Medicine in Microecology最新文献

{"title":"Insights of probiotics as an alternative medicine for cancer therapy, mechanism, and applications","authors":"Sourik Mukherjee ,&nbsp;Dharmender Kumar ,&nbsp;Dipanjan Guha","doi":"10.1016/j.medmic.2024.100111","DOIUrl":"10.1016/j.medmic.2024.100111","url":null,"abstract":"<div><p>Probiotics are microbes associated with a wide range of health benefits and modulate gut flora by releasing effector molecules. The efficacy of probiotics at various stages of cancer treatment has been well demonstrated. Probiotics can increase the potency of cancer-based immunotherapy, which can be administered before, during, or post-phase therapy. The consumption of probiotics among cancer patients can minimize the detrimental effects of chemotherapy and act as a potential tool for cancer therapy. Genetically engineered probiotics can express specific antigens that can combat cancer and deadly pathogens. These essential features of probiotics can be utilized in cancer treatment and for other applications. This review aims to provide updated information on the mechanism of action of probiotics and their applications in cancer therapy. Moreover, a few other significant applications like; antioxidative therapy, biotechnology-based improvement, and developing potent probiotic strains for effective cancer treatment are also discussed.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"22 ","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590097824000144/pdfft?md5=f9fc7a627134acd6897308d4ea1d87b1&pid=1-s2.0-S2590097824000144-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epsilon-poly-l-lysine inhibits biofilm formation and aids dispersion in Acinetobacter baumannii","authors":"Ujjayni Saha ,&nbsp;Sakshi Shinde ,&nbsp;Savita Jadhav ,&nbsp;Sunil D. Saroj","doi":"10.1016/j.medmic.2024.100110","DOIUrl":"10.1016/j.medmic.2024.100110","url":null,"abstract":"<div><p><em>Acinetobacter baumannii</em> is a prominent hospital-associated bacterium whose eradication is increasingly challenging due to its remarkable ability to resist antibiotics. The most common illnesses caused by antibiotic-resistant <em>A. baumannii</em> are biofilm-associated. Therefore, novel methods to combat <em>A. baumannii</em> are urgently needed. Application of antimicrobial peptides (AMPs) is one of the avenues to be explored. Epsilon poly-<span>l</span>-lysine (ε-PL) is an antimicrobial peptide with low mammalian toxicity. It is commonly used as a food preservative and has advantages such as biodegradability, good water solubility, and thermal stability.</p><p>Therefore, the antimicrobial activity of ε-PL against clinical isolates of <em>A. baumannii</em> was investigated. The effect of ε-PL on antimicrobial sensitivity was determined by broth dilution assay. The effect of ε-PL on biofilm formation and dispersion was studied using a crystal violet assay. The changes in the expression of quorum sensing related and virulence genes (<em>aba</em>I<em>, csu</em>E<em>, pil</em>T<em>, bap,</em> and <em>lux</em>I) were analyzed using qPCR by the Δ Δ CT method.</p><p>All the <em>A. baumannii</em> clinical isolates (n = 28) tested, were resistant to multiple drugs. The treatment with ε-PL resulted in a significant (p &lt; 0.05) reduction in the biofilm formation abilities of all the clinical isolates of <em>A. baumannii</em>. Also, ε-PL caused a significant (p &lt; 0.05) decrease in the dispersion of preformed biofilms. The reduction in the biofilm formation could be attributed to the inhibition of autoinducer synthase (<em>aba</em>I) which is required for biofilm development in <em>A. baumannii.</em> Also, it could be due to altering of expression of biofilm-related genes like <em>csu</em>E<em>, pil</em>T<em>, bap,</em> and <em>lux</em>I<em>.</em> These results suggest that ε-PL could be effective in the elimination of <em>A. baumannii</em> biofilms and decreasing its virulence.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"21 ","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590097824000132/pdfft?md5=ab0c3e88cafd5cef938210a1ce2873b9&pid=1-s2.0-S2590097824000132-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allicin and Probiotics: Double-edged sword for the management of Striae distensae","authors":"Reena Gupta ,&nbsp;Bhupinder Kapoor ,&nbsp;Ritam Bandopadhyay ,&nbsp;Monica Gulati ,&nbsp;Pooja Rani ,&nbsp;Rajpal Singh Kochhar","doi":"10.1016/j.medmic.2024.100109","DOIUrl":"10.1016/j.medmic.2024.100109","url":null,"abstract":"<div><p>Striae distensae (SD), commonly known as Stretch marks or striae, are one of the most common benign dermal lesions frequently seen in females that often cause a significant physical and psychological impact. A number of treatment modalities ranging from topicals to invasive approaches are commercially available, however, none of the available options is capable of complete eradication of SD. As effectiveness of most of the available topical formulations for SD is attributed to the combined effects of their antioxidant, anti-inflammatory and proliferative effects, allicin and probiotic based topical formulations are hypothesized to be effective in treatment and prevention of SD. Both allicin and probiotics are able to reduce the inflammatory response via suppression of transcription factor i.e., nuclear factor (NF)-<strong><em>κ</em></strong>B, and pro-inflammatory cytokines and chemokines levels. Moreover, the antioxidant effect of allicin and probiotics is considered to decrease the reactive oxygen species induced fragmentation of collagen. Also, the effects of allicin on the collagen and elastin tissue as well as beneficial effects of probiotics and their metabolites on skin elasticity and skin hydration are expected to provide multiple target approach for the management of SD. Altogether, a combination formulation containing both allicin and probiotics is considered to be novel approach for the prevention and management of SD.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"21 ","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590097824000120/pdfft?md5=dcd9d0d4eb790aa390f998e3a1cd53fe&pid=1-s2.0-S2590097824000120-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial consortia-The latest arsenal to inflammatory bowel disease bacteriotherapy","authors":"Mukta Gupta ,&nbsp;Bhupinder Kapoor ,&nbsp;Monica Gulati","doi":"10.1016/j.medmic.2024.100107","DOIUrl":"https://doi.org/10.1016/j.medmic.2024.100107","url":null,"abstract":"<div><p>The microbiota based dietary interventions have emerged as an unconventional bacteriotherapeutic approach for the treatment of a plethora of pathological conditions including inflammatory bowel disease. The potential side effects associated with the use of probiotics include systemic infections, deleterious metabolic activities, excessive immune stimulation in susceptible individuals and gene transfer. Moreover, probiotic strains are not very specific in offering health benefits and it is generally considered that a group of such bacteria are more effective than a single strain. Based on this assumption, fecal matter transplantation was proposed as a better alternative. Despite proving to be very effective in certain diseases, fecal microbiota transplantation has not found wide acceptability because of its poor aesthetic appeal, associated risk for infection transmission, and challenges in standardization and regulation policies. Bacterial consortia, however, emerge as multi-strain, more specific biotherapeutic agents with known composition of probiotics that are free from any risk for infections or uncertain metabolic processes. These are a group of complex microbial communities having ecological interactions among themselves. While offering therapeutic profile similar to fecal matter transplantation, bacterial consortia are free from the associated side effects. Bacterial consortia have demonstrated significant effectiveness in treatment of irritable bowel syndrome. Inflammatory bowel disease represents multifactorial inflammatory ailments comprising of both ulcerative colitis and Crohn's disease. It is generally attributed to disturbance in immunological and environmental factors while genetic factors are also known to play their role. Among all of the above, changes in gut microbiota (dysbiosis) is the main causative agent in etiology of inflammatory bowel disease. Therefore, changing the composition of microbiota through bacterial consortium offers a realistic option for treatment of inflammatory bowel disease. In this review, we decipher the relationship between dysbiosis and pathogenesis of inflammatory bowel disease. We also discuss various challenges regarding the use of bacterial consortia as inflammatory bowel disease therapy. Diving deeper, the pre-clinical and clinical studies conducted hitherto are also described. The potential and limitations of this emerging biotherapeutic approach are also discussed. Considering the worldwide prevalence of inflammatory bowel disease and constant struggle to find a safe, economical and convenient cure for it, bacterial consortia could be an attractive strategy.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"20 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590097824000107/pdfft?md5=5911caab9ed6b6658b19b760a6408bb4&pid=1-s2.0-S2590097824000107-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140604700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotics and the gut microbiome: Understanding the impact on human health","authors":"Rahul Harikumar Lathakumari,&nbsp;Leela Kakithakara Vajravelu,&nbsp;Abhishek Satheesan,&nbsp;Sujith Ravi,&nbsp;Jayaprakash Thulukanam","doi":"10.1016/j.medmic.2024.100106","DOIUrl":"https://doi.org/10.1016/j.medmic.2024.100106","url":null,"abstract":"<div><p>Antibiotic use has become problematic because it unintentionally upsets the delicate equilibrium of the human gut microbiota. Antibiotics, especially broad-spectrum ones, that were once regarded as life-saving treatments for bacterial infections instead indiscriminately destroy the good bacteria that are essential for preserving gut health in addition to their target pathogens. Antibiotic-induced gut dysbiosis, the term for this disturbance, sets off a series of adverse reactions that negatively impact the gut microbiome, resulting in a decline in microbial diversity and the creation of an environment that is favourable to the establishment of strains that are resistant to antibiotics. Antibiotic exposure has wide-ranging effects from prenatal to adulthood; research has shown long-term effects include increased risk of antibiotic resistance, obesity, allergies, asthma, and altered metabolic processes. This thorough investigation emphasises the critical need for a more sophisticated knowledge of the effects of antibiotic therapy on the gut microbiota and the necessity of implementing all-encompassing solutions that reduce its detrimental effects and protect human health throughout life.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"20 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590097824000090/pdfft?md5=76f746b93b356dd6230aa05c1357fa72&pid=1-s2.0-S2590097824000090-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying therapeutic effect of kombucha Pirdot (Saurauia vulcani Korth.) against colorectal cancer: The experimental data and in silico approach","authors":"Erlintan Sinaga ,&nbsp;Uswatun Hasanah ,&nbsp;Feimmy Ruth Pratiwi Sipahutar ,&nbsp;Murniaty Simorangkir ,&nbsp;Melati Nugrahalia Sipahutar","doi":"10.1016/j.medmic.2024.100105","DOIUrl":"https://doi.org/10.1016/j.medmic.2024.100105","url":null,"abstract":"<div><p>This study pioneers the evaluation of Kombucha Pirdot (KP) in combating colorectal cancer through combined in vivo and in silico methods. It involved categorizing rats into four groups (n = 6) consisting of the control, benzo(<em>a</em>)pyrene (B[<em>a</em>]P) treated, KP group, and a combination therapy for 30 days. The research focused on the interaction of <em>S.vulcani</em> and (B[<em>a</em>]P) compounds with colorectal signaling, using protein-protein interaction networks, molecular docking and dynamic simulation to assess compound affinity with target proteins. Furthermore, the epitope of colorectal cancer was aligned with the kombucha microorganism to explore the cross-reactivity. The experimental data demonstrated that B[<em>a</em>]P impaired colon histoarchitecture and elevated interleukin1β, whereas KP countered these effects. The study pinpointed key proteins and notable S. vulcani compounds linked to colorectal cancer. Moreover, six epitope candidates of colorectal cancer were obtained which have an identity of 65%–95 % for query coverage with <em>Lactiplantibacillus plantarum</em> and <em>Saccharomyces cerevisiae</em> that bind and fluctuate stability to core regions of HLA- A*0101 and HLA-DRB1*0101. Overall, the results underscore KP's potential as a viable option in developing colorectal cancer treatments.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"20 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590097824000089/pdfft?md5=db1a1cd437eeb2c6524ce26e8f4828be&pid=1-s2.0-S2590097824000089-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota nexus: Exploring the interactions with the brain, heart, lungs, and skin axes and their effects on health","authors":"Pallab Chakraborty ,&nbsp;Debolina Banerjee ,&nbsp;Paramita Majumder ,&nbsp;Joy Sarkar","doi":"10.1016/j.medmic.2024.100104","DOIUrl":"10.1016/j.medmic.2024.100104","url":null,"abstract":"<div><p>It is becoming widely understood that gut microbiota and human health are related. It is now well-accepted that healthy gut flora plays a significant role in the host's overall health. The gut flora is a diverse and dynamic collection of microorganisms in the human gastrointestinal (GI) tract, significantly impacting the host during homeostasis and disease. This microbial community's diversity is host-specific and changes throughout an individual's lifespan. The gut flora controls several metabolic pathways in the host, leading to interacting host-microbiota metabolic, signalling and immune-inflammatory axes that physiologically link the gut with the brain, heart, lung and skin. Numerous inflammatory illnesses and infections have been connected to altered gut bacterial composition or dysbiosis. Optimising therapeutic and probiotic approaches to control the gut microbiota to treat disease and promote health requires a deeper understanding of these axes. This review confers our current understanding of the connections between gut flora with the brain, heart, lungs, and skin and also portrays the diseases correlated with these axes.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"20 ","pages":"Article 100104"},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590097824000077/pdfft?md5=9f6103c6bfc1383a267d0d61f5dd849c&pid=1-s2.0-S2590097824000077-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140269002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subunit 76-kDa surface protein of Methicillin-Resistant Staphylococcus aureus (MRSA) is potentially useful for MRSA diagnostic tool","authors":"Zulvikar Syambani Ulhaq ,&nbsp;Lola Ayu Istifiani ,&nbsp;Syafrizal Aji Pamungkas ,&nbsp;Dewi Santosanigsih","doi":"10.1016/j.medmic.2024.100103","DOIUrl":"https://doi.org/10.1016/j.medmic.2024.100103","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the diagnostic performance of the polyclonal antibody generated from the subunit surface protein of MRSA for MRSA detection.</p></div><div><h3>Methods</h3><p>The MRSA clinical isolates were identified by the cefoxitin disc diffusion test and confirmed by <em>mecA</em> PCR. The surface protein from the clinical isolates of MRSA was extracted and characterized with hemagglutination and adherence inhibition assays. Polyclonal antibody against the selected protein was produced in mice and then used for Western blot experiments.</p></div><div><h3>Results</h3><p>Four conserved surface protein bands (63, 76, 88, and 114-kDa) were found in each MRSA clinical isolate. Hemagglutination reaction was demonstrated by the subunit 76 and 114-kDa surface protein of MRSA at 1:32 dilution. Such proteins were identified as adhesive molecules in the enterocytes. The sensitivity and specificity of the polyclonal 76-kDa antibody in detecting MRSA were 94.59% and 85.14%, respectively, with the Kappa values fall under the interpretation of substantial agreement (0.752) with the gold standard, suggesting it is useful for MRSA detection.</p></div><div><h3>Conclusion</h3><p>Subunit 76 and 114-kDa surface proteins of MRSA exhibit adhesive properties in mediating MRSA infection. The polyclonal antibody of 76-kDa generated from the surface protein of MRSA could be used as an alternative for the identification of clinical isolates suspected with MRSA infection.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"20 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590097824000065/pdfft?md5=57a42c8730f596f04d5f974a040048e1&pid=1-s2.0-S2590097824000065-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140135087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marburg virus is nature's wake-up call: A bird's-eye view","authors":"Sanjit Boora ,&nbsp;Sulochana Kaushik ,&nbsp;Jaya Parkash Yadav ,&nbsp;Samander Kaushik ,&nbsp;Dharmender Kumar","doi":"10.1016/j.medmic.2024.100102","DOIUrl":"https://doi.org/10.1016/j.medmic.2024.100102","url":null,"abstract":"<div><p>Marburg virus (MARV), a member of Filoviridae family, is notorious for causing Marburg virus disease (MVD), one of the deadliest known infectious diseases. Over the past five decades, more than 15 MVD outbreaks have been reported in the African countries, and this has been reported from Equatorial Guinea on February 2023. Few bat species like <em>Rousettus aegyptiacus</em> and <em>Hipposideros caffer</em>, among other members of the <em>Chiroptera</em> order, may serve as a natural reservoir for the virus, which can transmit the disease to humans and other mammals. In humans, severe infections have been reported due to MVD and are characterized by clinical symptoms such as abdominal pain, nausea, vomiting, pharyngitis, and diarrhea, eventually progressing to hemorrhagic manifestations. The disease carries an extremely high mortality and morbidity rate. Developing and implementing rapid, accurate, affordable, and efficient diagnostic and therapeutic measures is essential to address the substantial threat MARV poses. Increased focus on health education, enhancement of laboratory services and facilities, adherence to patient safety protocols, and robust surveillance systems are urgently needed to combat this fatal disease. This review aims to present a comprehensive summary of the various attributes and characteristics of MARV/MVD, along with strategies for its prevention and control. Further, this review article also discusses the potential role of medicinal plants in addressing health challenge.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"20 ","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590097824000053/pdfft?md5=2c71cdbae491266129b050b939bbab9d&pid=1-s2.0-S2590097824000053-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140042056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of human microbiota in the development of colorectal cancer: A literature review","authors":"Ariana Torres-Galarza ,&nbsp;Zorayda Toledo ,&nbsp;Natalia Bailón-Moscoso","doi":"10.1016/j.medmic.2024.100100","DOIUrl":"10.1016/j.medmic.2024.100100","url":null,"abstract":"<div><p>Colorectal carcinoma is the third most common neoplasm with the highest incidence and most second mortality in the world, being, for the most part, considered a multifactorial disease. Recent studies have shown a possible interaction with the intestinal microbiota as a factor for the development of cancer based on the tumour microenvironment. In this work we aim to perform a research of existing body of literature related to the link between the microbiome and cancer. Here, it discusses dysbiosis data found in humans, as well as genotoxicity studies and/o pro-carcinogenic mechanisms including <em>Fusobacterium nucleatum</em>, <em>Bacteroides fragilis</em>, <em>Parvimonas micra</em>, <em>Porphyromonas</em> and <em>Escherichia coli</em> pks+. In addition, the use of specific bacteria as diagnostic markers and carcinoma stage, host genetics as a conditioning factor, as well as the manipulation of the microbiota employing natural products and probiotics can have benefits in the response to treatments in patients with colorectal cancer.</p></div>","PeriodicalId":36019,"journal":{"name":"Medicine in Microecology","volume":"20 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2024-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259009782400003X/pdfft?md5=35fe9bc9435275ded656e1aed917d3bd&pid=1-s2.0-S259009782400003X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139892518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}