Current Transplantation Reports最新文献

Multimedia Approach to Living Donation Education for Transplant Professionals: Building a Professional Society Multimedia Work Group. 移植专业人员活体捐赠教育的多媒体途径：建立一个专业学会多媒体工作组。

IF 2.4

Current Transplantation Reports Pub Date : 2025-12-01 Epub Date: 2025-07-12 DOI: 10.1007/s40472-025-00483-7

Mallika Gupta, Gaurav Agarwal, Christina Mejia, Hector Madariaga, Vasanthi Balaraman, Tiffany Caza, Nader Dbouk, Sandeep Ghai, Divyanshu Malhotra, Rohini Parashar, Sarthak Virmani, Aileen Wang, Anju Yadav, Vineeta Kumar, Ann Marie Liapakis, Angie Nishio Lucar, Krista L Lentine

{"title":"Multimedia Approach to Living Donation Education for Transplant Professionals: Building a Professional Society Multimedia Work Group.","authors":"Mallika Gupta, Gaurav Agarwal, Christina Mejia, Hector Madariaga, Vasanthi Balaraman, Tiffany Caza, Nader Dbouk, Sandeep Ghai, Divyanshu Malhotra, Rohini Parashar, Sarthak Virmani, Aileen Wang, Anju Yadav, Vineeta Kumar, Ann Marie Liapakis, Angie Nishio Lucar, Krista L Lentine","doi":"10.1007/s40472-025-00483-7","DOIUrl":"10.1007/s40472-025-00483-7","url":null,"abstract":"Purpose of review: Currently, there are number of initiatives underway across the world to remove barriers and increase education about living donation and living donor transplantation, including among professionals. Widespread use of the internet and social media (SoMe) started a new era of online information sharing. Extensive studies have highlighted the significant role of visual abstracts (VAs) and infographics in disseminating medical information including related to donation and transplantation. SoMe can foster networking and collaboration between transplant professionals across the globe.Recent findings: The American Society of Transplantation Living Donor Community of Practice (LDCOP) Multimedia Workgroup (MMWG) was established to support the LDCOP's professional education mission by providing audiovisual support for various initiatives using visual abstracts, infographics, and professional community engagement. The MMWG employs rigorous multi-layered vetting by professionals with academic expertise to ensure the reliability and accuracy of the content, pioneering a model for creating visual educational content, collaborative learning and skill-building across experience levels.Summary: In this perspective review, we summarize the history of a professional society multimedia work group and our experience building a multimedia approach to living donation education for transplant professionals.","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Anti-interleukin-1 Agents in Kidney Transplant Recipients with Familial Mediterranean Fever and Amyloidosis: What have been learned so far? 抗白细胞介素-1药物在家族性地中海热和淀粉样变肾移植受者中的应用：迄今为止我们了解到什么？

IF 2.4

Current Transplantation Reports Pub Date : 2025-12-01 Epub Date: 2025-01-16 DOI: 10.1007/s40472-025-00461-z

Baris Afsar, Rengin Elsurer Afsar, Yasar Caliskan, Krista L Lentine

{"title":"Use of Anti-interleukin-1 Agents in Kidney Transplant Recipients with Familial Mediterranean Fever and Amyloidosis: What have been learned so far?","authors":"Baris Afsar, Rengin Elsurer Afsar, Yasar Caliskan, Krista L Lentine","doi":"10.1007/s40472-025-00461-z","DOIUrl":"https://doi.org/10.1007/s40472-025-00461-z","url":null,"abstract":"Purpose of review: Familial Mediterranean fever (FMF) is the most common monogenic auto-inflammatory disease causing amyloidosis (AA type) which may result in development of end-stage kidney disease (ESKD). Colchicine is the initial treatment option for patients FMF/amyloidosis both before and after KT. Although, kidney transplantation (KT) can be offered to patients with ESKD due to FMF/amyloidosis, FMF attacks did not resolve in some of kidney transplant recipients (KTRs) and de-novo development of amyloidosis after KT may be observed despite colchicine treatment. For these patients, other treatment options are warranted including anti-interleukin-1 agents such as anakinra and canakinumab. The purpose of the review is to summarize the use of anti-interleukin-1 agents in KTRs with FMF and amyloidosis.Recent findings: Recent studies showed that these agents are effective in KTRs in terminating FMF attacks and decreasing inflammatory parameters. Furthermore, no significant interaction with immunosuppressive drugs were recorded and side effects were few. However, there are various knowledge gaps.","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

State of the Art of Bioengineering Approaches in Beta-Cell Replacement. 生物工程方法在β细胞替代中的应用现状。

IF 2.4

Current Transplantation Reports Pub Date : 2025-01-01 Epub Date: 2025-05-06 DOI: 10.1007/s40472-025-00470-y

Jake Miller, Quentin Perrier, Arunkumar Rengaraj, Joshua Bowlby, Lori Byers, Emma Peveri, Wonwoo Jeong, Thomas Ritchey, Alberto Maria Gambelli, Arianna Rossi, Riccardo Calafiore, Alice Tomei, Giuseppe Orlando, Amish Asthana

{"title":"State of the Art of Bioengineering Approaches in Beta-Cell Replacement.","authors":"Jake Miller, Quentin Perrier, Arunkumar Rengaraj, Joshua Bowlby, Lori Byers, Emma Peveri, Wonwoo Jeong, Thomas Ritchey, Alberto Maria Gambelli, Arianna Rossi, Riccardo Calafiore, Alice Tomei, Giuseppe Orlando, Amish Asthana","doi":"10.1007/s40472-025-00470-y","DOIUrl":"https://doi.org/10.1007/s40472-025-00470-y","url":null,"abstract":"Purpose of the review: Despite recent advancements in technology for the treatment of type 1 diabetes (T1D), exogenous insulin delivery through automated devices remains the gold standard for treatment. This review will explore progress made in pancreatic islet bioengineering within the field of beta-cell replacement for T1D treatment.Recent findings: First, we will focus on the use of decellularized extracellular matrices (dECM) as a platform for pancreatic organoid development. These matrices preserve microarchitecture and essential biochemical signals for cell differentiation, offering a promising alternative to synthetic matrices. Second, advancements in 3D bioprinting for creating complex organ structures like pancreatic islets will be discussed. This technology allows for increased precision and customization of cellular models, crucial for replicating native pancreatic islet functionality. Finally, this review will explore the use of stem cell-derived organoids to generate insulin-producing islet-like cells. While these organoids face challenges such as functional immaturity and poor vascularization, they represent a significant advancement for disease modeling, drug screening, and autologous islet transplantation.Summary: These innovative approaches promise to revolutionize T1D treatment by overcoming the limitations of traditional therapies based on human pancreatic islets.","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"12 1","pages":"17"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complement-Mediated Kidney Disease and Living Donor Transplantation: Tailoring Approaches to Improve Outcomes. 补体介导的肾脏疾病和活体供体移植：改善预后的定制方法。

IF 2.4

Current Transplantation Reports Pub Date : 2025-01-01 Epub Date: 2025-04-16 DOI: 10.1007/s40472-025-00466-8

Aliza Anwar Memon, Krista L Lentine, Yasar Caliskan

{"title":"Complement-Mediated Kidney Disease and Living Donor Transplantation: Tailoring Approaches to Improve Outcomes.","authors":"Aliza Anwar Memon, Krista L Lentine, Yasar Caliskan","doi":"10.1007/s40472-025-00466-8","DOIUrl":"10.1007/s40472-025-00466-8","url":null,"abstract":"Purpose of review: To provide a comprehensive update on the evaluation of kidney transplant recipients with complement-mediated kidney diseases and their living donor (LD) candidates.Recent findings: Atypical hemolytic syndrome (aHUS) and C3 glomerulopathy (C3G) are rare complement-mediated diseases characterized by excessive activation of the alternative complement pathway. The evaluation of living kidney donor candidates for complement-mediated kidney diseases is evolving in response to emerging evidence and advancements in risk assessment tools. Criteria once considered contraindications to living donation are now part of standard practice, while novel genetic markers and risk factors are being identified. For complement-mediated kidney diseases, genetic testing is particularly relevant as it can identify variants that influence disease recurrence risk and donor suitability. Despite these advances, data to guide the evaluation of LD candidates for aHUS and C3G are still very limited. The application and interpretation of novel genetic testing technologies remain in the early stages, and standardized guidance is lacking. In this review, we summarize the approach to LD kidney transplantation for complement-mediated kidney diseases, addressing utility of genetic testing, risks, and ongoing challenges for recipients and LDs.Summary: The present review highlights the importance and complexity of kidney transplantation from an LD for patients with complement-related kidney disorders and motivates further research to determine the optimal risk-assessment for LD candidates to recipients with aHUS and C3G.","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Entecavir Prophylaxis in Hepatitis B Immune Patients Receiving Hepatitis B Infected Kidneys: A Single Center Experience 接受乙肝感染肾脏治疗的乙肝免疫患者恩替卡韦预防治疗的效果：单中心经验

IF 2.1

Current Transplantation Reports Pub Date : 2024-01-10 DOI: 10.1007/s40472-023-00425-1

Sameera Muqueet, Nikhil A Reddy, Anna Curtis, M. Madhrira, Sridhar R. Allam, Ashraf I Reyad

引用次数: 0

Have a Heart: Tie It Off — Update on Recommendations Regarding Vascular Access Ligation After Successful Renal Transplant 有心：结扎--关于肾移植成功后血管通路结扎建议的最新进展

IF 2.1

Current Transplantation Reports Pub Date : 2023-12-13 DOI: 10.1007/s40472-023-00421-5

Alyssa Stetson, Brianna Bangert, Saad Ahmad, Lulu Zhang, Alex Chang, Shalini Bumb, Madison Cuffy, Latifa Silski

引用次数: 0

Multi-omics Approach in Kidney Transplant: Lessons Learned from COVID-19 Pandemic. 肾移植中的多组学方法:从COVID-19大流行中吸取的教训

IF 2.4

Current Transplantation Reports Pub Date : 2023-12-01 Epub Date: 2023-08-23 DOI: 10.1007/s40472-023-00410-8

Hiroki Mizuno, Naoka Murakami

{"title":"Multi-omics Approach in Kidney Transplant: Lessons Learned from COVID-19 Pandemic.","authors":"Hiroki Mizuno, Naoka Murakami","doi":"10.1007/s40472-023-00410-8","DOIUrl":"10.1007/s40472-023-00410-8","url":null,"abstract":"Purpose of review: Multi-omics approach has advanced our knowledge on transplantation-associated clinical outcomes, such as acute rejection and infection, and emerging omics data are becoming available in kidney transplant and COVID-19. Herein, we discuss updated findings of multi-omics data on kidney transplant outcomes, as well as COVID-19 and kidney transplant.Recent findings: Transcriptomics, proteomics, and metabolomics revealed various inflammation pathways associated with kidney transplantation-related outcomes and COVID-19. Although multi-omics data on kidney transplant and COVID-19 is limited, activation of innate immune pathways and suppression of adaptive immune pathways were observed in the active phase of COVID-19 in kidney transplant recipients.Summary: Multi-omics analysis has led us to a deeper exploration and a more comprehensive understanding of key biological pathways in complex clinical settings, such as kidney transplantation and COVID-19. Future multi-omics analysis leveraging multi-center biobank collaborative will further advance our knowledge on the precise immunological responses to allograft and emerging pathogens.","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"1 1","pages":"173-187"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10751044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43066056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate Immune Responses in Transplant Immunity 移植免疫中的先天性免疫反应

IF 2.1

Current Transplantation Reports Pub Date : 2023-11-27 DOI: 10.1007/s40472-023-00422-4

Joseph M. Ladowski, Xunrong Luo

引用次数: 0

Outcomes, Attitudes, and Updated Ethical Analysis of Early Liver Transplantation for Severe Alcoholic Hepatitis 严重酒精性肝炎早期肝移植的结果、态度和最新伦理分析

IF 2.1

Current Transplantation Reports Pub Date : 2023-11-24 DOI: 10.1007/s40472-023-00417-1

Janetta Brundage, Olivia S. Kates

引用次数: 0

Clinical Genetic Testing in Kidney Disease and Transplantation: Logistical, Ethical, Legal, and Social Considerations 肾脏疾病和移植中的临床基因检测：后勤、伦理、法律和社会考虑因素