Clinical and Experimental Pediatrics最新文献

{"title":"Peripheral blood cell counts of prematurely born, small for gestational age neonates.","authors":"Mara O Zuiderwijk, Sophie Groene, Enrico Lopriore, Vincent Bekker, Michiel H D Schoenaker","doi":"10.3345/cep.2025.02978","DOIUrl":"10.3345/cep.2025.02978","url":null,"abstract":"<p><strong>Background: </strong>Neonates born small for gestational age (SGA) are at an increased risk of multiple severe complications, including infections. This suggests that immune cells and other peripheral blood cells may be affected.</p><p><strong>Purpose: </strong>Here we aimed to investigate whether SGA severity affects complete blood count and leukocyte differentiation of preterm neonates with a gestational age (GA) of <35 weeks and identify clinical factors that influence cell counts.</p><p><strong>Methods: </strong>This retrospective cohort study investigated the complete blood count sampled within 72 hours after birth in 1,940 preterm neonates admitted to the neonatal intensive care unit of Leiden University Medical Center. The neonates were divided into extreme SGA (<3rd birth weight percentile), moderate SGA (>3rd to <10th birth weight percentile), and controls (>10th birth weight percentile).</p><p><strong>Results: </strong>After multivariate analysis, extremely SGA neonates showed significantly decreased neutrophil, monocyte, lymphocyte, and thrombocyte counts. Thrombocyte counts were significantly lower in moderately SGA neonates than controls. In contrast, SGA status had no significant effect on erythrocyte count or hemoglobin concentration.</p><p><strong>Conclusion: </strong>Blood cell counts of extremely SGA neonates were decreased, mainly in the white blood cell line. The mechanisms underlying these decreased counts in SGA infants, especially their clinical effects, remain unclear.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"572-581"},"PeriodicalIF":3.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13337313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum metabolomic profile in children with sepsis-associated acute kidney injury.","authors":"Nisha Chaudhary, Praveen Singh, Abhijeet Saha, Shantanu Sengupta","doi":"10.3345/cep.2025.02439","DOIUrl":"10.3345/cep.2025.02439","url":null,"abstract":"<p><strong>Background: </strong>Sepsis-associated acute kidney injury (SA-AKI) contributes to high morbidity and mortality rates in children; however, current diagnostic tools (serum creatinine and urine output) lack sensitivity for early detection. Metabolomics can be used to discover novel metabolic markers to enable early diagnosis and prognosis and provide therapeutic targets for SA-AKI.</p><p><strong>Purpose: </strong>This study was aimed to identify the differentially expressed serum metabolites in children with SA-AKI.</p><p><strong>Methods: </strong>We conducted an untargeted serum metabolomic analysis using liquid chromatography-mass spectroscopy (LC-MS) in 75 children: 45 with sepsis and acute kidney injury (AKI) (15 each in Kidney Disease Improving Global Outcomes [KDIGO] stages 1-3), 15 with sepsis without AKI, and 15 healthy controls. Fasting blood samples were collected and centrifuged. Supernatant serum was stored at -80°C and subjected to untargeted metabolomic analysis using LC-MS. Reverse-phase and hydrophilic liquid interaction chromatographic separation was performed in positive and negative ion scan modes, while metabolite identification was performed using the SCIEX All-In-One HR-MS/MS Library with National Institute of Standards and Technology 2017 Library bundle.</p><p><strong>Results: </strong>The significantly altered metabolites in AKI stage 3 were lipids belonging to the glycerophosphoethanolamine subgroup of the phospholipid class. Eighteen metabolites were differentially expressed in patients with SA-AKI versus healthy controls, with phosphoethanolamines (e.g., 1-palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine) showing a consistent association with AKI stage. Thirty-one metabolites were significantly altered in severe AKI (KDIGO stages 2-3), of which only 4 could be annotated and increased proportionally with AKI severity. A pathway analysis revealed significant enrichment of glycerophospholipid, linoleic acid, and alpha-linolenic acid metabolism in stage 3 SA-AKI.</p><p><strong>Conclusion: </strong>Serum metabolomics is a feasible approach to identifying novel biomarkers of SA-AKI. Phosphoethanolamine metabolites both distinguished AKI from sepsis controls and were correlated with clinical severity (estimated glomerular filtration rate decline), suggesting its potential prognostic value. However, its diagnostic feasibility requires preliminary validation in larger multicenter cohorts.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"545-554"},"PeriodicalIF":3.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13337310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct age-dependent phenotypes of abnormal liver function tests derived from national Emergency Department data.","authors":"Dong-Uk Kim, Shinjie Choi, Yeji Kim, Lia Kim, Jung Ok Shim, Jin Soo Moon, Jong Woo Hahn, Hye Ran Yang, Ju Young Chang, Jae Sung Ko","doi":"10.3345/cep.2026.00038","DOIUrl":"10.3345/cep.2026.00038","url":null,"abstract":"<p><strong>Background: </strong>Abnormal liver function tests (LFTs) are frequently performed in Emergency Departments (EDs); however, the systematic characterization of age-dependent clinical phenotypes and pathogen associations remains limited.</p><p><strong>Purpose: </strong>Here we aimed to identify the distinct clinical presentations and pathogen-specific associations of pediatric and adult ED visits for abnormal LFTs.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 26,874 ED visits for abnormal LFTs in South Korea's National Emergency Department Information System (2019-2023). Patients were stratified into pediatric (0-18 years) and adult (19-64 years) groups. We characterized the clinical presentations, concurrent diagnoses, temporal correlations with infectious pathogens, and metabolic comorbidity patterns.</p><p><strong>Results: </strong>The ED visits included 3,152 pediatric (11.7%) and 23,722 adult patients (88.3%). Pediatric presentations demonstrated fever-predominant profiles (47.3%), respiratory symptoms (6.4%), and infectious disease diagnoses (39.8%) as well as temporal correlations with respiratory viruses (rhinovirus, r=0.30; adenovirus, r=0.28; P<0.001). Adult presentations revealed previously unreported population-level temporal associations with enteric pathogens, including astrovirus (r=0.35), sapovirus (r=0.32), enteropathogenic Escherichia coli (r=0.38), and enterotoxigenic Escherichia coli (r=0.36, all P<0.001) coupled with infectious gastroenteritis (20.9%) and upper gastrointestinal disorders, including gastritis (18.3%). Adults demonstrated clustering of the following metabolic comorbidities: dyslipidemia (7.9%), hypertension (7.8%), and diabetes (6.0%). During the coronavirus disease 2019 pandemic, pediatric visits remained stable, whereas adult visits increased following the implementation of social distancing measures (rate ratio, 0.82; P=0.004).</p><p><strong>Conclusion: </strong>The ED presentation of abnormal LFTs results demonstrated distinct age-dependent phenotypes with divergent temporal pathogen associations. Pediatric cases reflected acute respiratory viral infections, whereas adult presentations showed novel population-level enteric pathogen associations with upper gastrointestinal disorders and clusters of metabolic comorbidities. These findings provide evidence supporting age-stratified diagnostic approaches for EDs.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"563-571"},"PeriodicalIF":3.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13337314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between base excess levels and clinical outcomes among very low birth weight infants: a multicenter birth cohort study in South Korea.","authors":"Ji Yoo Kim, Hyeon Jin Kim, Heeyoon Choi, Minji Kim, Jinseok Lee, Yong Sung Choi, Dong Keon Yon","doi":"10.3345/cep.2025.02817","DOIUrl":"10.3345/cep.2025.02817","url":null,"abstract":"<p><strong>Background: </strong>The impact of metabolic acidosis on short-term outcomes and mortality in very low birth weight infants (VLBWIs) has not been well studied.</p><p><strong>Purpose: </strong>To investigate the potential association between metabolic acidosis and the clinical outcomes of VLBWIs in South Korea.</p><p><strong>Methods: </strong>Between 2013 and 2019, data were collected from the Korean Neonatal Network, which covers a multicenter birth cohort spanning 75 hospitals. Our study cohort included 14,519 infants with a birth weight of less than 1,500 g who were admitted to the neonatal intensive care unit. Blood gas measurements taken within 1 hour of birth were used to evaluate the clinical outcomes, which were categorized into 5 groups according to base excess (BE) levels. We assessed respiratory outcomes, neurological morbidities, and infection-related and gastrointestinal outcomes along with mortality rates.</p><p><strong>Results: </strong>We analyzed 10,394 VLBWIs based on the inclusion criteria. A BE level below -9 suggested a significantly high risk of various respiratory outcomes, including air leak syndrome (adjusted odds ratio [aOR], 2.071; 95% confidence interval [CI], 1.305-3.285), massive pulmonary hemorrhage (aOR, 2.317; 95% CI, 1.502-3.575), pulmonary hypertension (aOR, 2.296; 95% CI, 1.667-3.161), and neonatal respiratory distress syndrome (aOR, 2.219; 95% CI, 1.778-2.769). These infants also exhibited an elevated risk of neurological (aOR, 2.797; 95% CI, 2.314-3.380), infection-related (aOR, 2.082; 95% CI, 1.653-2.623), gastrointestinal (aOR, 1.979; 95% CI, 1.408-2.783), and mortality (aOR, 2.683; 95% CI, 2.076-3.466) outcomes.</p><p><strong>Conclusion: </strong>Our findings highlight the potential effect of metabolic acidosis at birth on the clinical outcomes of VLBWIs. A strong correlation was observed between metabolic acidosis and neurological morbidity. These findings offer important insights for managing VLBWIs with metabolic acidosis and suggest the need for future research on acid-base balance risk factors.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"555-562"},"PeriodicalIF":3.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13337311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fulminant early-onset subacute sclerosing panencephalitis masquerading as leukodystrophy: a diagnostic challenge.","authors":"Kaushik Ragunathan, Deb Kumar Boruah, Vishnupriya Veeraraghavan, Jaya Shankar Kaushik","doi":"10.3345/cep.2026.00696","DOIUrl":"10.3345/cep.2026.00696","url":null,"abstract":"","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"604-608"},"PeriodicalIF":3.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13337307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148279181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Risk CCL14 lineage drives severe Mycoplasma pneumoniae pneumonia in children: a study in central China.","authors":"Chunbo Hao, Zijie Li, Yanjuan Yu, Song Wang, Genhao Wang, Gaijing Jia, Tiantian Sun, Shouhang Chen, Yang Wu, Yu Tang, Fang Wang, Guangcai Duan, Yuefei Jin","doi":"10.3345/cep.2025.02796","DOIUrl":"10.3345/cep.2025.02796","url":null,"abstract":"<p><strong>Background: </strong>The post-coronavirus disease 2019 (COVID-19) pandemic resurgence of Mycoplasma pneumoniae (MP) infections, particularly in China, underscores the need to understand the drivers of disease severity.</p><p><strong>Purpose: </strong>This study aimed to evaluate the association between predominantly circulating MP strains and disease severity in Henan Province, central China.</p><p><strong>Methods: </strong>We integrated the clinical data of 3,060 pediatric patients and analyzed the epidemiological characteristics of MP pneumonia (MPP) in the Henan region in 2020-2024. Bronchoalveolar lavage fluid collected from 137 patients was analyzed using multilocus sequence typing and multilocus variable number tandem-repeat analysis to investigate the correlation between genotype and clinical outcome.</p><p><strong>Results: </strong>A significant post-COVID MPP outbreak was predicted in 2023. Genotyping revealed the cocirculation of 2 major genotypes: the prevalent ST3 (57.7%, severe ratio [31.6%]) and the less common but highly virulent ST14 (26.3%, severe ratio [72.2%]). Phylogenetic clustering confirmed ST14/3-5-6-2 as part of a broader hypervirulent lineage, common cluster label 14 (CCL14), which was significantly associated with disease severity (χ2=19.39; P<0.001). Patients infected with CCL14 strains exhibited a distinct hyperinflammatory profile marked by elevated D-dimer levels, complement C4 levels, and platelet count. The mutation ratio of macrolide resistance sites in the MP strains from Henan Province was approximately 75%.</p><p><strong>Conclusion: </strong>Our findings identified the CCL14 lineage as a key driver of disease severity in macrolide-resistant pediatric MPP in Henan Province, China. This under scores the importance of integrating molecular surveillance with clinical monitoring to mitigate disease burden.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"497-507"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intramuscular and subcutaneous gonadotropin-releasing hormone agonist tests for central precocious puberty in girls: a randomized controlled trial.","authors":"Worapimon Lerdrassameethad, Suttipong Wacharasindhu, Vichit Supornsilchai, Khomsak Srilanchakon","doi":"10.3345/cep.2026.00052","DOIUrl":"10.3345/cep.2026.00052","url":null,"abstract":"<p><strong>Background: </strong>Central precocious puberty (CPP) results from premature activation of the hypothalamic-pituitary-gonadal axis. Although the standard intravenous gonadotropin-releasing hormone (GnRH) stimulation test is often inaccessible, a subcutaneous (SC) GnRH analogue (GnRHa) test is used. However, the conventional SC route presents logistical challenges including prolonged observation times and the need for multiple blood draws. Thus, identifying a more efficient administration route could optimize clinical workflows and enhance patient comfort. This study aimed to determine whether intramuscular (IM) administration is comparable to SC administration by analyzing the time to peak luteinizing hormone (LH) levels.</p><p><strong>Purpose: </strong>To evaluate and compare the time to peak LH levels and diagnostic timing of IM versus SC GnRH stimulation tests in girls with CPP.</p><p><strong>Methods: </strong>This randomized controlled trial enrolled 92 girls with suspected CPP. Participants were assigned via 2:1 block randomization to receive 100 mcg triptorelin acetate via SC (n=62) or IM (n=30) injection. Serial blood samples for LH and follicle-stimulating hormone were collected at 0, 30, 60, 90, and 120 minutes.</p><p><strong>Results: </strong>There were no significant differences between the 2 groups in demographic characteristics. Peak LH responses were most frequent at 30 minutes in both groups (IM, 33.3%; SC, 35.5%; P=0.88). The mean LH levels at 30, 60, 90, and 120 minutes did not differ significantly between groups. Diagnostic confirmation of CPP occurred within 30 minutes in 96.7% and 96.8% of patients in the IM and SC groups, respectively.</p><p><strong>Conclusion: </strong>The IM GnRH stimulation test was comparable to the standard SC test in terms of LH response magnitude and timing.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"518-523"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic features of 5-aminosalicylic acid intolerance in pediatric ulcerative colitis.","authors":"Hirotoki Murashige, Yasufumi Sakata, Yoshihiro Azuma, Shunji Hasegawa","doi":"10.3345/cep.2025.02446","DOIUrl":"10.3345/cep.2025.02446","url":null,"abstract":"","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"524-526"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148057349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophagopleural fistula following coin impaction in a female toddler: successful management using through-the-scope clips.","authors":"Sarthak Chakrabarti, Nikhil Sonthalia, Kaustabh Chaudhuri, Tamashis Mukherjee, Uday Chand Ghoshal, Mahesh Kumar Goenka","doi":"10.3345/cep.2026.00654","DOIUrl":"10.3345/cep.2026.00654","url":null,"abstract":"","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":"69 6","pages":"527-530"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148164744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary fiber in pediatric gastrointestinal health: a narrative review of evidence and challenges.","authors":"Rohit Das, Bipashna Thatal, Buddhiman Tamang","doi":"10.3345/cep.2026.00276","DOIUrl":"10.3345/cep.2026.00276","url":null,"abstract":"<p><p>Dietary fiber plays a central role in pediatric gastrointestinal health; however, most children worldwide consume amounts well below recommended levels. Current pediatric guidelines from the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (2014) and global nutrition guidance from the World Health Organization recommend adequate dietary fiber intake as part of a balanced diet to support digestive health and prevent noncommunicable diseases. These recommendations generally correspond to daily fiber intake levels of approximately 14-31 g/day, or the practical rule of age (years) + 5 g/day for children, yet more than 80%-90% of children fail to meet these targets. This shortfall is clinically significant, as inadequate fiber intake is associated with increased risk of functional constipation, a condition affecting approximately 3%-29% of children globally. Dietary fiber contributes not only to stool bulk but also to the modulation of gut microbiota, gastrointestinal barrier function, and immune and metabolic pathways during critical developmental stages. Among common pediatric gastrointestinal disorders, the strongest evidence supports fiber use in constipation management, where supplementation or increased intake through whole foods has been shown to improve stool frequency and consistency in approximately 50%-60% of affected children. However, clinical trial outcomes remain inconsistent, varying according to fiber type, dosage, duration of intervention, and diagnostic criteria. Evidence for recurrent or functional abdominal pain remains limited and heterogeneous, with small sample sizes, differing endpoints, and high placebo response rates complicating interpretation. In pediatric inflammatory bowel disease, fermentable fibers have been shown to enhance short-chain fatty acid production. Nevertheless, robust pediatric clinical evidence remains insufficient, and findings from adult ulcerative colitis studies cannot be directly extrapolated to children. Dietary fiber represents an important supportive component of pediatric gastrointestinal management, but standardized dosing recommendations and high-quality pediatric clinical trials are still needed to establish evidence-based guidelines for clinical practice.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"456-472"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148036161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}