Russian Journal of Clinical Ophthalmology最新文献

{"title":"Frequency and structure of emergency calls to the eye centers at the third stage of ophthalmic care depending on its availability in the regions of Azerbaijan","authors":"Banovsha K Gadzhieva","doi":"10.32364/2311-7729-2022-22-3-161-167","DOIUrl":"https://doi.org/10.32364/2311-7729-2022-22-3-161-167","url":null,"abstract":"Aim: to evaluate the frequency and structure of emergency calls to the eye centers at the third stage of ophthalmic care depending on its availability in the regions of Azerbaijan. Patients and Methods: the article presents materials of emergency calls to the Zarifa Aliyeva National Center of Ophthalmology (NCO) during 2019. Depending on the availability of ophthalmic care, all settlements of the country were divided into categories. All emergency calls to the NCO were distributed according to the specified categories of settlements, main types (injuries, diseases), and characteristics of patients. For each category of settlements, the frequency of emergency calls to NCO due to injuries and diseases was calculated per 100 thousand populations. Results: 64.8% of emergency calls were associated with eye injuries. The frequency of emergency calls to the NCO as a whole (46.3±1.46) and due to injuries (34.9±1.27) is maximal among residents of Baku, minimal among residents of districts of republican subordination (10.8±1.17 and 18.4±1.53, respectively). Due to diseases, residents of Baku, cities — district centers and rural settlements had emergency calls with almost the same frequency (11,4±0,72, 11,5±0,81, 12,2±0,53 accordingly), sig-nificantly more than residents of districts of republican subordination (7.6±0.98). Among those who applied for injuries, men predominated (65.5±1.09%), and for eye diseases — patients of both sexes with the same frequency. Patients who had applied for injury were younger (20–39 years old) than patients with eye diseases (40–59 years old). Patients with eye injuries were treated at a later time (16–24 hours) than patients with eye diseases (8–16 hours). Corneal and conjunctival injuries are the leading among the traumatic type, while among eye diseases are inflammatory pathology of the conjunctiva. Conclusion: the frequency of emergency calls to the NCO depends on the availability of ophthalmic care at the local level. Men of working age predominate among the patients. Keywords: emergency call, ophthalmic care, third level, availability, Azerbaijan, nosological structure. For citation: Gadzhieva B.Kh. Frequency and structure of emergency calls to the eye centers at the third stage of ophthalmic care depending on its availability in the regions of Azerbaijan. Russian Journal of Clinical Ophthalmology. 2022;22(3):161–167 (in Russ.). DOI: 10.32364/2311- 7729-2022-22-3-161-167","PeriodicalId":36455,"journal":{"name":"Russian Journal of Clinical Ophthalmology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82958442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 is a risk factor for retinal vein occlusion in younger patients?","authors":"A. Shchuko, M. Akulenko, T. N. Yur'eva","doi":"10.32364/2311-7729-2022-22-1-62-67","DOIUrl":"https://doi.org/10.32364/2311-7729-2022-22-1-62-67","url":null,"abstract":"Retinal vein occlusions (RVOs) are thought to have more favorable outcomes in patients under-50 due to spontaneous regression. However, 20% develop severe neovascularization. In most cases, the causal link of occlusion remains elusive. Some authors report on clinical presentations typical for RVOs in the COVID-19 infection due to hypercoagulation. Management of younger patients with RVO required a complex diagnostic approach to assess systemic risk factors and obligatory evaluation of baseline retinal ischemia using fluorescein angiography (FA) or optical coherence tomography angiography (OCTA). Clinical criteria of escalating retinal ischemia are decreased central visual acuity, macular edema, increased area of ischemia, and (later) retinal and/or anterior segment neovascularization. We describe a young man with RVO after the COVID-19 infection. The COVID-19 infection had no significant effect on hemostasis parameters in this patient. Meanwhile, the COVID-19 infection cannot be ruled out as an aggravating factor in a patient with a genetic predisposition to (micro)vascular occlusions. Keywords: OCTA, retinal neovascularization, retinal vein occlusion, coagulogram, COVID-19. For citation: Shchuko A.G., Akulenko M.V., Yur’eva T.N. COVID-19 is a risk factor for retinal vein occlusion in younger patients? Russian Journal of Clinical Ophthalmology. 2022;22(1):62–67 (in Russ.). DOI: 10.32364/2311-7729-2022-22-1-62-67.","PeriodicalId":36455,"journal":{"name":"Russian Journal of Clinical Ophthalmology","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84699041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of neuroinflammation in the pathogenesis of glaucomatous optic neuropathy","authors":"E. Egorov, V. E. Korelina, D. V. Cherednichenko, I. Gazizova","doi":"10.32364/2311-7729-2022-22-2-116-121","DOIUrl":"https://doi.org/10.32364/2311-7729-2022-22-2-116-121","url":null,"abstract":"This article reviews recent studies on the etiology and pathogenesis of primary open-angle glaucoma (POAG). POAG is now considered a neurodegenerative disease associated with neuroinflammation. Neuroglia plays a key role in the development of neuroinflammation. In impaired homeostasis, microglia is activated to prevent retinal alterations triggered by glutamate excitotoxicity. Macrophages, being still active, release cytokines in the extracellular space and produce matrix metalloproteinases. The result is an increased degradation of collagen fibers of the lamina cribrosa and development of glaucomatous optic neuropathy. Macroglia (astrocytes and Muller cells) are also involved in retinal immunoregulation. Astrocytes produce neurotrophic brain factor which promote the survival of damaged neurons. Additionally, these cells secrete fibrillar proteins that regenerate the extracellular matrix but form a glial scar, thereby inhibiting axonal transport and limiting the regeneration of damaged axons. The activation of microglia and macroglia in glaucoma precedes the loss of retinal ganglion cells. Determining the activity of retinal ganglion cells helps identify specific biomarkers of early glaucoma. Early diagnosis of POAG prevents irreversible damage. The authors discuss potential ways to regulate the activity of glia by stimulating the release of neurotrophic factors and suppressing glia hyperactivity. Keywords: primary open-angle glaucoma, neurodegenerative disease, neuroinflammation, macroglia, microglia, neurotrophic factors. For citation: Egorov E.A., Korelina V.E., Cherednichenko D.V., Gazizova I.R. Role of neuroinflammation in the pathogenesis of glaucomatous optic neuropathy. Russian Journal of Clinical Ophthalmology. 2022;22(2):116–121 (in Russ.). DOI: 10.32364/2311-7729-2022-22-2-116-121","PeriodicalId":36455,"journal":{"name":"Russian Journal of Clinical Ophthalmology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78657794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dry eye disease in keratoconus: etiology and medical treatment","authors":"V. Averich","doi":"10.32364/2311-7729-2022-22-2-122-126","DOIUrl":"https://doi.org/10.32364/2311-7729-2022-22-2-122-126","url":null,"abstract":"This paper reviews published data on the studies on keratoconus associated with dry eye disease (DED) presentations. Despite the lack of a direct correlation between DED and keratoconus, many studies have demonstrated that keratoconus is associated with DED in more than 80% of cases. The author describes major endogenous and exogenous (inflammatory, immune/allergic, mechanical, neuropathic) factors triggering the development and association of these conditions. Approaches to the medical treatment of disorders resulting from the association of these entities are discussed. The primary management strategy implies tear film and ocular surface protection with tear substitutes based on the sodium salt of hyaluronic acid. In the lack of the effect of tear substitutes or in rigid gas permeable contact lens wearers, gel-based dexpanthenol in high concentrations is recommended. This treatment significantly increases drug bioavailability and prolongs the ocular surface reparation. Scleral contact lenses ensuring intact corneal epithelium and high visual acuity in irregular astigmatism caused by keratoconus are also used for corneal protection and DED therapy. Keywords: keratoconus, keratectasia, dry eye disease, epitheliopathy, tear film. For citation: Averich V.V. Dry eye disease in keratoconus: etiology and medical treatment. Russian Journal of Clinical Ophthalmology. 2022;22(2):122–126 (in Russ.). DOI: 10.32364/2311-7729-2022-22-2-122-126.","PeriodicalId":36455,"journal":{"name":"Russian Journal of Clinical Ophthalmology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89654211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosing glaucoma in optometry practice","authors":"A. V. Korneeva, I. Isakov, A. Kuroedov, O. N. Onufriychuk","doi":"10.32364/2311-7729-2022-22-4-258-264","DOIUrl":"https://doi.org/10.32364/2311-7729-2022-22-4-258-264","url":null,"abstract":"The article discusses the role of optometry practice in diagnosing early glaucoma in the context of the obviously increasing incidence of glaucoma and the ophthalmic staffing shortage. It elucidates the findings of domestic and international studies focused on the early glaucoma diagnosis in optometry. The evolving role of optometry personnel in the public health system is underpinned by the increasing number of patients with eye diseases and the growing demand for primary ophthalmic care due to a higher life expectancy of the population. So far, the optometry practice is not always considered as a part of the public health system, but it plays an important role in protecting the vision, as it often helps to identify patients with early stages of refractive disorders and other ophthalmic diseases. The opportunities of diagnosing of glaucoma in optometric practice usually depend on the set goals, available equipment, optometrist skills and commitments to achieving the results. Improving equipment availability in the optometrist’s office, professional development of specialists and their motivations for performing diagnostic tests may optimize the detection of glaucoma. It is also worth noting the importance of interaction between the optometrist and the ophthalmologist. Over the past years, a positive trend to optometry development has emerged shaping the future expansion of the scope of traditional professional interests of optometry staff. The trend is based on the improved situation with the equipment availability and the professional development of specialists. Keywords: glaucoma, optometrist, optometry practice, ophthalmologist, glaucoma diagnostics, glaucoma optic neuropathy. For citation: Korneeva A.V., Isakov I.N., Kuroedov A.V., Onufriychuk O.N. Diagnosing glaucoma in optometry practice. Russian Journal of Clinical Ophthalmology. 2022;22(4):258–264 (in Russ.). DOI: 10.32364/2311-7729-2022-22-4-258-264.","PeriodicalId":36455,"journal":{"name":"Russian Journal of Clinical Ophthalmology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75730267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of potential simultaneous operations for the surgical rehabilitation of patients with thyroid eye disease","authors":"D. Atarshchikov, E.Yu. Korchemkina","doi":"10.32364/2311-7729-2022-22-3-187-190","DOIUrl":"https://doi.org/10.32364/2311-7729-2022-22-3-187-190","url":null,"abstract":"The importance of revising the traditional multi-stage approach to the surgical rehabilitation of patients with thyroid eye disease is supported by multiple reasons, such as high operation costs, anesthesia-related increase in a burden for patients, and repeated surgical incisions associated with a delayed healing of surgical wounds. Over the past two decades, the orbital surgeons have attempted to solve the problem by combining several operations into a single-stage procedure. The article reviews the results of studies elucidating various simultaneous surgical techniques for orbital decompression, because the surgical treatment of exophthalmos is a \"cornerstone\" in solving functional problems arising from Graves’ orbitopathy. Moreover, the optimal planning depends on the severity of aesthetic problems in the periorbital region and the associated changes of eyelids and midface. Thus, it is necessary to consider multiple potential solutions within a single anesthesia exposure, the availability of surgeons with the appropriate skills or the involvement of a multidisciplinary team. In conclusion, the authors, referring to their own experience and the latest articles in international editions, propose anatomical and physiological criteria for selecting candidates for simultaneous orbit decompression surgery and for predicting surgical treatment outcomes in such patients. Keywords: orbital decompression, eyelid retraction, simultaneous operations, restrictive strabismus, thyroid eye disease, canthoplasty, exophthalmos. For citation: Atarshchikov D.S., Korchemkina E.Yu. Review of potential simultaneous operations for the surgical rehabilitation of patients with thyroid eye disease. Russian Journal of Clinical Ophthalmology. 2022;22(3):187–190 (in Russ.). DOI: 10.32364/2311-7729-2022-22-3-187-190","PeriodicalId":36455,"journal":{"name":"Russian Journal of Clinical Ophthalmology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81202981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-related choroiditis masquerading as a choroidal melanoma","authors":"A. F. Brovkina, S. Nechesnyuk, A. V. Dobroserdov","doi":"10.32364/2311-7729-2022-22-3-197-202","DOIUrl":"https://doi.org/10.32364/2311-7729-2022-22-3-197-202","url":null,"abstract":"In the last two years, considerable attention has focused on eye disorders in the COVID-19 infection. The damage to the inner tunic of the eye is the most dramatic. The authors address hemodynamic abnormalities in these patients occurring during the disease and in the post-COVID-19 syndrome as demonstrated by optical coherence tomography (OCT) and OCT angiography (OCTA). Clinical presentations of COVID-related choroiditis are similar to those of other choroidites. This paper discusses a 66-year-old man with COVID-related choroiditis masquerading as choroidal melanoma who experienced the COVID-infection in April–May 2021. Clinical echographic signs of COVID-related choroiditis are described. The pathomorphology of this condition is uncovered for the first time. By comparing morphological signs in the choroid typical for cell damage with viruses and signatures of the pathological process in the inner tunic of the eye, the disease was interpreted as a COVID- associated choroiditis. The authors conclude that attention should be paid to both early vision loss and its rate when differentiating between tumor- and non-tumor-related choroid disorders. Keywords: choroiditis, COVID-19, vasculitis, choroid disorders, choroidal melanoma, uveal melanoma. For citation: Brovkina A.F., Nechesnyuk S.Yu., Dobroserdov A.V. COVID-related choroiditis masquerading as a choroidal melanoma. Russian Journal of Clinical Ophthalmology. 2022;22(3):197–202 (in Russ.). DOI: 10.32364/2311-7729-2022-22-3-197-202.","PeriodicalId":36455,"journal":{"name":"Russian Journal of Clinical Ophthalmology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90148290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first experience with brolucizumab for neovascular age-related macular degeneration","authors":"A. Kulikov, D. Maltsev, A. Malafeeva, S.M. Perminova, V. R. Zhalimova, A. Vasiliev, A. Kazak","doi":"10.32364/2311-7729-2022-22-2-108-115","DOIUrl":"https://doi.org/10.32364/2311-7729-2022-22-2-108-115","url":null,"abstract":"Aim: to assess the efficacy and safety of brolucizumab in Russian patients with neovascular age-related macular degeneration (nAMD). Patients and Methods: this study enrolled 47 patients with nAMD divided into two groups. Group 1 included 13 treatment-naïve patients/13 eyes (12 men and 1 woman, mean age 72.4±9.5 years, mean best-corrected visual acuity (BCVA) 0.43±0.32). Group 2 included 34 patients having active nAMD despite ongoing treatment/34 eyes (25 men and 9 women, mean age 74.1±8.0 years, mean BCVA 0.46±0.25). All patients received at least two intravitreal injections of brolucizumab (in total, 137 injections) with a 1-month interval. Patients were examined one month after the 2nd injections. BCVA, central macular thickness (CMT), macular volume (MV), sub/intraretinal fluid, and adverse events were evaluated. Results: in group 1, a significant increase in BCVA from 34.9±6.6 letters to 44.1±4.2 letters (p=0.02) was reported. Meanwhile, in group 2, BCVA remained unchanged (35.0±3.5 letters before treatment vs. 33.8±3.7 letters after treatment, p>0.05). In group 1, CMT and MV significantly reduced, while in group 2, only MV significantly reduced (p<0.05). A significant reduction in the cumulative rate of sub/ intraretinal fluid was detected in both groups (p<0.05). Conclusions: treatment-naïve patients who received brolucizumab demonstrated a significant improvement of anatomical and functional parameters. Meanwhile, patients with active nAMD despite ongoing treatment who received brolucizumab demonstrated a significant reduction in disease activity and tendency to the improvement of anatomical (but not functional) parameters. Keywords: age-related macular degeneration, brolucizumab, optical coherence tomography, anti-VEGF therapy. For citation: Kulikov A.N., Maltsev D.S., Malafeeva A.Yu. et al. The first experience with brolucizumab for neovascular age-related macular degeneration. Russian Journal of Clinical Ophthalmology. 2022;22(2):108–115 (in Russ.). DOI: 10.32364/2311-7729-2022-22-2-108-115.","PeriodicalId":36455,"journal":{"name":"Russian Journal of Clinical Ophthalmology","volume":"148 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86251284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects of two-port vitrectomy in the treatment of patients with epiretinal fibrosis","authors":"D. V. Borisova, I. Frolychev, N. Pozdeeva","doi":"10.32364/2311-7729-2022-22-4-224-227","DOIUrl":"https://doi.org/10.32364/2311-7729-2022-22-4-224-227","url":null,"abstract":"Aim: to evaluate the efficacy and safety of two-port vitrectomy in the treatment of patients with epiretinal fibrosis. Patients and Methods: surgical treatment using a two-port vitrectomy technique was performed in 25 patients (25 eyes) with epiretinal fibrosis. Patients with concomitant retinal pathology (e.g. diabetic or post-thrombotic retinopathy) and glaucoma were not included in the study. Of the total number of patients, 64% (n=16) were women and 36% (n=9) were men. The mean age of the patients was 61±6,4 years. The surgical procedure was based on the developed technology and conducted by the same surgeon in the same clinical setting. The surgical technique included the installation of two ports in the opposite quadrants: in the upper hemisphere for the vitreotome and instruments, and in the lower hemisphere — for the infusion cannula with a built-in endo-illuminator-chandelier as a single light source. Then, vitrectomy was performed according to the classical technique — the vitreous body was removed centrally, followed by membrane staining and membrane peeling, and partial tamponade with an air mixture. Patients were examined on day 1, one and three months after the surgical procedure. They underwent the basic ophthalmic examination, including visometry and tonometry. Optical coherence tomography with retinal image analysis was used to assess the recovery of anatomical parameters. Results: intra- or postoperative adverse events were not reported. All patients had stable anatomical results: the absence of horizontal tractions in the foveal zone and a retinal height reduction to 297±32 μm. The maximum functional effect — a decrease in metamorphopsia expression and an increase in best-corrected visual acuity by 0.48±0.1 vs. that at the baseline was observed 3 months after the surgery. Conclusion: in addition to the classical three-port vitrectomy with xenon focal illuminator, it is possible to use the two-port vitrectomy with a mercury vapor chandelier illuminator. The advantage of this method is the reduction of surgical trauma. Keywords: epiretinal fibrosis, two-port vitrectomy, phototoxicity, tyndallometry. For citation: Borisova D.V., Frolychev I.A., Pozdeeva N.A. Prospects of two-port vitrectomy in the treatment of patients with epiretinal fibrosis. Russian Journal of Clinical Ophthalmology. 2022;22(4):224–227 (in Russ.). DOI: 10.32364/2311-7729-2022-22-4-224-227.","PeriodicalId":36455,"journal":{"name":"Russian Journal of Clinical Ophthalmology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90615838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological analysis primary open-angle glaucoma incidence and prevalence in Russia","authors":"A. Movsisyan, A. Kuroedov, M. A. Arkharov, V. V. Prokhorenko, I.A. Chepurnov","doi":"10.32364/2311-7729-2022-22-1-3-10","DOIUrl":"https://doi.org/10.32364/2311-7729-2022-22-1-3-10","url":null,"abstract":"Background: more than 50% of newly diagnosed primary open-angle glaucoma (POAG) patients are in the moderate or advanced stages. It is difficult to assess disease course due to limited official data. On a national scale, prevalence and incidence are measures that hardly provide a complete \"landscape\" of this issue in Russia. Aim: to determine the prognosis of changes in epidemiological indicators (prevalence and incidence) of POAG in Russia, assess disease duration and calculate presumed age of disease onset. Patients and Methods: we applied a scientific-analytical design implying literary statistical analysis of official epidemiological indicators of glaucoma in Russia and multicenter trials. These data were a basis for prediction (three variants) of glaucoma incidence and prevalence in Russia and the development of a mathematical model to determine the age of disease onset and duration. Results: the age of patients with POAG stage 0 was 54 (49;58) years. This age was calculated based on data from publications in 2000– 2016. These data were initially used to calculate the mean duration of each glaucoma stage. As a result, the \"true\" age of stage 1 onset was 57 (52;61) years. Meanwhile, the mean age of stage 1 diagnosis was 60 (56;65) years. According to these calculations and considering predicted changes in population size and average life expectancy, a growth in glaucoma incidence and prevalence is expected in low, medium, and high population projections. Conclusions: we demonstrated an expected growth in glaucoma incidence and prevalence in Russia in the coming 15 years. An increase in visual disability and, therefore, rapid loss of working capacity in various age groups due to \"late\" diagnosis and treatment are also likely. Collection of epidemiological data, further analysis of these findings, and searching for ways to improve diagnosis and course of socially significant diseases (e.g., glaucoma) are among strategic tasks for the healthcare system. Keywords: primary open-angle glaucoma, glaucoma diagnosis, glaucoma epidemiology, prognosis. For citation: Movsisyan A.B., Kuroedov A.V., Arkharov M.A. et al. Epidemiological analysis primary open-angle glaucoma incidence and prevalence in Russia. Russian Journal of Clinical Ophthalmology. 2022;22(1):3–10 (in Russ.). DOI: 10.32364/2311-7729-2022-22-1-3-10.","PeriodicalId":36455,"journal":{"name":"Russian Journal of Clinical Ophthalmology","volume":"4647 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85737515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}