Cell Stress最新文献_第9页

Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment. 天然产物和复杂组分激活免疫系统:癌症治疗中的网络药理学方法。

IF 6.4

Cell Stress Pub Date : 2020-05-18 DOI: 10.15698/cst2020.07.224

Alejandra Gomez-Cadena, Alfonso Barreto, Susana Fioretino, Camilla Jandus

引用次数: 10

Mitochondria, mitophagy, and metabolic disease: towards assembling the puzzle. 线粒体、线粒体自噬和代谢性疾病:走向拼图。

IF 6.4

Cell Stress Pub Date : 2020-05-14 DOI: 10.15698/cst2020.06.222

Zhiyong Chen, Marine Berquez, Alessandro Luciani

{"title":"Mitochondria, mitophagy, and metabolic disease: towards assembling the puzzle.","authors":"Zhiyong Chen, Marine Berquez, Alessandro Luciani","doi":"10.15698/cst2020.06.222","DOIUrl":"https://doi.org/10.15698/cst2020.06.222","url":null,"abstract":"Dysregulation of the mitochondrial network in terminally differentiated cells contributes to a broad spectrum of disorders. Methylmalonic acidemia (MMA) is an autosomal recessive inborn error of intermediary metabolism caused by the deficiency of methylmalonyl-CoA mutase (MMUT) - a mitochondrial enzyme that mediates the degradation of certain amino acids and lipids. The loss of MMUT activity triggers an accumulation of toxic endogenous metabolites causing severe organ dysfunctions and life-threatening complications. How MMUT deficiency instigates mitochondrial distress and tissue damage remains poorly understood. Using cell and animal-based models, we recently discovered that MMUT deficiency disables the PINK1-induced translocation of PRKN/Parkin to MMA-damaged mitochondria, impeding their delivery and subsequent dismantling by macroautophagy/autophagy-lysosome degradation systems (Luciani et al. Nat Commun. 11(1):970). This promotes an accumulation of damaged and/or dysfunctional mitochondria that spark epithelial distress and tissue damage. Using a systems biology approach based on drug-disease network perturbation modeling, we predicted targetable pathways, whose modulation repairs mitochondrial dysfunctions in patient-derived kidney cells and ameliorates disease-relevant phenotypes in mmut-deficient zebrafish. These results unveil a link between primary MMUT deficiency, defective mitophagy, and cell distress, offering promising therapeutic avenues for MMA and other mitochondria-related diseases.","PeriodicalId":36371,"journal":{"name":"Cell Stress","volume":"4 6","pages":"147-150"},"PeriodicalIF":6.4,"publicationDate":"2020-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38055233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

HIF1α or mitophagy: which drives cardiomyocyte differentiation? HIF1α和有丝分裂：哪个驱动心肌细胞分化？

IF 6.4

Cell Stress Pub Date : 2020-05-11 DOI: 10.15698/cst2020.05.219

Beatriz Villarejo-Zori, Juan Ignacio Jiménez-Loygorri, Patricia Boya

引用次数: 0

Mitochondria in cancer. 癌症中的线粒体。

IF 6.4

Cell Stress Pub Date : 2020-05-11 DOI: 10.15698/cst2020.06.221

Debora Grasso, Luca X Zampieri, Tânia Capelôa, Justine A Van de Velde, Pierre Sonveaux

引用次数: 94

Copper - a novel stimulator of autophagy. 铜——一种新的自噬刺激剂。

IF 6.4

Cell Stress Pub Date : 2020-04-24 DOI: 10.15698/cst2020.05.218

Hans Zischka, Guido Kroemer

引用次数: 17

Towards understanding the role of Receptor Expression Enhancing Protein 5 (REEP5) in cardiac muscle and beyond. 了解受体表达增强蛋白5 (REEP5)在心肌及其他部位的作用。

IF 6.4

Cell Stress Pub Date : 2020-04-15 DOI: 10.15698/cst2020.06.223

Shin-Haw Lee, Sina Hadipour-Lakmehsari, Anthony O Gramolini

{"title":"Towards understanding the role of Receptor Expression Enhancing Protein 5 (REEP5) in cardiac muscle and beyond.","authors":"Shin-Haw Lee, Sina Hadipour-Lakmehsari, Anthony O Gramolini","doi":"10.15698/cst2020.06.223","DOIUrl":"https://doi.org/10.15698/cst2020.06.223","url":null,"abstract":"The sarco-endoplasmic reticulum (SR/ER) is the largest membrane-bound organelle in eukaryotic cells and plays important roles in essential cellular processes, and in development and progression of many cardiac diseases. However, many aspects of its structural organization remain largely unknown, particularly in cells with a highly differentiated SR/ER network. In a recently published study led by Lee et al. (Nat Commun 11(1):965), we reported a cardiac enriched SR/ER membrane protein REEP5 that is centrally involved in regulating SR/ER organization and cellular stress responses in cardiac myocytes. In vitro REEP5 depletion in mouse cardiac myocytes resulted in SR/ER membrane destabilization and luminal vacuolization along with decreased myocyte contractility and disrupted Ca2+ cycling. Further, in vivo CRISPR/Cas9-mediated REEP5 loss-of-function zebrafish mutants showed sensitized cardiac dysfunction to heart failure induction upon short-term verapamil treatment. Additionally, in vivo adeno-associated viral (AAV9)-induced REEP5 depletion in the mouse demonstrated cardiac dysfunction with dilated cardiac chambers, increased cardiac fibrosis, and reduced ejection fraction. These results demonstrate the critical role of REEP5 in SR/ER organization and function.","PeriodicalId":36371,"journal":{"name":"Cell Stress","volume":"4 6","pages":"151-153"},"PeriodicalIF":6.4,"publicationDate":"2020-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38055234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Role of RNA Binding Proteins with prion-like domains in muscle and neuromuscular diseases. 带有朊病毒样结构域的RNA结合蛋白在肌肉和神经肌肉疾病中的作用。

IF 6.4

Cell Stress Pub Date : 2020-03-10 DOI: 10.15698/cst2020.04.217

Gina Picchiarelli, Luc Dupuis

引用次数: 33

HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation. 依赖于 HIF1α 的有丝分裂促进了心肌母细胞的分化。

IF 4.1

Cell Stress Pub Date : 2020-03-04 DOI: 10.15698/cst2020.05.220

Jin-Feng Zhao, Catherine E Rodger, George F G Allen, Simone Weidlich, Ian G Ganley

{"title":"HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation.","authors":"Jin-Feng Zhao, Catherine E Rodger, George F G Allen, Simone Weidlich, Ian G Ganley","doi":"10.15698/cst2020.05.220","DOIUrl":"10.15698/cst2020.05.220","url":null,"abstract":"Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process. Mitophagy is also involved in cell differentiation and maturation, potentially through modulating mitochondrial metabolic reprogramming. Here we examined mitophagy that is induced upon iron chelation and found that the transcriptional activity of HIF1α, in part through upregulation of BNIP3 and NIX, is an essential mediator of this pathway in SH-SY5Y cells. In contrast, HIF1α is dispensable for mitophagy occurring upon mitochondrial depolarisation. To examine the role of this pathway in a metabolic reprogramming and differentiation context, we utilised the H9c2 cell line model of cardiomyocyte maturation. During differentiation of these cardiomyoblasts, mitophagy increased and required HIF1α-dependent upregulation of NIX. Though HIF1α was essential for expression of key cardiomyocyte markers, mitophagy was not directly required. However, enhancing mitophagy through NIX overexpression, accelerated marker gene expression. Taken together, our findings provide a molecular link between mitophagy signalling and cardiomyocyte differentiation and suggest that although mitophagy may not be essential per se, it plays a critical role in maintaining mitochondrial integrity during this energy demanding process.","PeriodicalId":36371,"journal":{"name":"Cell Stress","volume":"4 5","pages":"99-113"},"PeriodicalIF":4.1,"publicationDate":"2020-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37947076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses. 冠状病毒感染:流行病学、临床和免疫学特征及假设。

IF 6.4

Cell Stress Pub Date : 2020-03-02 DOI: 10.15698/cst2020.04.216

Didier Raoult, Alimuddin Zumla, Franco Locatelli, Giuseppe Ippolito, Guido Kroemer

{"title":"Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses.","authors":"Didier Raoult, Alimuddin Zumla, Franco Locatelli, Giuseppe Ippolito, Guido Kroemer","doi":"10.15698/cst2020.04.216","DOIUrl":"https://doi.org/10.15698/cst2020.04.216","url":null,"abstract":"Coronaviruses (CoVs) are a large family of enveloped, positive-strand RNA viruses. Four human CoVs (HCoVs), the non-severe acute respiratory syndrome (SARS)-like HCoVs (namely HCoV 229E, NL63, OC43, and HKU1), are globally endemic and account for a substantial fraction of upper respiratory tract infections. Non-SARS-like CoV can occasionally produce severe diseases in frail subjects but do not cause any major (fatal) epidemics. In contrast, SARS like CoVs (namely SARS-CoV and Middle-East respiratory syndrome coronavirus, MERS-CoV) can cause intense short-lived fatal outbreaks. The current epidemic caused by the highly contagious SARS-CoV-2 and its rapid spread globally is of major concern. There is scanty knowledge on the actual pandemic potential of this new SARS-like virus. It might be speculated that SARS-CoV-2 epidemic is grossly underdiagnosed and that the infection is silently spreading across the globe with two consequences: (i) clusters of severe infections among frail subjects could haphazardly occur linked to unrecognized index cases; (ii) the current epidemic could naturally fall into a low-level endemic phase when a significant number of subjects will have developed immunity. Understanding the role of paucisymptomatic subjects and stratifying patients according to the risk of developing severe clinical presentations is pivotal for implementing reasonable measures to contain the infection and to reduce its mortality. Whilst the future evolution of this epidemic remains unpredictable, classic public health strategies must follow rational patterns. The emergence of yet another global epidemic underscores the permanent challenges that infectious diseases pose and underscores the need for global cooperation and preparedness, even during inter-epidemic periods.","PeriodicalId":36371,"journal":{"name":"Cell Stress","volume":"4 4","pages":"66-75"},"PeriodicalIF":6.4,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.15698/cst2020.04.216","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37836183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 298

Biomechanical stress regulates mammalian tooth replacement. 生物力学应力调节哺乳动物牙齿置换。

IF 6.4

Cell Stress Pub Date : 2020-02-18 DOI: 10.15698/cst2020.03.215

Xiaoshan Wu, Songlin Wang

引用次数: 0