Sleep Medicine: X最新文献

{"title":"From awareness to action: Tackling sleep issues in college students","authors":"Galit Levi Dunietz , Erica C. Jansen","doi":"10.1016/j.sleepx.2025.100171","DOIUrl":"10.1016/j.sleepx.2025.100171","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145938887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocturnal sleep-related scratching disorder as a possible variant of NREM arousal disorder: Clinical features and polysomnographic study of four newly reported cases","authors":"María Fernanda Gómez Morales ,&nbsp;Nicole Cresp Sinning ,&nbsp;Carlos H. Schenck","doi":"10.1016/j.sleepx.2025.100168","DOIUrl":"10.1016/j.sleepx.2025.100168","url":null,"abstract":"<div><div>A clinical variant of NREM arousal disorder is described manifesting with predominantly injurious, and exclusively sleep-related scratching without any conscious awareness, and without a history of dermatologic disease. Four patients were clinically evaluated and underwent videopolysomnography (vPSG). Case 1, a 30-year-old woman had a 20-yr history of non-injurious arm scratching/rubbing during sleep. vPSG: forearm rubbing against the chin during N2/N3. Two years later she developed restless bladder symptoms and leg movements before sleep onset. Serum ferritin level: 20.7 Intravenous iron therapy resulted in full control of bedtime leg movements, restless bladder symptoms, and nocturnal scratching. Case 2, a 28-year-old married man had a 1.5-yr history of perianal scratching with excoriations/bleeding during sleep, without other parasomnia. Medical and dermatologic evaluations were negative. vPSG: arousal index of 34/hr, with multiple episodes of perianal scratching. Paroxetine, 20 mg with clonazepam as (0.5–1.0 mg) at bedtime induced 50 % efficacy. Case 3, a 26-year-old African-American female had NREM parasomnias, vigorous sleep-related scratching with keloid formation, and major depression. Medical history was negative. vPSG: arousal index: 28/hr, without abnormal behaviors. Multiple sleep latency test (MSLT): mean sleep latency, 3.6 min, no REM sleep. Idiopathic hypersomnia and NREM parasomnias were diagnosed. Sleep-related scratching and NREM parasomnias responded fully to bedtime clonazepam, 0.5 mg. Case 4, a 50-year-old female had longstanding injurious sleep-related scratching, sleep terrors, and sleep bruxism. vPSG: 55 % sleep efficiency; arousal index: 25/hr, without abnormal behaviors or apneas. MSLT: no objective sleepiness. These cases of sleep-related scratching disorder represent a heterogeneous presumed variant of NREM arousal disorder with various comorbidities, and with full/partial control from diverse therapies.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145798229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality modifies the association between nocturnal sleep, daytime napping, and mild cognitive impairment: A population-based dose-response study","authors":"Xi Luo ,&nbsp;Zhonghua Yin ,&nbsp;Xueli Sun ,&nbsp;Ke Li","doi":"10.1016/j.sleepx.2026.100175","DOIUrl":"10.1016/j.sleepx.2026.100175","url":null,"abstract":"<div><h3>Objectives</h3><div>This cross-sectional study, based on the two-process model of sleep regulation, explored the nonlinear relationships and interactions among nocturnal sleep duration, daytime napping, sleep quality, and mild cognitive impairment (MCI) in middle-aged and older Chinese adults.</div></div><div><h3>Methods</h3><div>Data from 7480 participants in the 2018 wave of the China Health and Retirement Longitudinal Study (CHARLS) were analyzed. Restricted cubic splines modeled dose-response relationships, and stratified logistic regression assessed subgroup variations. Models were adjusted for sociodemographic, lifestyle, and clinical covariates.</div></div><div><h3>Results</h3><div>The lowest odds of MCI were observed among participants reporting 6–8 h of nocturnal sleep and 30–60 min of daytime napping. Short (&lt;6 h) and long (&gt;8 h) sleep durations, along with prolonged napping (≥90 min), were linked to higher odds of MCI. Sleep quality modified these associations: poor sleep quality elevated the odds of MCI, especially among long sleepers (OR = 1.88 vs. 1.33 for good sleep quality). Among short sleepers (&lt;6 h), 30–60 min naps were associated with lower odds of MCI (OR = 0.72).</div></div><div><h3>Conclusions</h3><div>These findings indicate that, in this cross-sectional sample, 7–8 h of nocturnal sleep combined with 30–60 min of daytime napping were associated with better cognitive status, whereas long sleep with poor sleep quality was associated with higher odds of impairment. These observational associations, considered within a circadian–homeostatic framework, are hypothesis-generating and warrant confirmation in future longitudinal and interventional studies.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting pediatric sleep health in low-resource settings: A specialist's perspective","authors":"Merrill S. Wise","doi":"10.1016/j.sleepx.2025.100166","DOIUrl":"10.1016/j.sleepx.2025.100166","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145749918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep without borders starts here: Principles and pathways for sleep health promotion","authors":"Reut Gruber ,&nbsp;Winfried Randerath","doi":"10.1016/j.sleepx.2025.100172","DOIUrl":"10.1016/j.sleepx.2025.100172","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100172"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiology of the subconscious: Autonomic activation during sexual dreaming","authors":"Emmanuel Eroumé A Egom ,&nbsp;Bernadette Sandrine Lema ,&nbsp;Elijah-Bill Christopher Nguem Nguem","doi":"10.1016/j.sleepx.2026.100174","DOIUrl":"10.1016/j.sleepx.2026.100174","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate self-reported autonomic-like symptoms following sexual dreams in the SLEEP Study and characterize their perceived physiological patterns.</div></div><div><h3>Methods</h3><div>In a cross-sectional online study, 301 female-identifying adults reported physical and emotional sensations experienced immediately after sexual dreams. We summarized symptom prevalence using descriptive statistics.</div></div><div><h3>Results</h3><div>Increased heart rate (57.4 %) and sweating (35.0 %) were most frequently reported, followed by anxiety (33.9 %) and muscle tension (23.0 %). A minority (20.8 %) reported no symptoms, indicating variability in perceived arousal or recall. Symptom patterns reflected common co-occurrence of self-reported cardiovascular-like and affective experiences.</div></div><div><h3>Discussion</h3><div>These findings suggest that sexual dreams are often accompanied by self-reported autonomic-like experiences, although these reports do not represent objective physiological measurements. This brief report isolates the symptom dimension of the SLEEP Study dataset—a component not analyzed in our prior <em>Sleep Research</em> publication—and highlights the potential value of self-reported responses for studying REM-linked emotional arousal.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative therapies for chronic insomnia: A randomized controlled trial of a traditional Thai Herbal Remedy and Cannabis sativa oil","authors":"Naruwat Pakdee,&nbsp;Nitcha Sribunrieng,&nbsp;Ronnachai Poowanna","doi":"10.1016/j.sleepx.2026.100173","DOIUrl":"10.1016/j.sleepx.2026.100173","url":null,"abstract":"<div><h3>Background</h3><div>This study compared the efficacy and safety of integrative and conventional therapies for chronic insomnia.</div></div><div><h3>Objective</h3><div>To evaluate the effects of the Suk-Sai-Yat traditional Thai herbal remedy, <em>Cannabis sativa</em> oil (Deja formula) and lorazepam on sleep quality and quality of life in patients with chronic insomnia.</div></div><div><h3>Methods</h3><div>In a randomized controlled parallel-group trial, 60 adults with chronic insomnia received Suk-Sai-Yat, <em>Cannabis sativa</em> oil, or lorazepam for four weeks. Sleep quality was assessed using the Pittsburgh leep Quality Index (PSQI) and quality of life was evaluated using EQ-5D-5L and EQ-VAS. Safety was monitored throughout the study.</div></div><div><h3>Results</h3><div>After four weeks, PSQI scores significantly improved in all groups: Suk-Sai-Yat (12.3–6.6), <em>Cannabis sativa</em> oil (13.6–3.68) and lorazepam (14.4–5.8) (all p &lt; 0.001), with no significant differences between groups. Quality-of-life scores improved significantly in the integrative therapy groups. Only mild adverse events were reported.</div></div><div><h3>Conclusion</h3><div>Suk-Sai-Yat and <em>Cannabis sativa</em> oil demonstrated comparable efficacy to lorazepam with favorable safety profiles, supporting their role as integrative, non-benzodiazepine options for chronic insomnia management.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100173"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of diamine oxidase (DAO) enzyme dietary supplementation in subjects with insomnia symptoms and single nucleotide polymorphisms of the AOC1 gene: a randomized double-blind placebo-controlled study","authors":"Júlia Ferrer-Garcia ,&nbsp;Maria D. Navarro ,&nbsp;Montserrat Abadias ,&nbsp;Raquel López-García ,&nbsp;Anna Sansalvador ,&nbsp;Georgia Gris ,&nbsp;Karol Uscamaita","doi":"10.1016/j.sleepx.2025.100167","DOIUrl":"10.1016/j.sleepx.2025.100167","url":null,"abstract":"<div><h3>Objective</h3><div>This exploratory study was designed to assess the effect of a diamine oxidase (DAO) enzyme supplement on insomnia symptoms in patients with alterations of the <em>AOC1</em> gene, which encodes the DAO enzyme.</div></div><div><h3>Methods</h3><div>Prospective randomized, double-blind placebo-controlled study. Patients were randomized (1:1:1:1) to 28-day supplementation with the DAO product (12.6 mg/day) or placebo. The Insomnia Severity Index (ISI) and the Pittsburg Sleep Quality Index (PSQI) were completed.</div></div><div><h3>Results</h3><div>We studied 101 patients (DAO group, n = 50; placebo, n = 51) (73.4 % women, mean age 48.3 years). Decreases in ISI scores were similar in both groups, but severe insomnia at day 28 was higher in the placebo group (5.9 % vs. 2 %). Improvement of PSQI at day 28 was higher in the DAO group (mean [SD] change −1.62 [3.45] vs. −1.47 [3.21]). Improvements of at least 1 point of PSQI in various subscales were higher in the DAO group. Also, in the DAO group and the once-daily regimen, sleep efficiency and use of sleep medication showed significant improvements vs. baseline (mean change of −0.71 [1.43], <em>p</em> = 0.023 and −0.54 [1.14], <em>p</em> = 0.043, respectively). In melatonin users, improvements in ISI at day 7 were higher in the DAO group and persisted until day 28. Overall PSQI and sleep efficiency improved significantly in the DAO group only.</div></div><div><h3>Conclusions</h3><div>In this exploratory study, the use of a DAO supplement for 28 days improved insomnia symptoms in the presence of genetic variants of the <em>AOC1</em> gene and showed a synergy with melatonin.</div><div>Registered in the <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> (NCT07027943).</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National trends in mortality associated with obstructive sleep apnea among adults with diabetes mellitus in the United States, 1999–2020","authors":"Ibrahim Nagmeldin Hassan ,&nbsp;Siddig Yaqub ,&nbsp;Muhsin Ibrahim ,&nbsp;Nagmeldin Abuassa ,&nbsp;Mohamed Ibrahim","doi":"10.1016/j.sleepx.2025.100148","DOIUrl":"10.1016/j.sleepx.2025.100148","url":null,"abstract":"<div><h3>Background</h3><div>Obstructive sleep apnea (OSA) and diabetes mellitus are two prevalent and interrelated chronic conditions that contribute significantly to cardiovascular and metabolic mortality. However, national trends in OSA-related mortality among adults with diabetes remain poorly characterized.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis of U.S. death certificate data from 1999 to 2020 using the CDC WONDER platform. Adults aged ≥25 years with diabetes mellitus (ICD-10: E10–E14) as the underlying cause of death and OSA (G47.33) as a contributing cause were included. Age-adjusted mortality rates (AAMRs) were calculated per 100,000 population, and temporal trends were assessed using Joinpoint regression.</div></div><div><h3>Results</h3><div>A total of 79,728 deaths were attributed to diabetes and OSA. The overall AAMR was 1.55 (95 % CI: 1.50 to 1.60), increasing significantly from 1999 to 2004 (APC: 19.42 %) and more gradually from 2005 to 2020 (APC: 6.86 %). Males had nearly double the mortality rate of females (2.13 vs. 1.07). The highest AAMRs were observed among American Indian or Alaska Native (2.16) and Black (1.98) individuals. Non-metropolitan areas had higher mortality than metropolitan areas (1.91 vs. 1.48), and the Midwest had the highest regional AAMR (1.95). Crude mortality increased with age, peaking at 5.42 in the 75–84 age group. State-level AAMRs varied nearly sixfold. Most deaths occurred at home (38.5 %), followed by inpatient facilities (32.8 %).</div></div><div><h3>Conclusions</h3><div>Mortality related to OSA in adults with diabetes has risen substantially across all demographics, underscoring the need for targeted interventions in high-risk groups.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between physical activity and sleep disorders in Peruvian schoolchildren: A cross-sectional study","authors":"Paula L. Arias-Segales ,&nbsp;Santos L. Chero-Pisfil ,&nbsp;Miguel A. Arce-Huamani","doi":"10.1016/j.sleepx.2025.100160","DOIUrl":"10.1016/j.sleepx.2025.100160","url":null,"abstract":"<div><h3>Background</h3><div>Physical activity and sleep are key determinants of child health, yet evidence from low- and middle-income settings remains limited. We examined the association between physical activity and sleep disorders in Peruvian schoolchildren.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study of 81 children aged 9–12 years from a public school in Callao, Peru (2024). Physical activity was assessed with the Assessment of Physical Activity Levels in Children Questionnaire (APALQ), and sleep disorders with the Tucson Children's Assessment of Sleep Apnea Questionnaire (TuCASA). Given non-normal distributions, associations between total and dimensional activity scores and TuCASA scores were tested using Spearman's rank correlation.</div></div><div><h3>Results</h3><div>Most participants showed some degree of sleep disturbance; 45.7 % had mild and 17.3 % moderate sleep disorders, while 37.0 % were normal. Regarding activity, 32.1 % were sedentary, 45.7 % moderately active, and 22.2 % very active. Total physical activity was strongly and inversely correlated with sleep disorder scores (ρ = −0.752, p &lt; 0.001). All dimensions type, frequency, duration, and intensity also showed significant inverse correlations with TuCASA scores (all p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Higher physical activity is consistently linked with fewer sleep problems in schoolchildren. Findings support school-based strategies that integrate movement behaviors with sleep health promotion in resource-limited contexts.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"10 ","pages":"Article 100160"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}