BMC Nutrition最新文献

{"title":"Factors associated with the serum 25-hydroxyvitamin D levels in adults.","authors":"Sue-Hsien Chen, Shu-Ching Chen, Yo-Ping Lai, Pin-Hsuan Chen, Kun-Yun Yeh","doi":"10.1186/s40795-025-01120-3","DOIUrl":"10.1186/s40795-025-01120-3","url":null,"abstract":"<p><strong>Background: </strong>Hypovitaminosis D has a significant negative impact on general health. Although some factors associated with hypovitaminosis D have been previously reported, they have seldom been analyzed simultaneously in community-based research. This study aims to investigate some potential factors associated with serum 25 (OH)D level, representing a vitamin concentration.</p><p><strong>Methods: </strong>A cross-sectional study recruiting 4,457 adults, aged over 18 years, was conducted between August 2019 and December 2023. Sociodemographic data were obtained through structured questionnaires, while anthropometric measurements, hemogram results, and biochemical markers were collected from medical records and physical examination findings. A self-reported depression rating score; health beliefs; and health-related quality of life (HRQoL) factors were assessed with questionnaires. Univariate and multivariate analyses were performed.</p><p><strong>Results: </strong>The mean serum 25(OH)D level was 29.22 ± 10.45 ng/mL. Multivariate linear regression analysis revealed that serum 25(OH)D levels were positively associated with age (β = 0.258, p < 0.001), male sex (β = 0.164, p < 0.001), high school education level (β = 0.118, p < 0.001), smoking exposure (β = 0.044, p = 0.011), alcohol consumption (β = 0.150, p < 0.001), hemoglobin concentration (β = 0.062, p = 0.001), calcium level (β = 0.047, p = 0.005), and the mental component score of health-related quality of life (HRQoL) (β = 0.086, p < 0.001). Conversely, serum 25(OH)D levels were negatively associated with coffee consumption (β = - 0.045, p = 0.002), estimated glomerular filtration rate (β = - 0.105, p < 0.001), blood levels of intact parathyroid hormone (β = - 0.184, p < 0.001), phosphorus (β = - 0.033, p = 0.040), and triglycerides (β = - 0.060, p < 0.001). The overall model explained 29.6% of the variance in serum 25(OH)D levels (R² = 0.296). There were close correlations between sociodemographic factors, anthropometric variables, hemograms, biochemical data, self-reported depression rating scores, health beliefs, and HRQoL factors.</p><p><strong>Conclusions: </strong>This study identified several key variables associated with serum 25(OH)D levels in adults. These findings provide important targets for designing health education programs aimed at reducing the prevalence of vitamin D insufficiency. Future community-based research should consider incorporating additional determinants of vitamin D status, including quantified sunlight exposure, dietary intake of vitamin D-rich foods, and supplementation patterns. Accounting for these broader lifestyle and environmental factors may enable subsequent studies to generate more robust insights into the multifactorial nature of vitamin D regulation and inform more effective public health strategies.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"132"},"PeriodicalIF":1.9,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional adequacy of charitable food aid packages to the needs of different household-types: a case study in Spain.","authors":"E Carrillo-Álvarez, J Muñoz-Martínez, I Cussó-Parcerisas, I Palma-Linares, M G Casucci, K Gunes","doi":"10.1186/s40795-025-01122-1","DOIUrl":"10.1186/s40795-025-01122-1","url":null,"abstract":"","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"133"},"PeriodicalIF":1.9,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sesame oil improves biomarkers of glycemic control in women with metabolic dysfunction-associated steatotic liver disease: a randomized, double-blind, controlled clinical trial.","authors":"Masoumeh Atefi, Hamid Vahedi, Mina Darand, Mohammad Hassan Entezari","doi":"10.1186/s40795-025-01123-0","DOIUrl":"10.1186/s40795-025-01123-0","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to investigate whether sesame oil (SO) consumption could improve biomarkers of glycemic control, inflammation, and oxidative stress in women with metabolic dysfunction-associated steatotic liver disease (MASLD).</p><p><strong>Methods: </strong>This randomized, double-blind, controlled trial included 60 women with MASLD (aged 20-50 years, body mass index (BMI) 25-40 kg/m²) assigned to either SO or sunflower oil (SFO) group (n = 30 each), who consumed 30 g/day for 12 weeks alongside a 500 kcal/day calorie-restricted diet. Serum fasting blood glucose (FBG), fasting serum insulin (FSI), homeostatic model assessment for insulin resistance (HOMA-IR), homeostasis model assessment of β-cell function (HOMA-β), quantitative insulin sensitivity check index (QUICKI), serum high-sensitivity C-reactive protein (hs-CRP), and serum malondialdehyde (MDA) were measured at the pre- and post-intervention phases.</p><p><strong>Results: </strong>Compared with the control, SO supplementation led to significant improvements in FBG (mean difference: -18.2 mg/dL; 95% confidence interval (CI): -25.0 to -11.4; Cohen's d = 0.84), FSI (-3.2 µIU/mL; 95% CI: -4.5 to -1.9; d = 0.76), HOMA-IR (-1.4; 95% CI: -2.0 to -0.8; d = 0.81), HOMA-β (+ 15.6; 95% CI: +7.4 to + 23.8; d = 0.67), and QUICKI (+ 0.07; 95% CI: +0.03 to + 0.11; d = 0.72) (p < 0.05 for all). The reductions in hs-CRP (-0.05 mg/dL; 95% CI: -0.15 to + 0.05; d = 0.12) and MDA (-0.6 µmol/L; 95% CI: -1.4 to + 0.2; d = 0.28) were not significant (p > 0.05). Both groups presented significant weight loss, with no significant difference between them (p > 0.05).</p><p><strong>Conclusions: </strong>SO consumption significantly improved glycemic control biomarkers in women with MASLD, suggesting potential metabolic benefits beyond weight loss.</p><p><strong>Trial registration: </strong>This study was approved by the Institutional Review Board of Isfahan University of Medical Sciences (code: IR.MUI.</p><p><strong>Research: </strong>REC.1399.548), and it is registered at https://www.irct.ir/trial/52288 , IRCT20140208016529N6, Registration Date: 2020-12-12).</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"134"},"PeriodicalIF":1.9,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 diabetes mellitus with chronic kidney disease benefits from long-term restriction of dietary protein intake: a 10-year retrospective cohort study.","authors":"Danfeng Liu, Qiuling Li, Runli Jia, Weiting He, Xuan Zhao, Mengting Pan, Xiaojie Chen, Yanhui Wang, Yaxi Zhu, Hanchen Hou, Jianteng Xie, Wenjian Wang","doi":"10.1186/s40795-025-01119-w","DOIUrl":"10.1186/s40795-025-01119-w","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the relationship between long-term dietary protein intake (DPI) restriction and clinical outcomes in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD).</p><p><strong>Methods: </strong>We conducted a retrospective study in both T2DM with CKD cohort from eight centers, with a follow-up period from January 2014 to September 2023 and the National Health and Nutrition Examination Survey (NHANES) dataset. DPI was evaluated based on the serum urea creatinine ratio (sUCR). The primary outcomes included initiation of dialysis, progression to end-stage renal disease, renal transplant, serum creatinine doubling, cardiovascular and cerebrovascular diseases.</p><p><strong>Results: </strong>In the T2DM with CKD cohort, 820 patients were selected from a total of 856 and categorized into three groups, propensity score matching at a 1:1:1 ratio, according to their DPI_sUCR levels. The median follow-up time was 32.94 months. Patients on a restricted protein diet (DPI_sUCR ≤ 1.0 g/kg·d) showed improved prognosis and delayed progression to primary endpoints. In CKD stages 3-4, patients with DPI_sUCR < 0.8 g/kg·d exhibited significantly improves prognosis. Similarly, in the NHANES cohort, 1723 patients were classified into 3 groups, with a median follow-up time of 87.19 months. A restricted protein diet (DPI_sUCR ≤ 1.0 g/kg·d) markedly improved prognosis and reduced mortality.</p><p><strong>Conclusion: </strong>Our data provide the strong evidence that T2DM patients with CKD benefits from long-term restriction of DPI_sUCR ≤ 1.0 g/kg·d by improving composite endpoints. In T2DM patients with CKD at stages 3-4, an intensive restriction of DPI_sUCR (< 0.8 g/kg·d) significantly improved composite endpoint.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"131"},"PeriodicalIF":1.9,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and facilitators to following dietary recommendations for bone health: a qualitative study.","authors":"Harleen Ghuttora, Lorena Kembel, Heidi Piovoso, Adrienne L Feasel, Julia MacLaren, April Matsuno, Tanis Fenton, Catherine B Chan, Gregory A Kline, Emma O Billington","doi":"10.1186/s40795-025-01116-z","DOIUrl":"10.1186/s40795-025-01116-z","url":null,"abstract":"<p><strong>Background: </strong>An estimated one in two women and one in five men will experience a low-trauma fracture after age 50. Diet is an important mediator of bone health but individuals with or at risk of osteoporosis do not always meet recommended intake of specific nutrients (protein, calcium, vitamin D) and whole foods. We aimed to identify barriers and facilitating factors to following dietary recommendations for bone health among adults with or at risk of osteoporosis.</p><p><strong>Methods: </strong>Adults aged ≥ 45 years who had been referred to a specialty osteoporosis clinic were recruited to participate in 4 virtual focus groups exploring barriers and facilitators to following dietary recommendations for bone health. Interest in a practical, bone-health focused Culinary Medicine program was also assessed.</p><p><strong>Results: </strong>A total of 29 individuals were enrolled, 26 completed a pre-survey which asked about demographics and dietary habits, and 24 (age range 56-89 years, 21 female) attended one of four virtual focus groups. Principle barriers to following dietary recommendations for bone health highlighted by the focus group participants were: (1) living alone and cooking for one, (2) low motivation to prepare meals, and (3) dietary restrictions. Principal facilitators were: (1) preparing meals in advance, (2) online grocery shopping, and (3) engaging in exercise. Focus group participants expressed enthusiasm about participating in a Culinary Medicine program for bone health.</p><p><strong>Conclusion: </strong>Our findings indicate that adults with or at risk of osteoporosis face multiple barriers to adhering with dietary recommendations. Bone-focused Culinary Medicine programming merits further study as a possible method of overcoming these barriers.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"122"},"PeriodicalIF":1.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet and risk of orthorexia nervosa among female post-graduate students in health-related and non-health-related fields.","authors":"Wioleta Faruga-Lewicka, Wiktoria Staśkiewicz-Bartecka, Marek Kardas","doi":"10.1186/s40795-025-01087-1","DOIUrl":"10.1186/s40795-025-01087-1","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to examine the dietary habits of female students during their college reunion and evaluate their risk of orthorexia nervosa in both health-related and non-health-related fields of study.</p><p><strong>Methods: </strong>The study was conducted using the Computer-Assisted Web Interview method. A survey questionnaire was used to conduct the study, which was developed based on a Questionnaire of Eating Behavior and ORTO-15, a questionnaire used tool to assess the risk of orthorexia nervosa. After taking into account the inclusion and exclusion criteria, 388 female students participated in the study (the average age 25.02 ± 5.11).</p><p><strong>Results: </strong>Polish female students eat an average of 2-3 meals a day during their college reunion and snack in between, reaching most often for fruits and sweets. At breakfast, they most often reach for coffee, bread, and meat products. A lunch consists of potatoes, meat, and vegetable salads, and a dinner of coffee, tea, bread, and cheese. Polish female students drink about 1 L of water a day and 1-2 coffees during their college reunion. In a survey on the risk of orthorexia nervosa, there were no significant differences between health-related female students and non-health-related students (p = 0.69). The nutritional status of most female extramural students was normal.</p><p><strong>Conclusions: </strong>The study found no differences in the risk of orthorexia or in eating habits between female students in health-related and non-health-related fields.</p><p><strong>Trial registration: </strong>The study was approved by the Bioethics Committee of the Silesian Medical University in Katowice (BNW/NWN/0052/KB1/44/I/23) in light of the Law of December 5, 1996, on the Profession of Physician and Dentist, which includes a definition of medical experimentation.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"123"},"PeriodicalIF":1.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are there prophylactic effects of vitamin D among healthier adult patients? A systematic review of randomized controlled trials.","authors":"Caroline Goswami, Sherrice Law, Hannah Zhang, Hannah Park, Bhagvat Maheta, Katherine Arnott, Megan Hsu, Kevin Truong, Mark Sheffield, Zahid Iqbal, Chainaronk Limanon, David Pai","doi":"10.1186/s40795-025-01107-0","DOIUrl":"10.1186/s40795-025-01107-0","url":null,"abstract":"<p><strong>Introduction: </strong>In 2017, a study uncovered increasing trends in vitamin D supplementation, revealing that 18% of adults exceeded 1000 international units (IU) daily, and 3% surpassed the safe limit of 4000 IU, raising concern for severe hypercalcemia and associated pathological effects on the kidneys, heart, and vascular system. While vitamin D is well-established for prophylactic use against osteomalacia and osteoporosis, its extra-skeletal benefits for healthy individuals, such as improving insulin sensitivity and low-density lipoprotein, remain unclear. This study focuses on defining healthy adults and exploring the potential benefits and drawbacks of prophylactic vitamin D supplementation.</p><p><strong>Methods: </strong>Using PubMed, EMBASE, and Scopus databases, 10,155 articles on vitamin D prophylaxis were identified. Randomized controlled trials targeting healthy patients receiving vitamin D for prophylaxis were included, with exclusions based on language, absence of reported outcomes, and patient history. Articles were screened and evaluated by Covidence and the Cochrane Risk of Bias tool, respectively. Dosage, form, frequency, duration, follow-up care, outcomes, and complications of included articles were recorded. This study protocol has been registered to PROSPERO: CRD42023446944.</p><p><strong>Results: </strong>Out of 18 articles, 4,415 patients showed low bias risk by the Cochrane tool. Seven studies found significant improvements: protection against autoimmune reactions, elevated hematological and iron profiles, reduced influenza-like illness, and enhanced cognitive tasks. 5000 IU Vitamin D for four weeks significantly reduced cholesterol, unlike 1000 IU for 16 weeks. Conversely, 11 studies revealed no Vitamin D impact on outcomes including hemoglobin-A1c, lipoproteins, BMI, blood pressures, and respiratory infections.</p><p><strong>Conclusion: </strong>Except for a few outcomes, most prophylactic Vitamin D supplementation was generally not found to have statistically significant benefits in the healthy adult population. Future directions can include additional prospective studies with larger sample sizes of healthy adults testing for benefits and adverse effects of prophylactic vitamin D use.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"118"},"PeriodicalIF":1.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal concentrations of vitamin D metabolites in response to high-dose oral vitamin D during first trimester pregnancy: a randomized controlled trial.","authors":"Inayah Syafitri, Rima Irwinda, Yudianto Budi Saroyo, Yuditiya Purwosunu, Noroyono Wibowo","doi":"10.1186/s40795-025-01104-3","DOIUrl":"10.1186/s40795-025-01104-3","url":null,"abstract":"<p><p>Vitamin D deficiency has become a common problem globally. The present study aimed to evaluate the effects of different vitamin D3 regimens on maternal concentrations of vitamin D metabolites during pregnancy. Subjects were ≤ 14 weeks gestation pregnant women with 25(OH)D serum level < 30 ng/mL]. Two intervention groups were randomly assigned: 5,000 IU of vitamin D3 daily or 50,000 IU weekly of vitamin D3. Maternal blood samples were collected before and after four weeks of intervention to assess changes in serum concentrations of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)₂D), vitamin D binding protein (VDBP), and 24,25-dihydroxyvitamin D (24,25(OH)2D). Sixty subjects were randomized into two groups, and eight subjects were dropped out. There were no differences in the baseline demographics or baseline levels of any of the vitamin D metabolites between the two groups. In the 50,000 group, the 25(OH)D levels increased from 15.3 ± 4.7 ng/mL to 26.9 ± 6.1 ng/mL (p < 0.001) and 34.6% of the subjects achieved vitamin D sufficiency. While in the 5,000 group, the 25(OH)D levels increased from 14.5 ± 4.3 ng/mL to 27.9 ± 9.3 ng/mL (p < 0.001) and 23.1% of the subjects achieved vitamin D sufficiency. Both groups showed an increasing trend in the total levels of 25(OH)D, 1,25(OH)2D, VDBP, and 24,25(OH)2D. However, the increment of all vitamin D metabolites were not significantly different between two groups. Vitamin D3 50,000 IU weekly is equally effective and safe as 5,000 IU daily in increasing vitamin D levels in pregnant women with vitamin D deficient or insufficient. This randomized controlled trial was retrospectively registered at ClinicalTrials.gov (NCT06054919) on 22nd September 2023.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"117"},"PeriodicalIF":1.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outpatient treatment of children with severe acute malnutrition within the health care system in a humanitarian crisis: a cross-sectional study in Uganda during the Horn of Africa drought response.","authors":"Florence Mary Turyashemererwa, Charles Njuguna, Tola Habteyes Hailu, George Opong, Ssekitoleko Richard, Kwikiriza Nicholas Magambo, Nabunya Phoebe, Kisibuka Richard, Gidongo Derrick, Andrew Bakainaga Niwagaba, Edson Katushabe, Bodo Bongomin, Ouedraogo NikiemaLaetitia, Wekesa Julius, Namukose Samalie, Timothy Mateeba, Yonas Tegegn Woldemariam","doi":"10.1186/s40795-025-01113-2","DOIUrl":"10.1186/s40795-025-01113-2","url":null,"abstract":"<p><strong>Background: </strong>Uganda, situated within the Greater Horn of Africa, is currently facing a severe food insecurity crisis with the Karamoja sub-region and its neighboring districts being the most severely impacted. This sub-region exhibits the highest rate of wasting among children under the age of five, at 10%, which is significantly higher than the national average of 3.6%. This study aimed to assess the capacity of the health care system to provide quality treatment outcomes for children with severe acute malnutrition (SAM) in outpatient therapeutic care facilities.</p><p><strong>Methods: </strong>A total of 150 health facilities across 15 districts were selected. Nutrition service delivery within the health system was assessed using an adapted Ministry of Health (MoH) Nutrition Services Delivery Assessment Tool. Key indicators-cure, death, and defaulter rates-from outpatient therapeutic care services for SAM treatment were extracted from the MoH District Health Management Information System 2 (DHIS2) for the period 2020-2023. Data analysis was conducted using SPSS.</p><p><strong>Results: </strong>The average cure rate for children with SAM in outpatient therapeutic care was 62.3%, falling below the MoH standard of 75%. While death rates remained within the recommended threshold (< 10%), defaulter rates consistently exceeded the 15% benchmark, except in 2023. Gaps in service delivery included frequent stockouts of Ready-to-Use Therapeutic Food (RUTF) (44.9%) and the absence of outpatient therapeutic care services at designated health facilities (35.6%). Positively, 98% of health facilities had a core management team, and 81.3% had a designated nutrition focal person.</p><p><strong>Conclusion: </strong>The quality of treatment outcomes for children admitted with severe acute malnutrition at outpatient therapeutic care facilities in this setting was below MoH standards. Strengthening supply chains and expanding services are essential to improving SAM outcomes. Despite these challenges, core management teams and designated nutrition focal persons in most facilities present an opportunity to enhance governance and integrate sustainable solutions.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"126"},"PeriodicalIF":1.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of multimodal nutrition intervention on glucose and lipid parameters of Arfa Iron and Steel Company workers.","authors":"Peyman Sarsangi, Sahand NikAsa, Jaber Ganji, Hossein Fallahzadeh, Azadeh Nadjarzadeh","doi":"10.1186/s40795-025-01063-9","DOIUrl":"10.1186/s40795-025-01063-9","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the impact of nutritional interventions on glycemic and lipid profile factors among workers.</p><p><strong>Design & participants: </strong>This prospective before-after study was conducted on 1097 employees of Arfa Iron and Steel Company, Yazd, Iran.</p><p><strong>Setting: </strong>At baseline, anthropometric indices, and laboratory parameters including lipid profiles, liver enzymes, glucose factors, and blood pressure were measured for all participants.</p><p><strong>Intervention: </strong>A six-month multimodal nutrition intervention program was implemented, including nutritional education, healthier factory menu options, healthy cooking method education, and nutritional counseling.</p><p><strong>Main outcome measures: </strong>After the six-month intervention, all initial anthropometric indices and laboratory parameters, (lipid profiles, liver enzymes, fasting blood glucose, and blood pressure) were reassessed.</p><p><strong>Results: </strong>After six months, mean weight (2.5%), BMI (2.5%), total cholesterol (11.9%), LDL cholesterol (18.5%), triglycerides (0.5%), systolic and diastolic blood pressure (2.6%) significantly decreased, while mean HDL cholesterol increased (17%) (p < 0.001). However, fasting blood sugar and liver enzymes showed no significant change.</p><p><strong>Conclusions and implications: </strong>The findings demonstrate that a multimodal nutrition intervention significantly improved anthropometric indices and lipid profiles among Arfa Iron and Steel Company workers. Such interventions could be considered for other factories to enhance worker health and potentially boost productivity.</p><p><strong>Trial registration: </strong>The trial is registered retrospectively at the US National Institutes of Health (ClinicalTrials.gov). The registration in the US National Institutes of Health was done in 23/10/2024 with the registration number: NCT06654362.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"124"},"PeriodicalIF":1.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}