Copper - a novel stimulator of autophagy.

IF 4.1 Q2 CELL BIOLOGY

Cell Stress Pub Date : 2020-04-24 DOI:10.15698/cst2020.05.218

Hans Zischka, Guido Kroemer

引用次数: 17

Abstract

Toxic copper accumulation causes Wilson disease, but trace amounts of copper are required for cellular and organismal survival. In a recent paper Tsang et al. (Nat Cell Biol, doi: 10.1038/s41556-020-0481-4) demonstrate that copper binds with high affinity to a designated interaction site in the pro-autophagic kinases ULK1 and ULK2. Chelation of copper or genetic deletion of this copper-binding site inhibits autophagy and hence reduces the fitness of KRAS-induced cancers. These findings suggest that copper chelation might constitute a novel therapeutic intervention on autophagy-dependent malignancies.

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铜——一种新的自噬刺激剂。

有毒的铜积累导致威尔逊病，但微量的铜是细胞和生物体生存所必需的。在最近的一篇论文中，Tsang等人(Nat Cell Biol, doi: 10.1038/s41556-020-0481-4)证明，铜与前自噬激酶ULK1和ULK2的指定相互作用位点具有高亲和力。铜的螯合或铜结合位点的基因缺失会抑制自噬，从而降低kras诱导的癌症的适应度。这些发现表明，铜螯合可能构成一种新的治疗干预自噬依赖性恶性肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.