BMC Nutrition最新文献

{"title":"Microbiome-directed food to promote sustained recovery in children with uncomplicated acute malnutrition: protocol for a randomized controlled trial in Burkina Faso.","authors":"Hermann Biénou Lanou, Jérôme Winetourefa Somé, Marie Arsène Aristide Koumbem, Seni Kouanda","doi":"10.1186/s40795-025-01045-x","DOIUrl":"10.1186/s40795-025-01045-x","url":null,"abstract":"<p><strong>Background: </strong>Acute malnutrition still affects millions of children under five years of age globally each year and contributes to approximately half of all annual childhood deaths. A considerable proportion of patients who recover from acute malnutrition experience poor health and nutrition and eventually relapse after they are discharged from community management of acute malnutrition programs. A microbiota-directed complementary food (MDCF) showed a superior effect compared to standard ready-to-use supplementary food (RUSF) in terms of ponderal growth and potential benefit for bacterial taxa that were correlated with weight-for-height z-score (WHZ). This paper describes a protocol for the MDCF phase III trial on a larger African sample for promoting sustained recovery.</p><p><strong>Methods: </strong>This study is an individually controlled open-label phase III trial to determine the efficacy of MDCF on programmatic and sustained recovery compared to standards RUTF and RUSF. Eligible MAM children will be randomly assigned to MDCF or RUSF and those with SAM to MDCF or RUTF. Supplementation and follow-up visits will be performed following national guidelines for acute malnutrition management. Primary outcomes are programmatic recovery at 12 weeks after enrollment and sustained recovery at 12 weeks after recovery. The secondary outcomes included the mean WHZ, weight-for-age z score, height-for-age z score change, average length of stay, nonresponse, failure and dropout.</p><p><strong>Discussion: </strong>The present study is designed to investigate the efficacy of a microbiota-targeted food in treating acute uncomplicated malnutrition and preventing relapses. It will provide evidence as a phase III clinical trial.</p><p><strong>Trial registration: </strong>Clinicaltrials.gov Protocol registration and results system (NCT05586139). Registered on 2022-10-14. https://register.</p><p><strong>Clinicaltrials: </strong>gov/ .</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"92"},"PeriodicalIF":1.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-based variations in the nutritional and functional status of hemodialysis patients in Palestine: a cross-sectional study.","authors":"Zakaria Hamdan, Zaher Nazzal, Souzan Zidan, Lawra Bsharat, Sanaa Ishtayah, Sarah Sammoudi, Manal Badrasawi","doi":"10.1186/s40795-025-01081-7","DOIUrl":"10.1186/s40795-025-01081-7","url":null,"abstract":"<p><strong>Introduction: </strong>Hemodialysis affects patients' nutritional status in several ways, resulting in malnutrition, which, in turn, increases the rates of morbidity and mortality worldwide. The main aim of this study was to comprehensively examine the effect of sex-based differences on the nutritional status of Palestinian patients on hemodialysis.</p><p><strong>Methodology: </strong>This study involved hemodialysis patients from An-Najah National University Hospital (NNUH) at Nablus/Palestine. A structured questionnaire was used in this study to collect data about sociodemographic data, medical history, lifestyle habits, and functional status, as well as nutritional status, which was assessed using 4 components (anthropometric measurements, biochemical data, clinical data, and dietary data). Patients' reports were reviewed to obtain laboratory values. The malnutrition-inflammation score was used to assess the prevalence of malnutrition. Data were analyzed using univariate and multivariate analysis.</p><p><strong>Results: </strong>A total of 188 hemodialysis patients participated in the study. The mean age was 57.8 ± 14.0 years, ranging from 19 to 86 years old. Females were more likely to experience nausea and headache during hemodialysis than men (p < 0.05). The findings also showed that the MIS score was significantly higher in women than in men. Biochemical findings revealed that female patients had significantly lower levels of blood urea nitrogen (p = 0.003), carbon dioxide (p = 0.020), ferritin levels (p = 0.025), and serum phosphate levels (p = 0.000). In addition, women had significantly lower intakes of total carbohydrate, total fat, saturated fat, monounsaturated fatty acids, water, vitamin B1, vitamin B2, vitamin B3, calcium, phosphate, sodium, and zinc, except for vitamin B12, which was higher in females. Furthermore, functional assessments indicated that males have significantly higher handgrip strength than females, while females represented more severe malnutrition compared to males.</p><p><strong>Conclusion: </strong>Our data indicates that women have more severe malnutrition compared to men, suggesting the need to consider sex-based nutritional and functional differences in hemodialysis patients by healthcare professionals.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"95"},"PeriodicalIF":1.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The accuracy of a novel stunting risk detection application based on nutrition and sanitation indicators in children aged under five years.","authors":"Tria Astika Endah Permatasari, Yudi Chadirin, Ernirita Ernirita, Anisa Nurul Syafitri, Devina Alifia Fadhilah","doi":"10.1186/s40795-025-01074-6","DOIUrl":"10.1186/s40795-025-01074-6","url":null,"abstract":"<p><strong>Background: </strong>Adaptive and innovative technologies to prevent stunting are being developed continuously in various countries. This study aimed to develop and evaluate the accuracy of a stunting risk detection application based on nutrition and sanitation indicators in children aged under five years.</p><p><strong>Methods: </strong>This cross-sectional study was conducted between June and September 2023 and involved 316 mother-child pairs selected by simple random sampling from urban (n = 244) and rural (n = 72) areas in Bogor, West Java Province, Indonesia. An application was developed to detect stunting risk based on 25 indicators: eight indicators of maternal and child characteristics, eight nutrition indicators, and nine indicators of personal hygiene and sanitation. The nutrition and sanitation indicators were determined according to the World Health Organization conceptual framework for stunting. The accuracy of the stunting prediction model was analyzed using the Area Under Curve (AUC) and the Receiver Operating Characteristics (ROC) Curve method.</p><p><strong>Results: </strong>Of the 316 included children, 29.5% were stunting. The developed stunting risk detection application exhibited good sensitivity (88.3%) and specificity (83.3%). It accurately detected children at risk of stunting with an AUC of 89.6%. In urban areas, eight indicators were significantly predictive of stunting: mother's height, child's age, exclusive breastfeeding, frequency of protein consumption, balanced diet, washing hands with soap, availability of complete room functions in the house, and good household waste management. In rural areas, eight indicators were significantly predictive of stunting: mother's height, history of infectious disease, early initiation of breastfeeding, frequency of protein consumption, complementary feeding, washing hands with soap, availability of safe food storage, and availability of clean water sources for drinking. Mother's height was the dominant factor in predicting stunting in urban (adjusted odds ratio [aOR] = 3.321, 95% confidence interval [CI] = 1.202-3.051, p = 0.006) and rural (aOR = 3.927, 95% CI = 1.132-4.281, p = 0.001).</p><p><strong>Conclusion: </strong>The developed application exhibited good accuracy and quickly assessed the risk of stunting in children, enabling it to provide appropriate recommendations to prevent stunting. However, it must be improved by simplifying the number of included indicators and re-testing on a broader scale.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"93"},"PeriodicalIF":1.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of resistant dextrin on glucose regulation markers in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.","authors":"Mohammad Rudiansyah, Dina Akeel Salman, Hardik Doshi, Renuka Jyothi S, Debasish Shit, Swati Sharma, Mehran Nouri","doi":"10.1186/s40795-025-01080-8","DOIUrl":"https://doi.org/10.1186/s40795-025-01080-8","url":null,"abstract":"<p><strong>Objectives: </strong>The increasing prevalence of type 2 diabetes (T2D) necessitates greater efforts to find effective therapeutic agents for this complex condition. This study conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of resistant dextrin (RD) supplementation on markers of glucose regulation in patients with T2D.</p><p><strong>Methods: </strong>The databases PubMed, Web of Science, Scopus, and the Cochrane Library were searched from inception to March 20, 2025 aiming to identify RCTs evaluating the effect of RD supplementation on fasting blood sugar (FBS), fasting insulin levels, and glycosylated hemoglobin (HbA1c) in patients with T2D. The meta-analysis was conducted using a random-effects model to calculate weighted mean differences (WMDs) and corresponding 95% confidence intervals (95% CI). The quality of the included RCTs was assessed using the Cochrane risk of bias tool. The outcome data was pooled using Stata software, version 11.2.</p><p><strong>Results: </strong>Four RCTs (260 participants) were included in the systematic review and meta-analysis. Meta-analyses indicated that RD supplementation was associated with a significant reduction in HbA1c levels (WMD: -0.30%; 95% CI: -0.56 to -0.03; P = 0.02; I²=0.0%). However, the effect of RD on FBS (WMD: -5.45 mg/dl, 95% CI: -12.38 to 1.93; P = 0.14; I²=55.3%) and fasting insulin levels (Hedges' g: -0.26; 95% CI: -0.74 to 0.21; P = 0.28; I²=70.4%) was not statistically significant.</p><p><strong>Conclusion: </strong>This systematic review and meta-analysis demonstrated that RD supplementation may effectively lower HbA1c levels in patients with T2D. However, it is crucial to conduct more clinical studies with adequate sample sizes and rigorous methodologies to develop evidence-based treatment guidelines.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"91"},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring current barriers and enablers of severe acute malnutrition management among children (6-59 months): perspectives from health professionals in northern Ghana.","authors":"Tamimu Yakubu, Charles Apprey, Reginald Adjetey Annan","doi":"10.1186/s40795-025-01075-5","DOIUrl":"https://doi.org/10.1186/s40795-025-01075-5","url":null,"abstract":"<p><strong>Introduction: </strong>Malnutrition is a common global health problem that affects children under five years of age. This study aimed to explore current barriers and facilitators from the perspective of health personnel at Tamale Teaching Hospital and Kings Medical Centre in the clinical management of severe acute malnutrition (SAM) among children (6-59 months).</p><p><strong>Methods: </strong>This study used a qualitative research approach and employed a semi-structured interview guide, interviews (key informants), in-depth interviews, and focus group discussions. A total of 30 staff from both facilities, who were directly involved in SAM management, were purposively sampled. The research explored areas of SAM management, including workload, training, referrals, staff collaboration, therapeutic formula availability and vital infrastructure. Findings The findings revealed a lack of standardised training, emphasising the critical role of capacity development for effective case management. The absence of ready-to-use therapeutic food in both facilities, worsened by global economic crises, has led to reliance on locally formulated alternatives. Late referrals, high workloads and limited staff collaboration were highlighted as notable obstacles, impacting the overall quality of care. The enablers of SAM management included integration between nutrition and healthcare services, the availability of locally prepared therapeutic formulae, albeit limited, supportive infrastructure, and successful collaboration with hospital administration.</p><p><strong>Conclusion: </strong>This study revealed critical obstacles and facilitators in the management of SAM among children (6-59 months). Recommendations are geared towards providing training protocols for health professionals, enhancing supply chain mechanisms to ensure the availability of therapeutic foods, and fostering a culture of collaboration within healthcare teams. Thus, when these challenges are addressed while at the same time leveraging existing enablers, health systems can significantly improve treatment outcomes of SAM cases. The findings will inform policy decisions by governmental bodies, health systems, and non-governmental organisations, guiding resource allocation, effective interventions, and overall improvement in care for malnourished children.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"90"},"PeriodicalIF":1.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of an antioxidant-rich diet on childhood asthma outcomes: A randomized controlled trial.","authors":"Theerapan Songnuy, Putrada Ninla-Aesong, Piyada Thairach, Janjira Thok-Ngaen","doi":"10.1186/s40795-025-01078-2","DOIUrl":"https://doi.org/10.1186/s40795-025-01078-2","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress contributes to the initiation of inflammatory processes in the airway passages of asthmatic patients. An antioxidant-rich diet may alleviate asthmatic outcomes; however, evidence for this is currently scant. Hence, we aimed to assess whether an antioxidant-rich diet with usual asthma care can improve clinical outcomes and pulmonary function.</p><p><strong>Methods: </strong>We enrolled mild to moderate asthmatic children who were being treated at two primary care settings in southern Thailand from October5, 2021 to May11, 2022. Participants were randomly assigned into a control group (n = 33) that received usual asthma care and an experimental group (n = 48) that received tomato juice and mixed fruit juice along with usual care for an 8-week period. Questionnaire, Inhaled Corticosteroids (ICS) dose usage, Asthma Control Test (ACT), Pediatric Asthma Quality of Life Questionnaire (PAQLQ), Pulmonary Function Test (PFT) and serum antioxidant levels (lycopene, beta-carotene and ascorbic acid) were compared for the 1st and 2nd visits.</p><p><strong>Results: </strong>A total of 80 participants completed the study with one control group participant lost in the follow up. Compared with the control group, the experimental group showed significant improvement in ACT scores (1.083 v.-0.786; p-value, 0.005) and PAQLQ total scores (2.208 v. -4.250; p-value, 0.002). In addition, serum beta-carotene increased in an experimental group after the 8-week duration (0.706 v. 0.783; p-value, 0.006) but not significantly changed in mean difference when compared with the control group (p-value, 0.879). However, ICS dose usage, PFT, and serum lycopene or ascorbic acid levels did not show significant differences over the 8-week study. Good compliance and low side effects regarding the fruit juice consumption were observed among participants.</p><p><strong>Conclusions: </strong>The antioxidant-rich diet supplementation with usual care in asthmatic children may improve asthma control, quality of life and serum beta-carotene level. Nevertheless, the intervention did not change ICS dose usage, PFT or other serum antioxidant levels. With favorable palatability and low undesirable effects, tomato juice and mixed fruit juice may be used as an adjuvant therapy to the regular childhood asthma care. The results suggest that for further investigation, a larger sample size and long-term multi-center trial are warranted.</p><p><strong>Trial registration: </strong>The clinical trial described in this paper was retrospectively registered on 29 May 2023 at The Thai Clinical Trials Registry under the registration number (ID: TCTR 20230529001).</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"89"},"PeriodicalIF":1.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between food intake frequency and psychological distress following the Great East Japan Earthquake: the Fukushima Health Management Survey FY 2012.","authors":"Junko Yoshida, Eri Eguchi, Fumikazu Hayashi, Masaharu Maeda, Hirooki Yabe, Seiji Yasumura, Tetsuya Ohira","doi":"10.1186/s40795-025-01059-5","DOIUrl":"https://doi.org/10.1186/s40795-025-01059-5","url":null,"abstract":"<p><strong>Background: </strong>Changes in diet following the Great East Japan Earthquake may affect the mental health of evacuees. However, a large-scale data analysis on this topic is still lacking. Therefore, this study aimed to investigate the relationship between the frequency of food intake per week and psychological distress and traumatic reactions among Fukushima residents two years after the disaster.</p><p><strong>Methods: </strong>Multivariable-adjusted logistic regression analysis was performed to predict the relationship between food intake frequency and psychological distress or traumatic reactions between individuals with and without evacuation experience. The study used data from the fiscal year (FY) 2012 Survey on Mental Health and Lifestyle two years after the Great East Japan Earthquake. A total of 42,160 participants aged 30-89 years were included in this study. Those who lived in the evacuation area after the earthquake and were residing in temporary housing or evacuation centers were categorized as having evacuation experience.</p><p><strong>Results: </strong>Non-evacuees and evacuees who consumed rice more frequently (≥ 5 times/week) had lower rates of psychological distress and traumatic symptoms. Furthermore, both non- evacuees and evacuees who frequently consumed light-colored vegetables and fruits exhibited less psychological distress, whereas those who frequently consumed vegetable juice (for only non-evacuees) and fruit juice (for both non-evacuees and evacuees) exhibited more psychological distress and traumatic symptoms.</p><p><strong>Conclusion: </strong>These findings indicate a potential relationship between dietary choices and mental health among residents in the evacuation area two years after an earthquake. It will be necessary to elucidate this relationship in more detail through longitudinal research in the future.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"88"},"PeriodicalIF":1.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between amino acid intake patterns and both general and central obesity.","authors":"Fahimeh Alijani, Ali Ahmadi, Nakisa Mohammadpour, Shima Jazayeri, Jamileh Abolghasemi, Hossein Shahinfar, Atie Sadat Khorasanian, Shahnaz Rimaz","doi":"10.1186/s40795-025-01073-7","DOIUrl":"https://doi.org/10.1186/s40795-025-01073-7","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a threat to public health. Dietary protein and certain amino acids (AAs) have been associated with obesity; however, the association of AAs patterns with excess body weight has not been considered, yet. We aimed to examine the relationship between patterns of AA intake and obesity.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on 3197 individuals aged 35 to 70 years. Sociodemographic, medical, physical activity, and anthropometric data were collected. Energy and AAs intake were obtained by food frequency questionnaire (FFQ). Factor analysis was utilized to determine the AA patterns. Using multiple logistic regression analysis, the odds ratio (OR) of obesity was calculated among individuals categorized into tertiles of the AAs patterns.</p><p><strong>Results: </strong>In this study, three AA patterns were identified. The aromatic pattern consists of phenylalanine, tryptophan, proline, glutamic acid, cysteine, serine, and leucine. Five essential AAs plus tyrosine, aspartic acid, arginine, and glycine were the components of the mixed pattern, and finally, the alanine pattern with high loadings for alanine and histidine was the third one. After adjusting for confounders, individuals in the highest tertile (T3) of the aromatic pattern had lower odds of central obesity compared to those in the lowest tertile (T1) (OR = 0.72, 95% CI: 0.58-0.89; p = 0.003), whereas this association was not observed in the alanine pattern. On the contrary, general obesity showed a positive association in T3 of the alanine pattern in comparison with T1 (OR = 1.65, 95% CI: 1.02-2.67; p = 0.039). Mixed pattern was not associated with any of the obesity types.</p><p><strong>Conclusions: </strong>The aromatic pattern intake may have an inverse association with central obesity, and following the alanine pattern my contribute to higher odds of general obesity. However, the elaborate relationship between AAs and adiposity warrants further investigation.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"87"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the vitamin D supplementation on clinical outcomes and inflammatory status in COVID-19 patients: an umbrella review.","authors":"Hamed Jafari-Vayghan, Mehran Rahimlou, Amir Almasi-Hashiani, Ehsan Aframehr, Sevda Saleh-Ghadimi","doi":"10.1186/s40795-025-01060-y","DOIUrl":"https://doi.org/10.1186/s40795-025-01060-y","url":null,"abstract":"<p><strong>Introduction: </strong>The role of vitamin D supplementation in modulating clinical outcomes and inflammatory responses in COVID- 19 patients has garnered significant interest. This umbrella review consolidates current evidence to evaluate the association between vitamin D supplementation and COVID- 19-related outcomes.</p><p><strong>Methods: </strong>A comprehensive search was conducted across multiple databases to identify relevant systematic reviews and meta-analyses. Studies assessing the impact of vitamin D supplementation on disease severity, mortality, hospitalization, and inflammatory markers in COVID- 19 patients were included. Methodological quality was assessed using standardized tools.</p><p><strong>Results: </strong>The findings suggest that vitamin D supplementation may be associated with reduced mortality and improved clinical outcomes in COVID- 19 patients. Several studies reported a decrease in inflammatory markers, such as C-reactive protein and interleukin- 6, following supplementation. However, variations in study design, dosage regimens, and baseline vitamin D status limit the generalizability of results.</p><p><strong>Conclusion: </strong>Vitamin D supplementation appears to have a potential role in improving clinical outcomes and modulating inflammatory responses in COVID- 19 patients. Nevertheless, due to heterogeneity among studies, further high-quality randomized controlled trials are warranted to confirm these findings.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"86"},"PeriodicalIF":1.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enigmatic link between familial mediterranean fever and dietary components: a novel approach to personalized nutrition.","authors":"Ninar AlJerf, Abdullah H Maad, Loai Aljerf, Muaaz Alajlani","doi":"10.1186/s40795-025-01071-9","DOIUrl":"https://doi.org/10.1186/s40795-025-01071-9","url":null,"abstract":"<p><strong>Background: </strong>Despite its prevalence, Familial Mediterranean Fever (FMF) remains poorly understood, with limited therapeutic options available to manage its debilitating symptoms. The discovery of a potential link between FMF and dietary components has sparked new hope for personalized nutritional interventions, yet the complex interplay between genetic and environmental factors underlying disease pathogenesis remains unclear.</p><p><strong>Objectives: </strong>This study aimed to investigate the complex relationships between dietary components, nutrient profiles, and FMF symptoms, with a focus on developing personalized nutrition strategies for FMF management.</p><p><strong>Methods: </strong>This cross-sectional study recruited 100 FMF patients and 50 healthy controls, matched for age, sex, and ethnicity. Participants completed a comprehensive food frequency questionnaire, and blood samples were analyzed for biomarkers of inflammation and nutrient profiles. Advanced statistical methods were employed to identify patterns and correlations between dietary components, nutrient profiles, and FMF symptoms.</p><p><strong>Results: </strong>The study revealed significant correlations between FMF symptom severity and specific dietary components, including pro-inflammatory omega-6 fatty acids, advanced glycation end-products, and lectins, as well as anti-inflammatory omega-3 fatty acids, antioxidants, and fiber. Factor analysis identified four distinct dietary patterns, which collectively explained 92.86% of the variance in FMF symptom severity. The adoption of an anti-inflammatory diet was associated with improved symptom management and quality of life.</p><p><strong>Conclusions: </strong>This study provides novel insights into the complex relationships between dietary components, nutrient profiles, and FMF symptoms, highlighting the potential for personalized nutrition strategies to revolutionize FMF management. The identification of specific dietary components associated with FMF symptom severity has significant implications for the development of targeted dietary recommendations that address individual patients' unique requirements. Further research is necessary to fully elucidate the mechanisms underlying these relationships and to develop effective personalized nutrition strategies for FMF management.</p><p><strong>Who clinical trial registry: </strong>TCTR20241022008 (Familial Mediterranean Fever - Dietary Habits and Symptom Management, Date of Registration: 17 November, 2024) ( https://www.thaiclinicaltrials.org/show/TCTR20241022008 ).</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"85"},"PeriodicalIF":1.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}