天然产物和复杂组分激活免疫系统:癌症治疗中的网络药理学方法。

IF 4.1 Q2 CELL BIOLOGY

Cell Stress Pub Date : 2020-05-18 DOI:10.15698/cst2020.07.224

Alejandra Gomez-Cadena, Alfonso Barreto, Susana Fioretino, Camilla Jandus

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引用次数: 10

摘要

天然产物和传统草药是替代生物活性化合物的重要来源，但很少有植物基制剂被科学地评估和验证其作为医学治疗的潜力。然而，在目前基于植物源性化合物的治疗中，一个有前景的领域是研究它们的免疫调节特性和激活免疫系统以对抗多因素疾病(如癌症)的能力。在这篇综述中，我们讨论了网络药理学如何帮助表征和验证天然单分子或更复杂的制剂作为基于其多靶点能力的有前途的癌症治疗方法。

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Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment.

Natural products and traditional herbal medicine are an important source of alternative bioactive compounds but very few plant-based preparations have been scientifically evaluated and validated for their potential as medical treatments. However, a promising field in the current therapies based on plant-derived compounds is the study of their immunomodulation properties and their capacity to activate the immune system to fight against multifactorial diseases like cancer. In this review we discuss how network pharmacology could help to characterize and validate natural single molecules or more complex preparations as promising cancer therapies based on their multitarget capacities.

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.