黑腹果蝇作为衰老药物干预研究的模型系统

Q2 Medicine

Translational Medicine of Aging Pub Date : 2019-01-01 DOI:10.1016/j.tma.2019.09.004

Shin-Hae Lee, Kyung-Jin Min

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引用次数: 25

摘要

长期以来，黑腹果蝇一直被用作生物学研究的模型系统，这些研究为阐明生命和衰老的主要机制做出了贡献。果蝇作为一种模式系统，其维持成本低、繁殖率高、繁殖时间短、寿命短等显著优势使果蝇成为抗衰老药物小分子初步筛选的研究平台。在这篇综述中，我们总结和回顾了果蝇作为药物抗衰老干预研究的模型系统的益处，并描述了先前报道的药物干预对果蝇的长寿作用。

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Drosophila melanogaster as a model system in the study of pharmacological interventions in aging

Drosophila melanogaster has been used as a model system in biological studies for a long time, and those studies have contributed to elucidating the principal mechanisms of life and aging. The notable advantages of Drosophila as a model system such as their low maintenance cost, high reproductive rate, and short generation time and lifespan make the flies a promising investigative platform for primary small-molecule screening of anti-aging drugs. In this review, we summarize and review the benefits of Drosophila as a model system for use in the study of pharmacological anti-aging interventions and describe the previously reported longevity effects of pharmacological interventions in Drosophila.

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来源期刊

Translational Medicine of Aging Medicine-Geriatrics and Gerontology

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

103 days