Current Transplantation Reports最新文献_第2页

Exosomes as Modulators and Biomarkers of Transplant Immunity 外泌体作为移植免疫的调节剂和生物标志物

Current Transplantation Reports Pub Date : 2023-10-04 DOI: 10.1007/s40472-023-00413-5

Liv Palma, Micaela Gentile, Nicholas Chun

引用次数: 0

COVID-19 in Kidney Transplant Recipients: What Did We Understand After Three Years Since the Pandemic Outbreak in Kidney Transplant Recipients? 肾移植受者的COVID-19:在肾移植受者大流行爆发三年后，我们了解了什么?

Current Transplantation Reports Pub Date : 2023-10-04 DOI: 10.1007/s40472-023-00414-4

Angelica Canossi, Alessandra Panarese, Valentina Savino, Tiziana Del Beato, Francesco Pisani

{"title":"COVID-19 in Kidney Transplant Recipients: What Did We Understand After Three Years Since the Pandemic Outbreak in Kidney Transplant Recipients?","authors":"Angelica Canossi, Alessandra Panarese, Valentina Savino, Tiziana Del Beato, Francesco Pisani","doi":"10.1007/s40472-023-00414-4","DOIUrl":"https://doi.org/10.1007/s40472-023-00414-4","url":null,"abstract":"Abstract Purpose of review In this study we describe the impact of COVID-19 infection on the immunological response of kidney transplant recipients of a single transplant center. We evaluated the seroconversion after vaccination and COVID-19 disease, the management of immunosuppressive therapy, and the effects of the withdrawal of immunosuppressive therapy on renal function and clinical outcome. Recent findings A prospective and cross-sectional observational study was performed on 156 kidney transplant recipients with a positive PCR test for SARS-CoV-2 and vaccinated with mRNA vaccine from November 2021 to September 2022. After examining the anti-Spike antibody production before and after COVID-19 infection, we detected a significant increase after disease both in kidney transplant recipients with three doses ( p = 0.011, 180.9 vs. 1186 IU/mL) and with four doses of vaccine ( p = 0.002, 19.5 vs. 1557.0 IU/mL). We also observed a correlation between age and critical symptoms of COVID-19 disease ( p = 0.005, R = 0.224); the pre-COVID-19 antibody levels are found to be linearly correlated to resolution time of disease ( p = 0.05, F = 3.986). Regarding the management of immunosuppressive therapy after infection, we noticed that the kidney transplant recipients with mycophenolate mofetil withdrawal had a stable graft function, in terms of serum creatinine and proteinuria, and a significant increase of the immune response, expressed as SARS-CoV-2 seroconversion (1557.0 vs. 32.4 IU/mL, p = 0.001). Summary We learned how to manage kidney transplant recipients affected by Covid-19 with patient-tailored therapy, thus improving the disease outcome without worsening the renal function.","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135591633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regenerative Surgery: Is This an Independent Field of Health Sciences or Only a Semantic Exercise? 再生外科:这是一个独立的健康科学领域还是仅仅是一个语义练习?

Current Transplantation Reports Pub Date : 2023-09-22 DOI: 10.1007/s40472-023-00409-1

Alexandra R. Monetti, John R. Savino, Jake B. Miller, Joshua J. Bowlby, Lori N. Byers, Arunkumar Rengaraj, Wonwoo Jeong, Emma Peveri, Ainsley J. Ruley, Amish Asthana, Giuseppe Orlando

引用次数: 0

Virologic Studies in COVID-Positive Donors covid - 19阳性供体的病毒学研究

Current Transplantation Reports Pub Date : 2023-09-09 DOI: 10.1007/s40472-023-00411-7

Ambreen Azhar, Bekir Tanriover, Ahmet B. Gungor, Miklos Z. Molnar, Gaurav Gupta

引用次数: 0

Pregnancy in Living Kidney Donors: An Evidence-Based Review. 活体肾脏捐献者的妊娠：一项基于证据的综述。

IF 2.4

Current Transplantation Reports Pub Date : 2023-09-01 Epub Date: 2023-08-17 DOI: 10.1007/s40472-023-00402-8

Ayse Serra Artan, Vidyaratna Fleetwood, Nurane Guller, Ozgur Akin Oto, Safak Mirioglu, Halil Yazici, Aydin Turkmen, Yasar Caliskan, Krista L Lentine

{"title":"Pregnancy in Living Kidney Donors: An Evidence-Based Review.","authors":"Ayse Serra Artan, Vidyaratna Fleetwood, Nurane Guller, Ozgur Akin Oto, Safak Mirioglu, Halil Yazici, Aydin Turkmen, Yasar Caliskan, Krista L Lentine","doi":"10.1007/s40472-023-00402-8","DOIUrl":"10.1007/s40472-023-00402-8","url":null,"abstract":"Purpose of review: To review the current studies and guidelines on the risk of adverse pregnancy outcomes in female kidney donors.Recent findings: Living kidney donors include a significant amount of young women of child-bearing age. Safety and possible risks of pregnancy after donation are a concern for female kidney donor candidates. Many current studies indicate a higher risk of preeclampsia in women after kidney donation. Considering the increasing number of living kidney donors, the maternal outcomes of living kidney donation is an active area of research.Summary: Guidelines and consensus statements on the risk of pregnancy in living kidney donors recommend close monitoring of blood pressure, weight gain, and proteinuria during pregnancy. Current studies indicate an increased risk of hypertensive disorders of pregnancy in living kidney donors. Counseling and informing donor candidates about the possible risks is important.","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 3","pages":"110-116"},"PeriodicalIF":2.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41151614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Imaging Technologies for Accurate Assessment of Cardiac Allograft Performance. 用于精确评估心脏移植物性能的新型成像技术

IF 2.4

Current Transplantation Reports Pub Date : 2023-09-01 Epub Date: 2023-07-17 DOI: 10.1007/s40472-023-00400-w

Manuela Lopera Higuita, Rohil Jain, Asishana A Osho, S Alireza Rabi, Timothy L Pruett, Richard N Pierson, Paul A Iaizzo, Shannon N Tessier

{"title":"Novel Imaging Technologies for Accurate Assessment of Cardiac Allograft Performance.","authors":"Manuela Lopera Higuita, Rohil Jain, Asishana A Osho, S Alireza Rabi, Timothy L Pruett, Richard N Pierson, Paul A Iaizzo, Shannon N Tessier","doi":"10.1007/s40472-023-00400-w","DOIUrl":"10.1007/s40472-023-00400-w","url":null,"abstract":"Purpose of the review: The current lack of objective and quantitative assessment techniques to determine cardiac graft relative viability results in risk-averse decision-making, which negatively impact the utilization of cardiac grafts. The purpose of this review is to highlight the current deficiencies in cardiac allograft assessment before focusing on novel cardiac assessment techniques that exploit conventional and emerging imaging modalities, including ultrasound, magnetic resonance, and spectroscopy.Recent findings: Extensive work is ongoing by the scientific community to identify improved objective metrics and tools for cardiac graft assessment, with the goal to safely increasing the number and proportion of hearts accepted for transplantation.Summary: This review briefly discusses the in situ and ex vivo tools currently available for clinical organ assessment, before focusing on the individual capabilities of ultrasound, magnetic resonance, and spectroscopy to provide insightful, non-invasive information regarding cardiac graft functional and metabolic status that may be used to predict outcome after transplantation.","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"100-109"},"PeriodicalIF":2.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11251714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45179182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Functional Adaptability of Hyporesponsive T Cells and its Impact on Transplant Outcomes. 低反应性T细胞的功能适应性及其对移植结果的影响

IF 1.6

Current Transplantation Reports Pub Date : 2023-09-01 Epub Date: 2023-05-31 DOI: 10.1007/s40472-023-00398-1

Dawei Zou, Xiaolong Zhang, Wenhao Chen

{"title":"The Functional Adaptability of Hyporesponsive T Cells and its Impact on Transplant Outcomes.","authors":"Dawei Zou, Xiaolong Zhang, Wenhao Chen","doi":"10.1007/s40472-023-00398-1","DOIUrl":"10.1007/s40472-023-00398-1","url":null,"abstract":"Purpose of review: The functional adaptability of hyporesponsive T cells in precluding transplant acceptance is not well recognized. This review aims to highlight the impact of this mechanism on transplant outcomes and explore potential strategies to overcome this challenge.Recent findings: Hyporesponsive T cells exist in two major distinct states: anergy and exhaustion. In response to infection, alloreactive anergic T cells can differentiate into IFN-γ producing effector cells, leading to the abrogation of transplant acceptance. Depleting anergic T cells has been shown to promote transplant acceptance under infection. In addition, \"precursor exhausted\" T (TPEX) cells can differentiate into effector cells during checkpoint inhibitor immunotherapy. This helps explain why using checkpoint inhibitors in transplant recipients heightens the risk of graft rejection.Summary: This review focuses on the functional adaptability of hyporesponsive T cells and highlights the importance of further investigations into strategies to disarm these cells. Such research could have significant clinical implications for transplant patients.","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"147-152"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49248289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active and Passive Immunization Approaches in Transplant Recipients 移植受者的主动和被动免疫方法

IF 2.1

Current Transplantation Reports Pub Date : 2023-08-22 DOI: 10.1007/s40472-023-00406-4

M. Ringer, M. Azar, M. Malinis

引用次数: 0

Heart-Kidney Allocation Policy and Proposals Impact Equity of Access for Patients with End-Stage Kidney Disease 心肾分配政策和建议影响终末期肾病患者获得公平

IF 2.1

Current Transplantation Reports Pub Date : 2023-08-03 DOI: 10.1007/s40472-023-00404-6

Brian I. Shaw, Moronke Ogundolie, Keenan Caddell, L. McElroy

引用次数: 0

Adverse Cardiovascular Events in Post-Renal Transplant Patients, a Retrospective Study of Five Hundred Cases Over Twenty-Two Years 肾移植术后患者心血管不良事件的回顾性研究（附500例病例）