Human Nutrition and Metabolism最新文献

{"title":"Visceral fat: A key mediator of NAFLD development and progression","authors":"Savita Bansal ,&nbsp;Meenakshi Vachher ,&nbsp;Taruna Arora ,&nbsp;Bhupender Kumar ,&nbsp;Archana Burman","doi":"10.1016/j.hnm.2023.200210","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200210","url":null,"abstract":"<div><p>Non-alcoholic fatty liver disease (NAFLD) has become a major public health concern affecting a quarter of the world's population. It encompasses a wide spectrum of liver pathologies from simple steatosis to steatohepatitis and fibrosis triggered by multiple risk factors. Besides overnutrition and obesity, recently a lot of attention has been focused on the role of visceral fat in development and progression of NAFLD and non-alcoholic steatohepatitis (NASH). Clinical and epidemiological studies suggest a direct correlation between liver fat content and abdominal fat which is mostly accounted for by the visceral fat. Free flow of fatty acids, bioactive and inflammatory molecules such as cytokines, and adipokines from visceral fat expose the liver to fat accumulation and inflammation. The constant release of pro-inflammatory factors and high-fat content in the circulation results in systemic inflammation and insulin resistance (IR). The metabolic consequences of IR result in hyperglycemia, dyslipidemia, elevated inflammatory markers and visceral adiposity, and this vicious cycle of visceral fat and IR induction further aggravates the fatty infiltration of hepatocytes. Also, high-fat content in hepatocytes modulates the mTOR signaling pathway further enhancing insulin secretion secondary to insulin resistance, lipid biosynthesis, and adipose expansion. This review expounds the pivotal role played by the visceral fat in inflammation, IR, and altered mTOR pathway leading to initiation and progression of NAFLD.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200210"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body physique rating as a factor to identify at-risk Mexicans for Metabolic Syndrome","authors":"Oscar Herrera-Fomperosa ,&nbsp;Sergio K. Bustamante-Villagomez ,&nbsp;Sarahí Vazquez-Álvarez ,&nbsp;Gabriela Vázquez-Marroquín ,&nbsp;Leonardo M. Porchia ,&nbsp;Enrique Torres-Rasgado ,&nbsp;Ricardo Pérez-Fuentes ,&nbsp;M. Elba Gonzalez-Mejia","doi":"10.1016/j.hnm.2023.200206","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200206","url":null,"abstract":"<div><h3>Background and aims</h3><p>Body physique rating (BPR) is an index in which fat mass and muscle mass are used to indicate nine different body types. To our knowledge, there are no studies testing if there is a correlation between BPR and the risk of developing Metabolic Syndrome (MetS). Our objective was to assess if the BPR classification is an acceptable tool for assessing MetS risk in a population from Central Mexico.</p></div><div><h3>Methods</h3><p>Subjects attending either IMSS UMF-2 or CSU-1 were asked to participate in this cross-sectional study. The participant's BPR was determined using the TANITA bio-analyzer (T-BPR) and an alternative BPR system (A-BPR), which was based on cutoffs for muscle and fat mass. MetS severity was determined with the ESF-I questionnaire. Using logistic regression, the odds ratio (OR) and 95% confidence interval (95%CI) were determined.</p></div><div><h3>Results</h3><p>MetS severity was correlated with body fat percent (rho = 0.603, p &lt; 0.001) and muscle mass (rho = −0.406, p &lt; 0.001). Comparing the T-BPR to the A-BPR classifications, there was no agreement between the two systems (kappa = 0.024, p = 0.372). Using the “standard” group as the referent, for the A-BPR system, there was a mitigating effect in the high-fat group with increasing muscle mass [hidden obese: OR = 17.8, 95%CI: 5.2–61.6; obese: OR = 10.3, 95%CI: 4.2–25.6; solidly built: OR = 8.6, 95%CI: 3.6–20.8, p &lt; 0.001], but for the T-BPR system, there was an additive effect [hidden obese: OR = 0.5, 95%CI: 0.1–2.5, p = 0.393; obese; OR = 6.1, 95%CI: 3.3–11.4, p &lt; 0.001; solidly built: OR = 31.9, 95%CI: 11.2–90.9, p &lt; 0.001].</p></div><div><h3>Conclusion</h3><p>Here, BPR does correlate with MetS risk. Interestingly, with the A-BPR system, increases in muscle mass were associated with a decreased risk for MetS, which is contrary to the T-BPR system.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200206"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The border between obesity and metabolic disease in children and adolescents. Why and how to investigate? A review of the literature","authors":"Marília Dornelles Bastos ,&nbsp;Fabiana Assmann Poll ,&nbsp;Cézane Priscila Reuter ,&nbsp;Beatriz Dornelles Bastos ,&nbsp;Gabriela Menta Endres ,&nbsp;Giovana Maria Fontana Weber ,&nbsp;Luciana Silva dos Santos","doi":"10.1016/j.hnm.2023.200208","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200208","url":null,"abstract":"<div><p>The prevalence of childhood overweight and obesity is increasing around the world, which is generating a search for new diagnostic alternatives. Differentiating between metabolically healthy and metabolically unhealthy individuals can help both in the therapeutic plan and in the prognostic view. In this review, we will address the role of the following markers: total cholesterol, high-density cholesterol; low density lipoprotein; triglycerides; uric acid; fasting blood glucose; glycated haemoglobin; insulin; <em>C</em>-peptide; interleukin-6; tumour necrosis factor-α; <em>C</em>-reactive protein; adipokines (leptin and adiponectin); micro ribonucleic acids, plasminogen activator inhibitor type 1, alanine aminotransferase, aspartate aminotransferase, vitamin D and thyroid-stimulating hormone. The presentation of specific reference values for children and adolescents in an objective and practical way will allow the identification the best moment for intervention in this population group.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200208"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How fad diets may jeopardize your oral well-being: The hidden consequences","authors":"Sneha Kalpe,&nbsp;Anmol Mathur,&nbsp;Priyanka Kharat","doi":"10.1016/j.hnm.2023.200214","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200214","url":null,"abstract":"<div><h3>Background</h3><p>In recent years, there has been growing interest in various food trends, including plant-based diets, the Mediterranean diet, the Flexitarian diet, the Paleo diet, Intermittent fasting, DASH (Dietary Approches to Stop Hypertension) diet and Vegan diet. Plant-based diets, which emphasize whole, plant-based foods while limiting or eliminating animal products, have been associated with a range of health benefits. Consumption of certain food trends can have an impact on oral health. However, there is a dearth of literature about the impact of these dietary trends on oral health. Hence, we reviewed the existing literature of these fad diets understanding its components as well as its impact on the oral health.</p></div><div><h3>Methods</h3><p>A systematic literature search was carried out on Pubmed, Google Scholar, Scopus and Web of Science for articles regarding the various types of in trend dietary patterns as well as the effect of these diets on oral health. A total of 241 articles were found after searching the databases for different types of diet and its oral implications. PubMed retrieved 156 titles, 38 articles were shortlisted from Google Scholar, 38 titles were obtained from Scopus and Web of Science yielded 9 titles. Titles and abstracts of the articles were evaluated and 79 articles were shortlisted for reviewing the full text. Out of these 63 articles were selected for inclusion for the review regarding the dietary patterns, general implications and oral health.</p></div><div><h3>Results</h3><p>It was found that while some of the dietary patterns are beneficial for the oral health of an individual there are others which can have some adverse effects.</p></div><div><h3>Conclusion</h3><p>Overall, eating whole, nutrient-dense foods while avoiding processed and acidic foods can improve oral and overall health.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200214"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in the salt amount of the bread sold in different regions of Turkey: A descriptive study","authors":"Şule Aktaç ,&nbsp;Aybike Cebeci ,&nbsp;Yeşim Öztekin ,&nbsp;Mustafa Yaman ,&nbsp;Mehmet Ağırbaşlı ,&nbsp;Fatma Esra Güneş","doi":"10.1016/j.hnm.2023.200211","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200211","url":null,"abstract":"<div><p>Excess salt intake is associated with the risk of cardiovascular diseases (CVD) and bread contributes to daily salt intake. The aim of this study was to determine the amount of salt in white bread (WB) and whole wheat bread (WWB). Breads were purchased from public selling points and bakeries in seven regions of Turkey. Mohr method was used to determine the salt ratio. Mean salt ratio of breads was 1.28 ± 0.39% (1.31 ± 0.37% WB; 1.25 ± 0.41% WWB) (p˃0.05). The salt ratio of bread sold at public selling points and bakeries was 1.31 ± 0.39%, and 1.22 ± 0.39%, respectively (p = 0.009). The majority of bread in Turkey was found appropriate to implemented legislation regulation and was not different according to the regions. However, it is noteworthy that there was a difference according to the place of sale.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200211"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessment of reference values of metabolic markers: A meta-analysis study","authors":"Saruby Sharma ,&nbsp;Shriya Mehta ,&nbsp;Nilakshi Mondal ,&nbsp;Mokshi Jain ,&nbsp;Divyanshi Verma ,&nbsp;Kajal Kamboj ,&nbsp;Kousheen Brar ,&nbsp;Nandita Narayanasamy","doi":"10.1016/j.hnm.2023.200216","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200216","url":null,"abstract":"<div><p>Assessment of the metabolic status of mixed populations is based on narrowly defined, standardized reference values. We performed a systematic review to collate data from 40 observational and case-controlled studies, in order to determine whether the screened randomized control studies lie within the normal range provided by internationally accepted guidelines. Forest plots show a significant increase in overall effect size compared to the computed reference ranges for several metabolic parameters. We conclude that all metabolic parameters need to be categorized in subgroups like age, gender and ethnicity for the precise assessment of metabolic status in a random, diverse population.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200216"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-response of acute capsiate supplementation on muscle endurance performance during CrossFit® in trained men: A randomized, crossover and double-blind study","authors":"Marcelo da Silva Mesquita Oliveira ,&nbsp;Paulo Renan Macêdo ,&nbsp;Nathanael Leal Santana ,&nbsp;Flávio Antônio de Sousa Nunes ,&nbsp;Jason Michael Cholewa ,&nbsp;Priscila Almeida Queiroz Rossi ,&nbsp;Ahecio Kleber Araújo Brito ,&nbsp;Nelo E. Zanchi ,&nbsp;Fabrício Eduardo Rossi","doi":"10.1016/j.hnm.2023.200215","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200215","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to verify the acute effect of Capsiate (CAP) on muscle endurance resistance training during CrossFit® and to compare the effects of two acute doses of CAP supplementation (12 vs. 24 mg) in trained men during this workout.</p></div><div><h3>Methods</h3><p>Using a randomized, crossover and double-blind design, 17 trained males with at least 1 year of CrossFit® (CF) experience were supplemented with 12 or 24 mg of CAP or placebo 45 min before the workout. The participant performed three random sessions separated by seven days, where they should complete as many repetitions as possible in 20 min, consisting of five pull-ups, 10 push-ups, and 15 air squats. The rate of perceived effort (RPE) was analyzed immediately after exercise and the heart rate at rest, five, 10, 15 and 20 min.</p></div><div><h3>Results</h3><p>There was no significant difference between doses for the number of repetitions (Placebo = 620.5 ± 137.8 vs. 12 mg = 627.7 ± 99.8 vs. 24 mg = 631.3 ± 120.1 repetitions, p = 0.768, <em>η</em>^<em>2</em> = 0.02) and RPE (Placebo = 7.4 ± 1.3 vs. 12 mg = 7.5 ± 0.9 vs. 24 mg = 7.3 ± 1.5, p = 0.772, <em>η</em>^<em>2</em> = 0.02). The heart rate increased across workouts (p &lt; 0.001) but no significant dose time interaction was observed (p = 0.109, <em>η</em>^<em>2</em> = 0.09).</p></div><div><h3>Conclusion</h3><p>In summary, 12 and 24 mg of CAP did not improve muscle endurance performance, RPE and heart rate during CF performance in trained men.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200215"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-hyperlipidaemic effect of thyme infused green coffee on human subjects","authors":"Richa Ghai ,&nbsp;Shubhra Saraswat","doi":"10.1016/j.hnm.2023.200199","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200199","url":null,"abstract":"<div><h3>Background</h3><p>Atherosclerosis and hyperlipidaemia are the primary cause of heart diseases and death in most developed countries. Herbs have the clinical ability to improve cardiovascular health. Green coffee (Coffee Arabica) and thyme (Thymus Vulgaris) have proved to have lowering effects on cholesterol, triglycerides, fasting blood sugar levels and anthropometric measurements.</p></div><div><h3>Objective(s)</h3><p>The present study was conducted to assess the anti hyperlipidaemic effect of thyme infused green coffee on human subjects.</p></div><div><h3>Materials and methods</h3><p>An oral ingestion of thyme infused green coffee in hot water was given in the form of beverage for 90 days. Different biochemical indices were assessed to check the efficiency of thyme infused green coffee on human subjects.</p></div><div><h3>Result</h3><p>Repeated administration of the combination of thyme and green coffee showed statistically significant decrease in weight, waist circumference, fasting blood sugar, total cholesterol, low density lipoproteins and triglycerides.</p></div><div><h3>Conclusion</h3><p>Marked variations in triglycerides, high density lipoproteins, low density lipoproteins and anthropometric measurements of human subjects are indicative of effectiveness of thyme infused green coffee. Continuous intake of this combination may hence prove to be beneficial to the body.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200199"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49868091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMI-for-age z-score and psychological distress associated with disordered eating: A comparative study among Indonesian and Malaysian urban female adolescents","authors":"Sharifah Intan Zainun Sharif Ishak ,&nbsp;Yit Siew Chin ,&nbsp;Chee Wee Tay ,&nbsp;Muhammad Nur Hasan Syah ,&nbsp;Dian Luthfiana Sufyan","doi":"10.1016/j.hnm.2023.200204","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200204","url":null,"abstract":"<div><p>Nutrition transition and globalization have affected the diet and body composition of all life stages including adolescents. This study aims to compare body weight status, psychological distress and disordered eating (DE), and to compare the association between BMI-for-age z-score (BAZ) and psychological distress with DE among Indonesian and Malaysian urban female adolescents. The adolescents’ weight and height were measured and a self-administered questionnaire was completed by each adolescent. A total of 713 girls (Indonesia = 47.8%, Malaysia = 52.2%), aged 12–19 years from Bekasi, Indonesia and Kuala Lumpur, Malaysia, participated in this study. The prevalence of overweight and obesity was not significantly different between Indonesian and Malaysian girls (18.2% vs 21.2%). Malaysian girls have a significantly higher prevalence of DE (23.9% vs 3.2%), depression (51.9% vs 26.1%), and stress (41.7% vs 29.6%) than Indonesian girls. However, the prevalence of anxiety in Indonesian girls was significantly higher compared to Malaysian girls (77.7% vs 66.4%). For Indonesian girls, BAZ and stress were significantly positive associated with DE, dieting, and bulimia and food preoccupation. For Malaysian girls, BAZ, anxiety and stress were significantly positive associated with DE. BAZ and stress were significantly positive associated with dieting. Depression and anxiety were significantly and positively associated with bulimia and food preoccupation. For both Indonesian and Malaysian girls, stress was significantly positive associated with oral control. Therefore, future intervention programme on promoting healthy eating among female adolescents should consider the psychological well-being component.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200204"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49868143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary intake and diversity among children of age 6–59 months in lowland and highland areas in Kilosa District in Morogoro, Tanzania","authors":"J.D. Mrema ,&nbsp;C.N. Nyaruhucha ,&nbsp;A.W. Mwanri","doi":"10.1016/j.hnm.2023.200205","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200205","url":null,"abstract":"<div><p>Adequate nutrition during infancy and early childhood is essential to ensure children's growth, health, and development to their full potential. Geographical area may influence dietary intake and, hence, the population's nutritional status. This study aimed to assess dietary intake among children aged 6–59 months in the lowland and highland areas in the Kilosa District, Morogoro. A cross-sectional study involved 200 randomly selected households from the lowland and 141 in the highland areas. Socio-demographic characteristics, feeding practices, and 24-h dietary recall information were collected using a pre-tested questionnaire. In assessing dietary intake, a single day 24-h dietary recall was used where a mother/care giver was asked to recall foods and beverages fed to the child in the 24 h prior to the interview. Mean daily nutrient intake (calorie, vitamin A, iron, calcium and zinc) were estimated using NutriSurvey version 2007 with food database from Tanzania Food composition table. Furthermore, Dietary Diversity Score was done by grouping the mentioned foods into the seven main food groups which are grains, roots and tubers; legumes and nuts; Vitamin A rich fruits and vegetables; other fruits and vegetable; dairy products; and flesh foods and eggs. For each food group consumed, a score of one was assigned and a zero score for the non-consumed group. Inadequate intakes of vitamin A, calcium, and iron were observed more in younger children of age 6–12 months, where none of them met the RDA in both areas. There was a significant difference only in fat intake in children aged 12–36 months between the lowland and highland areas. Children who reside in the lowland area had a significantly more diversified diet. Nutrition education with promotion of home gardening and keeping small animals is necessary to ensure household food availability which subsequently will facilitate dietary diversification.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200205"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49868145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}