BDJ Open最新文献

{"title":"Interactive workshops on improving dental students' understanding of environmentally sustainable dentistry: a quality improvement project.","authors":"Florence Mai, Edward Parkinson, Fleur Mumford, Zahra Shehabi","doi":"10.1038/s41405-026-00427-y","DOIUrl":"10.1038/s41405-026-00427-y","url":null,"abstract":"<p><strong>Background: </strong>Environmental sustainability in dentistry (ESD) is increasingly recognised by major organisations as essential, yet teaching of it remains fragmented and inconsistent across UK dental schools. This project evaluates teaching designed to enhance students' confidence and knowledge of ESD.</p><p><strong>Methods: </strong>A two-part interactive workshop series was delivered to dental and dental hygiene and therapy students at Queen Mary University London. Workshop 1 combined didactic lectures with group-based brainstorming of sustainability challenges. Workshop 2 centred on student-led presentations proposing responses to challenges for stakeholders. Pre- and post-workshop surveys assessed confidence in four domains with a 10-point Likert scale, and knowledge with six multiple-choice questions.</p><p><strong>Results: </strong>Confidence scores increased across domains and knowledge scores improved following the intervention. Participants rated the workshops highly on usefulness and enjoyment. Feedback identified the need to improve workshop timing and reduce assignment workload.</p><p><strong>Discussion: </strong>Low baseline confidence and knowledge scores indicated a need to incorporate ESD into the curriculum. The mixed-method approach was associated with positive change, with one proposal progressing toward real-world implementation.</p><p><strong>Conclusion: </strong>Workshop-based teaching was associated with improved student confidence and knowledge in ESD. Early curriculum integration is recommended, aligning with the 2025 GDC Safe Practitioner Framework requirements for ESD education.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Black is the new blue? A cross-sectional Gulf Cooperation Council (GCC) survey of colour preferences for scrubs, PPE and the dental clinical environment.","authors":"Abubaker Qutieshat, Reem T Al Amry, Zahra Mustafa, Mahmoud Rezk, Ghaid L Al Riyami, Majid Hamid-Oudjana, Laila Kebab, Ahmed Al Wahaibi, Rayhana Aouididi, Klara Avetisyan","doi":"10.1038/s41405-026-00426-z","DOIUrl":"10.1038/s41405-026-00426-z","url":null,"abstract":"<p><strong>Background: </strong>Colour cues in dental clinics may shape perceptions of professionalism, comfort, hygiene and anxiety, yet evidence from Gulf Cooperation Council (GCC) settings across attire, PPE and the operatory environment remains limited. This study examined colour preferences across Oman, the United Arab Emirates (UAE) and Bahrain.</p><p><strong>Methods: </strong>A cross-sectional, web-based survey was completed by non-healthcare university students in Oman (n = 193), UAE (n = 250) and Bahrain (n = 170) (total N = 613). Participants selected preferred colours for scrubs and multiple dental items (PPE, chairside disposables, dental chair and wall colour), indicated scrub colour by clinical scenario (routine, surgical, paediatric), endorsed 'comfortable' colours (select-all), and rated five attitudinal statements on a 5-point Likert scale. Between-country differences were examined using chi-square tests (Cramer's V) and Kruskal-Wallis tests; additional modelling included GEE for comfort endorsements and exploratory logistic regression for scenario switching.</p><p><strong>Results: </strong>Scrub preferences clustered around classic colours (blue/black), with modest between-country differences (χ² = 24.09, df = 10, p = 0.007; V = 0.14). Oman most preferred black (50.3%) then blue (41.5%); the UAE preferred blue (52.8%) then black (42.0%); Bahrain preferred blue (47.1%) then black (37.1%). Scenario framing increased openness to non-classic colours in paediatric care (red and yellow), and only 16.6% retained the same scrub colour across all scenarios. For other items, classic/neutral tones predominated, with significant country differences for most categories (including masks, wall colour, dental chair, dental bib, disposable kit and suction tips), while glove colour distributions were broadly similar. Warm/yellow operatory lighting was preferred over white lighting overall (60.2%) with negligible between-country differences (p = 0.881). Comfort endorsements were highest for blue and white; patterned prints showed the clearest country separation (UAE 50.4% vs Oman 36.8% and Bahrain 35.9%), persisting in adjusted GEE models. Most respondents disagreed that darker colours appear less hygienic, although distributions differed modestly across countries (Kruskal-Wallis p = 0.010).</p><p><strong>Conclusions: </strong>Colour preferences in GCC dental settings are anchored in a stable 'classic' palette, while scenario and item context introduce actionable departures, particularly for paediatric care. Black competed directly with blue across several domains and was not generally viewed as less hygienic, supporting its inclusion within a 'safe' procurement palette. Preference for warm lighting suggests a practical environmental lever to enhance perceived comfort.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-cultural adaptation and validation of the Arabic version of the Malocclusion Impact Scale for Early Childhood (MIS-EC/Ar).","authors":"Ahmed Kamal El-Motayam, Rim Fathalla, Marwah Salah Abdel-Latif, Iman Ali El-Baraky, Lamia Khairy Gadallah","doi":"10.1038/s41405-026-00411-6","DOIUrl":"10.1038/s41405-026-00411-6","url":null,"abstract":"<p><strong>Background: </strong>Malocclusion is a highly prevalent oral disease in children. It could detrimentally affect their oral health-related quality of life (OHR-QoL). The Malocclusion Impact Scale for Early Childhood (MIS-EC) is a newly developed scale for the assessment of OHR-QoL in this population aged 3-5 years-old. The aim of this study is to translate and validate an Arabic version of the MIS-EC scale (MIS-EC/Ar).</p><p><strong>Materials and methods: </strong>Translation and cross-cultural adaptation of the MIS-EC/Ar scale were performed conforming to relevant WHO guidelines. A sample of mothers/caregivers of children aged between 3 and 6 years was recruited (n = 236). Clinical examination of children and assessment of malocclusion were performed before taking MIS-EC/Ar. The internal consistency was assessed using Cronbach's alpha. Test-retest reliability performed after two weeks (n = 30) employed intraclass correlation coefficient (ICC). Construct validity, including convergent, discriminant, and structural validity, was evaluated in addition to criterion validity.</p><p><strong>Results: </strong>MIS-EC/Ar showed good internal consistency (standardized Cronbach's alpha = 0.797) and excellent test-retest reliability (ICC = 0.929, 95% CI 0.884-0.962). Convergent validity, Spearman correlation coefficients for the MIS-EC/Ar total score with the overall oral health question, was limited (r = 0.159, P < 0.05). Discriminant validity was significant (p < 0.05). Criterion validity was fair (r = 0.298, p = 0.01). Exploratory factor analysis suggested a reduced scale of six items.</p><p><strong>Conclusions: </strong>The MIS-EC/Ar is a reliable instrument with good discriminant validity for assessing malocclusion impact on preschool children's OHR-QoL. Limited convergent validity and altered factor structure suggest cultural adaptation effects.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical performance of low-shrinkage giomer compared to nanohybrid resin composite in proximal restorations after one year: a randomized clinical trial.","authors":"Marwa I AbdelHafez, Omar Shaalan, Heba Hamza","doi":"10.1038/s41405-026-00423-2","DOIUrl":"10.1038/s41405-026-00423-2","url":null,"abstract":"<p><strong>Objectives: </strong>The present study assesses the clinical performance and occlusal wear of low-shrinkage giomer and nanohybrid composite in proximal restorations.</p><p><strong>Methods: </strong>Fifty participants with proximal caries in posterior teeth (n = 25) were recruited. Teeth were restored with either conventional nano-hybrid composite (Filtek Z250XT, 3M ESPE, USA) or low-shrinkage giomer (Beautifil II LS, Shofu Inc, Japan). Clinical performance was assessed using revised FDI criteria at baseline, 6 and 12 months. Wear was assessed after 12 months by using 3D inspection and metrology software (Geomagic Control X; 3D Systems, USA). FDI scores were analyzed using Chi‑square test for intergroup comparisons and Cochran's Q‑test for intragroup comparisons. Wear data were analyzed using independent t test for intergroup comparison and paired t test for intragroup comparisons.</p><p><strong>Results: </strong>At the 12-month follow-up, both Beautifil II LS and Filtek Z250XT exhibited high clinical success rates, with 100% and 96% success rates, respectively. Beautifil II LS restorations had a 4% lower risk of failure compared to Filtek Z250XT (ARR = 4.0 (95% CI -12.6 to 19.5, P > 0.05)). The mean wear after 12 months was 0.036 ± 0.01 mm for Beautifil II LS and 0.038 ± 0.01 mm for Filtek Z250XT. The difference between groups was minimal (0.0026 mm; 95% CI: -0.0271 to 0.0324) and not statistically significant (P = 0.8178).</p><p><strong>Conclusion: </strong>Low-shrinkage giomer showed satisfactory clinical performance and wear resistance compared to nanohybrid resin composite after one year. Both materials are considered clinically acceptable as per the American Dental Association (ADA) standards.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of enamel surface treatment via Er, Cr: YSGG laser and nano-hydroxyapatite toothpaste on mineral content of primary teeth via x-ray diffractometer: an in-vitro study.","authors":"Fatma Mohamed Elhussini, Dina Hamdy, Ahmed Hammad Abodouh, Gehan Gaber Allam","doi":"10.1038/s41405-026-00418-z","DOIUrl":"10.1038/s41405-026-00418-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the effect of Er,Cr:YSGG laser treatment, with or without nano-hydroxyapatite (nHAP) toothpaste, on the mineral content of primary enamel specimens, with emphasis on their remineralization potential in pediatric dentistry.</p><p><strong>Materials and methods: </strong>This in vitro study included 33 sound primary anterior teeth, from which enamel slabs were prepared and subjected to demineralization for 96 hours. Specimens were randomly assigned to three groups (n = 11): Group A (nHAP toothpaste), Group B (Er,Cr:YSGG laser, 2780 nm), and Group C (combined laser and nHAP toothpaste). Mineral phase composition was assessed using X-ray diffraction (XRD).</p><p><strong>Results: </strong>Quantitative phase analysis revealed an increase in apatite crystal content in all groups following treatment. Group C showed the highest increase (7.4%) and exhibited a complete transformation into apatite structures. Groups A and B demonstrated comparable increases (5.1% and 4.8%, respectively), with no statistically significant difference between them.</p><p><strong>Conclusions: </strong>Both Er,Cr:YSGG laser irradiation and nHAP toothpaste enhanced apatite formation in demineralized primary enamel; however, their combined application produced the most pronounced remineralization effect.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitude, and practice in diagnostic dental radiology: an Egyptian survey with a global perspective.","authors":"Mohamed F Rashed, Lamia Khairy Gadallah, Mohamed Abdelfattah Galal, Khaled Helmi El-Wakeel, Hend S ElSayed","doi":"10.1038/s41405-026-00415-2","DOIUrl":"10.1038/s41405-026-00415-2","url":null,"abstract":"<p><strong>Objectives: </strong>Many surveys report less than optimum knowledge, attitude, and practice (KAP) of dental imaging for patient and operator safety. This study aimed to assess the KAP for diagnostic imaging among dentists in light of global practices and recent recommendations.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted using a structured questionnaire that was electronically distributed through dental social media platforms between March 1st and June 30th, 2022. Forty-seven questions evaluating demographics, knowledge, practice, and attitude were included. The survey targeted Egyptian dentists practicing in Egypt.</p><p><strong>Results: </strong>Two hundred and twenty-eight dentists of different specialties responded. Fifty-nine percent of the dentists were not familiar with the ALARA principle. Fifty-three percent never use lead aprons. Dentists (16.6%) who practiced in facilities with cone-beam computerized tomography (CBCTs) showed significantly (p = 0.000) higher knowledge scores (7.89 ± 2.63) than those who didn't have CBCTs (6.16 ± 2.67). There was no statistical difference in training received (p = 0.345) between the different specialties. Most dentists (79.4%) were interested in increasing their knowledge of radiation safety.</p><p><strong>Conclusions: </strong>Within the limitations of this study, there is a need to educate dentists on radiation hazards, child-sized imaging protocols, and how to implement the ALARA principle. Training materials freely available on reliable websites should be disseminated. Regulations should include auditing referrals and periodic calibration of X-ray units.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of clip material on the retention of implant retained mandibular overdenture: randomized clinical study.","authors":"Sara Medhat Mohamed, Ahmed M Sayed","doi":"10.1038/s41405-026-00419-y","DOIUrl":"10.1038/s41405-026-00419-y","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the retention of implant retained mandibular overdenture with polyether-ether-ketone (PEEK) bar using either ready-made nylon clips or custom-made PEEK clips over a one-year randomized clinical study.</p><p><strong>Materials and methods: </strong>Twenty completely edentulous patients received two implants inserted bilaterally in the canine-premolar region. A milled PEEK bar was screwed to the multiunit abutment screwed to the implants. Patients were divided equally into two groups (n = 10) according to clip material; group1: ready-made nylon clip and group 2; PEEK clip (Pressed BioHPP®). Clips were picked up into the fitting surface of the overdenture. Retention force was measured at insertion, three months, six months and one year using universal testing machine. Data were analysed using two-way repeated measure ANOVA followed by Bonferroni post-hoc tests (p ≤ 0.5).</p><p><strong>Results: </strong>Retention values between nylon clip group and PEEK group revealed non-statistically significant difference at insertion (28.98 N ± 3.40 and 28.38 N ± 4.80 respectively), three months (30.93 N ± 3.52 and 30.43 N ± 4.7 respectively), six months (30.63 N ± 3.50 and 30.48 N ± 4.63 respectively) and one year (27.13 N ± 3.38 and 27.69 N ± 4.41 respectively).</p><p><strong>Conclusion: </strong>PEEK clips used for retention of PEEK bar-implant retained mandibular overdentures showed comparable retention values to nylon clips up to one year.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing a postgraduate programme in orthodontics in the Caribbean: governance, collaborations and challenges, at the University of the West Indies.","authors":"Trudee Hoyte","doi":"10.1038/s41405-026-00424-1","DOIUrl":"10.1038/s41405-026-00424-1","url":null,"abstract":"<p><strong>Objective: </strong>To describe the development and implementation of the first postgraduate orthodontic training programme in the English-speaking Caribbean and situate its establishment within international outlines for postgraduate dental education and global health workforce development.</p><p><strong>Methods: </strong>A descriptive analysis was undertaken of the governance processes, curriculum development and institutional collaborations involved in establishing a postgraduate orthodontic programme at The University of the West Indies (UWI). Programme development incorporated regional workforce needs assessment, stakeholder consultation and benchmarking against internationally recognised competency frameworks, including those of the UK Specialist Advisory Committee and European postgraduate orthodontic education guidelines.</p><p><strong>Results: </strong>The programme was developed through a multi-stage governance pathway within UWI and in collaboration with the Royal College of Surgeons of Edinburgh. A competency-based curriculum was constructed through structured mapping of programme learning outcomes to international orthodontic training standards. The three-year full-time programme integrates supervised clinical training, theoretical instruction and a research dissertation. Clinical training comprises approximately 24-28 hours weekly with structured workplace-based assessments and competency-based progression. Hybrid teaching models and international faculty support were introduced to address regional staffing limitations.</p><p><strong>Conclusions: </strong>The establishment of this programme represents a significant milestone in specialist dental education in the Caribbean. By combining international educational standards with regional contextual adaptation, the initiative provides a model for developing sustainable specialist training programmes in small-island and resource-constrained settings.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13049017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental, mandibular and parotid gland radiation doses in curatively treated head and neck squamous cell carcinoma: a retrospective cohort study.","authors":"Veera Emilia Kärkkäinen, Henna Hietala, Petri Koivunen, Juha Nikkinen, Kaisa Lehtiö","doi":"10.1038/s41405-026-00416-1","DOIUrl":"10.1038/s41405-026-00416-1","url":null,"abstract":"<p><strong>Background and purpose: </strong>Radiation therapy (RT) is a cornerstone of head and neck squamous cell carcinoma (HNSCC) treatment, often used alongside surgical approaches, delivering curative doses between 50-70 Gy. Pre-RT dental screenings aim to prevent oral complications by extracting teeth with poor prognosis, particularly in high-dose areas exceeding 40 Gy. The aim of the present study was to measure the planned radiation doses received on dentition during definitive or postoperative radiation therapy for HNSCC.</p><p><strong>Material and methods: </strong>This retrospective study analyzed 91 HNSCC cases treated with RT at Oulu University Hospital (2018-2021), assessing radiation doses to dentition, mandible, and parotid glands across different tumor sites.</p><p><strong>Results: </strong>Results showed that ipsilateral RT spared contralateral and frontal dental regions more effectively than bilateral RT, particularly in oral cavity and oropharyngeal cancers. Conversely, hypopharyngeal and laryngeal cancers rarely exposed dentition to doses above 40 Gy. Bilateral RT often exceeded the 40 Gy threshold in mandibular and parotid regions, particularly in oral cavity cancers, underscoring the need for precise dose planning to balance tumor control with oral health preservation.</p><p><strong>Conclusion: </strong>The findings highlight that ipsilateral RT can reduce the need for pre-RT dental extractions in contralateral regions and provide a basis for optimizing dental care strategies. By understanding dose distributions, balance can be addressed between minimizing oral health impacts and ensuring effective HNSCC treatment.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between systemic immune-inflammation index and periodontitis in adults with and without hyperlipidemia: a population-based study.","authors":"Ying Xie, Shuangying Zhou","doi":"10.1038/s41405-026-00422-3","DOIUrl":"10.1038/s41405-026-00422-3","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between SII and periodontitis, and to determine whether this association differs by hyperlipidemia status in adults.</p><p><strong>Methods: </strong>21,283 U.S. adults aged ≥18 years were enrolled from NHANES 1999-2014. Multivariable logistic regression models were employed to assess the association between SII and periodontitis while controlling for potential confounding factors. We further explored non-linear dose-response relationships using two-piecewise regression model to identify any threshold effect of SII on periodontitis risk. Robustness of the findings was evaluated through sensitivity analyses.</p><p><strong>Results: </strong>Periodontitis was prevalent in 6,758 individuals (31.75%). In stratified analyses, this pattern was evident among individuals with hyperlipidemia: we identified an inflection point at SII ≈ 522. Within the lower SII range, a 500-unit increment demonstrated an inverse association with periodontitis susceptibility, yielding a significant 18% risk reduction (OR = 0.82, 95% CI 0.68-0.99, P = 0.036). Conversely, in the upper SII spectrum, identical 500-unit increments corresponded to a substantial 15% heightened periodontitis risk (OR = 1.15, 95% CI 1.05-1.25, P = 0.002). A significant non-linear dose-response was found in hyperlipidemic individuals (P for threshold effect = 0.005). In contrast, among individuals without hyperlipidemia, no significant association between SII and periodontitis was detected. Sensitivity analyses, including the exclusion of participants with malignancies, stratification by sex and using alternative periodontitis definitions, yielded consistent results, reinforcing the robustness of our findings.</p><p><strong>Conclusions: </strong>SII demonstrated a non-linear association with periodontitis that was restricted to individuals with hyperlipidemia. In hyperlipidemic adults, moderate increases in SII (within a lower range) were associated with reduced odds of periodontitis, whereas an SII beyond ~522 was significantly associated with higher disease prevalence.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}