Biomechanical stress regulates mammalian tooth replacement.

IF 4.1 Q2 CELL BIOLOGY

Cell Stress Pub Date : 2020-02-18 DOI:10.15698/cst2020.03.215

Xiaoshan Wu, Songlin Wang

引用次数: 0

Abstract

Cyclical renewal of integumentary organs, including hair, feathers, and teeth occurs throughout an organism's lifetime. Transition from the resting to the initiation stage is critical for each cycle, but the mechanism remains largely unknown. Humans have two sets of dentitions-deciduous and permanent-and tooth replacement occurs only once. Prior to eruption of the permanent tooth (PT), the successional dental lamina (SDL) of the PT can be detected as early as the embryonic stage, even though it then takes about 6-12 years for the SDL to develop to late bell stage. Little is known about the mechanism by which resting SDL transitions into the initiation stage inside the mandible. As a large mammal, the miniature pig, which is also a diphyodont, was a suitable model for our recent study (EMBO J (2020)39: e102374). Using this model, we found that the SDL of PT did not begin the transition into the bud stage until the deciduous tooth (DT) began to erupt.

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生物力学应力调节哺乳动物牙齿置换。

包括毛发、羽毛和牙齿在内的被皮器官的周期性更新贯穿于生物体的一生。从静止阶段到起始阶段的过渡对每个周期都是至关重要的，但其机制在很大程度上仍然未知。人类有两套牙齿——乳牙和恒牙——牙齿替换只发生一次。恒牙的连续牙板(SDL)在恒牙出牙之前，早在胚胎阶段就可以被发现，尽管SDL需要6-12年的时间才能发育到钟形晚期。关于静息SDL在下颌骨内转变为起始阶段的机制知之甚少。作为一种大型哺乳动物，微型猪也是一种双齿兽，是我们最近研究的合适模型(EMBO J (2020)39: e102374)。使用该模型，我们发现PT的SDL直到乳牙(DT)开始出牙时才开始向芽期过渡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.