post-stroke cognitive recovery","authors":"Petra Levicka , Miriam Slavkovska , Dominik Koren , Joaquim Ventosa , Ján Hlodak , Jana Papikova , Zuzana Gdovinova , Eva Feketeova","doi":"10.1016/j.sleepx.2025.100142","DOIUrl":"10.1016/j.sleepx.2025.100142","url":null,"abstract":"<div><div>Stroke is a leading cause of disability worldwide, with cognitive impairment following stroke influenced by a complex interplay of modifiable and non-modifiable risk factors.</div><div>This study investigated the impact of obstructive sleep apnea (OSA) on cognitive outcomes after ischemic stroke (IS) and the predictive value of plasma neurofilament light chain (pNFL) levels. Seventy-three acute IS patients were analyzed, with 59 completing a three-month follow-up. Cognitive function (Montreal Cognitive Assessment, MoCA) was assessed. Patients underwent polygraphic screening for OSA in the acute phase, with treatment recommended when indicated, and pNFL levels measured at baseline and follow-up.</div><div>Results showed that 93.2 % of IS patients had OSA. Forty (72.7 %) of OSA patients (moderate, severe OSA) were recommended continuous positive airway pressure (CPAP). CPAP-treated patients in the acute phase demonstrated cognitive improvement at three-month follow-up (CPAP-treated: MoCA 23 vs 25 points, CPAP indicated untreated, MoCA 22 vs 22 points, p = 0.05). However, long-term adherence to CPAP was poor - only 25 % remained on therapy at three months. While pNFL levels correlated with infarct volume and significantly decreased over time, no correlation was found between OSA severity and CPAP treatment. Regression analysis identified age, prior stroke history, and anxiety as key predictors of cognitive and functional post-stroke outcome.</div><div>Early CPAP therapy could contribute to improved post-stroke cognitive performance. Decline in pNFL levels shows ongoing neuronal recovery; a direct relationship with OSA is inconclusive. Furthermore, advanced age, history of prior stroke, and anxiety symptoms emerged as significant contributors to poorer cognitive outcomes.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100142"},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine: XPub Date : 2025-03-07DOI: 10.1016/j.sleepx.2025.100139
Nadia Hussain , Amal Hussain Ibrahim Al Haddad , Saima Abbass , Zina Alfahl
{"title":"The potential impact of habitual sleep quality on glycaemic control and inflammation: A study on geriatric patients recently diagnosed with type 2 diabetes mellitus (T2DM)","authors":"Nadia Hussain , Amal Hussain Ibrahim Al Haddad , Saima Abbass , Zina Alfahl","doi":"10.1016/j.sleepx.2025.100139","DOIUrl":"10.1016/j.sleepx.2025.100139","url":null,"abstract":"<div><div>Sleep quality and its relationship with glycaemic control is of particular interest in the context of geriatric diabetes. We aimed to investigate the potential impact of habitual sleep quality on glycaemic control status among geriatric patients recently diagnosed with type 2 diabetes mellitus (T2DM). A total of 193 geriatric patients recently diagnosed with T2DM in a tertiary-care hospital were selected. A developed questionnaire was used to assess various aspects of sleep quality. Glycaemic control was evaluated through fasting blood glucose levels, HbA1c measurements and number of admissions to the hospital for hypoglycaemic or hyperglycaemic episodes. Patients were divided into Poor Sleep Quality (PSQ, n = 132) and Adequate Sleep Quality (ASQ, n = 61) groups. The PSQ group exhibited significantly worse sleep outcomes, including longer sleep latency (35 ± 9.2 min vs. 15 ± 6.4 min), shorter sleep duration (5 h 42 min vs. 7 h 18 min) and greater use of sleep medications (72 % vs. 22 %). Glycaemic control, measured by HbA1c, was worse in the PSQ group (8.7 ± 1.9 vs. 7.2 ± 1.2; p < 0.01), which also had more frequent severe hypoglycaemic (35 ± 1.4 vs. 8 ± 2.1; p = 0.02) and ketoacidotic episodes (72 ± 1.0 vs. 5 ± 1.1; p = 0.01). These findings suggest an association between poor sleep quality and poorer glycaemic control, with more frequent diabetes-related complications, highlighting the need for further research to explore potential causal relationships and targeted interventions in this population.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"9 ","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143591634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine: XPub Date : 2025-01-16DOI: 10.1016/j.sleepx.2025.100138
Mari Hysing , Allison G. Harvey , Ann Kristin Skrindo Knudsen , Jens C. Skogen , Anne Reneflot , Børge Sivertsen
{"title":"Mind at rest, mind at risk: A prospective population-based study of sleep and subsequent mental disorders","authors":"Mari Hysing , Allison G. Harvey , Ann Kristin Skrindo Knudsen , Jens C. Skogen , Anne Reneflot , Børge Sivertsen","doi":"10.1016/j.sleepx.2025.100138","DOIUrl":"10.1016/j.sleepx.2025.100138","url":null,"abstract":"<div><h3>Background</h3><div>Depression and anxiety disorders are highly prevalent among young adults, with evidence suggesting sleep problems as key risk factors.</div></div><div><h3>Objective</h3><div>This study aimed to examine the association between insomnia and sleep characteristics with major depressive episode (MDE) and anxiety disorders, and the association after accounting for baseline mental health symptoms.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study using data from the Students’ Health and Wellbeing Study (SHoT), surveying Norwegian higher education students aged 18 to 35 (N = 53,362). A diagnostic assessment of 10,460 participants was conducted in 2023. Self-reported insomnia, sleep duration, sleep onset latency, and wake after sleep onset were recorded in 2022. MDE and five types of anxiety disorders were assessed after one year using a self-administered CIDI 5.0. Analyses adjusted for age, sex, baseline mental health symptoms, and somatic conditions.</div></div><div><h3>Results</h3><div>Insomnia in young adults was associated with a significantly increased risk of MDE (adjusted RR = 3.50, 95 % CI = 3.18–3.84) and generalized anxiety disorder (GAD) (adjusted RR = 2.82, 95 % CI = 2.55–3.12) one year later. Sleep duration showed a reversed J-shaped association with mental disorders, with both short and, to a lesser extent, long sleep durations linked to elevated risks, even after adjusting for baseline mental health symptoms and somatic conditions. Although the associations were attenuated after adjustment, they remained statistically significant.</div></div><div><h3>Conclusion</h3><div>Sleep disturbances, including insomnia and abnormal sleep durations, predict mental health issues in young adults, even after accounting for baseline mental health and somatic health. Addressing sleep problems early may help prevent subsequent mental health conditions in this population.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"9 ","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine: XPub Date : 2024-12-20DOI: 10.1016/j.sleepx.2024.100137
Giovana Longo-Silva , Renan Serenini , Roberto Antunes , Márcia Lima , Anny Pedrosa , Risia Menezes
{"title":"Determinants of variations in sleep patterns across Brazil: Exploring geographic influences","authors":"Giovana Longo-Silva , Renan Serenini , Roberto Antunes , Márcia Lima , Anny Pedrosa , Risia Menezes","doi":"10.1016/j.sleepx.2024.100137","DOIUrl":"10.1016/j.sleepx.2024.100137","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the influence of latitude, longitude, sunrise, and daylight, in conjunction with individual and behavioral factors, on sleep duration, wake time, and bedtime in a country with the world's broadest latitude range, yet characterized by homogeneity in language, cultural traits, and consistent time zones.</div></div><div><h3>Methods</h3><div>Participants (n = 1440; 18-65y) were part of a virtual population-based survey (2021–22). Sleep patterns were spatially represented through maps using Multilevel B-spline Interpolation. Relationships between and within biological/personal/socio-economic, behavioral and environment characteristics, and sleep outcomes were examined by Lasso regression. Restricted cubic splines were employed to examine the shape of the association of latitude and sunrise with sleep variables and of screen time before bed with bedtime.</div></div><div><h3>Results</h3><div>Latitude emerged as the primary geographic factor influencing variations in sleep duration and wake time, shortening and advancing, respectively, as latitude increased (towards equatorial line). Younger individuals, those living without partners, with depression, engaging in more frequent evening alcohol consumption, and with poorer diet quality, tended to wake up later. All the variables influenced bedtime, with daylight emerging as the environmental factor exerting the strongest association. While the variability in bedtime showed a non-linear association with latitude and sunrise, it displayed a dose-response relationship with screen time before bed.</div></div><div><h3>Conclusions</h3><div>Given that adults living in the same country, potentially with a similar timetable, could be having shorter sleep durations according to their latitude position, further studies are required to contemplate advocating for policies that implement schedules based on the sun position rather than the national time zone.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"9 ","pages":"Article 100137"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine: XPub Date : 2024-12-19DOI: 10.1016/j.sleepx.2024.100136
Adina Arshad , Muhammad Abdul Muqtadir Qureshi , Muhammad Abdullah Masood , Hafiz Shahbaz Zahoor , Ayesha Nazakat , Anfal Fatima , Javed Iqbal
{"title":"Comparative efficacy of sodium oxybate versus placebo on improvement of nighttime sleep in adult patients with narcolepsy: A systematic review and meta-analysis","authors":"Adina Arshad , Muhammad Abdul Muqtadir Qureshi , Muhammad Abdullah Masood , Hafiz Shahbaz Zahoor , Ayesha Nazakat , Anfal Fatima , Javed Iqbal","doi":"10.1016/j.sleepx.2024.100136","DOIUrl":"10.1016/j.sleepx.2024.100136","url":null,"abstract":"<div><h3>Background</h3><div>Narcolepsy, a central hypersomnolence disorder, disrupts sleep regulation. Sodium oxybate, a CNS (central nervous system) depressant, is widely used as a treatment, but there are surprisingly very few rigorous studies comparing its effectiveness to placebo in adults.</div></div><div><h3>Objectives</h3><div>To measure the comparative efficacy of sodium oxybate at a dosage regimen of 9 g versus placebo in improving nighttime sleep quality, reducing nocturnal arousals and sleep stage shifts, and enhancing the overall refreshed nature of sleep in adult patients with narcolepsy.</div></div><div><h3>Methods</h3><div>The methodology included a literature review of PubMed, Cochrane, Scopus, Google Scholar, and Clinicaltrials.gov, retrieving 53 randomized controlled trials (RCT) after removing 14 duplicates. Four studies met the criteria for gauging the efficacy of sodium oxybate compared to placebo in the adult population with narcolepsy. The primary efficacy outcome was improved sleep quality, whereas secondary outcomes were reduced nocturnal arousals and sleep stage shifts with an overall refreshed sleep nature. Analyses used RevMan 5.3 software, and SMD (standardized mean differences) with 95 % CI (confidence intervals) were calculated. Risk and publication biases were measured with Cochrane risk of bias tools and Comprehensive Meta-Analysis Software. Evidence certainty was measured using GRADEpro.</div></div><div><h3>Results</h3><div>Four RCT involving 1079 participants were analyzed for said outcomes, and relevant forest plots were generated. Statistical analysis showed a substantial improvement in sleep quality [SMD = 0.74(95%Cl:0.53,0.95; p < 0.00001; I<sup>2</sup> = 0 %; (high certainty)] and refreshing nature of sleep [SMD = 0.81(95%CI:0.51,1.11; P < 0.00001; I<sup>2</sup> = 0 %; (moderate certainty)], reduction in nocturnal arousals [SMD = −0.62(95%CI: 0.92,-0.32; p < 0.00001; I<sup>2</sup> = 0 %; (moderate certainty)] and sleep stage shifts [SMD = −1.22(95%CI: 1.46,-0.98; p < 0.00001; I<sup>2</sup> = 0 %; (high certainty)]. The risk of bias was located high for one study. Symmetrical funnel plots and Egger's regression intercepts testified to no significant publication bias.</div></div><div><h3>Conclusions</h3><div>The results showed that sodium oxybate considerably improved the quality of nocturnal sleep, resulting in substantial restorative advantages as well as a decrease in nocturnal arousals and sleep stage transitions. Significant results with low heterogeneity and p-values <0.05, showing consistent effects, were obtained from the analysis. However, overall reliability may be impacted by a high risk of bias in one study.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"9 ","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep Medicine: XPub Date : 2024-12-15DOI: 10.1016/j.sleepx.2024.100131
Sara Girolami, Marta Tardio, Serpetti Loredana, Nadia Di Mattia, Pamela Micheletti, Mario Di Napoli
{"title":"Erratum to “Sleep body position correlates with cognitive performance in middle-old obstructive sleep apnea subjects” [Sleep Med: X 4 (2022) 100050]","authors":"Sara Girolami, Marta Tardio, Serpetti Loredana, Nadia Di Mattia, Pamela Micheletti, Mario Di Napoli","doi":"10.1016/j.sleepx.2024.100131","DOIUrl":"10.1016/j.sleepx.2024.100131","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100131"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum to “The importance of sleep studies in improving the health indices of a nation” [Sleep Med: X 4 (2022) 100049]","authors":"Jitendra Kumar Sinha , Kshitij Vashisth , Shampa Ghosh","doi":"10.1016/j.sleepx.2024.100130","DOIUrl":"10.1016/j.sleepx.2024.100130","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100130"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}