Biomedical and Biotechnology Research Journal最新文献

Investigating the effect of bioactive glasses on enamel remineralization through morphological and elemental analysis 通过形态学和元素分析探讨生物活性玻璃对牙釉质再矿化的影响

IF 1.4

Biomedical and Biotechnology Research Journal Pub Date : 2023-04-01 DOI: 10.4103/bbrj.bbrj_24_23

Britina, M. Yuwanati, S. Chitra

{"title":"Investigating the effect of bioactive glasses on enamel remineralization through morphological and elemental analysis","authors":"Britina, M. Yuwanati, S. Chitra","doi":"10.4103/bbrj.bbrj_24_23","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_24_23","url":null,"abstract":"Background: Functionally and esthetically, enamel is the most important dental hard tissue in the tooth structure. It is composed of hydroxyapatite crystals and is the hardest calcified matrix in the body. Erosion of this dental hard tissue due to any underlying pathological disease or regurgitation, vomiting, and gastroesophageal reflux disease is termed tooth erosion or demineralization. Remineralization has to be achieved to prevent sensitivity and altered occlusion. Methods: The sample teeth were cleaned with 1% sodium hypochlorite and then demineralized using 17% ethylenediaminetetraacetic acid, which were later brushed twice a till 7 and 14 days using bioactive glass to figure out the extent of demineralization. Scanning electron microscopy (SEM) was analyzed on the 7th and 14th day, respectively. Analysis of Variance (ANOVA) model. Results: Remineralization was observed with the help of field-emission-Scanning electron microscopy (SEM) analysis on the exposed surface of the teeth samples which were brushed with a bioactive glass of 100 mg and 200 mg concentrations twice a day till the incubation period. Conclusions: Bioglass explicates the enhanced mineralization on the tooth surface with respect to concentration as well as in incubation. Hence, we found that bioglass is one of the significant materials for tooth remineralization.","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":"7 1","pages":"181 - 186"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44101534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative molecular docking study of phytocompounds of Ziziphus jujuba lam. with multiple receptors for the cardioprotective activity 枣属植物化合物的分子对接比较研究。具有多种心脏保护活性的受体

IF 1.4

Biomedical and Biotechnology Research Journal Pub Date : 2023-04-01 DOI: 10.4103/bbrj.bbrj_202_22

Deepali Bansode, Naman Jain, Omkar Tambekar, S. Bodhankar

{"title":"A comparative molecular docking study of phytocompounds of Ziziphus jujuba lam. with multiple receptors for the cardioprotective activity","authors":"Deepali Bansode, Naman Jain, Omkar Tambekar, S. Bodhankar","doi":"10.4103/bbrj.bbrj_202_22","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_202_22","url":null,"abstract":"Background: In this study, we have investigated the binding affinity, ADME, and toxicity analysis of various phytocompounds which are present in Ziziphus jujuba on different receptors related to cardioprotective activity by performing molecular docking studies. Determination of binding affinity of phytocompounds of Z. Jujuba with different receptors involved in the cardioprotective activity. AutoDock Vina, PyMol, Discovery Studio, AutoDock tools, ChemDraw, Swiss ADME, PROTOX-II. Methods: Molecular docking. Results: The binding results of the selected plant compounds and target proteins, namely 108a, 7Q29, 5JMY, 4DLI, 2YCW, and 1CX2, showed that the selected phytochemicals from Z. Jujuba had good binding affinity and good receptor binding mode selected target. However, among all plant compounds, Jujuboside-B has the lowest binding energy with angiotensin-converting enzyme (ACE) (binding energy – 11.2 Kcal/mol), ACE and neutral endopeptidase inhibitors (binding energy – 10.9 Kcal/mol). Neprilysin receptor (binding energy – 10.4 Kcal/mol), COX-2 receptor (binding energy – 10.9 Kcal/mol), Spinosyn with β-1 adrenergic receptor (binding energy – 9.3 Kcal/mol), 3-O-methylellagic acid-3'-rhamnoside has superior binding affinity (−9.4 Kcal/mol) to the P38 mitogen-activated protein kinase receptor compared to the standard synthetic compound nebivolol. Conclusions: The present work was an attempt to computationally identify phytocompounds from Z. Jujuba which can bind to the various targets of cardiovascular disease. The docking scores, analysis of the interactions of the compounds suggest that most of the compounds have the ability to bind to multiple targets involved in cardiovascular disease. Absorption, distribution, metabolism, excretion, and toxicity and toxicity prediction showed various phytocompounds such as rutin, jujuboside-A, B, epicatechin could be used as potential candidate against cardiovascular disease.","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":"7 1","pages":"136 - 162"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47074571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro study of the spectrum antiviral activity of aliphatic acid toward the prototype coronavirus strain 脂肪酸对冠状病毒原型株的广谱抗病毒活性的体外研究

IF 1.4

Biomedical and Biotechnology Research Journal Pub Date : 2023-04-01 DOI: 10.4103/bbrj.bbrj_36_23

I. Dziublyk, S. Soloviov, O. Trokhimenko, O. Dziublyk, M. Smetiukh, O. Yakovenko, V. Vasylenko, M. Sidorenko, S. Mickevicius, M. Gumeniuk

{"title":"In vitro study of the spectrum antiviral activity of aliphatic acid toward the prototype coronavirus strain","authors":"I. Dziublyk, S. Soloviov, O. Trokhimenko, O. Dziublyk, M. Smetiukh, O. Yakovenko, V. Vasylenko, M. Sidorenko, S. Mickevicius, M. Gumeniuk","doi":"10.4103/bbrj.bbrj_36_23","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_36_23","url":null,"abstract":"Background: The aim of this study was to perform an in vitro evaluation of the antiviral activity of several well-known organic substances against infectious bronchitis virus (IBV), the prototype strain of the coronavirus family. The new betacoronavirus SARS-CoV-2 caused COVID-19 and is the fifth pandemic of respiratory disease since the 1918 flu pandemic. There is an urgent need to find new antiviral drugs against respiratory coronaviruses but also to study the antiviral effect of well-known substances in order to identify new therapeutic approaches for people with COVID-19. Methods: The cytotoxic effect of organic substances was evaluated on a monolayer of cell culture baby hamster kidney (BHK)-21. Cultivation, accumulation, and determination of the infectious titer of IBV by cytopathic action were performed using cell cultures of chicken embryo fibroblasts and BHK-21. The antiviral effect of a substance was assessed by measurement of its chemotherapeutic index across three regimens of substance administration: (1) 2 h before infection, (2) simultaneously with infection, and (3) 2 h after infection. Results: This study's results were established in vitro. All the substances showed antiviral activity in the range of nontoxic concentrations in prophylactic regimen. Of the substances tested, 4-aminobutyric acid was the least toxic. Conclusions: Effective inhibition of virus reproduction in preventive and treatment regimens indicated that 4-aminobutyric acid and 6-aminocaproic acid affected the early stages of coronavirus reproduction. 6-aminocaproic acid hydrochloride and 7-aminoheptanoic acid may potentially also affect the early stages of coronavirus reproduction, which requires further in-depth study.","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":"7 1","pages":"218 - 224"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45056489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum amyloid a as acute phase protein and its association with dyslipidemia in type 2 diabetes 血清淀粉样蛋白a作为2型糖尿病急性期蛋白及其与血脂异常的关系

IF 1.4

Biomedical and Biotechnology Research Journal Pub Date : 2023-04-01 DOI: 10.4103/bbrj.bbrj_27_23

A. Atere, Cinderella Chukwuemeka, Korede O. Oluwatuyi, Blessing Olupeka

{"title":"Serum amyloid a as acute phase protein and its association with dyslipidemia in type 2 diabetes","authors":"A. Atere, Cinderella Chukwuemeka, Korede O. Oluwatuyi, Blessing Olupeka","doi":"10.4103/bbrj.bbrj_27_23","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_27_23","url":null,"abstract":"Background: Serum amyloid A (SAA) has many pro-inflammatory and proatherogenic activities which are demonstrated to affect atherosclerosis development and may be a good target in managing cardiovascular diseases in Type 2 diabetes mellitus (T2DM). This study is aimed at evaluating the role of SAA as an acute phase protein and its correlation with atherogenic indices in T2DM. Methods: This research was carried out on a total of 30 naive diabetic patients, 30 diabetic patients under treatment (DSUT), and 30 nondiabetic subjects as control groups. Six milliliter of venous blood was collected from each patient and dispensed into an appropriate bottle. SAA, fasting blood sugar (FBS), body mass index (BMI) in diabetic patients, and atherogenic indices [total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)] were determined using standard laboratory techniques. The data were statistically analyzed correctly, and P < 0.05 was regarded as statistically significant. Results: The mean values of SAA, TC, HDL-C, and LDL-C were significantly higher in both naive and DSUT when compared with the control group (P < 0.05). BMI showed a significant correlation with TG, HDL-C, and LDL-C in naive diabetes patients. Furthermore, SAA had an excellent higher area under the receiver operating characteristic curve than FBS. Conclusions: This study demonstrates a definite relationship between SAA, FBS, and lipid profile parameters in diabetic patients. However, in this study, the role of SAA as an acute phase reactant was established. Furthermore, SAA is noted as a better potential indicator that could facilitate improved diagnosis and management of subjects with T2DM.","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":"7 1","pages":"195 - 200"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44990325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of sex hormone-binding globulin gene polymorphism and sex hormone-binding globulin levels in postmenopausal women in relation to type 2 diabetes mellitus – A case–Control study 绝经后妇女性激素结合球蛋白基因多态性和性激素结合球蛋白水平与2型糖尿病的关系——一项病例对照研究

IF 1.4

Biomedical and Biotechnology Research Journal Pub Date : 2023-04-01 DOI: 10.4103/bbrj.bbrj_51_23

Priyadharshini Alva, NSuchetha Kumari, A. Bhandary, Lakshmi Manjeera, Neetha Nandan

{"title":"Association of sex hormone-binding globulin gene polymorphism and sex hormone-binding globulin levels in postmenopausal women in relation to type 2 diabetes mellitus – A case–Control study","authors":"Priyadharshini Alva, NSuchetha Kumari, A. Bhandary, Lakshmi Manjeera, Neetha Nandan","doi":"10.4103/bbrj.bbrj_51_23","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_51_23","url":null,"abstract":"Background: In women, menopause constitutes the end of a fertile life as a result of ovarian aging. It is characterized by a significant decrease in estrogen concentration along with the change in the body weight, altered distribution of adipose tissue, less energy expenditure as well as modification in insulin secretion, and insulin sensitivity resulting in the development of type 2 diabetes mellitus (T2DM). The low circulating concentration of sex hormone-binding globulin (SHBG) contributes to the increased risk of type 2 diabetes in postmenopausal women. Methods: The present study was conducted at Justice K. S. Hegde Charitable Hospital, Deralakatte, Mangaluru. This case–control study was performed on 400 postmenopausal women with and without T2DM, aged 45–65 years, recruited based on the eligibility criteria. Five milliliters of fasting blood were collected, centrifuged, and stored at −80°C until analysis. Genomic DNA was isolated from the whole blood using a standard protocol. DNA was amplified using the polymerase chain reaction. Amplified products were sequenced using the Sanger sequencing method. Statistical analyses were performed using the SPSS software version 26. Results: Based on the SHBG single-nucleotide polymorphisms (SNP) rs1799941, the circulating levels of SHBG showed a significant difference between the genotype. Conclusions: The major allele of rs1799941 has shown reduced the levels of circulating SHBG with an increased risk of T2DM. Hyperglycemia along its association with endogenous hormone and SNP in the SHBG gene may contribute to the diabetic risk in the postmenopausal women.","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":"7 1","pages":"233 - 237"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41675630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Coronavirus Disease 2019 on human biological timekeeping 2019冠状病毒病对人类生物计时的影响

IF 1.4

Biomedical and Biotechnology Research Journal Pub Date : 2023-04-01 DOI: 10.4103/bbrj.bbrj_57_23

Aditi Chaudhary, Manikantan Pappuswamy, K. Paari, S. Malik, A. Meyyazhagan, H. Bhotla, B. Balasubramanian, V. Arumugam

{"title":"Influence of Coronavirus Disease 2019 on human biological timekeeping","authors":"Aditi Chaudhary, Manikantan Pappuswamy, K. Paari, S. Malik, A. Meyyazhagan, H. Bhotla, B. Balasubramanian, V. Arumugam","doi":"10.4103/bbrj.bbrj_57_23","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_57_23","url":null,"abstract":"To stay in sync with environmental cues, the body's metabolic activities must be rhythmic, and these rhythmic functions are known as circadian rhythms, which repeat every 24 h. People's sleep–wake and eating patterns were interrupted as a result of house confinement, making them more vulnerable to noncommunicable chronic diseases during the coronavirus disease 2019 (COVID-19) period. During the epidemic, there was a greater degree of misalignment with this synchronization. The effects of severe acute respiratory syndrome coronavirus 2 (COVID-19) on the human circadian clock are studied in depth. The literature review was conducted fully online, with the website utilized to collect all of the papers from PubMed, and duplicates were handled only in the first phase. Researchers found that individuals of all ages who are pushed to adjust their daily routines shift to the later chronotype, resulting in lifestyle modifications and an altered biological timing system that contributes to noncommunicable chronic illnesses. Chronic illnesses have bidirectional conductance, which means they can be caused by both environmental and self-modification in daily activity, as was the case during the COVID-19 outbreak, which forced people to stay at home. This review comes to the conclusion that fighting the pandemic may be best done by changing medications and focusing on immune health.","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":"7 1","pages":"127 - 135"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46429344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the effect of propolis varnish and green tea varnish on treatment of dentinal hypersensitivity: An In vitro scanning electron microscope study 蜂胶清漆和绿茶清漆治疗牙本质过敏症的疗效比较：体外扫描电镜研究

IF 1.4

Biomedical and Biotechnology Research Journal Pub Date : 2023-04-01 DOI: 10.4103/bbrj.bbrj_71_23

V. Doddawad, M. Parinitha, H. Sowmya, B. Gurupadayya, BY Akshitha

{"title":"Comparison of the effect of propolis varnish and green tea varnish on treatment of dentinal hypersensitivity: An In vitro scanning electron microscope study","authors":"V. Doddawad, M. Parinitha, H. Sowmya, B. Gurupadayya, BY Akshitha","doi":"10.4103/bbrj.bbrj_71_23","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_71_23","url":null,"abstract":"Background: Dentin hypersensitivity (DH) is perceived as pain to any stimuli, affecting all individuals. Propolis and green tea are natural, nontoxic substances. The use of resinous propolis is effective in treating dentinal hypersensitivity, but green tea was unknown, even though it has medicinal properties. There is a lack of information on the application of varnish providing longer exposure than solutions and its efficacy in treating dentinal hypersensitivity. Therefore, the present study aims to evaluate and compare the result of propolis varnish and green tea varnish on the treatment of dentinal hypersensitivity by occlusion of dentinal tubules using scanning electron microscope (SEM) imaging. Methods: Forty-five sound human posterior teeth freshly extracted were stored in formalin until in vitro assessment. Three groups of 15 discs each were divided out of 45 discs and coated with respective varnish such as Group A (saline, control), Group B (propolis varnish, experimental), and Group C (green tea varnish, experimental). All the discs were examined under SEM to observe the occlusion of the dentinal tubules. Results: Statistically significant analysis of Group B and Group C showed more tubule occlusion as compared to control Group A where P = 0.05. Conclusions: Based on our study, the dentinal tubule can be occluded to prevent tooth hypersensitivity by applying varnish with natural products such as propolis and green tea. In addition, propolis varnish and green tea varnish have low toxicity and multiple biological activities that strengthen their application in health care, which is useful and effective in treating DH.","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":"7 1","pages":"277 - 282"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45818424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico functional network analysis for the identification of novel target associated with SCN1A gene 用于鉴定SCN1A基因相关新靶点的In Silico功能网络分析

IF 1.4

Biomedical and Biotechnology Research Journal Pub Date : 2023-04-01 DOI: 10.4103/bbrj.bbrj_46_23

Aparna Khatri, Vinay Singh, R. Prasad, Amit Kumar, V. Singh, D. Joshi

{"title":"In Silico functional network analysis for the identification of novel target associated with SCN1A gene","authors":"Aparna Khatri, Vinay Singh, R. Prasad, Amit Kumar, V. Singh, D. Joshi","doi":"10.4103/bbrj.bbrj_46_23","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_46_23","url":null,"abstract":"Background: The aim of our study is to identify the novel targets for the SCN1A gene so that we can come up with the potential antiepileptic drugs (AEDs) with the least side effects and best efficacy. Methods: Literature review for candidate genes associated with febrile seizure, generalized epilepsy with febrile seizure plus, dravet syndrome and other idiopathic epilepsy subtypes was done using PubMed, PMC, Google Scholar, and Science Direct. Network analysis of selected candidate genes was done based on molecular function and biological processes using Cytoscape software. Selection of candidate proteins targets receptors for AEDs on the basis of first neighbor, structural retrieval analysis, and verification of selected receptors was done using Ramachandran plot analysis server (RAMPAGE) and Protein Data Bank sum server. Molecular docking calculation and analysis were performed using YASARA and BIOVIA Discovery Studio 2019 software. Results: We screened 157 epileptic genes among which 84 genes were classified as purely epileptic genes and 73 genes were classified as neurodevelopment-associated epilepsy genes. 62 childhood-onset and juvenile-onset epilepsy genes were screened excluding neonatal group due to in born errors of metabolism. In this investigation using SCN1A as a candidate gene, we found SCN9A, HCN2, and FGF12 gene-encoding proteins as potential target receptors. Further, the SCN1A protein receptor was used to screen suitable AEDs using molecular docking investigation. We got three novel AEDs against the SCN1A target gene. Conclusions: In silico network analysis has provided various best-screened target receptors from the huge network interaction group of genes for AED targeting. This will help in better understanding of disease mechanisms, analysis, and knowledge of the molecular structure of protein.","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":"7 1","pages":"163 - 169"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48458267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cycle threshold value and coronavirus disease 2019 clinical type among smokers and nonsmokers reveal no significant association despite clinical type shows smokers are at high risk: A retrospective study 一项回顾性研究显示，吸烟者和非吸烟者的周期阈值和2019年冠状病毒病临床类型没有显著关联，尽管临床类型显示吸烟者处于高风险中

IF 1.4

Biomedical and Biotechnology Research Journal Pub Date : 2023-04-01 DOI: 10.4103/bbrj.bbrj_86_23

A. Azad, Suboor Naik, A. Malik, Varshiesh Raina

{"title":"Cycle threshold value and coronavirus disease 2019 clinical type among smokers and nonsmokers reveal no significant association despite clinical type shows smokers are at high risk: A retrospective study","authors":"A. Azad, Suboor Naik, A. Malik, Varshiesh Raina","doi":"10.4103/bbrj.bbrj_86_23","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_86_23","url":null,"abstract":"Background: Emerging epidemiological studies indicate a paradoxical association between smoking and coronavirus disease 2019 (COVID-19). This retrospective study aimed to investigate the association between cycle threshold (Ct) values and clinical type among COVID-19-positive smokers and nonsmokers. Methods: The study was conducted from October 3, 2020, to October 3, 2022. Five hundred and sixty COVID-19 patients were enrolled, which included 320 smoking group (SG) and 240 non-SG (NSG). Demographic and clinical features were acquired, and comparison was based drawn on gender, age, Ct range, and clinical type (mild/mild-moderate/severe COVID-19). COVID-19 was confirmed by real time reverse-transcription polymerase chain reaction test based on Ct value below 35. Results: Initial evaluation revealed no significant association between Ct range and clinical type either within or between SG and NSG. Follow-up at 7/14 days revealed no significant difference between the groups for Ct range/clinical type; however, within groups Ct range showed a clear change towards higher values. The recovery rate was also evaluated which displayed no difference at 7 days while at 14 days' recover rate was 47.5% for SG and 80.0% for NSG. Moreover, in both groups un-recovered patients were mostly observed either in mild-moderate and severe COVID state; however, SG showed more patients in mild-moderate group and longer discharge time. Conclusions: We found that Ct value and clinical type have no significant association in COVID-19 smokers versus nonsmokers and smokers are at high risk and take a longer time to recover from COVID.","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":"7 1","pages":"312 - 318"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41964522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the prevalence of severe acute respiratory syndrome Coronavirus-2 in Theni District, Tamil Nadu 泰米尔纳德邦Theni地区严重急性呼吸综合征冠状病毒2型流行病学研究

IF 1.4

Biomedical and Biotechnology Research Journal Pub Date : 2023-04-01 DOI: 10.4103/bbrj.bbrj_30_23

R. Gopinath, R. Gopinathan, R. Jegatheesh, A. Dhanasezhiyan, M. Amudhan, S. Lallitha

{"title":"Study on the prevalence of severe acute respiratory syndrome Coronavirus-2 in Theni District, Tamil Nadu","authors":"R. Gopinath, R. Gopinathan, R. Jegatheesh, A. Dhanasezhiyan, M. Amudhan, S. Lallitha","doi":"10.4103/bbrj.bbrj_30_23","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_30_23","url":null,"abstract":"Background: The population-based studies that target the prevalence measure the extent of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in a particular area over a particular period. In this study, we report the findings of the data regarding SARS-CoV-2 in the Theni District, Tamil Nadu. Methods: The study employed 6,21,140 patients with COVID-19 who were tested at the Government Theni Medical College and hospital from March 2020 to May 2022. The data were also accessed from the state COVID-19 portals. Results: A total of 6,21,140 patients were analyzed during the study. Of these, 42,210 confirmed cases of COVID-19 were identified and included in the study. Out of the 6,21,140 patients tested with COVID-19, 533 deaths were reported. The findings reported higher death in older age and higher death in males. The severity of COVID-19 was high in cases with comorbidities and in those who were alcoholics and smokers. Conclusions: As most of the populations are susceptible to infection, the strategy for public health needs to be designed for an inevitable increase in transmission. Surveillance studies are crucial as they created awareness of the extent and speed of transmission.","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":"7 1","pages":"176 - 180"},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47695915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0