Human Nutrition and Metabolism最新文献

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Reassessment of reference values of metabolic markers: A meta-analysis study 代谢指标参考值的重新评估:一项荟萃分析研究
Human Nutrition and Metabolism Pub Date : 2023-09-01 DOI: 10.1016/j.hnm.2023.200216
Saruby Sharma , Shriya Mehta , Nilakshi Mondal , Mokshi Jain , Divyanshi Verma , Kajal Kamboj , Kousheen Brar , Nandita Narayanasamy
{"title":"Reassessment of reference values of metabolic markers: A meta-analysis study","authors":"Saruby Sharma ,&nbsp;Shriya Mehta ,&nbsp;Nilakshi Mondal ,&nbsp;Mokshi Jain ,&nbsp;Divyanshi Verma ,&nbsp;Kajal Kamboj ,&nbsp;Kousheen Brar ,&nbsp;Nandita Narayanasamy","doi":"10.1016/j.hnm.2023.200216","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200216","url":null,"abstract":"<div><p>Assessment of the metabolic status of mixed populations is based on narrowly defined, standardized reference values. We performed a systematic review to collate data from 40 observational and case-controlled studies, in order to determine whether the screened randomized control studies lie within the normal range provided by internationally accepted guidelines. Forest plots show a significant increase in overall effect size compared to the computed reference ranges for several metabolic parameters. We conclude that all metabolic parameters need to be categorized in subgroups like age, gender and ethnicity for the precise assessment of metabolic status in a random, diverse population.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200216"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dose-response of acute capsiate supplementation on muscle endurance performance during CrossFit® in trained men: A randomized, crossover and double-blind study 急性capate补充对训练男性CrossFit®期间肌肉耐力表现的剂量反应:一项随机、交叉和双盲研究
Human Nutrition and Metabolism Pub Date : 2023-09-01 DOI: 10.1016/j.hnm.2023.200215
Marcelo da Silva Mesquita Oliveira , Paulo Renan Macêdo , Nathanael Leal Santana , Flávio Antônio de Sousa Nunes , Jason Michael Cholewa , Priscila Almeida Queiroz Rossi , Ahecio Kleber Araújo Brito , Nelo E. Zanchi , Fabrício Eduardo Rossi
{"title":"Dose-response of acute capsiate supplementation on muscle endurance performance during CrossFit® in trained men: A randomized, crossover and double-blind study","authors":"Marcelo da Silva Mesquita Oliveira ,&nbsp;Paulo Renan Macêdo ,&nbsp;Nathanael Leal Santana ,&nbsp;Flávio Antônio de Sousa Nunes ,&nbsp;Jason Michael Cholewa ,&nbsp;Priscila Almeida Queiroz Rossi ,&nbsp;Ahecio Kleber Araújo Brito ,&nbsp;Nelo E. Zanchi ,&nbsp;Fabrício Eduardo Rossi","doi":"10.1016/j.hnm.2023.200215","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200215","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to verify the acute effect of Capsiate (CAP) on muscle endurance resistance training during CrossFit® and to compare the effects of two acute doses of CAP supplementation (12 vs. 24 mg) in trained men during this workout.</p></div><div><h3>Methods</h3><p>Using a randomized, crossover and double-blind design, 17 trained males with at least 1 year of CrossFit® (CF) experience were supplemented with 12 or 24 mg of CAP or placebo 45 min before the workout. The participant performed three random sessions separated by seven days, where they should complete as many repetitions as possible in 20 min, consisting of five pull-ups, 10 push-ups, and 15 air squats. The rate of perceived effort (RPE) was analyzed immediately after exercise and the heart rate at rest, five, 10, 15 and 20 min.</p></div><div><h3>Results</h3><p>There was no significant difference between doses for the number of repetitions (Placebo = 620.5 ± 137.8 vs. 12 mg = 627.7 ± 99.8 vs. 24 mg = 631.3 ± 120.1 repetitions, p = 0.768, <em>η</em><sup><em>2</em></sup> = 0.02) and RPE (Placebo = 7.4 ± 1.3 vs. 12 mg = 7.5 ± 0.9 vs. 24 mg = 7.3 ± 1.5, p = 0.772, <em>η</em><sup><em>2</em></sup> = 0.02). The heart rate increased across workouts (p &lt; 0.001) but no significant dose time interaction was observed (p = 0.109, <em>η</em><sup><em>2</em></sup> = 0.09).</p></div><div><h3>Conclusion</h3><p>In summary, 12 and 24 mg of CAP did not improve muscle endurance performance, RPE and heart rate during CF performance in trained men.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200215"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-hyperlipidaemic effect of thyme infused green coffee on human subjects 百里香咖啡对人体的抗高脂血作用
Human Nutrition and Metabolism Pub Date : 2023-09-01 DOI: 10.1016/j.hnm.2023.200199
Richa Ghai , Shubhra Saraswat
{"title":"Anti-hyperlipidaemic effect of thyme infused green coffee on human subjects","authors":"Richa Ghai ,&nbsp;Shubhra Saraswat","doi":"10.1016/j.hnm.2023.200199","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200199","url":null,"abstract":"<div><h3>Background</h3><p>Atherosclerosis and hyperlipidaemia are the primary cause of heart diseases and death in most developed countries. Herbs have the clinical ability to improve cardiovascular health. Green coffee (Coffee Arabica) and thyme (Thymus Vulgaris) have proved to have lowering effects on cholesterol, triglycerides, fasting blood sugar levels and anthropometric measurements.</p></div><div><h3>Objective(s)</h3><p>The present study was conducted to assess the anti hyperlipidaemic effect of thyme infused green coffee on human subjects.</p></div><div><h3>Materials and methods</h3><p>An oral ingestion of thyme infused green coffee in hot water was given in the form of beverage for 90 days. Different biochemical indices were assessed to check the efficiency of thyme infused green coffee on human subjects.</p></div><div><h3>Result</h3><p>Repeated administration of the combination of thyme and green coffee showed statistically significant decrease in weight, waist circumference, fasting blood sugar, total cholesterol, low density lipoproteins and triglycerides.</p></div><div><h3>Conclusion</h3><p>Marked variations in triglycerides, high density lipoproteins, low density lipoproteins and anthropometric measurements of human subjects are indicative of effectiveness of thyme infused green coffee. Continuous intake of this combination may hence prove to be beneficial to the body.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200199"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49868091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BMI-for-age z-score and psychological distress associated with disordered eating: A comparative study among Indonesian and Malaysian urban female adolescents 年龄bmi z-score与饮食失调相关的心理困扰:印度尼西亚和马来西亚城市女性青少年的比较研究
Human Nutrition and Metabolism Pub Date : 2023-09-01 DOI: 10.1016/j.hnm.2023.200204
Sharifah Intan Zainun Sharif Ishak , Yit Siew Chin , Chee Wee Tay , Muhammad Nur Hasan Syah , Dian Luthfiana Sufyan
{"title":"BMI-for-age z-score and psychological distress associated with disordered eating: A comparative study among Indonesian and Malaysian urban female adolescents","authors":"Sharifah Intan Zainun Sharif Ishak ,&nbsp;Yit Siew Chin ,&nbsp;Chee Wee Tay ,&nbsp;Muhammad Nur Hasan Syah ,&nbsp;Dian Luthfiana Sufyan","doi":"10.1016/j.hnm.2023.200204","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200204","url":null,"abstract":"<div><p>Nutrition transition and globalization have affected the diet and body composition of all life stages including adolescents. This study aims to compare body weight status, psychological distress and disordered eating (DE), and to compare the association between BMI-for-age z-score (BAZ) and psychological distress with DE among Indonesian and Malaysian urban female adolescents. The adolescents’ weight and height were measured and a self-administered questionnaire was completed by each adolescent. A total of 713 girls (Indonesia = 47.8%, Malaysia = 52.2%), aged 12–19 years from Bekasi, Indonesia and Kuala Lumpur, Malaysia, participated in this study. The prevalence of overweight and obesity was not significantly different between Indonesian and Malaysian girls (18.2% vs 21.2%). Malaysian girls have a significantly higher prevalence of DE (23.9% vs 3.2%), depression (51.9% vs 26.1%), and stress (41.7% vs 29.6%) than Indonesian girls. However, the prevalence of anxiety in Indonesian girls was significantly higher compared to Malaysian girls (77.7% vs 66.4%). For Indonesian girls, BAZ and stress were significantly positive associated with DE, dieting, and bulimia and food preoccupation. For Malaysian girls, BAZ, anxiety and stress were significantly positive associated with DE. BAZ and stress were significantly positive associated with dieting. Depression and anxiety were significantly and positively associated with bulimia and food preoccupation. For both Indonesian and Malaysian girls, stress was significantly positive associated with oral control. Therefore, future intervention programme on promoting healthy eating among female adolescents should consider the psychological well-being component.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200204"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49868143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary intake and diversity among children of age 6–59 months in lowland and highland areas in Kilosa District in Morogoro, Tanzania 坦桑尼亚莫罗戈罗Kilosa地区低地和高地地区6-59个月儿童的膳食摄入量和多样性
Human Nutrition and Metabolism Pub Date : 2023-09-01 DOI: 10.1016/j.hnm.2023.200205
J.D. Mrema , C.N. Nyaruhucha , A.W. Mwanri
{"title":"Dietary intake and diversity among children of age 6–59 months in lowland and highland areas in Kilosa District in Morogoro, Tanzania","authors":"J.D. Mrema ,&nbsp;C.N. Nyaruhucha ,&nbsp;A.W. Mwanri","doi":"10.1016/j.hnm.2023.200205","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200205","url":null,"abstract":"<div><p>Adequate nutrition during infancy and early childhood is essential to ensure children's growth, health, and development to their full potential. Geographical area may influence dietary intake and, hence, the population's nutritional status. This study aimed to assess dietary intake among children aged 6–59 months in the lowland and highland areas in the Kilosa District, Morogoro. A cross-sectional study involved 200 randomly selected households from the lowland and 141 in the highland areas. Socio-demographic characteristics, feeding practices, and 24-h dietary recall information were collected using a pre-tested questionnaire. In assessing dietary intake, a single day 24-h dietary recall was used where a mother/care giver was asked to recall foods and beverages fed to the child in the 24 h prior to the interview. Mean daily nutrient intake (calorie, vitamin A, iron, calcium and zinc) were estimated using NutriSurvey version 2007 with food database from Tanzania Food composition table. Furthermore, Dietary Diversity Score was done by grouping the mentioned foods into the seven main food groups which are grains, roots and tubers; legumes and nuts; Vitamin A rich fruits and vegetables; other fruits and vegetable; dairy products; and flesh foods and eggs. For each food group consumed, a score of one was assigned and a zero score for the non-consumed group. Inadequate intakes of vitamin A, calcium, and iron were observed more in younger children of age 6–12 months, where none of them met the RDA in both areas. There was a significant difference only in fat intake in children aged 12–36 months between the lowland and highland areas. Children who reside in the lowland area had a significantly more diversified diet. Nutrition education with promotion of home gardening and keeping small animals is necessary to ensure household food availability which subsequently will facilitate dietary diversification.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200205"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49868145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The potential of esculin as a therapeutic modality in diabetes mellitus and its complications 内皮素作为糖尿病及其并发症治疗方式的潜力
Human Nutrition and Metabolism Pub Date : 2023-09-01 DOI: 10.1016/j.hnm.2023.200207
Nida Naseem , Md. Fahim Ahmad , Nazia Imam , Haseeb Ahsan , Waseem A. Siddiqui
{"title":"The potential of esculin as a therapeutic modality in diabetes mellitus and its complications","authors":"Nida Naseem ,&nbsp;Md. Fahim Ahmad ,&nbsp;Nazia Imam ,&nbsp;Haseeb Ahsan ,&nbsp;Waseem A. Siddiqui","doi":"10.1016/j.hnm.2023.200207","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200207","url":null,"abstract":"<div><p>The available medications for diabetes mellitus (DM) are not sufficient to reverse the pathophysiological abnormalities and complications associated with the disease. Considering the undesirable side-effects linked to existing anti-diabetic drugs, there is a paradigm shift towards natural substances for the management and treatment of DM. Plant products such as secondary metabolites or bioactive phytoconstituents are a remarkable source of natural medicines used in ameliorating various diseases, including diabetes. This review article focuses on a natural compound esculin, a coumarin derivative, which possesses multiple biological properties such as anti-inflammatory, anti-oxidative, analgesic, diuretic, anti-coagulative, anti-apoptotic and anti-depressive. It could be a possible candidate as a therapeutic agent in ameliorating diabetes and its complications. Although studies related to the pharmacodynamics of esculin are limited and not fully understood, the anti-diabetic properties of esculin could be exploited as an alternative treatment for type-2 diabetes mellitus (T2DM) either in combination therapy in integrative medicine or as a natural anti-diabetic medicine. However, comprehensive chemical and pharmacological studies are required to validate the available data on esculin from both in vivo and in vitro studies before it can be considered as a potential therapeutic agent in DM.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200207"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Snacking and weight status in Malaysian Chinese primary school children 马来西亚华裔小学生的零食与体重状况
Human Nutrition and Metabolism Pub Date : 2023-09-01 DOI: 10.1016/j.hnm.2023.200209
Shu Hwa Ong , Kanimolli Arasu , Den Yen Leow , Jia Xin Lim , Wai Yew Yang
{"title":"Snacking and weight status in Malaysian Chinese primary school children","authors":"Shu Hwa Ong ,&nbsp;Kanimolli Arasu ,&nbsp;Den Yen Leow ,&nbsp;Jia Xin Lim ,&nbsp;Wai Yew Yang","doi":"10.1016/j.hnm.2023.200209","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200209","url":null,"abstract":"<div><h3>Background</h3><p>The exponential increase in childhood obesity poses a global health problem including Malaysia. Increased snacking behaviours could be one of the contributing factors to unhealthy eating habits and excessive energy intake. This study aimed to investigate the influence of snacking pattern (portion, frequency, energy contribution) and preference on the energy intake and weight status among Malaysian Chinese children aged 7–12 years in Klang Valley, Malaysia.</p></div><div><h3>Methods</h3><p>A total of 99 Chinese children (37 boys, 62 girls) with a mean age of 10.4 ± 1.5 years old were recruited from three local primary schools. Weight and height were measured. Snacking behaviours (frequency, portion size, and preference) were assessed using a questionnaire. Two days of 24-h dietary recall were used to assess the children's dietary intake.</p></div><div><h3>Results</h3><p>Most of the children (62.6%) had normal body weight status. Snacking contributed to 23.3% and 21.6% of total daily energy intake on weekdays and weekends respectively. The most preferred snacks were ice cream, yoghurt, and chocolate drinks, whereas the least preferred snacks were syrup, traditional <em>kuih,</em> and breads. There were no significant differences in snacking frequency and portion size by the amount of pocket money given for snacks (Pearson χ<sup>2</sup> = 1.52, p = 0.47; Pearson χ<sup>2</sup> = 3.19, p = 0.53, respectively).</p></div><div><h3>Conclusion</h3><p>Education regarding the right choice of snacks is important to ensure better diet quality to optimise children's growth.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200209"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum concentrations of retinol, β-carotene and zinc in women with breast cancer submitted to radiotherapy according to prior treatment modality and toxicity 根据先前的治疗方式和毒性,接受放疗的乳腺癌妇女血清视黄醇、β-胡萝卜素和锌的浓度
Human Nutrition and Metabolism Pub Date : 2023-09-01 DOI: 10.1016/j.hnm.2023.200202
Cintia Rosa , Carlos Franca , Sérgio Lanes , Antônio Carvalho , Antônio Penna , Carla Nogueira , Mariana Luna , Andrea Ramalho
{"title":"Serum concentrations of retinol, β-carotene and zinc in women with breast cancer submitted to radiotherapy according to prior treatment modality and toxicity","authors":"Cintia Rosa ,&nbsp;Carlos Franca ,&nbsp;Sérgio Lanes ,&nbsp;Antônio Carvalho ,&nbsp;Antônio Penna ,&nbsp;Carla Nogueira ,&nbsp;Mariana Luna ,&nbsp;Andrea Ramalho","doi":"10.1016/j.hnm.2023.200202","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200202","url":null,"abstract":"<div><h3>Objective</h3><p>To analyze serum concentrations of retinol, β-carotene and zinc in women with breast cancer undergoing radiotherapy, considering different modalities of previous treatment and toxic effects.</p></div><div><h3>Methods</h3><p>longitudinal study in a cohort of women with breast cancer assessed in pre-treatment (T0), 7 (T2) and 120 (T3) days after radiation therapy. Patients were divided into 3 groups, according to treatment modality prior radiation: breast-conserving surgery (G1), chemotherapy (G2) and breast-conserving surgery and chemotherapy (G3). Serum concentrations of retinol, β-carotene and zinc was assessed. Presence and degree of toxicity were assessed according to the scale of the RTOG for and RTOG/EORTC for acute and late toxicity, respectively.</p></div><div><h3>Results</h3><p>230 patients were assessed, mean age of 63.6 (±9.3) years. There was significant reduction in the mean of all micronutrients studied when comparing T0 to T1. At T2, all nutrients increased when compared to T1. For acute toxicity, there was no difference in antioxidant levels according to the degree of toxicity for any of the groups, with the exception of G3, which presented lower serum zinc concentrations in women with a higher degree of acute toxicity. In late toxicity, G1 had lower serum concentrations of retinol and B-carotene, when compared to G2 and G3.</p></div><div><h3>Conclusion</h3><p>The significant reduction of all micronutrients after radiotherapy, regardless of the type of the previous treatment, reinforces the oxidative impact of radiation and draws attention to the importance of maintaining an adequate nutritional status of antioxidants to improve the prognosis.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"33 ","pages":"Article 200202"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49868144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-term fasting affects biomarkers of creatine metabolism in healthy men and women 短期禁食影响健康男性和女性肌酸代谢的生物标志物
Human Nutrition and Metabolism Pub Date : 2023-08-30 DOI: 10.1016/j.hnm.2023.200217
Marijana Ranisavljev , Nikola Todorovic , Jovana Panic , Bogdan Andjelic , Milan Vranes , Sergej M. Ostojic
{"title":"Short-term fasting affects biomarkers of creatine metabolism in healthy men and women","authors":"Marijana Ranisavljev ,&nbsp;Nikola Todorovic ,&nbsp;Jovana Panic ,&nbsp;Bogdan Andjelic ,&nbsp;Milan Vranes ,&nbsp;Sergej M. Ostojic","doi":"10.1016/j.hnm.2023.200217","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200217","url":null,"abstract":"<div><p>We studied the effects of 24-h fasting on serum levels of guanidinoacetic acid (GAA), creatine, and creatinine in 24 non-vegetarian healthy adults. Blood was taken before and following an intervention, with levels corrected for fasting-induced changes in plasma volume. Food abstention induced a significant decrease in serum GAA by 39.5% (<em>p</em> &lt; 0.001), while creatinine levels increased by 14.7% (<em>p</em> &lt; 0.01); the concentration of creatine remains unchanged. The reduction in GAA during fasting may indicate an increased demand for creatine production for this energy-demanding condition and/or potential kidney dysfunction which requires further exploration.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"34 ","pages":"Article 200217"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49783522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship among dietary intake of vitamin D, magnesium, and calcium, 25-hydroxyvitamin D levels, and glycemic control markers in individuals with type 2 diabetes 2型糖尿病患者膳食中维生素D、镁和钙的摄入量、25-羟基维生素D水平与血糖控制标志物的关系
Human Nutrition and Metabolism Pub Date : 2023-08-28 DOI: 10.1016/j.hnm.2023.200218
Ramara Kadija Fonseca Santos , Vivianne de Sousa Rocha , Juliana de Souza Oliveira , Gabrielli Barbosa de Carvalho , Aline Rocha Reis , Cynthia Batista Santos , Beatriz da Cruz Santos , Paula Nascimento Brandão-Lima , Cinthia Fontes da Silva Santos , Liliane Viana Pires
{"title":"Relationship among dietary intake of vitamin D, magnesium, and calcium, 25-hydroxyvitamin D levels, and glycemic control markers in individuals with type 2 diabetes","authors":"Ramara Kadija Fonseca Santos ,&nbsp;Vivianne de Sousa Rocha ,&nbsp;Juliana de Souza Oliveira ,&nbsp;Gabrielli Barbosa de Carvalho ,&nbsp;Aline Rocha Reis ,&nbsp;Cynthia Batista Santos ,&nbsp;Beatriz da Cruz Santos ,&nbsp;Paula Nascimento Brandão-Lima ,&nbsp;Cinthia Fontes da Silva Santos ,&nbsp;Liliane Viana Pires","doi":"10.1016/j.hnm.2023.200218","DOIUrl":"https://doi.org/10.1016/j.hnm.2023.200218","url":null,"abstract":"<div><h3>Aims</h3><p>To investigate the associations of 25-hydroxyvitamin D (25(OH)D) concentrations, vitamin D intake, magnesium, and calcium with glycemic control in individuals with type 2 diabetes mellitus (T2DM).</p></div><div><h3>Methods</h3><p>A total of 107 adult with T2DM, residing in the state of Sergipe/Brazil (latitude: 10°), were evaluated for serum concentrations of 25(OH)D, parathyroid hormone, fasting glucose, %HbA1c, insulin, <em>C</em>-peptide, total cholesterol and fractions, homeostasis of beta-cell function (HOMA-B), insulin sensitivity (HOMA-S) and resistance (HOMA-IR), anthropometry, body composition, and usual food intake. The results were analyzed according to 25(OH)D status (insufficient/deficient &lt;30 ng/mL; adequate ≥30 ng/mL). Mann–Whitney, chi-square, and binary logistic regression tests were performed. <em>P</em>-value&lt;0.05 was considered significant.</p></div><div><h3>Results</h3><p>The median age and time to T2DM diagnosis were 49 and 5 years, respectively. High inadequacy was observed in the dietary intake of vitamin D, magnesium, and calcium. Higher HOMA-B values were observed in the vitamin D adequate group (p = 0.032) and higher fasting serum glucose concentrations (p = 0.012) and %body fat (p = 0.048) in the insufficient/deficient group, which had a higher chance of elevated serum glucose (odds ratio [OR]:2.937; p = 0.020) and HOMA-IR (OR:2.496; p = 0.045).</p></div><div><h3>Conclusion</h3><p>Vitamin D deficiency is associated with poor glycemic control and insulin resistance, and these aspects are unrelated to inadequate dietary intake of vitamin D, magnesium, and calcium.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"34 ","pages":"Article 200218"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49783521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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