Clinical and Experimental Pediatrics最新文献_第5页

Clinical characteristics and associated factors of pediatric acute necrotizing encephalopathy: a retrospective study. 小儿急性坏死性脑病的临床特征和相关因素：一项回顾性研究。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-11-11 DOI: 10.3345/cep.2024.00794

Huiling Zhang, Yilong Wang, Qianyun Ding, Xuekun Li, Sheng Ye

{"title":"Clinical characteristics and associated factors of pediatric acute necrotizing encephalopathy: a retrospective study.","authors":"Huiling Zhang, Yilong Wang, Qianyun Ding, Xuekun Li, Sheng Ye","doi":"10.3345/cep.2024.00794","DOIUrl":"https://doi.org/10.3345/cep.2024.00794","url":null,"abstract":"Background: In the clinic, pediatric acute necrotizing encephalopathy (ANE) primarily affects children under five years of age and is characterized by severe brain damage and high mortality. However, some challenges remain regarding the diagnosis and treatment of ANE. In the present study, we analyzed the clinical characteristics and related factors of ANE with the aim of providing improved diagnostic and treatment strategies.Methods: Thirty-four pediatric ANE patients admitted to Zhejiang University School of Medicine Hospital between February 2019 and December 2023 were included in this study. To identify the factors associated with mortality, clinical, laboratory and imaging data were analyzed with independent-sample t tests, Mann‒Whitney U tests, Fisher's exact probability tests and receiver operating characteristic (ROC) curve analyses.Results: In this cohort of 34 patients, the most common symptoms were fever, seizures, altered consciousness, vomiting, diarrhea and shock. The mortality rate was 55.9%. Laboratory tests revealed that patients who died had higher creatinine, lactate, activated partial thromboplastin time (APTT), thrombin time (TT), interleukin-6 (IL-6), interleukin-10 (IL-10), creatine kinase (CK), and D-dimer than survivors. Imaging examinations predominantly revealed symmetrical lesions in the thalamus. The fatal group displayed lower Glasgow Coma Scale (GCS) scores and severe complications. Other factors related to mortality included the arterial pH, GCS score and hospitalization duration.Conclusion: The most common symptoms of ANE are fever, seizures, altered consciousness, vomiting, diarrhea and shock, and ANE has a high mortality rate. The GCS score and arterial pH are critical biomarkers for assessing the severity of ANE.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of pediatric migraine triggers: a single-center study. 评估小儿偏头痛诱因：一项单中心研究。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-11-11 DOI: 10.3345/cep.2024.00738

Hey-Joon Son, Joo-Ok Jin, Kon-Hee Lee

{"title":"Evaluation of pediatric migraine triggers: a single-center study.","authors":"Hey-Joon Son, Joo-Ok Jin, Kon-Hee Lee","doi":"10.3345/cep.2024.00738","DOIUrl":"https://doi.org/10.3345/cep.2024.00738","url":null,"abstract":"Background: Pediatric migraines are primarily treated with medications. However, recognizing the triggers related to patient behaviors and lifestyle is also important.Purpose: This study aimed to evaluate the factors that trigger pediatric migraines.Methods: This study included 102 pediatric patients with migraine diagnosed using the third edition of the International Classification of Headache Disorders who visited our pediatric headache clinic between November 2021 and October 2022. We reviewed the patients' clinical features, imaging studies, screening tests for behaviors and emotions, and questionnaires regarding triggers. Statistical analyses were performed using the independent sample Student's t-test and linear-by-linear association test.Results: The 102 patients (44 male, 58 female; mean age, 12.0 ± 2.9 years) were classified into migraine without aura (n = 58) and migraine with aura (n = 44) groups. Sleep disturbances were the most frequent trigger (76.5%). Other triggers included academic stress (66.7%), motion sickness (62.7%), and fatigue (52.9%). Academic stress was the most significant trigger for pain severity in 44.1% of patients. Abnormal behavioral or psychiatric assessment results were associated with a higher number of triggers.Conclusion: This study identified sleep disturbance and academic stress as common triggers of pediatric migraine, with academic stress being the most intense. Clinicians should understand these triggers and advise patients to avoid them by changing their lifestyles, if possible.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of vitamin D deficiency and vitamin D receptor polymorphisms in endocrine related disorders. 综述内分泌相关疾病中的维生素 D 缺乏症和维生素 D 受体多态性。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-11-06 DOI: 10.3345/cep.2024.00227

Nur Faten Hafizah Rosli, Noor Shafina Mohd Nor, Rose Adzrianee Adnan, Siti Hamimah Sheikh Abdul Kadir

{"title":"A review of vitamin D deficiency and vitamin D receptor polymorphisms in endocrine related disorders.","authors":"Nur Faten Hafizah Rosli, Noor Shafina Mohd Nor, Rose Adzrianee Adnan, Siti Hamimah Sheikh Abdul Kadir","doi":"10.3345/cep.2024.00227","DOIUrl":"https://doi.org/10.3345/cep.2024.00227","url":null,"abstract":"The endocrine system is a complex network of glands that produce and release hormones that regulate various physiological processes. In the past few decades, the human skin has been identified as an important peripheral endocrine organ that is the main site for the synthesis of vitamin D through exposure to sunlight. Mutations in downstream vitamin D-related gene pathways are associated with disease development. The vitamin D receptor (VDR) gene, which regulates the pleiotropic effects of vitamin D, has been extensively studied in adult populations. Several studies have reported the prevalence of vitamin D deficiency in children and adolescents. With changes in socioeconomic status and lifestyle, vitamin D-deficient individuals are prone to developing the disease at a young age. However, geographical and racial differences affect the association between VDR gene polymorphisms and vitamin D endocrine disorders, explaining the non-consensus effects of polymorphisms and their association with disease development across populations. In this review, we discuss the connection between the vitamin D endocrine system and polymorphisms in the gene encoding VDR in children and adolescents, focusing on its effects on growth, puberty, insulin resistance, and the immune system.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microplastic and human health with focus on pediatric well-being: a comprehensive review and call for future studies. 微塑料与人类健康，关注儿科健康：全面回顾与未来研究呼吁。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-11-06 DOI: 10.3345/cep.2023.01739

Rogers Wainkwa Chia, Venant Atem Ntegang, Jin-Yong Lee, Jihye Cha

{"title":"Microplastic and human health with focus on pediatric well-being: a comprehensive review and call for future studies.","authors":"Rogers Wainkwa Chia, Venant Atem Ntegang, Jin-Yong Lee, Jihye Cha","doi":"10.3345/cep.2023.01739","DOIUrl":"https://doi.org/10.3345/cep.2023.01739","url":null,"abstract":"Although humans are highly dependent on plastics from infancy to adolescence, these materials can degrade into ubiquitous microplastics (MPs) that affect individuals at every stage of life. However, information on the sources, mechanisms, detection techniques, and detrimental effects of MPs on children's health from infancy to adolescence is limited. Hence, here we identified and reviewed original research papers published in 2017-2023 across 11 database categories in PubMed, Google Scholar, Scopus, and Web of Science to improve our understanding of MPs with a focus on pediatric well-being. These studies found that milk and infant formulas are common sources of MP exposure in infants. Infant formula is the dominant source of MPs in babies, while plastic toys are a common source of MPs in toddlers. Adolescents are frequently exposed to MPs through the consumption of food contaminated with MPs and the use of plastics in food packaging. Water and air are sources of MP exposure in children from infancy through adolescence. This study thoroughly summarized how MP exposure in children of all ages causes cell damage and leads to adverse health effects such as cancer. With appropriate authorization from the relevant authorities, small amounts of human biological samples (10 g of feces) were collected from volunteers to assess the amounts of MPs in children with the aim of promoting pediatric well-being. The samples were then treated with Fenton's reagent, stored in glass jars, and filtered through nonplastic filters. Finally, MPs in children were quantified using stereomicroscopy and characterized using micro-Fourier transform infrared spectroscopy.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polysomnographic features of children with obesity: body mass index predict severe obstructive sleep apnea in obese children? 肥胖儿童的多导睡眠图特征：体重指数能否预测肥胖儿童的严重阻塞性睡眠呼吸暂停？

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-11-06 DOI: 10.3345/cep.2024.00066

Rungrat Sukharom, Prakarn Tovichien, Kanokporn Udomittipong, Pinyapach Tiamduangtawan, Wattanachai Chotinaiwattarakul

{"title":"Polysomnographic features of children with obesity: body mass index predict severe obstructive sleep apnea in obese children?","authors":"Rungrat Sukharom, Prakarn Tovichien, Kanokporn Udomittipong, Pinyapach Tiamduangtawan, Wattanachai Chotinaiwattarakul","doi":"10.3345/cep.2024.00066","DOIUrl":"https://doi.org/10.3345/cep.2024.00066","url":null,"abstract":"Background: Few studies have explored the polysomnographic features of children with obesity.Purpose: This study aimed to explore the demographic and polysomnographic features of obese children and determine whether body mass index (BMI) could predict severe obstructive sleep apnea (OSA).Methods: This cross-sectional study recruited obese children who underwent diagnostic polysomnography between January 2019 and March 2022. We explored demographic and anthropometric measures as well as polysomnographic abnormalities among them. We used receiver operating characteristic curves and logistic regression analyses to determine the optimal cut-off values of anthropometric variables for predicting severe OSA.Results: A total of 132 children with obesity (76.5% male; mean age, 12.5 ± 3.2 years) were included. Severe OSA was identified in 64 (48.5%) children. Desaturation was observed in 59.8%, while 23.5% had hyperarousal, 20.5% had sleep-related hypoventilation, 60.6% had positional OSA, 40.2% had REM-related OSA, and 5.0% had obesity hypoventilation syndrome. Among them, BMI (odds ratio [OR], 1.11; 95% confidence interval [CI], 1.05-1.17; p < 0.001), neck circumference (OR, 1.15; 95% CI, 1.07-1.25; p < 0.001), and waist circumference (OR, 1.04; 95% CI, 1.02-1.07; p = 0.001) were significantly associated with severe OSA. These findings suggest a cut-off BMI for predicting severe OSA of greater than 29.2 kg/m2 with 81.3% sensitivity and 48.5% specificity.Conclusion: Severe OSA is common in children with obesity; thus, we recommend screening children with obesity and a BMI greater than 29.2 kg/m2 for severe OSA.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predetermined future: tackling South Korea's total fertility rate crisis. 预定的未来：应对韩国的总和生育率危机。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-11-06 DOI: 10.3345/cep.2024.00871

Jin Kyu Kim

引用次数: 0

What we should know about pediatric heart failure: children are not small adults. 关于小儿心力衰竭，我们应该知道：儿童不是小大人。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-11-06 DOI: 10.3345/cep.2023.01130

Ja-Kyoung Yoon

引用次数: 0

Efficacy of leuprolide acetate versus triptorelin pamoate administered every 3 months for treatment of central precocious puberty. 在治疗中枢性性早熟方面，醋酸亮丙瑞林与帕莫酸曲普瑞林每 3 个月给药一次的疗效对比。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-11-06 DOI: 10.3345/cep.2024.00822

Thanaporn Thaneetrakool, Suphab Aroonparkmongkol, Nattakarn Numsriskulrat, Vichit Supornsilchai, Suttipong Wacharasindhu, Khomsak Srilanchakon

{"title":"Efficacy of leuprolide acetate versus triptorelin pamoate administered every 3 months for treatment of central precocious puberty.","authors":"Thanaporn Thaneetrakool, Suphab Aroonparkmongkol, Nattakarn Numsriskulrat, Vichit Supornsilchai, Suttipong Wacharasindhu, Khomsak Srilanchakon","doi":"10.3345/cep.2024.00822","DOIUrl":"https://doi.org/10.3345/cep.2024.00822","url":null,"abstract":"Background: Central precocious puberty (CPP) is typically treated with gonadotropin-releasing hormone (GnRH) agonists. Although numerous GnRH agonist variants are available, limited research has compared the efficacy of leuprolide acetate and triptorelin pamoate administered at 3-month intervals.Purpose: This study aimed to assess the efficacy of CPP treatment with triptorelin pamoate and leuprolide acetate administered at 3-month intervals.Methods: This retrospective cohort study included 116 girls with CPP: 71 treated with leuprolide acetate every 3 months and 45 treated with triptorelin pamoate every 3 months. Anthropometric measurements were compared before and after therapy. At 6 months after the therapy, luteinizing hormone (LH) suppression was evaluated.Results: When administered every 3 months, leuprolide acetate and triptorelin pamoate significantly suppressed LH. The predicted adult height (PAH) and degree of bone age advancement at the end of treatment were comparable.Conclusion: Treatment with leuprolide acetate and triptorelin pamoate every 3 months did not have significantly different effects on LH suppression or PAH.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent updates on systemic treatment of atopic dermatitis. 特应性皮炎系统治疗的最新进展。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-11-01 DOI: 10.3345/cep.2024.00339

Jiyoung Ahn

引用次数: 0

Growth plate closure and therapeutic interventions. 生长板闭合和治疗干预。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-11-01 Epub Date: 2024-10-28 DOI: 10.3345/cep.2023.00346

Ja Hyang Cho, Hae Woon Jung, Kye Shik Shim

{"title":"Growth plate closure and therapeutic interventions.","authors":"Ja Hyang Cho, Hae Woon Jung, Kye Shik Shim","doi":"10.3345/cep.2023.00346","DOIUrl":"10.3345/cep.2023.00346","url":null,"abstract":"Height gains result from longitudinal bone growth, which is largely dependent on chondrocyte differentiation and proliferation within the growth plates of long bones. The growth plate, that is, the epiphyseal plate, is divided into resting, proliferative, and hypertrophic zones according to chondrocyte characteristics. The differentiation potential of progenitor cells in the resting zone, continuous capacity for chondrocyte differentiation and proliferation within the proliferative zone, timely replacement by osteocytes, and calcification in the hypertrophic zone are the 3 main factors controlling longitudinal bone growth. Upon adequate longitudinal bone growth, growth plate senescence limits human body height. During growth plate senescence, progenitor cells within the resting zone are depleted, proliferative chondrocyte numbers decrease, and hypertrophic chondrocyte number and size decrease. After senescence, hypertrophic chondrocytes are replaced by osteocytes, the extracellular matrix is calcified and vascularized, the growth plate is closed, and longitudinal bone growth is complete. To date, gonadotropin-releasing hormone analogs, aromatase inhibitors, C-type natriuretic peptide analogs, and fibroblast growth factor receptor 3 inhibitors have been studied or used as therapeutic interventions to delay growth plate closure. Complex networks of cellular, genetic, paracrine, and endocrine signals are involved in growth plate closure. However, the detailed mechanisms of this process remain unclear. Further elucidation of these mechanisms will enable the development of new therapeutic modalities for the treatment of short stature, precocious puberty, and skeletal dysplasia.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"553-559"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0