BDJ Open最新文献

{"title":"Comparison of the remineralization effectiveness of three remineralizing agents on artificial enamel lesions: an in vitro study.","authors":"Maha Mohamed Montaser, Heba Youssef, Ghada Mohamed Mahmoud","doi":"10.1038/s41405-025-00330-y","DOIUrl":"https://doi.org/10.1038/s41405-025-00330-y","url":null,"abstract":"<p><strong>Introduction: </strong>Early enamel demineralization can be reversed through remineralization, which restores lost minerals to strengthen enamel and prevent decay.</p><p><strong>Aim: </strong>This study evaluated the remineralization efficiency of three commercial treatments on artificially demineralized primary enamel.</p><p><strong>Methods: </strong>Forty exfoliated primary anterior teeth were demineralized and divided into five groups: untreated control, artificial saliva, fluoridated toothpaste, Curasept toothpaste, and BioMin toothpaste. The treatments were applied for 28 days. Remineralization efficacy was assessed using Vickers microhardness testing, surface roughness measurement, and Scanning electron microscope combined with EDX (SEM-EDX). One-way ANOVA and Tukey's HSD test were used for statistical analysis.</p><p><strong>Results: </strong>Microhardness and surface roughness tests confirmed BioMin's superior remineralization potential. Scanning electron microscopy showed that untreated enamel exhibited extensive demineralization, whereas treated groups displayed varying degrees of remineralization. BioMin demonstrated the highest calcium, phosphate, and fluoride incorporation, followed by Curasept and fluoridated toothpaste. The artificial saliva group showed no significant improvement over the control.</p><p><strong>Conclusion: </strong>BioMin, followed by Curasept and fluoridated toothpaste, effectively remineralized demineralized enamel. BioMin's bioactive glass formulation provided the highest mineral gain, suggesting its potential for non-invasive enamel restoration in pediatric dentistry.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"44"},"PeriodicalIF":2.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing white spot lesions around orthodontic brackets: efficacy of pre-reacted glass-ionomer barrier coat versus silver diamine fluoride: an in vitro study.","authors":"Enas A Elshenawy, Safa B Alawy, Wafaa Yahia Alghonemy, Ahmed Ibrahime El Dosoky","doi":"10.1038/s41405-025-00332-w","DOIUrl":"https://doi.org/10.1038/s41405-025-00332-w","url":null,"abstract":"<p><strong>Objectives: </strong>to compare the effect of using a pre-reacted glass-ionomer (PRG) barrier coat versus silver diamine fluoride (SDF) varnish treatment before orthodontic bracket bonding to prevent white spot lesions (WSL). The effect of these materials on the shear bond strength of orthodontic brackets was evaluated through an in vitro study.</p><p><strong>Methods: </strong>One hundred-five premolars were used; forty-two specimens were designated for comparing SDF versus PRG-barrier coat using a scanning electron microscope (SEM) with elemental analysis and microhardness testing (n = 21/group). Tested materials were applied in a split-tooth design protocol (side A: control, side B: treated). Measurement was made at baseline and after bracket placement and exposure to the pH cycle. A polarized light microscope (PLM) was used for qualitative examination. Sixty-three specimens were intended for shear bond strength (SBS) testing after the pH cycle as follows: control group (no treatment), SDF group, and PRG-barrier coat group (n = 21/group). Statistical analysis was done using Paired T-test.</p><p><strong>Results: </strong>SEM for specimens treated by SDF or PRG revealed enamel remineralization with calcium deposits and small porosities between the crystallites. All groups had a significant difference regarding the Ca/P ratio and microhardness. Baseline hardness for both groups was significantly higher than the treated sides, which was significantly higher than the non-treated sides (P = 0.000*) and (P = 0.000*) in accordance with the Paired T-test. In comparing SDF with PRG-coat groups, the T-test showed non-significant differences in mean differences between treated and baseline hardness values (T = 0.32, P = 0.74). PLM for treated specimens by SDF or PRG depicted an evident remineralized surface enamel layer. SBS values did not differ significantly between groups.</p><p><strong>Conclusions: </strong>As confirmed by SEM and PLM, applying either SDF varnish or PRG-barrier coat before bonding orthodontic brackets could effectively prevent the development of WSL and achieve surface enamel protection. In addition, the two applied varnishes showed slightly higher shear bond strength of orthodontic brackets compared to the control group, with the SDF slightly higher than PRG. Also, clinical translation is needed in future research to evaluate the study.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"45"},"PeriodicalIF":2.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the effectiveness of an e-learning module at different levels of magnification for detecting occlusal caries in permanent teeth, utilizing the international caries detection and assessment system (ICDAS): an ex vivo study.","authors":"Mary Byju, Kundabala Mala, Srikant Natarajan, Manuel S Thomas, Abhishek Parolia","doi":"10.1038/s41405-025-00323-x","DOIUrl":"https://doi.org/10.1038/s41405-025-00323-x","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to compare the effectiveness of low and high magnifications in detecting occlusal caries in permanent posterior teeth using the International Caries Detection and Assessment System (ICDAS) II criteria through the ICDAS e-learning program.</p><p><strong>Materials and methods: </strong>Forty extracted permanent posterior teeth were used. Two examiners received e-learning training on the ICDAS webpage for detecting occlusal caries before visual examinations. Visual inspections were performed under ×2.5 magnification with a magnifying loupe and ×25 magnification with a dental surgical microscope within a week. The ICDAS scores assigned by both examiners were validated by an ICDAS expert. The visual assessment results were compared with the histological analysis results using Downer's criteria as the gold standard.</p><p><strong>Results: </strong>Inter-examiner reliability for ICDAS-II scoring at low magnification (×2.5 loupe) and high magnification (×25 operating microscope) was moderate. However, the lenient (binary) criteria showed substantial agreement at both magnifications. Specificity was highest for both the low and high treatment thresholds (88.2% and 81.5%, respectively) at low magnification, whereas sensitivity peaked at high magnification for the high treatment threshold criterion (91.7%). Image-based ICDAS scoring by an expert also demonstrated good diagnostic accuracy (76.9%), though it was not superior to ICDAS scoring performed under ×2.5 magnification (82.1%).</p><p><strong>Conclusion: </strong>The ICDAS-II score, particularly the lenient criterion, demonstrated a strong correlation with histological depth. The e-learning program effectively equips dentists with diagnostic skills. Extreme magnification resulted in the overestimation of dental caries, whereas low magnification (2.5x) resulted in greater diagnostic accuracy.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"43"},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Protocol for a systematic review and meta-analysis of the prevalence of viral infections in acute apical abscesses.","authors":"José Ángel Hernández-Mariano, Gustavo Adolfo Sánchez-Ramírez, Guillermo Cano-Verdugo, Myriam Angélica De la Garza-Ramos, Martín Andrés Chávez-Méndez, Claudio Peña-Soto, Mónica Alethia Cureño-Díaz","doi":"10.1038/s41405-025-00334-8","DOIUrl":"https://doi.org/10.1038/s41405-025-00334-8","url":null,"abstract":"","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"42"},"PeriodicalIF":2.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of LASER- induced precipitation of MTA-nanoparticles on root canal dentin surface.","authors":"Mohammed Hamdi Atteia, Abeer Ahmed Saba, Eman M Fouad","doi":"10.1038/s41405-025-00322-y","DOIUrl":"https://doi.org/10.1038/s41405-025-00322-y","url":null,"abstract":"<p><strong>Aim of the study: </strong>This study aims to evaluate the effectiveness of a 980-nm diode laser in inducing mineral trioxide aggregate (MTA) nanoparticle precipitation on root canal dentin surfaces for dentinal coverage.</p><p><strong>Materials and methods: </strong>Sixty mature single-rooted teeth were decoronated at a fixed length of 16 mm and instrumented to size #40/0.04. Canals were filled with either distilled water or nanoMTA suspension and randomly divided based on the treatment modality into: G I and G II flooded with distilled water and laser irradiated at 2 Watt and 4 Watt respectively, GIII and GIV flooded with nanoMTA suspension and laser irradiated at 2 Watt and 4 Watt respectively, G V, flooded with nanoMTA suspension without laser irradiation, and G VI flooded with distilled water without laser irradiation. All samples were longitudinally split and scanned by environmental scanning electron microscopy (ESEM) to evaluate dentinal tubule (DT) occlusion and MTA surface precipitation. Image J analysis software was used to quantify open DTs, while a scoring system assessed dentine coverage.</p><p><strong>Results: </strong>Laser irradiation significantly enhanced nanoMTA precipitation and dentinal tubule occlusion. The highest dentinal surface coverage, indicated by the lowest pixel percentage, was in laser-irradiated nanoMTA suspension groups G IV (3.4 ± 3.1) and G III (16.7 ± 3), while the lowest coverage was in the non-irradiated saline group G VI (53.4 ± 9.6) (p < 0.05). Median dentinal coverage scores were also highest in G III and G IV (both = 4). G VI showed the least dentinal occlusion, with a statistically significant difference from other groups (p < 0.05).</p><p><strong>Conclusion: </strong>The 980-nm diode laser effectively enhances MTA nanoparticle precipitation on root canal surfaces, improving dentinal tubule occlusion and sealing potential. Further research is warranted to optimize laser parameters, MTA suspension ratios and to assess clinical outcomes.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"41"},"PeriodicalIF":2.5,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon footprint of private dental laboratories in Egypt: A cross-sectional study.","authors":"Amira H Elwan, Ahmed Mahmoud Fouda","doi":"10.1038/s41405-025-00316-w","DOIUrl":"https://doi.org/10.1038/s41405-025-00316-w","url":null,"abstract":"<p><strong>Background: </strong>Climate change poses a serious threat to the planet, mainly driven by greenhouse gas (GHG) emissions. Dental laboratories contribute to GHG emissions through staff travel, waste, energy and water consumption, and procurement. Carbon footprinting is the process of quantifying the direct and indirect GHG emissions associated with a service. This study aimed to assess the Carbon Footprint (CFP) of private dental laboratories in Egypt.</p><p><strong>Materials and methods: </strong>Data were collected from private dental laboratories in Cairo, Alexandria, and Elbeheira, Egypt in August 2024 through interview questionnaires. A CFP calculator was used to estimate carbon emissions from staff travel, waste, energy and water consumption, and procurement. The data of all laboratories was summed and divided to determine the average CFP per laboratory and per prothesis/appliance, both with and without the depreciation of dental equipment.</p><p><strong>Results: </strong>Data from 21 dental laboratories were collected. An average private dental laboratory in Egypt worked 309 days with a staff of around 7 persons and makes around 7119 prostheses/appliance per year. The CFP of dental laboratories was around 20,820 kg CO₂e, equal to 2.9 kg CO₂e per prosthesis/appliance. The largest contributor to the CFP was staff travel (43.6%), followed by procurement (27.8%), energy consumption (25%), waste (3.3%), and water consumption (0.1%). After including the depreciation of dental equipment, the CFP increased by 7.7%.</p><p><strong>Conclusion: </strong>Private dental laboratories in Egypt produce a significant amount of carbon emissions. Staff travel was the major contributor to the carbon emission because each laboratory hired several couriers to deliver the prostheses/appliances and impressions. The CFP of electricity consumption was significant, likely because the air conditioning ran throughout the year to cool the machines down. Future studies are needed to develop customized country-specific CFP calculators to accurately measure the carbon emissions of dental laboratories in various settings. Preventing oral diseases, educating technicians on sustainable dental practices, optimizing public transportation, using bulk delivery services, shifting to renewable energy, and adopting circular economy are essential to mitigate the carbon emissions of dental laboratories.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"40"},"PeriodicalIF":2.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The outcomes of calcium silicate cement putty apical plugs in traumatised permanent maxillary teeth in paediatric patients: a retrospective evaluation.","authors":"Dariusz Kasperek, Samantha Beattie, Nicholas Longridge, Fadi Jarad, Sondos Albadri","doi":"10.1038/s41405-025-00317-9","DOIUrl":"https://doi.org/10.1038/s41405-025-00317-9","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate the clinical and radiographic outcomes of root canal treatment of traumatised necrotic permanent maxillary teeth in paediatric patients.</p><p><strong>Methods: </strong>A retrospective analysis of clinical and radiographic records of patients aged 16 or under, who underwent apexification of permanent maxillary teeth, between 2016 and 2023, using TotalFill BC Putty was conducted. Success was assessed radiographically using periapical radiographs and clinically, against the European Society of Endodontology quality guideline consensus report.</p><p><strong>Results: </strong>A total of 66 teeth from 57 patients were included, with the mean age of 10 years old ( ± 2.1). The mean follow-up time was 14 months ( ± 12.2) with the average number of 3.5 visits ( ± 1.8). Success outcome at latest review was favourable in 48.5% (n = 32), uncertain in 36.4% (n = 24) and unfavourable in 15.1% (n = 10) of cases. In 84.9% (n = 56) of cases, there was evidence of complete or partial radiographic healing.</p><p><strong>Conclusions: </strong>Within the limits of this service evaluation, TotalFill BC Putty showed favourable outcomes in managing necrotic maxillary permanent teeth in children, demonstrating success rates comparable to MTA, suggesting that it may be a viable alternative for apexification in this patient cohort.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"39"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of personalized oral health education with behavioural modification using HAPA-MI constructs and oral care kit in residents of informal settlements.","authors":"Prasad Rath, Rupsa Das, Karishma Rathor, Swagatika Panda","doi":"10.1038/s41405-025-00329-5","DOIUrl":"https://doi.org/10.1038/s41405-025-00329-5","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Oral health is a crucial determinant of overall well-being, yet 'residents of informal settlement', previously referred as 'slum dwellers', face significant barriers to maintaining it. Personalized oral health education and behavior modification using models like the Health Action Process Approach (HAPA) and Motivational Interviewing (MI) can address these barriers. While HAPA and MI have shown promise, their individual limitations highlight the need for a combined approach. Integrating these models with personalized education and oral care kits provides a holistic solution to address both motivational and practical barriers. This study evaluates the effectiveness of such an intervention on oral health behaviors and outcomes in residents of informal settlement.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methodology: &lt;/strong&gt;A quasi-experimental pre and post interventional study was conducted among 45 participants aged 18-60 years from three wards in Bhubaneswar. The study was conducted between October 24, 2023, to December 24, 2023. Participants were recruited through dental camps organised by our institute. Baseline oral health behavior was assessed using a validated questionnaire based on four behavioral constructs: outcome expectancy (OE), self-efficacy (SE), intention (I), and perceived barriers (PB) by faculty and postgraduate students of public health dentistry department. Participants also received personalized oral health education and an oral care kit. Plaque index (PI), Oral Hygiene Index-Simplified (OHI-S), and behaviour towards oral health were recorded both at baseline (T0) and one-month post-intervention (T1) by same examiners. Statistical analyses included paired t-tests, chi-square tests, and Cronbach's alpha for internal consistency of the questionnaire, with p ≤ 0.05 considered significant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Post-intervention, significant improvements were observed in all behavioral constructs. The mean outcome expectancy (OE) increased from 2.49 ± 0.20 to 4.15 ± 0.07 (p = 0.000), self-efficacy (SE) from 1.90 ± 0.14 to 3.81 ± 0.14 (p = 0.000), intention (I) from 1.92 ± 0.11 to 4.30 ± 0.33 (p = 0.001), and perceived barriers (PB) from 1.85 ± 0.11 to 4.04 ± 0.03 (p = 0.002). Clinical outcomes also showed significant improvements: the mean plaque index (PI) decreased from 1.9 ± 0.8 to 0.9 ± 0.4 (p = 0.000), and the mean oral hygiene index-simplified (OHI-S) decreased from 2.3 ± 1.4 to 1.5 ± 0.9 (p = 0.003). Internal consistency of the questionnaires was good across constructs, with Cronbach's alpha values ranging from 0.715 to 0.751.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study demonstrates that a holistic behavioural intervention combining personalized education, behavior modification using HAPA and MI models, and oral care kit distribution significantly improves oral hygiene behavior and clinical outcomes among residents of informal settlement. The model addresses both motivational and access barriers, providin","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"38"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the rotation angles on the mechanical behavior of the one reci instrument.","authors":"Renaud Giess, Éric Mortier, Marie Delanoë, Romain Hocquel, Jean-Marc Martrette, Rémy Balthazard, Marin Vincent","doi":"10.1038/s41405-025-00327-7","DOIUrl":"https://doi.org/10.1038/s41405-025-00327-7","url":null,"abstract":"<p><strong>Aims: </strong>The reciprocity is a complex endodontic kinematic involving many parameters. The most important of these is undoubtedly the selection of clockwise and counterclockwise rotation angles. In this context, the aim of this study was to determine the influence of clockwise and counterclockwise rotation angles on the mechanical properties of 25/0.06 One Reci reciprocity instruments.</p><p><strong>Method: </strong>For this purpose, 5 groups of 10 25/0.06 One Reci instruments were used and each group was associated with a pair of counterclockwise/clockwise rotation angles (CCW/CW). In order to study only one variable at a time, one of the two angles was fixed and the second was increased or decreased. The distribution of angles was as follows: Group 1: 170°/60°; Group 2: 150°/60°; Group 3: 170°/30°; Group 4: 170°/90°; Group 5: 210°/60°. Thanks to a load/unload endodontic protocol carried out on a tensile bench, we quantified for each tested pair of angles (i) the cutting efficiency, (ii) the screwing effect and (iii) the generated torque.</p><p><strong>Results: </strong>Increasing or decreasing one of the two rotation angles influences the mechanical behavior of the instruments, as does the resulting range. Therefore, our results showed a direct influence of rotation angles on the mechanical behavior of endodontic instruments.</p><p><strong>Conclusion: </strong>This study analyzes the influence of clockwise and counterclockwise rotation angles on the mechanical properties of 25/0.06 One Reci reciprocity instruments. The results of this work tend to demonstrate a direct influence of rotation angles on the mechanical behavior of 25/0.06 One Reci instruments.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"37"},"PeriodicalIF":2.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and radiographic outcomes of non-surgical retreatment of mature maxillary incisions using two regenerative endodontic techniques in adolescents: a 24-month randomized clinical trial.","authors":"Ahmad Abdel Hamid Elheeny, Sherif Shafik El Bahnasy, Yassmin Mohamed ElMakawi, Mohammed Turky, Eman Farouk Ahmed, Norhan Khaled Omar Wahba","doi":"10.1038/s41405-025-00324-w","DOIUrl":"https://doi.org/10.1038/s41405-025-00324-w","url":null,"abstract":"<p><strong>Aims: </strong>The primary aim was to monitor the healing of the periapical radiolucencies of adolescents' mature permanent teeth with apical periodontitis after root canal retreatment with two REPs techniques at 24 months of follow-up. The secondary aim was to assess clinical outcomes and positive responses of retreated teeth to pulp sensibility tests.</p><p><strong>Methodology: </strong>Forty adolescents with 48 teeth were enroled and randomly allocated into two equal groups after being matched according to their periapical index (PAI) scores. Root canal retreatment was performed with blood clot (BC) formation in one group and platelet-rich fibrin (PRF) in the other group. The healing process was tracked using standardized two-dimensional radiographic images to record the changes in the PAI scores after 3, 6, 12, and 24 months. Additionally, the clinical signs and symptoms and the positive responses to pulp sensibility tests were monitored. The difference between the PAI medians was analysed using the Mann-Whitney U test. The main impact of time on the PAI values and the interaction between time and the REPs technique were assessed using the general linear model (GLM). The alpha level of significance was 5%.</p><p><strong>Results: </strong>After two years of follow-up, there was no significant difference between the two groups clinically and in the PAI medians. The overall success rates in the BC and PRF groups were 95% and 100%, respectively (P > 0.05). Positive pulp responses were detected in 71% of the BC group and 73% in the PRF group (P > 0.05). The EPT mean values in the BC and PRF groups were 40.86 ± 6.60 and 37.9 ± 15.22, respectively (P > 0.05). Time had a significant impact on the PAI scores over the follow-up periods (P > 0.0001), while the interaction effect of time with the REPs technique had no significant effect on the PAI scores (P = 0.126).</p><p><strong>Conclusions: </strong>REPs were effective in the retreatment of mature maxillary permanent incisors with apical periodontitis with a comparable reduction in the periapical radiolucencies and clinical outcomes associated with approximately similar positive responses to thermal and electric pulp tests.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"36"},"PeriodicalIF":2.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11985920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}