BDJ Open最新文献

{"title":"Remineralization of early caries lesions by calcium hypophosphite in vitro: a surface microhardness study.","authors":"Bennett Tochukwu Amaechi, Razina Vohra, Sima Abdollahi, Kelly Yang, Amos Chinedu Obiefuna, Erik Schulze Zur Wiesche, Joachim Enax","doi":"10.1038/s41405-026-00440-1","DOIUrl":"https://doi.org/10.1038/s41405-026-00440-1","url":null,"abstract":"<p><strong>Aim: </strong>This in vitro study used a pH cycling model to compare the caries remineralizing efficacy of toothpaste formulations containing calcium hypophosphite (CaP), hydroxyapatite (HAP), or sodium fluoride (NaF).</p><p><strong>Methods: </strong>Bovine enamel blocks with plaque-induced initial caries lesions were randomized (n = 30/group) to toothpaste formulations containing 1% CaP, 20% HAP, 1% CaP+20% HAP, or 1450 ppm fluoride provided as NaF. Lesion-bearing samples were subjected to a 14-day remineralization using a pH-cycling model with daily regimen of three 2-min applications of toothpaste slurry (1:3 toothpaste: water), one 2-h acid exposure, and storage in artificial saliva for the rest of the day. Remineralization was quantified as change in surface microhardness (SMH) of each sample measured before and after toothpaste treatment and expressed as percent remineralization (%Rem). Statistical analyses included paired t tests for within-group changes and one-way ANOVA with Tukey's post hoc tests for between-group comparisons (α = 0.05).</p><p><strong>Results: </strong>All groups exhibited significant (paired t test, p < 0.001) increase in SMH from baseline, indicating remineralization. Combining CaP and HAP achieved significantly (ANOVA/Tukey's, p < 0.001) greater %Rem (89.7 ± 3.3) when compared with CaP alone (75.4 ± 5.5), HAP alone (62.4 ± 4.8), or NaF alone (60.3 ± 7.8). While %Rem achieved with CaP alone was significantly (p < 0.001) greater than that of HAP and NaF, there was no significant difference in %Rem between HAP and NaF.</p><p><strong>Conclusion: </strong>This in vitro study demonstrates that CaP alone, and in combination with HAP, increases enamel surface microhardness, confirming that CaP-based formulations are efficient strategies for the remineralization of early caries lesions.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of digital splints versus traditional splints for bruxism management: a systematic review.","authors":"Ravinder S Saini, Kanwalpreet Kaur, Seyed Ali Mosaddad, Artak Heboyan","doi":"10.1038/s41405-026-00438-9","DOIUrl":"https://doi.org/10.1038/s41405-026-00438-9","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of bruxism in the adult population varies widely. Splints are commonly used to treat bruxism, protect teeth, and alleviate the adverse effects of grinding or clenching. This systematic review aimed to compare the effectiveness of digital versus traditional splints in managing bruxism, focusing in clinical outcomes such as symptom severity, pain reduction, bruxism event frequency, and muscle activity.</p><p><strong>Methods and material: </strong>A Systematic review was conducted following PRISMA guidelines. A comprehensive electronic database search was conducted across PubMed, Scopus, the Cochrane Library, Dimensions, and Google Scholar for scholarly journal articles comparing digital and traditional splints. Eligibility criteria included randomized controlled trials (RCTs) published in peer-reviewed journals that investigated the effectiveness of splints in bruxism management. The Cochrane Risk of Bias 2.0 was used to appraise the quality of the included randomized controlled trials.</p><p><strong>Results: </strong>The literature search yielded 2115 records, of which eight articles met the eligibility criteria. Additionally, the risk of bias assessment results indicated that most randomized controlled trials reported a low to moderate risk of bias. This study's findings demonstrate the superiority of digital splints over traditional splints in managing bruxism. However, this difference was not statistically significant.</p><p><strong>Conclusions: </strong>Digital splints showed a tendency toward improved outcomes in managing bruxism compared to traditional splints, but the lack of statistical significance highlights the need for further research to confirm these findings.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of alloplastic and biologic grafts in maxillary sinus augmentation: a systematic review.","authors":"Jonathan Varghese Thomas, Santosh Martande, Joshua Thomas Meenathathil, Bhushan Bhagat, Swathi Pv, Shambhavi Thakur, Krishna Suryawanshi, Nomita Yein","doi":"10.1038/s41405-026-00435-y","DOIUrl":"https://doi.org/10.1038/s41405-026-00435-y","url":null,"abstract":"<p><strong>Background: </strong>Maxillary sinus augmentation is a well-established procedure to increase posterior maxillary bone volume for implant placement. Various graft materials are used, including autografts, allografts, xenografts, and alloplasts, but the clinical performance of alloplasts remains debated.</p><p><strong>Methodology: </strong>A systematic review was performed following PRISMA guidelines to compare histological, histomorphometric, radiographic, and clinical outcomes of sinus lift procedures using different grafts. Electronic searches were conducted in eight databases. Eligible studies were human clinical trials (RCTs, cohorts) comparing at least two graft materials and reporting new bone formation, graft resorption, implant survival, or complications. Eighteen studies met the inclusion criteria. Risk of bias was assessed using Cochrane RoB 2.0 and ROBINS I V2 tool.</p><p><strong>Results: </strong>Alloplastic grafts demonstrated comparatively lower new bone formation than autogenous and allogeneic grafts, and were generally inferior to xenografts in terms of regenerative potential. They exhibited higher residual graft content, suggesting slower resorption when compared with biologic grafts. In contrast, xenografts and allografts showed more favorable integration. Volumetric outcomes indicated that alloplastic grafts provided better dimensional stability than autografts but were less effective than xenografts in maintaining graft volume and space. Radiographic findings further supported superior space maintenance with xenografts compared to alloplastic grafts. Implant survival rates were high across all graft types; however, biologic grafts demonstrated relatively improved success and lower marginal bone loss compared with alloplastic grafts.</p><p><strong>Conclusion: </strong>Autografts demonstrated the highest effectiveness in maxillary sinus augmentation, followed by xenografts and alloplastic grafts, indicating a comparatively lower regenerative potential of alloplastic materials. Nevertheless, alloplastic grafts may still be considered a viable alternative in selected clinical scenarios, particularly where minimizing donor-site morbidity or reducing immunological and infection-related risks is a priority. High-quality, long-term randomized trials are needed to confirm these findings and optimize graft selection.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alkaline phosphatase activity in gingival crevicular fluid during orthodontic treatment with different extraction protocols for maxillary canines: a randomized controlled trial.","authors":"Yahya Dakdouk, Kindah Sultan, Shadi Azzawi","doi":"10.1038/s41405-026-00425-0","DOIUrl":"10.1038/s41405-026-00425-0","url":null,"abstract":"<p><strong>Background: </strong>Alkaline phosphatase (ALP) activity in gingival crevicular fluid (GCF) reflects localized periodontal and alveolar bone remodeling during orthodontic tooth movement. Although ALP changes have been investigated during leveling and alignment or active orthodontic movement, the biological impact of tooth extraction timing relative to orthodontic force application remains insufficiently characterized.</p><p><strong>Objective: </strong>This randomized controlled trial aimed to compare ALP activity in gingival crevicular fluid between different extraction protocols in maxillary canines over a 6-week period. The primary outcome was the between-group difference in ALP activity across repeated time points.</p><p><strong>Methods: </strong>Sixty patients with moderate maxillary crowding were randomly allocated, using concealed allocation into three equal groups: Group A (leveling and alignment only with delayed extraction), Group B (extraction only), and Group C (simultaneous extraction with leveling and alignment). GCF samples were collected weekly from Mesial and Distal sites of maxillary canines from baseline to week six. ALP activity was quantified using a spectrophotometric method. Data distribution was assessed prior to analysis. Due to predominantly non-normal distributions, non-parametric tests were primarily applied, including Friedman's test for intragroup comparisons and Kruskal-Wallis test for intergroup comparisons, with appropriate post-hoc analyses.</p><p><strong>Results: </strong>Distinct temporal patterns of ALP activity were observed across the three groups. Group B (extraction only) demonstrated the highest ALP activity during the early time points, particularly at weeks 1-3, while Group C showed intermediate responses and Group A exhibited consistently lower levels. At T1, significant intergroup differences were observed. At Mesial sites, Group C showed higher ALP activity than Group A (mean difference: 0.59 IU/L), followed by Group B (mean difference: 0.28 IU/L compared with Group A; p < 0.05). At Distal sites, Group B demonstrated the highest ALP activity compared to Group A (mean difference: 1.00 IU/L; p < 0.01), with Group C showing intermediate values compared with Group A (mean difference: 0.73 IU/L).</p><p><strong>Conclusions: </strong>Tooth extraction was associated with increased ALP activity in gingival crevicular fluid during the early phase of orthodontic treatment. Variations in ALP patterns between extraction protocols indicate that extraction timing modulates early biochemical responses in periodontal tissues.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence factors of early childhood caries risk among children aged 1-2 years in Beijing: a prospective cohort study.","authors":"Shuxi Miao, Mei Zhao, Wen Ren, Wei Chen, Hui Zhang, Min Liu","doi":"10.1038/s41405-026-00432-1","DOIUrl":"10.1038/s41405-026-00432-1","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate risk factors for early childhood caries (ECC) among 1-2-year-old children in Beijing and to assess the effect modification of baseline caries experience on the associations between other risk factors and subsequent caries outcomes.</p><p><strong>Methods: </strong>A 12-24-month prospective study was conducted from 2021 to 2023, a total of 919 participants with valid data were included in this study, with a follow-up rate of 76.9%. Oral health information and related factors were collected through parent-completed questionnaires and clinical dental examinations. Univariate analyses and a zero-inflated negative binomial (ZINB) regression model were used to identify risk factors.</p><p><strong>Results: </strong>Caries incidence during follow-up was 29.8%, and the mean increase in decayed, missing, and filled primary teeth (Δdmft) was 0.94 ± 1.94. In the full-sample ZINB model, significant predictors of caries risk were frequency of snack intake, frequency of candy consumption, frequency of bedtime tooth brushing, frequency of bottle use at bedtime, and baseline caries status. In the baseline caries-free group, additional significant predictors of incident caries risk were parents' caries status, frequency of saliva-sharing behavior, frequency of post-meal mouth rinsing, and the presence of additives in daily drinking water. Interaction analyses showed that the effects of parents' caries status, saliva-sharing frequency, post-meal mouth rinsing frequency, presence of additives in daily drinking water, bedtime brushing frequency, and history of dental attendance on caries risk differed significantly between children with and without baseline caries.</p><p><strong>Conclusion: </strong>The risk of early childhood caries (ECC) among 1-2-year-old children in Beijing was associated with multiple oral health-related factors. Baseline caries experience was a strong predictor of subsequent caries risk and significantly modified the effects of other risk factors.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OSRA^QMUL: a digital application for oral surgery risk assessment.","authors":"Haidar Hassan, Hussein Al-Tamimi, Rawand Shado, Saffa Dean, Ravi Rathod, Paulo Oliva, Atif Matin","doi":"10.1038/s41405-026-00437-w","DOIUrl":"https://doi.org/10.1038/s41405-026-00437-w","url":null,"abstract":"<p><strong>Background: </strong>Adherence to clinical guidelines is central to patient safety in oral surgery, yet guideline uptake in routine dental practice remains inconsistent. Traditional guideline formats, such as static PDF documents, can be difficult to navigate at the point of care. Digital decision-support tools may improve accessibility, efficiency and clinician confidence, but evidence specific to oral surgery is limited.</p><p><strong>Aim: </strong>To evaluate whether the Oral Surgery Risk Assessment (OSRA) digital application improves usability, efficiency, perceived clinical impact and user satisfaction compared with conventional PDF-based guideline access.</p><p><strong>Methods: </strong>A randomised crossover study was conducted among 30 participants from a single academic centre, including undergraduate dental students, junior dental surgeons (DFTs/DCTs) and senior clinicians. Participants used both the OSRA digital application and conventional PDF guidelines across standardised oral surgery clinical scenarios. Outcomes were assessed using a structured questionnaire covering usability, reliability and trust, efficiency and workflow, satisfaction and future use and perceived clinical impact, measured on five-point Likert scales. Paired comparisons were analysed using Wilcoxon signed-rank tests, with effect sizes reported. Qualitative free-text feedback was analysed thematically.</p><p><strong>Results: </strong>Across all domains, the OSRA application was consistently rated higher than PDF guidelines (all p < 0.05), with large to very large effect sizes (r = 0.55-0.75). The greatest differences were observed for efficiency and workflow (r = 0.75) and satisfaction and future use (r = 0.73). Participants reported reduced cognitive load, faster access to guidance and greater confidence in clinical decision making when using the app. Reliability analysis demonstrated excellent internal consistency for app-based ratings (Cronbach's α = 0.96). Qualitative feedback highlighted clarity, intuitive navigation and workflow integration as key strengths, alongside requests for enhanced transparency of evidence sources and expanded functionality.</p><p><strong>Conclusions: </strong>In this pilot study, the OSRA digital application outperformed conventional PDF guidelines across all evaluated domains, suggesting that digital, point of care decision support tools can improve guideline accessibility, efficiency and user experience in oral surgery. With further development and validation, such tools have the potential to support safer, more consistent evidence-based clinical practice.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13133352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary evaluation of quercetin-mediated osteogenic gene expression in lipopolysaccharide-treated human periodontal ligament cells: an in vitro study.","authors":"Srishta Radhakrishnan, Prem Blaisie Rajula M, P L Ravi Shankar, Merita S, V Kalaivani, Rahila C","doi":"10.1038/s41405-026-00434-z","DOIUrl":"https://doi.org/10.1038/s41405-026-00434-z","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to evaluate the effect of quercetin on osteogenic gene expression in lipopolysaccharide (LPS) stimulated human periodontal ligament cells (hPDLCs) under in vitro conditions.</p><p><strong>Materials and methods: </strong>hPDLCs were cultured with LPS for 24 hours to simulate an inflammatory microenvironment. Following this pre-stimulation, cells were treated with quercetin at concentrations of 2.5 µM, 5 µM, and 10 µM for up to 14 days. No further exposure to LPS was performed during the subsequent culture period. The mRNA expression levels of osteogenic markers, osteopontin (OPN) and osteocalcin (OCN), were assessed on day 14 using Quantitative Real-Time PCR (RT-qPCR). Statistical analysis was performed using Welch's one-way ANOVA with Holm-adjusted post hoc comparisons.</p><p><strong>Results: </strong>LPS stimulation significantly suppressed the expression of both OPN and OCN compared with the control group. However, quercetin treatment restored and dose-dependently increased the expression of these markers, with the greatest effect observed at 10 µM. At this concentration, OPN and OCN expression levels reached 5.80 ± 0.26 and 6.62 ± 0.30, respectively, relative to the control. A consistent dose-dependent upregulation was observed for both markers, indicating restoration of osteogenic gene expression.</p><p><strong>Conclusion: </strong>Quercetin modulates the expression of osteogenic markers, including OPN and OCN, in LPS-stimulated hPDLCs under in vitro conditions. These findings suggest a potential modulatory role for quercetin in influencing osteogenic gene expression. However, additional in vitro functional assays and in vivo studies are necessary to establish its role in periodontal regeneration.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reasons for tooth extraction in a Swedish county dental service: a 5-year longitudinal cohort study with focus on endodontic pathology.","authors":"Simon Persson, Fernando Mota De Almeida, Pontus Lundqvist, Anna Levinsson, Emine Camci, Thomas Kvist, Emma Wigsten","doi":"10.1038/s41405-026-00430-3","DOIUrl":"https://doi.org/10.1038/s41405-026-00430-3","url":null,"abstract":"<p><strong>Aims: </strong>The aim of this study was to investigate tooth extractions in a Swedish public general dental practice setting, including the proportion of endodontically treated teeth, reasons for extraction, and subsequent prosthetic replacement.</p><p><strong>Materials and methods: </strong>A prospective cohort study was conducted in 20 clinics within the Public Dental Service of Västra Götaland, Sweden. During an 8-week period, general dental practitioners consecutively registered reasons for tooth extraction. Patients' pain levels were assessed. Pre-extraction radiographs were assessed for tooth status. Five-year follow-up data from electronic dental records were used to determine whether the extracted teeth had been prosthetically replaced and to classify the type of replacement. Descriptive and inferential statistics were used.</p><p><strong>Results: </strong>A total of 133 patients (61 men and 72 women; mean age 54.0 years, SD = ± 15.8) underwent extractions. Endodontic pathology (36.8%) and fractures (24.8%) were the most common reasons. Sixty-one patients had previous endodontic treatment, and one-third of extracted teeth were root-filled. Thirty-five teeth were prosthetically replaced, most often with removable prostheses (45.7%).</p><p><strong>Conclusions: </strong>Endodontically treated teeth, including those with initiated or completed root canal treatment, were markedly overrepresented among extractions, yet prosthetic replacement was infrequent. Younger patients less often opted for replacement, warranting further investigation of factors influencing replacement decisions.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between parental mental health and early childhood caries: a meta-analysis and systematic review.","authors":"Lili Ma, Liying Jia, Kaixuan Han, Yanyan Zhang, Shu Fan, Hong Shi","doi":"10.1038/s41405-026-00429-w","DOIUrl":"https://doi.org/10.1038/s41405-026-00429-w","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to systematically evaluate the relationship between parental mental health and early childhood caries (ECC), providing scientific basis for researching the etiology and enabling clinical prediction and prevention of ECC.</p><p><strong>Materials and methods: </strong>A comprehensive search was conducted across five databases to identify relevant studies published up to October 2025. Eligible studies were those investigating the relationship between parental mental health and ECC. Data extraction and synthesis were performed following PRISMA guidelines using Stata 16.0. Robustness, heterogeneity, certainty of evidence, and publication bias were evaluated.</p><p><strong>Results: </strong>Out of 2889 studies, 12 were included in the meta-analysis. From 12 included studies, 3 explored parental depression, 7 explored parental dental anxiety, 4 explored parental stress, and 1 explored parental general anxiety disorder. The meta-analysis results showed that parental mental conditions increased the risk of ECC (ECC prevalence rate: OR = 1.54, 95%CI: 1.12-2.12) and (dmft: SMD = 0.19, 95%CI: 0.13-0.26), significantly.The subgroup results showed that parental dental anxiety and depression were both associated with ECC (OR = 1.59, 95% CI: 1.00-2.51; OR = 1.49, 95% CI: 1.09-2.04). There was no relationship between parental stress and ECC (OR = 2.19, 95%CI: 0.36-13.20). The meta-analysis results of adjustment ORs about parental stress were similar to the crude ORs (OR = 0.81, 95%CI: 0.58-1.14).</p><p><strong>Conclusions: </strong>The results indicated a strong association between parental mental conditions and ECC. Furthermore, higher levels of dental anxiety and depression in parents were associated with a higher prevalence of ECC in their children. However, the relationship between psychological stress and ECC was not observed. Results must be interpreted with caution due to the limitations of the evidence base.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain parcellation for TMD neuroimaging: a critical narrative review.","authors":"Natalia Savychuk, Vasyl Pekhno, Anastasiia Liakhovska, Roman Sulik, Ivan Riabko","doi":"10.1038/s41405-026-00407-2","DOIUrl":"https://doi.org/10.1038/s41405-026-00407-2","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze modern brain mapping for neurobiological mechanisms of temporomandibular disorders, with particular emphasis on structural and functional alterations, employing advanced neuroimaging techniques such as fMRI and DTI. Furthermore, this study aims to identify the most appropriate combination of brain parcellation schemes that comprehensively cover cortical, subcortical, and brainstem structures to enhance the accuracy and standardization of neuroimaging protocols in TMD research.</p><p><strong>Methods: </strong>Scientific sources were searched in PubMed, Scopus, Web of Science and Google Scholar as of 29.06.2025, 689 records were identified for PRISMA workflow, of which 676 records remained for screening after the removing duplicates and irrelevant items, 630 records were excluded per prespecified criteria (inappropriate diagnoses, insufficiently described rapid studies, metabolic disorders), and 46 studies were included in the qualitative analysis.</p><p><strong>Results: </strong>We compare anatomical, functional, and multimodal atlases (Desikan-Killiany, Destrieux, Schaefer, HCP-MMP1.0, Brainnetome, SUIT, Brainstem atlases) in terms of fMRI/DTI compatibility and relevance of regions of interest.</p><p><strong>Conclusions: </strong>The authors suggest that the use of a combined parcellation scheme: HCP-MMP1.0 for the highly detailed cortex, SUIT for the cerebellum, specialized brainstem atlases-which cover corticocortical, cerebellar, and brainstem connections-increases mapping accuracy and meets modern requirements for the standardization of neuroimaging protocols in studies of the TMD.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"12 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13099999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}