Human Nutrition and Metabolism最新文献

{"title":"Associations and interactions of clinical and genetic variables for type 2 diabetes mellitus in the mexican population","authors":"C.M. Martínez-Lara ,&nbsp;L. Casas-Avila ,&nbsp;M.L. Ramos-García ,&nbsp;C. Castro-Hernández ,&nbsp;D.A. Salazar-Piña ,&nbsp;A. Hidalgo-Bravo ,&nbsp;A.I. Barrera-Molina ,&nbsp;O.C. Martínez- Ramírez","doi":"10.1016/j.hnm.2025.200301","DOIUrl":"10.1016/j.hnm.2025.200301","url":null,"abstract":"<div><div>Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by high blood sugar levels (hyperglycemia).</div><div>It is among the top ten causes of death worldwide and involves non-modifiable (genetic risk variants) and modifiable factors (BMI, triglycerides and cholesterol).</div></div><div><h3>Methods</h3><div>We included 199 subjects with T2DM and 213 subjects without T2DM, both groups of the Mexican population. Genotyping was determined using real-time PCR with TaqMan probes. We determined the associations and interactions of clinical and genetic variables for T2DM in the Mexican population using Multifactor-Dimensionality Reduction (MDR; Version 3.0.2).</div></div><div><h3>Results</h3><div>The polymorphisms showed a strong association with the risk of suffering from T2DM when they occur additively and the interaction between clinical and genetic variables explains much of the weight of both factors in the etiology of the disease.</div></div><div><h3>Conclusion</h3><div>The associations and interactions show that, regarding the risk of T2DM in this population, the most crucial is a BMI &gt;24.9 kg/m², followed by triglycerides &gt;150 mg/dL and cholesterol &lt;200 mg/dL; after this, ranked in importance for the risk of T2DM, are genetic polymorphisms in <em>LEP</em>, <em>LEPR</em>, <em>FTO</em>, and <em>ADIPOQ</em> in Mexican population.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"40 ","pages":"Article 200301"},"PeriodicalIF":1.9,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Bifidobacterium animalis subsp. lactis Langg JZ-08 on lipid metabolism in individuals with obesity and dyslipidemia: A randomised, double-blind, and placebo-controlled trial","authors":"Xiaokang Niu ,&nbsp;Qi Zhang ,&nbsp;Yong Zhang ,&nbsp;Ran Wang ,&nbsp;Kai Yao ,&nbsp;Yue Sang ,&nbsp;Bing Fang ,&nbsp;Yuyang Zhao ,&nbsp;Liwei Liu ,&nbsp;Langrun Wang ,&nbsp;Rong Liu ,&nbsp;Yixuan Li ,&nbsp;Meiwen Sun ,&nbsp;Hong Cui ,&nbsp;Yinghua Liu ,&nbsp;Jingjing He","doi":"10.1016/j.hnm.2025.200300","DOIUrl":"10.1016/j.hnm.2025.200300","url":null,"abstract":"<div><div>Dyslipidemia is an established risk factor for cardiovascular disease, especially for individuals with obesity. Probiotics have been studied for their potential lipid-lowering properties, but the evidence in individuals with obesity and dyslipidemia is limited. For trial feasibility purposes, this study explored the effects of <em>Bifidobacterium animalis</em> subsp. <em>lactis</em> Langg JZ-08 (Langg JZ-08) on lipid metabolism in individuals with obesity and dyslipidemia. In a randomized, double-blind, placebo-controlled pilot trial, 40 individuals (7 males and 13 females in the placebo group, 10 males and 10 females in the probiotic group) with obesity and dyslipidemia, aged 18–65 years consumed daily probiotics (5 × 10¹⁰ CFU/day Langg JZ-08) or placebo for 12 weeks. Body composition, blood lipids, markers of glycometabolism, antioxidants, and inflammation were measured before and after the intervention. Langg JZ-08 consumption significantly decreased low-density lipoprotein cholesterol (<em>P</em> = 0.01), body fat percentage (<em>P</em> = 0.01), visceral fat area (<em>P</em> = 0.04), serum insulin (<em>P</em> = 0.01), glycosylated hemoglobin (<em>P</em> = 0.02), tumor necrosis factor-α (<em>P</em> &lt; 0.05), and increased glutathione peroxidase (GPX) (<em>P</em> &lt; 0.001) and total antioxidant capacity (T-AOC) (<em>P</em> &lt; 0.01) compared to the baseline. The decrease in total cholesterol was significantly greater in the probiotic group than in the placebo group after 12 weeks of intervention (<em>P</em> = 0.04). After the intervention, the serum superoxide dismutase, GPX and T-AOC levels were significantly higher in the Langg JZ-08 group than that of the placebo group (<em>P</em> &lt; 0.05). There were no significant inter- and intra-group differences in triglycerides, high-density lipoprotein cholesterol, body mass index, waist, hip, and fasting blood glucose after the intervention. 12-week Langg JZ-08 intervention improved lipid metabolism, oxidative stress, and inflammation in individuals with obesity and dyslipidemia. This pilot trial supports the feasibility of a larger scale randomized controlled trial to determine the efficacy of Langg JZ-08 on obesity with dyslipidemia.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"40 ","pages":"Article 200300"},"PeriodicalIF":1.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteins from insects: A sustainable alternative for oral health within the one health concept and the planetary health diet","authors":"Marta Mazur ,&nbsp;Maciej Jedliński ,&nbsp;Irena Duś-Ilnicka ,&nbsp;Artnora Ndokaj ,&nbsp;Florence Carrouel ,&nbsp;Livia Ottolenghi ,&nbsp;Denis Bourgeois","doi":"10.1016/j.hnm.2025.200299","DOIUrl":"10.1016/j.hnm.2025.200299","url":null,"abstract":"<div><div>The growing use of insect-derived proteins as a food source, driven by their nutritional benefits and low environmental impact, raises questions about their impact on human health, particularly oral health. This position paper analyzes the potential implications of integrating insect proteins into the diet, with a special focus on dental, periodontal, and oral microbiome health. By offering complete amino acid profiles, omega-3 fatty acids, and antimicrobial peptides, insect proteins may help address nutritional gaps and positively influence oral tissue regeneration and microbiome balance. Their low-carbohydrate content also reduces substrate availability for cariogenic bacteria, making them a valuable alternative to starch- or sugar-rich diets. We justify this dietary transition in light of present nutritional deficiencies and demonstrate how insect proteins can register within a holistic approach to global health (<em>One Health</em>) and the <em>Planetary Health Diet</em>, supporting sustainability and improving overall health. However, further studies are needed to evaluate their safety as potential sources of allergens and contaminants. Both in-vitro and in-vivo studies are needed to assess correlations with the oral microbiota and its most frequent dysbiosis-related manifestations.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"39 ","pages":"Article 200299"},"PeriodicalIF":1.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolite profiling in assessing ulcerative colitis activity: A systematic review","authors":"Danyang Cui ,&nbsp;Xu Han ,&nbsp;Jiazhu Jin ,&nbsp;Yanhong Wang ,&nbsp;Zijia Chen ,&nbsp;Yang Gong ,&nbsp;Miao Jiang","doi":"10.1016/j.hnm.2025.200298","DOIUrl":"10.1016/j.hnm.2025.200298","url":null,"abstract":"<div><h3>Background</h3><div>Ulcerative colitis (UC) is an immune-mediated chronic inflammatory condition of the colon, characterized by defects in the intestinal epithelial barrier, dysbiosis of the microbiota, and immune dysregulation. Metabolite profile has been widely and successfully used to characterize patient features in UC, as the development of metabolomics technology. Specific combinations of small metabolites can accurately depict the real-time pathological state of the body. Previous systematic reviews have focused on metabolite analysis between UC patients and healthy individuals, but have not systematically evaluated metabolite changes in different disease stages. This study focused on distinguish between patients in active and inactive phases, and even have the potential to predict changes in disease activity.</div></div><div><h3>Aim</h3><div>To summarize the distinct metabolites between the active and remission phases in serum and colonic mucosa in patients with UC.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted in PubMed, Embase, the Cochrane Library, Web of Science, WanFang Data, and China National Knowledge Infrastructure from 1995 to 2022. Studies were selected which included metabolomics detection on serum or mucosal samples from patients with active or remission phase UC. The disease activity was assessed by using the Mayo score, Ulcerative colitis activity index score, or Geboes score. The risk of bias was assessed using the Newcastle-Ottawa Scale.</div></div><div><h3>Results</h3><div>Eleven articles (10 in English and 1 in Chinese) and 357 patients were included. Qualitative analysis was performed according to the classification of gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry, or nuclear magnetic resonance. In the active period of UC, metabolites such as lipids, Amino acids showed a certain trend of change. Arachidonic acid showed specific upregulation in both serum and mucosal samples during the active stage in patients with UC.</div></div><div><h3>Conclusion</h3><div>There exists an association between metabolite profile and disease activity in patients with UC. Especially in patients with active UC, the lipid metabolite (arachidonic acid) is highly expressed simultaneously in the serum and mucosa. This finding will identify small molecule biomarkers that may potentially replace colonoscopy in the assessment and prediction of UC disease activity in the future, which indicates a significant potential for biomarker development.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"39 ","pages":"Article 200298"},"PeriodicalIF":1.9,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between exposure to volatile organic compounds with obesity in adults","authors":"Runmiao Wu ,&nbsp;Lei Jia ,&nbsp;Xu Zhu ,&nbsp;Gongchang Guan ,&nbsp;Junkui Wang ,&nbsp;Rutai Hui ,&nbsp;Meijuan Ma ,&nbsp;Zhao Zhao ,&nbsp;Hui Pang ,&nbsp;Ling Zhu","doi":"10.1016/j.hnm.2024.200296","DOIUrl":"10.1016/j.hnm.2024.200296","url":null,"abstract":"<div><h3>Objective</h3><div>This study was to investigate the correlation between urine volatile organic compound (VOC) metabolites and obesity-related outcomes, including BMI, waist circumference, obesity, and abdominal obesity.</div></div><div><h3>Methods</h3><div>Data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2016 were utilized for this analysis. Linear regression and logistic regression models were employed to estimate β-coefficients or odds ratios (ORs) along with their corresponding 95 % confidence intervals (CIs). Quantile g-computation (Qgcomp) regression, a method designed to evaluate the combined effects of multiple correlated chemical exposures, was used to assess the mixed influence of VOC metabolites on obesity-related outcomes.</div></div><div><h3>Results</h3><div>A total of 4950 adults were included in this analysis. The median age of the participants was 47 (33, 60) years, with 49.3 % being male. The median BMI was 27.7 (24.2, 32.4) kg/m², and the median waist circumference was 98.0 (87.3, 109.0) cm. The prevalence of obesity and abdominal obesity was 36.8 % and 56.5 %, respectively. After adjusting for all covariates, urine VOC metabolites (including AAMA, AMCC, BMA, CYMA, DHBMA, 3HPMA, 2HPMA, MA, 2MHA, 3MHA+4MHA, MHBMA3, PGA, and HPMMA) exhibited a negative association with obesity. With the exception of BMA and DHBMA, similar results were observed regarding the association between urine VOC metabolites and the prevalence of abdominal obesity. Additionally, Qgcomp regression analysis revealed a significant negative correlation between the mixture of urine VOC metabolites and all obesity-related outcomes, with 2HPMA demonstrating the strongest influence on this negative association.</div></div><div><h3>Conclusion</h3><div>Our findings suggest a negative relationship between exposure to VOCs, as measured by urine VOC metabolite levels, and obesity in adults.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"39 ","pages":"Article 200296"},"PeriodicalIF":1.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific association of blood triglyceride and uric acid with body shapes in Chinese adults","authors":"Xixiang Wang ,&nbsp;Jingjing Xu ,&nbsp;Yiyao Gu ,&nbsp;Jie Mu ,&nbsp;Shaobo Zhou ,&nbsp;Xiaojun Ma ,&nbsp;Lu Liu ,&nbsp;Yu Liu ,&nbsp;Zhi Duan ,&nbsp;Linhong Yuan ,&nbsp;Ying Wang","doi":"10.1016/j.hnm.2024.200297","DOIUrl":"10.1016/j.hnm.2024.200297","url":null,"abstract":"<div><h3>Background</h3><div>Abnormal metabolic syndrome, adipose distribution and different body shapes caused by obesity are associated with the levels of blood biochemical indexes. However, the sex-specific relationship between body shapes and blood biochemical indexes is poorly investigated.</div></div><div><h3>Research design and methods</h3><div>A cross-sectional study was conducted on 1828 subjects matched by age and sex. The scatter plot and restricted cubic spline were used to analyze the correlation between variables. Logistic regression was used to explore the relationship between body shapes and the risk of abnormal blood biochemical indexes level.</div></div><div><h3>Results</h3><div>Compared with the non-obesity group, the compound obesity group had a higher risk of abnormal Glu and TG levels independent of sex. Besides, the sex-specific association showed that the risk of abnormal TG levels was higher in males with peripheral obesity but in females with central obesity. Meanwhile, female subjects with peripheral obesity had a higher risk of abnormal UA levels.</div></div><div><h3>Conclusions</h3><div>This study showed that obese subjects had a higher risk of abnormal UA and TG compared to non-obese subjects, and there were sex differences in this relationship, suggesting that future studies exploring the relationship between body shapes and blood biochemical indexes also need to consider the potential role of sex.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"39 ","pages":"Article 200297"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving gut microbiome through diet rich in dietary fibre and polyphenols: The case for orange peels","authors":"Ayokunle Olubode Ademosun ,&nbsp;Olufunke Florence Ajeigbe ,&nbsp;Mary Tosin Ademosun ,&nbsp;Omodesola Oluwafisayo Ogunruku ,&nbsp;Ganiyu Oboh","doi":"10.1016/j.hnm.2024.200295","DOIUrl":"10.1016/j.hnm.2024.200295","url":null,"abstract":"<div><div>The search for cost-effective and innovative dietary fiber sources that promote probiotic growth and support healthy gut microbiota development has become increasingly important in food product innovation. The gut microbiota is crucial for various physiological functions, such as nutrient absorption, immune system enhancement, gut structural integrity, and detoxifying harmful substances. One effective way to foster a beneficial relationship with gut microbiota is through dietary choices, which significantly affect the microbiota's structure, composition, metabolism, and overall function. Notably, orange peels not only promote the growth of probiotic bacteria but also enable these beneficial microbes to convert the polyphenols in the peels into even more healthful forms. The combination of probiotics and orange peels can lead to the creation of synbiotics, which are functional foods aimed at improving human health. In contrast, the typical Western diet, high in refined sugars, trans fats, and sodium, negatively impacts gut health and the growth of beneficial gut microorganisms. To enhance gut microbiota health, there should be a focus on food products low in processed sugars, sodium, and unhealthy fats, while being high in dietary fiber and polyphenols. Orange peels are particularly notable for their high levels of dietary fiber and polyphenolic compounds, both of which can positively affect the growth of beneficial gut microorganisms.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"39 ","pages":"Article 200295"},"PeriodicalIF":1.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut health-promoting foods intake in Argentine adults: The impact of knowledge, socio-demographic factors, and clinical-nutritional health","authors":"Georgina Noel Marchiori ,&nbsp;Mayra Ainelén Loyola ,&nbsp;Clara Marián Levy Sánchez ,&nbsp;María Daniela Defagó ,&nbsp;María Georgina Oberto","doi":"10.1016/j.hnm.2024.200294","DOIUrl":"10.1016/j.hnm.2024.200294","url":null,"abstract":"<div><h3>Background</h3><div>The increasing acceptance of gut health-promoting foods emphasizes the need of understanding which factors influence their consumption. This study aimed to investigate the population's knowledge about probiotics, prebiotics, and fermented foods, and how this impacts their intake, considering socio-demographic factors and clinical-nutritional health.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted on 2128 Argentine adults aged 18-82 years-old. An online questionnaire was used to collect socio-demographic, clinical-nutrition and dietary data, as well as information about population's knowledge. Logistic regression models were used for analysis.</div></div><div><h3>Results</h3><div>Fermented foods and probiotic-rich yogurts were consumed occasionally, while prebiotic food intake was more frequent. Yogurt with L<em>.casei and bifidobacterium</em>, onions and olives were the most popular foods, while kefir was the most discontinued food. More than sixty percent participants answered &gt;50 % of knowledge-based questions correctly. However, a significant proportion of people were not aware of prebiotics’ definition and their dietary source. A suitable knowledge was associated with increased chances of consuming probiotic nutraceuticals and fermented foods. Female gender, age, being in a couple, recent antibiotic use, a history of medical conditions associated with higher probiotic nutraceuticals intake, and overweight were associated with a lower intake likelihood. A mixed diet showed opposite results on probiotic yogurts and fermented foods consumption.</div></div><div><h3>Conclusion</h3><div>Findings reveal a low frequency of gut health-promoting foods consumption, particularly sources rich in probiotics. Interventions aimed at increasing public awareness, as well as promoting a healthier diet and nutritional status, could be effective in boosting consumption of fermented foods and probiotics.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"39 ","pages":"Article 200294"},"PeriodicalIF":1.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allium cepa L. as a natural antioxidant: Its efficacy in combating heat stress-induced physiological alterations","authors":"Ayobami O. Sobanke ,&nbsp;Afusat Aiyeola ,&nbsp;Frances I. Okwuonu ,&nbsp;Wuraola S. Nnaemeka ,&nbsp;Jeremiah C. Ndubuisi ,&nbsp;Franklin I. Udeoji ,&nbsp;Jane N. Adiele","doi":"10.1016/j.hnm.2024.200293","DOIUrl":"10.1016/j.hnm.2024.200293","url":null,"abstract":"<div><div>Heat stress (HS) is a major physiological stressor that induces oxidative damage, inflammation, and metabolic disruptions, all of which cause harm to health. This study investigates the potential protective effects of <em>Allium cepa</em> L. (AC), against the physiological alterations brought on by HS. Twenty male rats were utilized in this study and divided into 4 groups: Control, HS, AC, and HS + AC. Rats were exposed to 38–39 °C for 2 h each day for three weeks to induce HS while 1.0 ml/100 g body weight of ethanolic extract of AC was administered orally for three weeks. Hematological parameters, inflammatory markers, and lipid profiles were analyzed using blood samples obtained through heart puncture.</div><div>The findings demonstrated that HS significantly lowered levels of hemoglobin (HB), red blood cell (RBC) counts, and antioxidant enzyme activity. However, there was a significant rise in the levels of inflammatory markers, platelet counts, LDL-c triglyceride (TG), total cholesterol (TC), and white blood cell (WBC). Many of these alterations were reversed by AC supplementation, by increasing RBC counts, HB levels, and antioxidant enzyme activities while decreasing LDL-c, TG and TC, MDA, and TNF-α (tumor necrosis factor-α). However, the positive benefits of AC were partially diminished in the HS + AC group, perhaps due to the severe oxidative stress caused by heat stress (HS).</div><div>This study highlights the probable potential of AC as a natural antioxidant in modifying heat stress-induced oxidative damage, hematological changes, and lipid metabolism disruptions; however, its protective effects are insufficient to mitigate heat stress. Therefore, further research is required to explore the other possible underlying mechanisms.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"39 ","pages":"Article 200293"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Almond snacking modestly improves diet quality and waist circumference but not psychosocial assessments and other cardiometabolic markers in overweight, middle-aged adults: A randomized, crossover trial","authors":"Vernon Uganiza Rayo ,&nbsp;Lauren Okamoto ,&nbsp;Maricarmen Cervantes ,&nbsp;Mee Young Hong ,&nbsp;Nathaniel Jason ,&nbsp;Mark Kern ,&nbsp;Changqi Liu ,&nbsp;Elise North ,&nbsp;Svitlana Storm ,&nbsp;Oliver C. Witard ,&nbsp;Shirin Hooshmand","doi":"10.1016/j.hnm.2024.200291","DOIUrl":"10.1016/j.hnm.2024.200291","url":null,"abstract":"<div><div>Almonds are a plant-based source of lipids, proteins, fibers, micronutrients, and phytochemicals associated with cardiometabolic health benefits. We examined blood glucose homeostasis, lipid profile, anthropometrics, blood pressure, food cravings, and mood both pre- and post-feeding, using a randomized, crossover design with 26 healthy adults (37±6 y) consuming either ALMOND (57 g/d) or an isocaloric amount of pretzels (CONTROL) for 8 weeks. Almond supplementation was expected to improve all primary outcomes when compared to CONTROL. ALMOND improved diet quality through increased intakes of monounsaturated fat (Δ+58 %), polyunsaturated fat (Δ+24 %), α-tocopherol (Δ+133 %), β-tocopherol (Δ+33 %), and magnesium (Δ+30 %) relative to CONTROL (Interaction: all p &lt; 0.05). Copper intake increased (Δ+27 %) and sodium decreased (Δ-20 %) during ALMOND (Time: all p &lt; 0.05). A reduction in waist circumference (Δ-1.1 cm) and decrease in carbohydrate intake (Δ-20 %) was observed during ALMOND <em>vs.</em> CONTROL (Trial: all p &lt; 0.05). Insulin sensitivity decreased during CONTROL (Time: p &lt; 0.05) but remained constant during ALMOND. Frequency of food cravings over the last 7 days of experimentation increased during ALMOND <em>vs</em>. CONTROL (Interaction: all p &lt; 0.05). No differences in blood lipid profile, physical activity, and assessments of mood were observed between trials (all p &gt; 0.05). This study demonstrates that a 57 g/d serving of almonds modestly improves diet quality and waist circumference. However, almond supplementation elicited no clinically significant benefits on lipid profile, blood pressure, physical activity, and assessments of cravings and mood. Future mechanistic studies are warranted to understand the effect of almond supplementation on cardiometabolic health in various populations. <em>ClinicalTrials.gov Identifier</em>: NCT04787718.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"39 ","pages":"Article 200291"},"PeriodicalIF":1.9,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}