Haeri Choi , Sung Chun Cho , Young Wan Ha , Billie Ocampo , Shirley Park , Shiwen Chen , Christopher F. Bennett , Jeehae Han , Ryan Rossner , Jong-Sun Kang , Yun-ll Lee , Sang Chul Park , Matt Kaeberlein
{"title":"DDS promotes longevity through a microbiome-mediated starvation signal","authors":"Haeri Choi , Sung Chun Cho , Young Wan Ha , Billie Ocampo , Shirley Park , Shiwen Chen , Christopher F. Bennett , Jeehae Han , Ryan Rossner , Jong-Sun Kang , Yun-ll Lee , Sang Chul Park , Matt Kaeberlein","doi":"10.1016/j.tma.2019.07.001","DOIUrl":"10.1016/j.tma.2019.07.001","url":null,"abstract":"<div><p>The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in <em>Caenorhabditis elegans</em> through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in <em>C. elegans</em> by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"3 ","pages":"Pages 64-69"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2019.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37754178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Consequences of senotherapies for tissue repair and reprogramming","authors":"T. Van Vliet , J. Kohli , M. Demaria","doi":"10.1016/j.tma.2019.01.003","DOIUrl":"10.1016/j.tma.2019.01.003","url":null,"abstract":"","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"3 ","pages":"Pages 31-36"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2019.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55175572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Evandro F. Fang , Hilde L. Nilsen , Jon Storm-Mathisen , Linda H. Bergersen
{"title":"NO-age in Norway","authors":"Evandro F. Fang , Hilde L. Nilsen , Jon Storm-Mathisen , Linda H. Bergersen","doi":"10.1016/j.tma.2019.04.001","DOIUrl":"10.1016/j.tma.2019.04.001","url":null,"abstract":"","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"3 ","pages":"Pages 37-39"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2019.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55175598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Drosophila melanogaster as a model system in the study of pharmacological interventions in aging","authors":"Shin-Hae Lee, Kyung-Jin Min","doi":"10.1016/j.tma.2019.09.004","DOIUrl":"10.1016/j.tma.2019.09.004","url":null,"abstract":"<div><p><em>Drosophila melanogaster</em> has been used as a model system in biological studies for a long time, and those studies have contributed to elucidating the principal mechanisms of life and aging. The notable advantages of <em>Drosophila</em> as a model system such as their low maintenance cost, high reproductive rate, and short generation time and lifespan make the flies a promising investigative platform for primary small-molecule screening of anti-aging drugs. In this review, we summarize and review the benefits of <em>Drosophila</em> as a model system for use in the study of pharmacological anti-aging interventions and describe the previously reported longevity effects of pharmacological interventions in <em>Drosophila</em>.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"3 ","pages":"Pages 98-103"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2019.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55175649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jean Woo , Sherlin Ong , Ruth Chan , Liz Li , Jianqin Sun , Yoke Mun Chan , Shiou-Liang Wee , Nghiem Nguyet Thu , Pham Thang , Siti Setiati , Yi-Chen Huang , Mark L. Wahlqvist , Lisette CPGM. de Groot
{"title":"Nutrition, sarcopenia and frailty: An Asian perspective","authors":"Jean Woo , Sherlin Ong , Ruth Chan , Liz Li , Jianqin Sun , Yoke Mun Chan , Shiou-Liang Wee , Nghiem Nguyet Thu , Pham Thang , Siti Setiati , Yi-Chen Huang , Mark L. Wahlqvist , Lisette CPGM. de Groot","doi":"10.1016/j.tma.2019.11.001","DOIUrl":"10.1016/j.tma.2019.11.001","url":null,"abstract":"<div><p>Despite a growing body of evidence that nutrition plays a key role in the pathophysiology, prevention and intervention programs of frailty and sarcopenia, as well as in promoting brain health, the awareness and the need to study the relationship between nutrition and functional goals of healthy ageing have not received as much attention or support from research or policy makers. This review reports on the state of knowledge relating to availability of nutrition survey data for older people relating to prevalence of frailty and sarcopenia in Asia, using data from Netherlands for comparison. Data were obtained from a meeting of a group of nutrition experts from Asia supplemented by literature search using key terms of nutrition, frailty, and sarcopenia. Although nutrition surveys may be carried out regularly in several countries, surveys are mainly carried out for the general adult population rather than specifically among the elderly population, and little data is available relating to the impact of nutrition on sarcopenia and frailty. There is an urgent need for more nutritional data relating to maintaining function with age as opposed to disease prevention, to guide health promotion policies and clinical management of increasingly older population and patients. A shift in the gathering of national nutrition data may need to include such functional measurements in relation to older people, as the latter forms the rapidly growing sector of ageing populations world-wide.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"3 ","pages":"Pages 125-131"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2019.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55175667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypothesis: Plant stem cells hold the key to extreme longevity","authors":"Paul P. Dijkwel , Alvina G. Lai","doi":"10.1016/j.tma.2018.12.002","DOIUrl":"10.1016/j.tma.2018.12.002","url":null,"abstract":"<div><p>Theories of ageing explain how multicellular organisms age by means of an immortal germ line and a perishable soma, whereby accumulated damage is preferentially distributed to the soma. Plants do not clearly separate germline and somatic cells, which questions whether current theories of ageing are applicable to plants. Plant stem cells have germline-like features, while plant tissue that dies in a mostly seasonal manner, such as leaves and xylem, have soma-like properties. Plant stem cells may therefore hold the key to understanding how plants can reach extreme ages and we discuss model systems that may be suitable to advance the field of plant ageing.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"3 ","pages":"Pages 14-16"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2018.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55175519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The function of lncRNAs in aging-related diseases and 3D genome","authors":"Wanying Zhang, Tengfei Hu, Xiaoyuan Song","doi":"10.1016/j.tma.2019.06.001","DOIUrl":"10.1016/j.tma.2019.06.001","url":null,"abstract":"<div><p>In the past decades, long noncoding RNAs (lncRNAs) have been indicated to play important roles in almost every biological process. Aging is a gradual and irreversible biological processes and associated with many human diseases. In this review, we will discuss the function and mechanism of lncRNAs in influencing the progression of aging-related diseases. Moreover, we will discuss the roles of lncRNAs in 3D genome organization.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"3 ","pages":"Pages 57-63"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2019.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55175618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kenneth L. Chen , Toby N. Ven , Matthew M. Crane , Dexter E. Chen , Yen-Chi Feng , Nozomi Suzuki , Adam E. Russell , Diogo de Moraes , Matt Kaeberlein
{"title":"An inexpensive microscopy system for microfluidic studies in budding yeast","authors":"Kenneth L. Chen , Toby N. Ven , Matthew M. Crane , Dexter E. Chen , Yen-Chi Feng , Nozomi Suzuki , Adam E. Russell , Diogo de Moraes , Matt Kaeberlein","doi":"10.1016/j.tma.2019.05.001","DOIUrl":"10.1016/j.tma.2019.05.001","url":null,"abstract":"<div><p>Recently, microfluidic technologies have been developed to allow higher throughput collection of yeast replicative lifespan data. Adoption of these devices has been limited, in part, due to the high cost of the motorized microscopy instrumentation from mainline manufacturers. Inspired by recent development of open source microscopy hardware and software, we developed minimal-cost hardware attachments to provide long-term focus stabilization for lower-cost microscopes and open source software to manage concurrent time-lapse image acquisition from multiple microscopes. We hope that these tools will help spur the wider adoption of microfluidic technologies for the study of aging in yeast.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"3 ","pages":"Pages 52-56"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2019.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41731100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joseph C.P. Kruempel , Marshall B. Howington , Scott F. Leiser
{"title":"Computational tools for geroscience","authors":"Joseph C.P. Kruempel , Marshall B. Howington , Scott F. Leiser","doi":"10.1016/j.tma.2019.11.004","DOIUrl":"10.1016/j.tma.2019.11.004","url":null,"abstract":"<div><p>The rapid progress of the past three decades has led the geroscience field near a point where human interventions in aging are plausible. Advances across scientific areas, such as high throughput “-omics” approaches, have led to an exponentially increasing quantity of data available for biogerontologists. To best translate the lifespan and healthspan extending interventions discovered by basic scientists into preventative medicine, it is imperative that the current data are comprehensively utilized to generate testable hypotheses about translational interventions. Building a translational pipeline for geroscience will require both systematic efforts to identify interventions that extend healthspan across taxa and diagnostics that can identify patients who may benefit from interventions prior to the onset of an age-related morbidity. Databases and computational tools that organize and analyze both the wealth of information available on basic biogerontology research and clinical data on aging populations will be critical in developing such a pipeline. Here, we review the current landscape of databases and computational resources available for translational aging research. We discuss key platforms and tools available for aging research, with a focus on how each tool can be used in concert with hypothesis driven experiments to move closer to human interventions in aging.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"3 ","pages":"Pages 132-143"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2019.11.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38647892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Meeting report: Asian Society for Aging Research Symposium 2018","authors":"Yujin Lee, Seung-Jae V. Lee, Kyung-Jin Min","doi":"10.1016/j.tma.2018.06.001","DOIUrl":"10.1016/j.tma.2018.06.001","url":null,"abstract":"","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"2 ","pages":"Pages 11-14"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2018.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55175107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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