Current Transplantation Reports最新文献

Use of Anti-interleukin-1 Agents in Kidney Transplant Recipients with Familial Mediterranean Fever and Amyloidosis: What have been learned so far? 抗白细胞介素-1药物在家族性地中海热和淀粉样变肾移植受者中的应用：迄今为止我们了解到什么？

IF 2.4

Current Transplantation Reports Pub Date : 2025-12-01 Epub Date: 2025-01-16 DOI: 10.1007/s40472-025-00461-z

Baris Afsar, Rengin Elsurer Afsar, Yasar Caliskan, Krista L Lentine

{"title":"Use of Anti-interleukin-1 Agents in Kidney Transplant Recipients with Familial Mediterranean Fever and Amyloidosis: What have been learned so far?","authors":"Baris Afsar, Rengin Elsurer Afsar, Yasar Caliskan, Krista L Lentine","doi":"10.1007/s40472-025-00461-z","DOIUrl":"https://doi.org/10.1007/s40472-025-00461-z","url":null,"abstract":"Purpose of review: Familial Mediterranean fever (FMF) is the most common monogenic auto-inflammatory disease causing amyloidosis (AA type) which may result in development of end-stage kidney disease (ESKD). Colchicine is the initial treatment option for patients FMF/amyloidosis both before and after KT. Although, kidney transplantation (KT) can be offered to patients with ESKD due to FMF/amyloidosis, FMF attacks did not resolve in some of kidney transplant recipients (KTRs) and de-novo development of amyloidosis after KT may be observed despite colchicine treatment. For these patients, other treatment options are warranted including anti-interleukin-1 agents such as anakinra and canakinumab. The purpose of the review is to summarize the use of anti-interleukin-1 agents in KTRs with FMF and amyloidosis.Recent findings: Recent studies showed that these agents are effective in KTRs in terminating FMF attacks and decreasing inflammatory parameters. Furthermore, no significant interaction with immunosuppressive drugs were recorded and side effects were few. However, there are various knowledge gaps.","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

State of the Art of Bioengineering Approaches in Beta-Cell Replacement. 生物工程方法在β细胞替代中的应用现状。

IF 2.4

Current Transplantation Reports Pub Date : 2025-01-01 Epub Date: 2025-05-06 DOI: 10.1007/s40472-025-00470-y

Jake Miller, Quentin Perrier, Arunkumar Rengaraj, Joshua Bowlby, Lori Byers, Emma Peveri, Wonwoo Jeong, Thomas Ritchey, Alberto Maria Gambelli, Arianna Rossi, Riccardo Calafiore, Alice Tomei, Giuseppe Orlando, Amish Asthana

{"title":"State of the Art of Bioengineering Approaches in Beta-Cell Replacement.","authors":"Jake Miller, Quentin Perrier, Arunkumar Rengaraj, Joshua Bowlby, Lori Byers, Emma Peveri, Wonwoo Jeong, Thomas Ritchey, Alberto Maria Gambelli, Arianna Rossi, Riccardo Calafiore, Alice Tomei, Giuseppe Orlando, Amish Asthana","doi":"10.1007/s40472-025-00470-y","DOIUrl":"https://doi.org/10.1007/s40472-025-00470-y","url":null,"abstract":"Purpose of the review: Despite recent advancements in technology for the treatment of type 1 diabetes (T1D), exogenous insulin delivery through automated devices remains the gold standard for treatment. This review will explore progress made in pancreatic islet bioengineering within the field of beta-cell replacement for T1D treatment.Recent findings: First, we will focus on the use of decellularized extracellular matrices (dECM) as a platform for pancreatic organoid development. These matrices preserve microarchitecture and essential biochemical signals for cell differentiation, offering a promising alternative to synthetic matrices. Second, advancements in 3D bioprinting for creating complex organ structures like pancreatic islets will be discussed. This technology allows for increased precision and customization of cellular models, crucial for replicating native pancreatic islet functionality. Finally, this review will explore the use of stem cell-derived organoids to generate insulin-producing islet-like cells. While these organoids face challenges such as functional immaturity and poor vascularization, they represent a significant advancement for disease modeling, drug screening, and autologous islet transplantation.Summary: These innovative approaches promise to revolutionize T1D treatment by overcoming the limitations of traditional therapies based on human pancreatic islets.","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"12 1","pages":"17"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Entecavir Prophylaxis in Hepatitis B Immune Patients Receiving Hepatitis B Infected Kidneys: A Single Center Experience 接受乙肝感染肾脏治疗的乙肝免疫患者恩替卡韦预防治疗的效果：单中心经验

IF 2.1

Current Transplantation Reports Pub Date : 2024-01-10 DOI: 10.1007/s40472-023-00425-1

Sameera Muqueet, Nikhil A Reddy, Anna Curtis, M. Madhrira, Sridhar R. Allam, Ashraf I Reyad

引用次数: 0

Have a Heart: Tie It Off — Update on Recommendations Regarding Vascular Access Ligation After Successful Renal Transplant 有心：结扎--关于肾移植成功后血管通路结扎建议的最新进展

IF 2.1

Current Transplantation Reports Pub Date : 2023-12-13 DOI: 10.1007/s40472-023-00421-5

Alyssa Stetson, Brianna Bangert, Saad Ahmad, Lulu Zhang, Alex Chang, Shalini Bumb, Madison Cuffy, Latifa Silski

引用次数: 0

Multi-omics Approach in Kidney Transplant: Lessons Learned from COVID-19 Pandemic. 肾移植中的多组学方法:从COVID-19大流行中吸取的教训

IF 2.4

Current Transplantation Reports Pub Date : 2023-12-01 Epub Date: 2023-08-23 DOI: 10.1007/s40472-023-00410-8

Hiroki Mizuno, Naoka Murakami

{"title":"Multi-omics Approach in Kidney Transplant: Lessons Learned from COVID-19 Pandemic.","authors":"Hiroki Mizuno, Naoka Murakami","doi":"10.1007/s40472-023-00410-8","DOIUrl":"10.1007/s40472-023-00410-8","url":null,"abstract":"Purpose of review: Multi-omics approach has advanced our knowledge on transplantation-associated clinical outcomes, such as acute rejection and infection, and emerging omics data are becoming available in kidney transplant and COVID-19. Herein, we discuss updated findings of multi-omics data on kidney transplant outcomes, as well as COVID-19 and kidney transplant.Recent findings: Transcriptomics, proteomics, and metabolomics revealed various inflammation pathways associated with kidney transplantation-related outcomes and COVID-19. Although multi-omics data on kidney transplant and COVID-19 is limited, activation of innate immune pathways and suppression of adaptive immune pathways were observed in the active phase of COVID-19 in kidney transplant recipients.Summary: Multi-omics analysis has led us to a deeper exploration and a more comprehensive understanding of key biological pathways in complex clinical settings, such as kidney transplantation and COVID-19. Future multi-omics analysis leveraging multi-center biobank collaborative will further advance our knowledge on the precise immunological responses to allograft and emerging pathogens.","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"1 1","pages":"173-187"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10751044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43066056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate Immune Responses in Transplant Immunity 移植免疫中的先天性免疫反应

IF 2.1

Current Transplantation Reports Pub Date : 2023-11-27 DOI: 10.1007/s40472-023-00422-4

Joseph M. Ladowski, Xunrong Luo

引用次数: 0

Outcomes, Attitudes, and Updated Ethical Analysis of Early Liver Transplantation for Severe Alcoholic Hepatitis 严重酒精性肝炎早期肝移植的结果、态度和最新伦理分析

IF 2.1

Current Transplantation Reports Pub Date : 2023-11-24 DOI: 10.1007/s40472-023-00417-1

Janetta Brundage, Olivia S. Kates

引用次数: 0

Clinical Genetic Testing in Kidney Disease and Transplantation: Logistical, Ethical, Legal, and Social Considerations 肾脏疾病和移植中的临床基因检测：后勤、伦理、法律和社会考虑因素

IF 2.1

Current Transplantation Reports Pub Date : 2023-11-23 DOI: 10.1007/s40472-023-00418-0

Tamar Schiff

引用次数: 0

Approaches to Mitigate Longer Cold Ischemic Times and Increased Rates of Delayed Graft Function Associated With the Revised Kidney Allocation System 缓解修订后的肾脏分配系统导致的冷缺血时间延长和移植物功能延迟率增加的方法

IF 2.1

Current Transplantation Reports Pub Date : 2023-11-18 DOI: 10.1007/s40472-023-00419-z

Tyler York, O. Eletta, Joshua Kurian, Mital Shah, Sonika Puri, Advaith Bongu

引用次数: 0

Statistical Confounding in Observational Research and Center Performance Evaluations in Organ Transplantation 器官移植观察研究和中心绩效评估中的统计混杂问题

IF 2.1

Current Transplantation Reports Pub Date : 2023-11-15 DOI: 10.1007/s40472-023-00420-6

Jesse D. Schold, J. Malamon, Bruce Kaplan

引用次数: 0