Chinese Neurosurgical Journal最新文献

{"title":"Multimodal techniques for maximal safe resection of IDH-mutant low-grade glioma involving corpus callosum, a retrospective study and prognosis analysis.","authors":"Meng Cui, Meng Zhang, Chunhui Zhou, Guochen Sun, Jianning Zhang","doi":"10.1186/s41016-026-00432-y","DOIUrl":"https://doi.org/10.1186/s41016-026-00432-y","url":null,"abstract":"<p><strong>Background: </strong>The IDH-mutant low-grade glioma (LGG) involving corpus callosum (ccLGG) is a rare type of LGG which has a poorer prognosis. To evaluate the efficacy of multimodal techniques (comprising neuronavigation, intraoperative MRI, and neuromonitoring) compared with the conventional approach guided solely by neuronavigation in the resection of IDH-mutant ccLGG, and to identify prognostic factors of ccLGG.</p><p><strong>Methods: </strong>The IDH-mutant ccLGG cases that received resection in our center between 2014 and 2022 were collected and reviewed retrospectively. Comparisons were made between the multimodal and conventional groups regarding patient demographics, tumor characteristics, extent of resection (EOR), neurological function, Karnofsky Performance Status (KPS), progression-free survival (PFS), and overall survival (OS). Both univariate and multivariate analysis were employed to assess potential prognostic factors.</p><p><strong>Results: </strong>Ultimately, 64 patients in the multimodal group and 34 in the conventional group were enrolled. Compared with the conventional group, the multimodal group achieved a significantly higher median EOR (100% vs. 93.55%, P = 0.001) and a greater gross total resection (GTR) rate (62.5% vs. 35.3%, P = 0.010). No significant differences were observed in postoperative neurological function or KPS between the two groups at any of the time points assessed. Compared with the conventional group, the multimodal group demonstrated significantly longer median PFS (78.5 vs. 48.1 months, P = 0.010) and OS (106.1 vs. 66.9 months, P = 0.009). Non-butterfly ccLGG, less tumor volume, genu invasion of CC (compared to splenium invasion), less volume of CC invasion, higher EOR, longer chemotherapy cycles of Temozolomide (TMZ), higher KPS on 3 months and MGMT methylation were positive factors for PFS of ccLGG. While four factors were associated with the longer OS of ccLGG, including genu of CC invasion compared to both genu and body invasion of CC, higher EOR, longer TMZ cycles and MGMT methylation.</p><p><strong>Conclusion: </strong>Multimodal techniques are useful for achieving maximal safe resection and better prognosis of ccLGG. As higher EOR independently predicts improved survival in IDH-mutant ccLGG, maximal safe resection should be suggested and achieved by appropriate means tailored to available resources. The postoperative chemotherapy should also be recommended to patients with high risks. While whether postoperative radiotherapy should be performed should consider and balance many factors.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe stenosis of major intracranial arteries: an important risk factor for infarction complications after combined revascularization in adult patients with ischemic moyamoya disease.","authors":"Cunxin Tan, Xun Ye, Hongchuan Niu, Ran Duan, Guangchao Shi, Yuanli Zhao, Rong Wang","doi":"10.1186/s41016-026-00430-0","DOIUrl":"https://doi.org/10.1186/s41016-026-00430-0","url":null,"abstract":"<p><strong>Background: </strong>Revascularization is the main effective treatment for moyamoya disease Moyamoya disease (MMD) but is associated with a high risk of postoperative cerebral infarction. We aimed to analyze the correlation between lesions in intracranial major arteries and postoperative cerebral infarction.</p><p><strong>Methods: </strong>Adult patients with ischemic MMD were enrolled in this analysis from June 1, 2021, to October 31, 2024. The preoperative clinical characteristics and features of digital subtraction angiography were recorded. Postoperative computed tomography or magnetic resonance imaging was performed to identify infarction complications. The Suzuki stage and lesions of the intracranial major arteries were analyzed to determine their correlations with postoperative cerebral infarction.</p><p><strong>Results: </strong>A total of 119 adult patients with ischemic moyamoya disease were included in the final analysis. When the degree of stenosis was considered a disordered variable and the normal artery was taken as the reference, the logistic regression analysis showed that severe stenosis of the internal carotid artery (ICA), anterior cerebral artery (ACA), middle cerebral artery (MCA), and posterior cerebral artery (PCA) was significantly correlated with postoperative infarction (ICA (OR, 8.833; 95% CI, 0.730-106.821; p = 0.046), ACA (OR, 49.500; 95% CI, 5.083-482.011; p = 0.001), MCA (OR, 24.000; 95% CI, 1.459 - 394.881; p = 0.026), and PCA (OR, 54.333; 95% CI, 4.307-685.462; p = 0.002)). Digital subtraction angiography (DSA) was performed on three patients with postoperative cerebral infarction and showed acute occlusion or aggravated stenosis of the major intracranial arteries with severe preoperative stenosis.</p><p><strong>Conclusions: </strong>Severe stenosis of major intracranial arteries is an important risk factor for cerebral infarction after combined revascularization in adult patients with ischemic MMD.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidural hematoma in a pediatric patient with Hutchinson-Gilford progeria syndrome: management considerations: a case report.","authors":"Ali Imran Ozmarasali, Zuhal Zeybek Sivas, Ilken Uguz, Arzu Oto","doi":"10.1186/s41016-026-00431-z","DOIUrl":"10.1186/s41016-026-00431-z","url":null,"abstract":"<p><strong>Background: </strong>Hutchinson-Gilford progeria syndrome (HGPS) is an exceedingly rare genetic disorder characterized by accelerated aging and profound vascular fragility. While cerebrovascular accidents are common in this population, traumatic epidural hematomas (EDH) are clinical rarities, with only two pediatric cases previously documented. Currently, it is estimated that fewer than 200 children with HGPS are living worldwide. The primary objective of this report is to present a comprehensive multidisciplinary management strategy for traumatic EDH in a 15-year-old HGPS patient, highlighting the critical interplay between progerin-induced vascular stiffening, reduced intracranial compliance, and the formidable anesthetic challenges encountered in the oldest reported survivor of this pathology.</p><p><strong>Case presentation: </strong>A 15-year-old female with HGPS presented with a right frontoparietal EDH following a ground-level fall. Initial Glasgow Coma Scale (GCS) was 14 but declined to 12 within 4 h. Cranial computed tomography (CT) revealed a large EDH measuring 22 mm at maximum thickness, causing a 6 mm midline shift. Due to severe glottic sclerosis and anatomical distortion, multiple orotracheal and fiberoptic (2.8 mm) intubation attempts failed. An emergency percutaneous tracheostomy was performed to secure the airway. Intraoperative findings revealed active bleeding from a coronal suture diastasis, which was managed with bone wax and dural tenting sutures. The patient achieved full neurological recovery and was discharged on postoperative day 10.</p><p><strong>Conclusion: </strong>Managing HGPS patients requires a high index of clinical suspicion for intracranial injury even after minor trauma, as progerin-induced vasculopathy accelerates hematoma expansion. Standard airway techniques can fail due to progressive laryngeal changes, necessitating early consideration of surgical airways. Prompt multidisciplinary intervention and meticulous neurosurgical technique are essential to mitigate risks associated with extreme vascular fragility and complex anatomy in this high-risk population.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term clinical follow-up of intracranial aneurysms treated with flow diverter devices: a bicentric retrospective study.","authors":"Mahmoud Moubark, Alessandra Biondi, Moustafa Othman, Michael Findler, Giovanni Vitale, Francis Turjman","doi":"10.1186/s41016-026-00429-7","DOIUrl":"10.1186/s41016-026-00429-7","url":null,"abstract":"<p><strong>Background: </strong>Flow diverter devices (FDDs) have revolutionized the treatment of intracranial aneurysms. However, comprehensive long-term outcome data across multiple device platforms remain limited, with most prior studies focusing exclusively on Pipeline embolization device (PED) outcomes. This study reports extensive long-term clinical follow-up of patients treated with various types of FDDs, providing critical safety and efficacy data for contemporary practice.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of intracranial aneurysms treated with FDDs from February 2011 to July 2016 in two tertiary care centers in France. The study included 209 patients with 216 cerebral aneurysms (91.2% anterior circulation, 8.8% posterior circulation; 66.2% unruptured, 31.0% recanalized, 2.8% ruptured). The duration of clinical and angiographic follow-up ranged from 24 to 156 months. Kaplan-Meier analysis performed for complication-free survival and aneurysm occlusion durability. Multivariate analysis showed risk factors for delayed complications.</p><p><strong>Results: </strong>Long-term follow-up data were available for 202/209 (96.7%) patients. The early permanent morbidity and mortality rates were 3.8% and 1.4%, respectively. Between 12 and 18 months, procedure-related complications occurred in 5 of 202 patients (2.5%): two ischemic events, one delayed rupture, one silent intrastent stenosis, and one case of seizures following antiplatelet withdrawal. Only three patients (1.5%) were symptomatic. At the 24-month follow-up, complete aneurysm occlusion achieved in 81.0% of the patients, with adequate occlusion in 93.3%. Kaplan-Meier analysis revealed 97.5% complication-free survival at 18 months, with sustained durability thereafter. Multiple FDDs were the only significant independent predictor of delayed complications (OR: 7.066, 95% CI: 1.049-47.606, P < 0.045). No procedure-related complications or deaths occurred after 18 months.</p><p><strong>Conclusion: </strong>Beyond 18 months of follow-up, FDD treatment for intracranial aneurysms proves exceptional safety with no delayed complications, regardless of device type. However, the findings of this study also show 18 months as a critical threshold for complication risk assessment, a key implication that clinicians and researchers need to be aware of. The study also underscores the need for modified management strategies when multiple overlapping FDDs are deployed, which significantly increases the risk of delayed complications.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alteration of functional connectivity and network properties after stereo-electroencephalography guided radiofrequency thermocoagulation.","authors":"Danyi Shen, Lanling Zhou, Nianshun Liao, Sixun Yu, Xin Chen, Haifeng Shu","doi":"10.1186/s41016-026-00428-8","DOIUrl":"10.1186/s41016-026-00428-8","url":null,"abstract":"<p><strong>Background: </strong>Stereo-electroencephalography guided radiofrequency thermocoagulation (RF-TC) aims at changing epileptogenic networks to achieve therapeutic purpose. However, the functional connectivity mechanism of RF-TC remains unknown. We sought to determine the effects of RF-TC on functional connectivity and the relationship between these variations and the clinical outcome.</p><p><strong>Methods: </strong>For this retrospective cohort study, we analyzed resting-state stereoelectroencephalography (SEEG) data segments to assess functional connectivity across sampling areas in seventeen epilepsy patients. We analyzed the variance of functional connectivity and graph theory indicators and assessed the relationship between variation and clinical response to RF-TC.</p><p><strong>Results: </strong>We found decreased functional connectivity both within and between epileptogenic zone in alpha band (p < 0.05) after RF-TC. We also discovered the alteration of most graph theory properties in the alpha band. Moreover, within connectivity and betweenness were significantly decreased in alpha band in the non-improvement group (p < 0.05), while clustering coefficient showed opposite change in the improvement group (p < 0.05). Eventually, compared to improvement group, we discovered a greater decrease of within connectivity of alpha band in the epileptogenic zone (p < 0.01).</p><p><strong>Conclusion: </strong>The research on network changes after radiofrequency thermocoagulation (RF-TC) is still an evolving field. Our research results indicate that significant changes occurred in functional connectivity and network characteristics in specific frequency bands and brain regions after RF-TC. Notably, the reduction in the internal connectivity within the alpha frequency band of the epileptic lesion not only provides early electrophysiological feedback for RF-TC, but also serves as a potential indicator for evaluating clinical response and prognosis.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12980985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular treatment for basilar trunk artery aneurysm in the flow diverter era: a consecutive series and review of literature.","authors":"Hengwei Jin, Jian Lv, Wei You, Xinke Liu, Hongwei He, Wei Feng, Youxiang Li","doi":"10.1186/s41016-025-00422-6","DOIUrl":"10.1186/s41016-025-00422-6","url":null,"abstract":"<p><strong>Background: </strong>Endovascular treatment (EVT) for basilar artery trunk aneurysm (BTA) is inadequately studied due to its rarity. The aim of this study was to report our experience regarding treatment modalities, complications and outcomes.</p><p><strong>Methods: </strong>A retrospective analysis of 2759 aneurysm patients who underwent EVT between January 2018 and December 2022 was performed. Patients with BTAs were involved, and their clinical characteristics, treatment modalities, complications, and clinical and angiographic outcomes were collected. Literatures from 2013 to 2024 were reviewed and studies included more than 5 BTA cases were summarized.</p><p><strong>Results: </strong>Thirty-seven patients were involved, including 6 (16.2%) patients with ruptured BTAs. Treatment modalities included simple coiling for 5 (13.5%) patients, traditional low-metal-coverage stent for 1 (2.7%) patient, stent-assisted coiling for 20 (54.1%) patients, and flow diverter (FD) for 11 (29.7%) patients. Four (10.8%) procedure-related complications occurred, including 1 (2.7%) hemorrhage and 3 (8.1%) ischemia cases. The last angiographic follow-up (mean 9.5 ± 8.6 months) of 32(86.5%) patients showed complete occlusion in 23 (71.8%) patients, near-complete occlusion in 6 (18.8%) patients, and incomplete occlusion in 3 (9.4%) patients. Clinical follow-up (mean 33 ± 18.6 months) showed mRS 0-2 in 33 (89.2%) patients and mRS ≥ 3 in 4 (10.8%) patients, including 2 deaths. Large BTAs tended to be a risk factor for procedure-related complications(p = 0.08) and unfavorable clinical outcomes(p = 0.08).</p><p><strong>Conclusions: </strong>Traditional coiling and stent-assisted coiling were still the dominant methods for BTAs, supplemented by FD for some complicated conditions such as large/giant or fusiform BTAs. Large size tends to pose additional risks for EVT.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12961886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNA-seq analysis reveals altered gene expression profiles in HMEC-1 cells overexpressing KRAS gene associated with brain arteriovenous malformation.","authors":"Kexin Yuan, Yahui Zhao, Haibin Zhang, Ke Wang, Yunfan Zhou, Yu Chen, Xiaolin Chen, Yuanli Zhao, Qiang Hao","doi":"10.1186/s41016-026-00427-9","DOIUrl":"10.1186/s41016-026-00427-9","url":null,"abstract":"<p><strong>Background: </strong>Brain arteriovenous malformation (bAVM) is a rare vascular disorder that can lead to severe neurological symptoms. The molecular mechanisms driving bAVM development and progression of bAVM remain poorly understood. This study aimed to investigate the molecular changes potentially associated with bAVM pathogenesis by performing RNA-seq on human microvascular endothelial cells (HMEC-1) overexpressing KRAS, a key driver of BAVM.</p><p><strong>Results: </strong>HMEC-1 cells overexpressing KRAS were established as an in vitro model of bAVM. RNA-seq were conducted and transcriptomic analysis revealed that differentially expressed genes in HMEC-1 cells overexpressing KRAS were predominantly enriched in pathways related to cell adhesion, signaling, and transport, which may contribute to bAVM pathogenesis. Specifically, upregulated genes were mainly located in the cell-substrate junctions and focal adhesion, whereas downregulated genes were primarily located in the ribosomal subunits, ribosome, mitochondrial protein complex, and mitochondrial inner membrane.</p><p><strong>Conclusions: </strong>Our findings provided a preliminary delineation of molecular mechanisms after KRAS overexpression in endothelial cells, which may contribute to the development of bAVM. Future work will focus on validating these results in clinical specimens, functionally characterizing the dysregulated pathways, and exploring their potential as novel therapeutic targets.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147322357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of intraoperative visual evoked potential monitoring for postoperative visual outcomes following extended endoscopic endonasal resection of recurrent craniopharyngiomas.","authors":"Xiaorong Tao, Ke Li, Xiaocui Yang, Jiajia Liu, Jun Yang, Jiawei Shi, Yingzhun Liang, Songbai Gui, Chuzhong Li, Xing Fan, Hui Qiao","doi":"10.1186/s41016-026-00425-x","DOIUrl":"10.1186/s41016-026-00425-x","url":null,"abstract":"<p><strong>Background: </strong>Recurrent craniopharyngiomas pose high risks of postoperative visual dysfunction (POVD) during surgery. The current study aimed to explore the application value of intraoperative visual evoked potential (VEP) monitoring during the extended endonasal endoscopic approach (EEEA) for recurrent craniopharyngiomas.</p><p><strong>Methods: </strong>A total of 42 patients with recurrent craniopharyngiomas undergoing EEEA with VEP monitoring were analyzed. The amplitude reduction ratios of N75-P100 and P100-N145 were calculated, and their predictive values for POVD were evaluated using group comparisons, receiver operating characteristic (ROC) curve analysis, and binary logistic regression analysis.</p><p><strong>Results: </strong>POVD was observed in 8 eyes (8/84, 9.52%) from 7 patients (7/42, 16.67%). Eyes with POVD exhibited significantly greater N75-P100 and P100-N145 amplitude reduction ratios than those without (p < 0.001 and p = 0.002, respectively). The threshold values of the two ratios for predicting POVD were 36.59% (AUC 0.862, p < 0.001) and 36.65% (AUC 0.791, p=0.007), respectively. Multivariate analysis identified that abnormal N75-P100 change was the sole independent predictor of POVD (Odds ratio 9.257, 95% Confidence interval 1.124-76.263; p = 0.039).</p><p><strong>Conclusions: </strong>Intraoperative VEP monitoring was particularly recommended for patients undergoing EEEA for recurrent craniopharyngiomas. A one-third reduction in N75-P100 amplitude was proposed as an early warning criterion for VEP monitoring in this patient population.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel superficial temporal artery patency concept of cerebral revascularization for patients with moyamoya disease: a multicenter study.","authors":"Zhiyong Shi, Xin Li, Xinhua Chen, Lingyun Wu, Rong Wang, Chunhua Hang, Yongbo Yang, Dong Zhang","doi":"10.1186/s41016-025-00424-4","DOIUrl":"10.1186/s41016-025-00424-4","url":null,"abstract":"<p><strong>Background: </strong>To summarize the clinical and radiological outcomes of a novel cerebral revascularization technique based on the superficial temporal artery patency concept (STAPC) in patients with moyamoya disease (MMD).</p><p><strong>Methods: </strong>A retrospective review was conducted of adult patients with MMD treated at Beijing Hospital and Nanjing Drum Tower Hospital between January 2019 and December 2021. The cohort comprised 170 patients who underwent superficial temporal artery-middle cerebral artery bypass with encephalo-duro-arterio-synangiosis (EDAS) (STA-MCA/EDAS), and 133 who underwent EDAS alone. Radiological follow-up included computed tomography (CT) angiography (CTA) to assess bypass patency and CT perfusion (CTP) for hemodynamic staging at 3 and 12 months post-revascularization. Clinical follow-up recorded perioperative complications and recurrent stroke events that occurred > 12 months postoperativerly.</p><p><strong>Results: </strong>Of the 303 patients, 37 cases (12.21%) had perioperative complications including 27 cases (15.9%) in the STA-MCA/EDAS group and 10 cases (7.5%) in the EDAS group. Perfusion improvement was observed in 23.76% of patients (25.7% in the STA-MCA/EDAS group and 17.8% in the EDAS group) at 3 months postsurgical, and in 40.17% of patients (48.68% in the STA-MCA/EDAS group and 24.39% in the EDAS group) at 12 months postsurgical. Bypass patency was observed in 95.29% of patients (96.1% in the STA-MCA/EDAS group and 93.5% in the EDAS group) at 3 months postoperative, and in 96.43% patients (95.2% in the STA-MCA/EDAS group and 97.1% in the EDAS group) at 12 months postoperative. Of the 249 patients with a median follow-up period of 50 months (range 12-70 months), 40 cases (16.06%, 3.85% per year) had recurrent stroke events including 22 (15.41%, 3.69% per year) in the STA-MCA/EDAS group and 18 (16.67%, 3.91% per year) in the EDAS group.</p><p><strong>Conclusions: </strong>Cerebral revascularization using STAPC is an acceptable surgical strategy for preventing stroke recurrence in patients with MMD.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147309977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical validation and literature review of robot-assisted cerebral angiography.","authors":"Qi Liu, Siming Gui, Yang Zhao, Fei Wang, Chen Xu, Qiuju Cui, Youxiang Li, Yuanli Zhao","doi":"10.1186/s41016-026-00426-w","DOIUrl":"10.1186/s41016-026-00426-w","url":null,"abstract":"<p><strong>Background: </strong>To validate the clinical safety and efficacy of a domestically produced robotic-assisted system (YDHB-NS01) for cerebral angiography and to review the current status, advantages, and challenges of robot-assisted technology in cerebrovascular interventions.</p><p><strong>Methods: </strong>From May to October 2025, 25 consecutive patients who underwent robotic-assisted cerebral angiography and 25 consecutive patients who underwent manual cerebral angiography at our center were prospectively enrolled. The primary endpoints were technical success rate and clinical success rate. Secondary endpoints included procedure time, fluoroscopy time, radiation dose, contrast volume, total angiography room time, device performance evaluation, and complication rate. Additionally, a literature review was conducted to summarize the applications and developments of various robotic systems in neurointervention.</p><p><strong>Results: </strong>All 50 (25 in the robotic-assisted group and 25 in the manual group) procedures were successfully completed with a 100% technical success rate. There were no differences between the two groups in patients' demographic data, fluoroscopy time, patient radiation dose, contrast agent dose, or total angiography room time (all p > 0.05). The robotic-assisted group had a shorter procedure time than the manual group (27 [15, 143] vs. 38 [21, 105], p = 0.005). A learning curve for the robotic-assisted system was observed. The robotic-assisted system operated stably without malfunctions. No procedure-related or device-related complications occurred.</p><p><strong>Conclusion: </strong>The preliminary clinical application demonstrates that the YDHB-NS01 robot-assisted system is feasible for diagnostic cerebral angiography and shows early indications of safety and comparable procedural performance to those of conventional manual methods. Given the small, single-center cohort and the exploratory nature of this study, larger multicenter controlled trials are required to confirm these findings.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"12 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}