Clinical and Experimental Pediatrics最新文献_第5页

Differences in immune cells and gene expression in human milk by parity on integrated scRNA sequencing. 根据综合 scRNA 测序的奇偶性分析人乳中免疫细胞和基因表达的差异。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2025-02-01 Epub Date: 2025-01-10 DOI: 10.3345/cep.2024.01585

Dae Yong Yi, Hong-Jai Park, Min Sun Shin, Hyoungsu Kim, Sang Jin Lee, Insoo Kang

{"title":"Differences in immune cells and gene expression in human milk by parity on integrated scRNA sequencing.","authors":"Dae Yong Yi, Hong-Jai Park, Min Sun Shin, Hyoungsu Kim, Sang Jin Lee, Insoo Kang","doi":"10.3345/cep.2024.01585","DOIUrl":"10.3345/cep.2024.01585","url":null,"abstract":"Background: Human breast milk (HBM) is an important source of tolerogenic immune mediators that influence the infant immune system. HBM-derived immune components are affected by various factors; however, few studies have examined the relationship between parity and immune cell profiles of HBM.Purpose: This study aimed to clarify the effects of parity on HBM immune cell heterogeneity and gene expression by integrating and analyzing publicly available single-cell RNAsequencing (scRNA-seq) datasets.Methods: We clarified the effects of parity on HBM immune cell heterogeneity and gene expression by integrating and analyzing publicly available scRNA-seq datasets.Results: The proportion of innate immune cells was significantly higher in the primiparous versus multiparous group, whereas the proportion of adaptive immune cells was significantly higher in the multiparous group (P=0.021). The 2 immune clusters were reannotated and classified into monocyte, T/B cell, and CD45¯ groups. The proportions of monocytes and T/B cells were higher in the primiparous and multiparous groups, respectively. In a gene set enrichment analysis of monocytes, genes with a direct role in the infant immune system and immune response-related genes were more highly expressed in the primiparous group.Conclusion: Our results support the parity-dependent differences in gene expression between innate and adaptive immune cells.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"141-152"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of pediatric migraine triggers: a single-center study. 评估小儿偏头痛诱因：一项单中心研究。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-11 DOI: 10.3345/cep.2024.00738

Hey-Joon Son, Joo-Ok Jin, Kon-Hee Lee

{"title":"Evaluation of pediatric migraine triggers: a single-center study.","authors":"Hey-Joon Son, Joo-Ok Jin, Kon-Hee Lee","doi":"10.3345/cep.2024.00738","DOIUrl":"10.3345/cep.2024.00738","url":null,"abstract":"Background: Pediatric migraines are primarily treated with medications. However, recognizing the triggers related to patient behaviors and lifestyle is also important.Purpose: This study aimed to evaluate the factors that trigger pediatric migraines.Methods: This study included 102 pediatric patients with migraine diagnosed using the third edition of the International Classification of Headache Disorders who visited our pediatric headache clinic between November 2021 and October 2022. We reviewed the patients' clinical features, imaging studies, screening tests for behaviors and emotions, and questionnaires regarding triggers. Statistical analyses were performed using the independent sample Student t test and linear-by-linear association test.Results: The 102 patients (44 males, 58 females; mean age, 12.0±2.9 years) were classified into migraine without aura (n=58) and migraine with aura (n=44) groups. Sleep disturbances were the most frequent trigger (76.5%). Other triggers included academic stress (66.7%), motion sickness (62.7%), and fatigue (52.9%). Academic stress was the most significant trigger for pain severity in 44.1% of patients. Abnormal behavioral or psychiatric assessment results were associated with a higher number of triggers.Conclusion: This study identified sleep disturbance and academic stress as common triggers of pediatric migraine, with academic stress being the most intense. Clinicians should understand these triggers and advise patients to avoid them by changing their lifestyles, if possible.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"163-169"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of high-frequency oscillatory ventilation with intermittent sigh breaths on carbon dioxide levels in neonates. 间歇叹气的高频振荡通气对新生儿二氧化碳水平的影响。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-13 DOI: 10.3345/cep.2024.01011

Kulthida Baingam, Anucha Thatrimontrichai, Manapat Praditaukrit, Gunlawadee Maneenil, Supaporn Dissaneevate

{"title":"Effect of high-frequency oscillatory ventilation with intermittent sigh breaths on carbon dioxide levels in neonates.","authors":"Kulthida Baingam, Anucha Thatrimontrichai, Manapat Praditaukrit, Gunlawadee Maneenil, Supaporn Dissaneevate","doi":"10.3345/cep.2024.01011","DOIUrl":"10.3345/cep.2024.01011","url":null,"abstract":"Background: High-frequency oscillatory ventilation (HFOV) minimizes ventilator-induced lung injuries. Spontaneous sigh breathing may augment the functional residual capacity, increase lung compliance, and recruit atelectatic alveoli.Purpose: To evaluate the difference in the partial pressure of carbon dioxide (PaCO2) in neonates receiving invasive HFOV as the primary mode of respiratory support before versus after sigh breaths (Sighs).Methods: This prospective study was conducted between January and December 2023. Intubated preterm and term neonates who underwent HFOV with an available arterial line were enrolled in this study after informed parental consent was obtained. Sighs were set at a frequency of 3 breaths/min and pressure of 5 cmH2O above the mean airway pressure for 2 hours. Arterial blood gas was collected before and after Sighs and analyzed using 2 dependent tests.Results: Thirty neonates with a mean gestational age of 33.6±4.1 weeks and median date of intervention of 1.88 days (interquartile range, 0.87-3.79 days) were enrolled. The mean PaCO2 level was significantly lower in the HFOV with Sighs group (45.2±6.6 mmHg) versus the HFOV alone group (48.8±3.1 mmHg) with a mean difference (MD) of -3.6 mmHg (95% confidence interval [CI], -6.3 to -0.9; P=0.01). Subgroup analyses indicated the ability of Sighs to reduce the PaCO2 level in neonates with respiratory distress syndrome (n=15; MD [95% CI]=-4.2 [-8.2 to -0.2] mmHg; P= 0.04).Conclusion: Sighing can reduce PaCO2 levels in neonates ventilated with HFOV, particularly those with respiratory distress syndrome.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"178-184"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of temper tantrums in 1-6-year-old children and impact on caregivers. 1-6 岁儿童发脾气的特点及对照顾者的影响。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-13 DOI: 10.3345/cep.2024.00766

Warangkana Prutipaisan, Issarapa Chunsuwan, Tippawan Hansakunachai, Paskorn Sritipsukho

{"title":"Characteristics of temper tantrums in 1-6-year-old children and impact on caregivers.","authors":"Warangkana Prutipaisan, Issarapa Chunsuwan, Tippawan Hansakunachai, Paskorn Sritipsukho","doi":"10.3345/cep.2024.00766","DOIUrl":"10.3345/cep.2024.00766","url":null,"abstract":"Background: Temper tantrums are common behavioral difficulties in children. Although they are generally considered a normal part of development, certain characteristics- such as aggression, prolonged duration, and frequent occurrences-have been linked to psychological issues and can negatively impact both the child and their caregivers.Purpose: To study the prevalence and characteristics of temper tantrums in children aged 1-6 years at daycare and in kindergarten in Thailand as well as the impact of problematic and nonproblematic tantrums on their caregivers' emotional well-being.Methods: This cross-sectional descriptive study was conducted in 2021. The main caregivers of the participants completed self-reported questionnaires that collected their demographic information and the temper tantrum characteristics and impacts on the caregivers' emotions.Results: Data from 211 children were included in this study. The mean child age was 4.4±1.2 years. Two hundred one parents (95.3%) reported that their children had at least one tantrum behavior, of which verbal were the most common (94.5%). One hundred and 11 children (55.2%) had tantrums defined as problematic: exhibiting aggressive physical behavior, duration >15 minutes, frequency >3 days/ wk. The mean emotional burden scores of the children's problematic and nonproblematic temper tantrums on their parents were 23.3±8.4 and 17.7±8.3 (maximum, 55; P=0.001), respectively, showing a statistically significant difference.Conclusion: Tantrums are common in children aged 1-6 years, but their expression varies. Problematic tantrums were reported for approximately half of the children and significantly impacted their caregivers' emotions. Therefore, children with problematic tantrums and their families should receive assistance.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"170-177"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Value of transabdominal ultrasonography for diagnosing functional constipation in children: a systematic review and meta-analysis. 经腹超声波检查诊断儿童功能性便秘的价值：系统回顾和荟萃分析。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-13 DOI: 10.3345/cep.2024.00927

Duc Long Tran, Phu Nguyen Trong Tran, Paweena Susantitaphong, Phichayut Phinyo, Palittiya Sintusek

{"title":"Value of transabdominal ultrasonography for diagnosing functional constipation in children: a systematic review and meta-analysis.","authors":"Duc Long Tran, Phu Nguyen Trong Tran, Paweena Susantitaphong, Phichayut Phinyo, Palittiya Sintusek","doi":"10.3345/cep.2024.00927","DOIUrl":"10.3345/cep.2024.00927","url":null,"abstract":"Transabdominal ultrasonography is increasingly used as a novel modality for detecting pediatric functional constipation (FC). This systematic review and metaanalysis aimed to assess the diagnostic parameters of FC including rectal diameter (RD) and anterior rectal wall thickness. A systematic search was conducted of the Ovid MEDLINE, Embase, Scopus, and PubMed databases through September 29, 2023, to identify studies comparing RD and anterior wall thickness using transabdominal ultrasonography in children with versus without FC. Metaanalyses were performed using random-effects models to calculate the weighted mean differences (MDs) in RD and anterior wall thickness. Comprehensive Meta-Analysis ver. 3, R, and Review Manager ver. 5.4.1 software were used to assess the optimal cutoff, sensitivity, specificity, and area under the curve (AUC). Fourteen studies involving 1,255 children (mean age, 6.21±2.3 years) were included. The mean RD was significantly larger in constipated children versus controls (MD, 10.35 mm; 95% confidence interval [CI], 6.97-13.74; P<0.001; I2=94%). A meta-regression showed no significant effects of age, weight, or height on RD. An optimal RD cutoff point of 31 mm was suggested by a pooled analysis with an AUC of 0.86 (95% CI, 0.8-0.91; P<0.001), sensitivity of 0.75 (95% CI, 0.59-0.86), and specificity of 0.84 (95% CI, 0.68-0.93). The mean anterior rectal wall thickness was greater among constipated children than among controls (MD, 0.44; 95% CI, -0.26 to 1.13; P=0.22), but this difference was not statistically significant. RD measured using transabdominal ultrasonography with a cutoff point of 31 mm exhibited good diagnostic accuracy for diagnosing FC in children.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"127-135"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absolute versus functional iron deficiency. 绝对缺铁与功能性缺铁

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-13 DOI: 10.3345/cep.2023.01732

Hye Lim Jung

引用次数: 0

Screen time and neurodevelopment in preschoolers: addressing a growing concern in pediatric practice. 学龄前儿童的屏幕时间和神经发育：解决儿科实践中日益关注的问题。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2025-01-13 DOI: 10.3345/cep.2024.01536

Soongang Park, Hyewon Woo

引用次数: 0

Peripheral nerve sheath tumors in the head and neck in patients with APC gene deletion mutations: a case report and scoping review of the literature. APC基因缺失突变患者的头颈部周围神经鞘瘤：病例报告和文献综述。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2025-01-13 DOI: 10.3345/cep.2024.01375

Koral Blunt, Monirah Albathi, Miriam Conces, Tendy Chiang

{"title":"Peripheral nerve sheath tumors in the head and neck in patients with APC gene deletion mutations: a case report and scoping review of the literature.","authors":"Koral Blunt, Monirah Albathi, Miriam Conces, Tendy Chiang","doi":"10.3345/cep.2024.01375","DOIUrl":"10.3345/cep.2024.01375","url":null,"abstract":"Adenomatous Polyposis Coli (APC) is a tumor suppressor gene expressed throughout the body. APC mutations increase the risk of malignancy and are often characterized by syndromes that encompass a spectrum of neoplastic manifestations, such as familial adenomatous polyposis (FAP). We present a rare case of palatal peripheral nerve sheath tumor in the context of APC gene mutation. A 17-year-old male with a significant history of FAP presented to our clinic for with globus sensation for 5 months with increasing discomfort. Flexible nasolaryngoscopy revealed a pedunculated lesion attached to the posterior surface of the soft palate. Imaging was obtained and confirmed a soft tissue homogenous mass contiguous with the soft palate. Endoscopic-assisted transoral resection was performed and pathologic features were consistent with schwannoma. We also discuss the spectrum of benign neoplastic lesions. Current literature fails to describe pharyngeal masses in the setting of APC gene mutations. The purpose of this case report is to describe a patient presentation of a symptomatic pharyngeal tumor with a known APC gene mutation and explore the differential diagnoses that must be considered.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiety disorders presenting as gastrointestinal symptoms in children - a scoping review. 儿童表现为胃肠道症状的焦虑症——范围综述

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2025-01-13 DOI: 10.3345/cep.2024.01732

Anjali Kumar, Pramodh Vallabhaneni

{"title":"Anxiety disorders presenting as gastrointestinal symptoms in children - a scoping review.","authors":"Anjali Kumar, Pramodh Vallabhaneni","doi":"10.3345/cep.2024.01732","DOIUrl":"https://doi.org/10.3345/cep.2024.01732","url":null,"abstract":"Functional gastrointestinal disorders (FGID) and their association with anxiety disorders in children significantly impact a child's functioning and treatment response. This study aimed to scope the evidence of anxiety disorders manifesting as FGID in children up to 16 years old. A comprehensive search strategy was conducted on Embase (1974-2024), Medline (via EBSCOHost 1946-2024), and APA PsycINFO (via EBSCOHost 1967-2024). Articles were retrieved, screened, and assessed for bias using the GRADE system. Our initial search yielded 1984 articles. After screening titles and abstracts, 53 articles remained. Full-text screening further narrowed this to four eligible studies. The first study found that anxiety indirectly influenced abdominal pain severity in children with irritable bowel syndrome (IBS). The second study reported an association between anxiety and abdominal pain but found that anxiety might not predict abdominal pain in later childhood. The third study suggested FGID could be a risk factor for anxiety, with higher anxiety rates in children with FGID compared to those without. The fourth study found no significant difference in pain intensity between children with functional abdominal pain disorders (FAPD) alone and those with FAPD and anxiety. The reviewed studies indicate a relationship between anxiety and FGID but lack clarity on directionality or causation. The limited number of studies calls for more research, including case-control studies with large sample sizes and longitudinal cohort studies to investigate the incidence and causation.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic role of midregional proadrenomedullin in predicting infection in pediatric cancer with febrile neutropenia. 中部肾上腺髓质素在预测儿童癌症伴发热性中性粒细胞减少感染中的预后作用。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2025-01-13 DOI: 10.3345/cep.2024.01620

Seham Ragab, Sara El-Deeb, Ahmed Saeed, Asmaa Mahmoud

{"title":"Prognostic role of midregional proadrenomedullin in predicting infection in pediatric cancer with febrile neutropenia.","authors":"Seham Ragab, Sara El-Deeb, Ahmed Saeed, Asmaa Mahmoud","doi":"10.3345/cep.2024.01620","DOIUrl":"https://doi.org/10.3345/cep.2024.01620","url":null,"abstract":"Background: Febrile neutropenia (FN) remains an important complication of cytotoxic chemotherapy for which an urgent and appropriate evaluation is imperative.Purpose: To assess the diagnostic and prognostic roles of mid-regional pro-adrenomedullin (MR-ProADM) levels in predicting infection in patients with FN.Methods: This comparative cross-sectional study included 137 patients with chemotherapy-induced FN. Complete blood count, C-reactive protein (CRP), procalcitonin, and MR-ProADM were evaluated on the 1st day of FN. Chest computed tomography (CT) was performed on the 5th day.Results: MR-ProADM levels were significantly higher in patients with FN than in controls. CRP and MR-ProADM levels were significantly higher and ANC was significantly lower in patients with versus without bacterial infections. CRP, procalcitonin, and MR-ProADM levels were significantly negatively correlated with absolute neutrophil count (ANC). CRP, procalcitonin, and MR-ProADM levels were significantly and positively correlated with FN degree, FN duration, and hospital stay length. A multivariate regression analysis showed that a longer FN duration and hospital stay length, along with elevated CRP, procalcitonin, and MR-ProADM levels, were significant risk factors for mortality.Conclusion: MR-ProADM is a reliable prognostic and diagnostic tool for predicting infection in patients with FN.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0