Human Nutrition and Metabolism最新文献

{"title":"The effect of probiotic (Clostridium butyricum) on adult patients with atopic dermatitis: a retrospective cohort study from TriNetX","authors":"Kuo-Hsiung Shu ,&nbsp;Yun-Chien Tsai ,&nbsp;Cheng-Hsu Chen ,&nbsp;Shang-Feng Tsai","doi":"10.1016/j.hnm.2025.200332","DOIUrl":"10.1016/j.hnm.2025.200332","url":null,"abstract":"<div><h3>Background</h3><div>Previous research on probiotics has mainly focused on eczema in infants and pregnant women, with limited benefits observed in adults. Miyarisan, a probiotic known for supporting gut barrier function, has not been extensively studied for its effects on eczema in adult populations.</div></div><div><h3>Methods</h3><div>We used the TriNetX global network (2014–2024) to compare Miyarisan users with non-users among eczema or dermatitis patients. Propensity score matching (PSM) reduced bias, and hazard ratios (HRs) with 95 % confidence intervals (CIs) and Kaplan-Meier curves assessed skin outcomes based on the SCORAD index. Subgroup analyses explored variations by sex, age, and medication refill frequency, with a sensitivity analysis focusing on atopic dermatitis patients.</div></div><div><h3>Results</h3><div>Following 1:1 PS M, the study analyzed 1600 cases in each group (Miyarisan users and non-users) without difference between baseline variables. The incidence of itching (HR = 0.372, 95 % CI: 0.287–0.481, p &lt; 0.001), redness (HR = 0.065, 95 % CI: 0.040–0.108, p &lt; 0.001), dryness (HR = 0.358, 95 % CI: 0.285–0.449, p &lt; 0.001), swelling (HR = 0.164, 95 % CI: 0.101–0.265, p &lt; 0.001), scratching (HR = 0.426, 95 % CI: 0.296–0.612, p &lt; 0.001), and thickening (HR = 0.325, 95 % CI: 0.225–0.467, p &lt; 0.001) were significantly lower in the Miyarisan group compared to the non-Miyarisan group. These benefits were consistent across different gender and age subgroups. According to individual SCORAD measures, reduced skin redness was consistently observed across all subgroups. When focusing on atopic dermatitis, Miyarisan users also showed a lower risk of adverse skin outcomes, similar to patients with eczema or dermatitis.</div></div><div><h3>Conclusion</h3><div>Miyarisan use in adults may reduce the recurrence of eczema or dermatitis, with consistent benefits across both sex and age groups. These findings are also observed in patients with atopic dermatitis.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200332"},"PeriodicalIF":1.9,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to the mediterranean diet and risk of hypoglycemia in insulin-treated type 2 diabetic patients","authors":"Caterina Formichi ,&nbsp;Sonia Caprio ,&nbsp;Stefano Auddino ,&nbsp;Felicia Rizza ,&nbsp;Barbara Paolini ,&nbsp;Laura Nigi ,&nbsp;Francesco Dotta","doi":"10.1016/j.hnm.2025.200330","DOIUrl":"10.1016/j.hnm.2025.200330","url":null,"abstract":"<div><h3>Background and aims</h3><div>Lifestyle intervention, aimed at weight loss and increasing physical activity, is widely known as the first-line treatment in diabetes. Adherence to a medical nutritional therapy (MNT) is even more relevant in patients on insulin therapy. However, data on the relationship between diet composition and glycemic control indexes derived from continuous glucose monitoring (CGM) in type 2 diabetes (T2D) are scarce and inconsistent. Our aim was to evaluate the association between adherence do Mediterranean diet (MD) and CGM metrics in a cohort of T2D patients treated with insulin.</div></div><div><h3>Methods and results</h3><div>We retrospectively collected data of 25 patients with T2D on insulin therapy, at the Diabetes Unit of University Hospital in Siena. They were prescribed a flash glucose monitoring (FGM) system and accepted to answer the MEDLIFE questionnaire, a validated tool designed to explore the adherence to MD. Adherence to MD did not seem to influence glycemic control indexes in our cohort. It is worth mentioning that the risk of hypoglycemia and time spent in hypoglycemia was found to be highly influenced by alcohol consumption, even in minimal amounts (according to national guideline recommendations).</div></div><div><h3>Conclusion</h3><div>Nutritional counselling for patients with insulin-treated T2DM should include a focus on alcohol consumption – ideally to be avoided - and related hypoglycemic risk.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200330"},"PeriodicalIF":1.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of liraglutide on metabolic and reproductive outcomes in infertile women with PCOS: A prospective cohort study","authors":"Rossella Cannarella ,&nbsp;Aldo E. Calogero ,&nbsp;Federica Barbagallo ,&nbsp;Cristina Petralia ,&nbsp;Antonio Aversa ,&nbsp;Rosita A. Condorelli ,&nbsp;Sandro La Vignera","doi":"10.1016/j.hnm.2025.200331","DOIUrl":"10.1016/j.hnm.2025.200331","url":null,"abstract":"<div><h3>Objective</h3><div>To prospectively evaluate the effects of the administration of liraglutide plus calorie deprivation, metformin plus calorie deprivation, or calorie deprivation alone on hirsutism, metabolic profile, and ovarian reserve in infertile patients with polycystic ovary syndrome (PCOS).</div></div><div><h3>Patients and methods</h3><div>This is a prospective observational study conducted on 80 insulin-resistant and infertile PCOS women. Enrolled patients received liraglutide (Saxenda®) + calorie deprivation (Group 1, n = 50), metformin + calorie deprivation (Group 2, n = 15), or calorie deprivation only (Group 3, n = 15). Endpoints were assessed in all patients before and after 120 days.</div></div><div><h3>Results</h3><div>At the end of treatment, BMI was significantly reduced in all groups, while the HOMA index decreased statistically significantly only in groups 1 and 2. Hormonal evaluation showed that serum SHBG and progesterone levels increased significantly in all three groups, while AMH levels significantly decreased in groups 1 and 3. Finally, the Ferriman-Gallwey score improved significantly in all groups. Percentage of decrease vs. baseline in BMI, HOMA index, AMH, Ferriman-Gallway score, and of increase in SHBG were higher in Group 1 than in Group 2 and Group 3. The percentage of increase in progesterone in Group 1 and Group 2 was higher than in Group 3.</div></div><div><h3>Conclusion</h3><div>The results support the use of liraglutide in insulin-resistant and infertile women with PCOS. The improvement in AMH and progesterone following liraglutide administration could be clinically useful in preparation for controlled ovarian hyperstimulation if patients with PCOS need to resort to an assisted reproductive technique.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200331"},"PeriodicalIF":1.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"There was an association between sulfur microbial diet score and ulcerative colitis severity: the result of a cross-sectional study","authors":"Zeinab Nikniaz ,&nbsp;Reza Mahdavi ,&nbsp;Zahra Bakhtiari ,&nbsp;Kourosh Masnadi Shirazi","doi":"10.1016/j.hnm.2025.200333","DOIUrl":"10.1016/j.hnm.2025.200333","url":null,"abstract":"<div><h3>Background</h3><div>Considering the pivotal role of diet and microbiome in modulating the disease's severity and progression in patients with ulcerative colitis (UC), we performed a cross-sectional study to elucidate the link between the Sulfur microbial diet (SMD) score and the clinical course of UC.</div></div><div><h3>Methods</h3><div>158 patients with UC were enrolled. An expert gastroenterologist reported the disease severity using the Mayo score. An expert nutritionist recorded the amount and frequency of intake of 168 food items by the valid Food Frequency Questionnaire (FFQ). The method introduced by Nguyen et al. was used to calculate SMD score. The association between disease severity and adapted SMD score was analyzed by the logistic regression adjusting for dietary factors, demographic values, and lifestyle factors.</div></div><div><h3>Results</h3><div>The mean age of participants was 42.52 ± 12.61 years old and there were no significant differences in baseline information of patients in different adapted SMD score tertiles except for protein intake. There were significant differences in dietary intake of all components across the tertile of the adapted SMD score except for processed meat (p = 0.97). In the fully adjusted model, the odds of severe disease were 4.29 times higher in the patients in the third tertile of the adapted SMD score compared with the first tertile (OR: 4.29, 95 %CI: 1.42, 12.91).</div></div><div><h3>Conclusions</h3><div>The higher score of adapted SMD was associated with higher severity of UC. However, due to the limitations of this study, more longitudinal and clinical trials considering the different confounders should be undertaken to improve this conclusion.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200333"},"PeriodicalIF":1.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between diet quality evaluated using the Meiji nutritional profiling system and serum 25-hydroxyvitamin D levels in Japanese adults and older adults: A cross-sectional study from the NILS-LSA","authors":"Tao Yu ,&nbsp;Shu Zhang ,&nbsp;Ryota Wakayama ,&nbsp;Tomohito Horimoto ,&nbsp;Chikako Tange ,&nbsp;Yukiko Nishita ,&nbsp;Rei Otsuka","doi":"10.1016/j.hnm.2025.200328","DOIUrl":"10.1016/j.hnm.2025.200328","url":null,"abstract":"<div><h3>Background</h3><div>The serum 25-hydroxyvitamin D (25OHVD) insufficiency is a recognized public health nutrition concern globally. The relationship between dietary factors and serum 25OHVD levels remains unclear in the Japanese population.</div></div><div><h3>Objective</h3><div>This study aimed to evaluate diet quality using the Meiji Nutritional Profiling System (Meiji NPS) and investigated its cross-sectional association with serum 25OHVD levels in Japanese middle-aged and older adults.</div></div><div><h3>Methods</h3><div>Data were analyzed from 1272 middle-aged adults and 873 older adults participating in the National Institute for Longevity Sciences - Longitudinal Study of Aging in Japan. Participants with complete dietary records and serum 25OHVD measurements were included. Diet quality was assessed using the Meiji NPS, and a dietary index was calculated for each individual. Associations between diet quality and serum 25OHVD levels were examined using general linear model adjusted for various covariates.</div></div><div><h3>Results</h3><div>The median age, dietary index, and prevalence of serum 25OHVD insufficiency (&lt;30 ng/ml) were 53 years, 10.1 points, and 74.2 % in adults, and 73.0 years, 12.0 points, and 60.5 % in older adults, respectively. Higher dietary indices were positively associated with serum 25OHVD levels in both adults (partial regression coefficient 0.11; 95 % confidence interval: 0.04–0.18), and older adults (0.17, 0.07–0.26).</div></div><div><h3>Conclusions</h3><div>This study suggests a positive association between diet quality, as evaluated by the Meiji NPS, and serum 25OHVD levels in middle-aged and older adults.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200328"},"PeriodicalIF":1.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of dietary amino acid and fatty acid intake profiles of US adults: NHANES 2017–March 2020 Pre-pandemic","authors":"Miyu Kenzaka ,&nbsp;Haruka Nishiyama ,&nbsp;Miyuki Imafuku ,&nbsp;Sae Nakao ,&nbsp;Sari Natsume ,&nbsp;Chika Oue ,&nbsp;Hisami Yamanaka-Okumura","doi":"10.1016/j.hnm.2025.200329","DOIUrl":"10.1016/j.hnm.2025.200329","url":null,"abstract":"<div><div>Recently, the digitalization of data science in nutrition has highlighted the need for comprehensive dietary databases to interpret dietary habits accurately. Previous studies have elucidated detailed profiles of amino acids (AAs) and fatty acids (FAs) in the Japanese diet beyond the general categories of proteins and lipids. This study aimed to profile the intake of AAs and FAs in the United States (U.S.) population, focusing on the quantity of these nutrients. By linking the USDA National Nutrient Database for Standard Reference with the National Health and Nutrition Examination Survey 2017–March 2020 data, we estimated the average dietary intake of 18 AAs and 19 FAs in the U.S. population, expressed in mg/1000 kcal and calculated their respective contributions. Among the 18 AAs, glutamic acid, aspartic acid, and leucine were the most consumed, accounting for 19.8 %, 9.1 %, and 8.1 % of the total intake, respectively. Among the 19 FAs, 18:1 constituted the most significant proportion at 36.5 %, followed by 18:2 at 23.3 % and 16:0 at 20.1 %. Although the intake contribution profiles of AA were similar across different food groups, those of FA varied significantly. Overall, we successfully developed a database showing the average intake of AA and FA in the U.S. population rather than focusing solely on proteins and lipids. This database provides a foundation for accurately understanding and interpreting dietary habits in the U.S. population and suggests its potential use as a reference for future international dietary comparisons.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200329"},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food insecurity and health behaviors in a disaster-affected population: A case study of Tacloban, Philippines","authors":"Gashaw Enbiyale Kasse ,&nbsp;Abdo Megra Geda ,&nbsp;Aregash Wendimu Tumebo ,&nbsp;Elvis Akem Tambe ,&nbsp;Abraham Belete Temesgen ,&nbsp;Mulusew Tesfaye Yitie ,&nbsp;Tadesse Mihiret Yimam ,&nbsp;Samuel Atalay Shiferaw","doi":"10.1016/j.hnm.2025.200327","DOIUrl":"10.1016/j.hnm.2025.200327","url":null,"abstract":"<div><h3>Background</h3><div>Food insecurity is a widespread issue that poses a major global challenge with far-reaching impacts.</div></div><div><h3>Objective</h3><div>Investigate the relationship between food insecurity and health behaviors among the population of Tacloban, Philippines, affected by Typhoon Haiyan in 2013.</div></div><div><h3>Methods</h3><div>This study employed a cross-sectional design, surveying 226 households between April 2022 and June 2023. Households were selected using a systematic random sampling technique to ensure representative coverage. To evaluate food insecurity, we utilized the Food Insecurity Experience Scale-a robust tool that captures the degree to which individuals or households face challenges in accessing sufficient and nutritious food due to economic and social constraints. In addition, we explored a variety of health-related behaviors among participants, including the use of traditional healing practices, engagement in physical activity, sleep patterns and duration, dietary habits, medication adherence, as well as alcohol and tobacco use. The relationships between food insecurity and these health behaviors were rigorously examined using multiple logistic regression analysis, providing valuable insights into the interplay between access to food and lifestyle choices within the community.</div></div><div><h3>Results</h3><div>The results showed that 94 % of households experienced food insecurity, with 27 % severely, 52 % moderately, and 15 % mildly food insecure. The analysis revealed significant associations between food insecurity and several health behaviors. Food insecurity was found to be significantly associated with lower medication adherence, greater use of traditional healers, poorer dietary habits, and sleeping problems. However, no significant associations were found between food insecurity and smoking behavior, physical activities, or alcohol consumption.</div></div><div><h3>Conclusion</h3><div>Based on these findings, the study concluded that food insecurity negatively impacts health behaviors. Therefore, the authors suggested that improving food security in households could potentially lead to improvements in health behaviors.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200327"},"PeriodicalIF":1.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic potential of waist–triglyceride index, triglyceride–glucose index and related indices for the detection of metabolic syndrome in Nepali adults: A cross-sectional study","authors":"Daya Ram Pokharel ,&nbsp;Abhishek Maskey ,&nbsp;Ramchandra Kafle ,&nbsp;Goma Kathayat ,&nbsp;Binod Manandhar ,&nbsp;Krishna Das Manandhar","doi":"10.1016/j.hnm.2025.200324","DOIUrl":"10.1016/j.hnm.2025.200324","url":null,"abstract":"<div><div>Metabolic Syndrome (MetS) is a major public health concern associated with elevated risk of cardiometabolic diseases. Conventional diagnostic criteria for MetS require multiple clinical and biochemical measurements, limiting feasibility in resource-constrained settings. Novel anthropo-metabolic indices offer a simplified, surrogate approach for risk prediction and stratification. This study aimed to evaluate the diagnostic performance of the triglyceride-glucose (TyG) index, waist-triglyceride index (WTI), and their derivatives TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), and TyG-body mass index (TyG-BMI) for detecting the risk of MetS in Nepali adults.</div><div>A cross-sectional study was conducted among 1116 adults (424 females, 692 males) recruited from the premises of Manipal Teaching Hospital, Pokhara, Nepal. Baseline sociodemographic, anthropometric, and biochemical data were collected. MetS was defined using National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. Indices were calculated using standard formulae and their associations with MetS were examined using Spearman's correlation, multivariable logistic regression, and receiver operating characteristic (ROC) curve analyses.</div><div>All indices demonstrated significant diagnostic capability for the detection of MetS (p &lt; 0.001). The TyG index showed the highest overall accuracy, with area under the curve (AUC) of 0.920 in females and 0.874 in males. At optimal sex-specific cutoffs (≥8.66 for females, ≥8.87 for males), TyG demonstrated excellent sensitivity (female: 88.40 %, male: 85.55 %) and specificity (female: 88.00 %, male: 81.20 %). WTI and TyG-WC showed strong performance in identifying hypertriglyceridemia and central obesity, respectively. Logistic regression confirmed the TyG index as the strongest independent predictor of MetS (adjusted odds ratio (AOR): females = 58.59, males = 30.94, p &lt; 0.001). Predictive accuracy was lower for hypertension and low high density lipoprotein cholesterol (HDL-C). Comparative AUC analysis revealed greater index variability among females than males.</div><div>The TyG, TyG-WC and WTI are found to be robust, gender-specific tools for diagnosis of MetS and its components in Nepali adults. Their simplicity, affordability and high diagnostic accuracy support their integration into large-scale MetS screening in resource-limited settings. Sex-specific cutoffs enhance the precision of risk assessments, emphasizing the need for tailored screening strategies.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200324"},"PeriodicalIF":1.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between nutrient intake and cataracts in a Chinese type 2 diabetic population","authors":"Chongyang She ,&nbsp;Wenying Fan ,&nbsp;Yunyun Li ,&nbsp;Hong Lu ,&nbsp;Mengxuan Zou","doi":"10.1016/j.hnm.2025.200326","DOIUrl":"10.1016/j.hnm.2025.200326","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigates the association between daily nutrient intake, including antioxidants, minerals, and other essential nutrients, and cataract development in a diabetic Chinese population.</div></div><div><h3>Methods</h3><div>A total of 398 patients with type 2 diabetes from an urban Chinese community were recruited between January 2010 and January 2011. Participants underwent standardized evaluation, including questionnaires, ocular and anthropometric examinations, and laboratory tests. Dietary data were collected by 3-day food records. Cataract including nuclear, cortical, and posterior subcapsular cataracts (PSC), were graded according to Lens Opacities Classification System III. Multivariable logistic regressions were conducted to analyze associations between each dietary nutrient and cataract development, adjusting for social-demographic factors, lifestyle, age at onset of diabetes, and diabetes-related biomarkers in different models.</div></div><div><h3>Results</h3><div>Of the participants, 230 were in the cataract group, while 168 in the non-cataract group. The mean age was higher in the cataract group (68.3 ± 6.4 years) compared to non-cataract group (59.4 ± 9.4 years, <em>P</em> &lt; 0.001). PSC were more severe in patients with diabetic retinopathy (<em>P</em> = 0.020). Dietary vitamin C was positively associated with nuclear cataracts (<em>P</em> &lt; 0.05 across all models). Riboflavin (<em>P</em> = 0.023) and phosphorus (<em>P</em> = 0.026) were associated with cortical cataracts, while phosphorus (<em>P</em> = 0.043) and folic acid (<em>P</em> = 0.044) were associated with PSC cataracts. No associations were found for other nutrients.</div></div><div><h3>Conclusions</h3><div>Dietary vitamin C was associated with an increased risk of nuclear cataracts, while riboflavin and phosphorus were linked to cortical cataracts, phosphorus and folic acid were associated with PSC cataract. The severity of cataracts was more pronounced in patients with diabetic retinopathy.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200326"},"PeriodicalIF":1.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The miracle Berry: Unveiling the therapeutic attributes of sea buckthorn – A review","authors":"Rabiya Zulfiqar ,&nbsp;Kainat Fatima ,&nbsp;Iahtisham-Ul Haq ,&nbsp;Robert Mugabi ,&nbsp;Aanchal Sharma ,&nbsp;Sarvesh Rustagi ,&nbsp;Rattan Singh ,&nbsp;Gulzar Ahmad Nayik","doi":"10.1016/j.hnm.2025.200321","DOIUrl":"10.1016/j.hnm.2025.200321","url":null,"abstract":"<div><div>Sea buckthorn (<em>Hippophae rhamnoides</em> L.) is a versatile plant renowned for its exceptional nutritional and therapeutic properties. Native to mountainous regions of Asia and Europe, it has been traditionally utilized for its medicinal benefits. Its promising nutritional profile highlighted by significant levels of omega-3 and omega-6 fatty acids, along with omega-7 palmitoleic acid and vitamin C content makes it unique from other plants. Omega-7 palmitoleic acid is an extremely beneficial MUFA that can be crucial in treating different metabolic disorders. Its valuable role in glucose metabolism, skin health, liver functions, inflammatory diseases etc. has been well-reported in the literature. In addition, sea buckthorn has a range of bioactive compounds like antioxidants, polyphenols, flavonoids, sugars, organic acids, vitamins, and minerals that are cardinal for added health benefits. These compounds contribute to the therapeutic potential of sea buckthorn delivering antioxidants, anti-cancer, anti-diabetic, anti-inflammatory, immune boosting and cardio-protective properties. This review sums up the chemical composition, botanical features, uses and therapeutic properties of sea buckthorn to unveil its extraordinary potential and its possible inclusion in routine therapies to improve human health its possible inclusion in routine therapies to improve human health. However, further high-quality studies are needed to firmly establish the clinical efficacy of the plant.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200321"},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}