Clinical and Experimental Pediatrics最新文献

{"title":"Abdominal pain in a young girl: a twist in the tale.","authors":"Upasana Ghosh, Ankit Agrawal, Umesh Shukla, Vikas Jain, Deeksha Bhalla","doi":"10.3345/cep.2024.01949","DOIUrl":"10.3345/cep.2024.01949","url":null,"abstract":"","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"395-397"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Korea Infant Physical Growth Examination Survey (KIPGroS): a study protocol.","authors":"Jong Woo Hahn, MinSoo Shin, Jin Gyu Lim, Yoon-Joo Kim, Ki Soo Kang, Narae Lee, Seong Hee Jeong, Mun Hui Jeong, Yeoun Joo Lee, Eui Kyung Choi, Jung Ok Shim, Jee Yoon Park, Chan-Wook Park, Joo Young Kim, Su Jin Jeong, Young Hwa Jung, Jaehyun Kim, Chang Won Choi, Ju Whi Kim, Seung Han Shin, Yun Jeong Lee, Young Ah Lee, Choong-Ho Shin, Seung-Sik Hwang, Young Eun Kim, Youn Ha Kang, Kyungwon Oh, Sungha Yun, Jae Sung Ko, Jin Soo Moon","doi":"10.3345/cep.2024.00297","DOIUrl":"10.3345/cep.2024.00297","url":null,"abstract":"<p><p>Growth charts are important tools used to evaluate the growth status of children and estimate the nutritional and health status of the general population. In Korea, the national standardized growth charts were updated in 2017. However, the growth charts developed by the World Health Organization (WHO) are being adopted for children under 3 years of age despite a lack of evidence for their applicability to Koreans. Here we aimed to collect accurate physical measurement data, develop growth charts for infants and toddlers under 3 years of age based on breastfeeding, and evaluate the feasibility of adopting WHO growth standards as a reference in Korea. Beginning April 2020, 6 general and local hospitals were selected nationwide. Mothers and newborns without growth restriction-related factors were enrolled at birth, and they were followed up monthly until 12 months and every 3 months until 36 months. Data were collected on physical measurements; eating habits; childhood morbidity; perinatal factors; and socioeconomic, demographic, and environmental characteristics. All participating hospitals used the same standard equipment. The Korea Infant Physical Growth Examination Survey evaluated the suitability of the WHO growth charts and contributed to the next revision of the Korean growth charts. The results of this study provide a basis for developing health-related strategies for treating children in South Korea.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"352-358"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum bactericidal activity against meningococcus in patients with systemic lupus erythematosus.","authors":"Soyoung Lee, Kyung-Hyo Kim, Ji Hyen Lee, Han Wool Kim","doi":"10.3345/cep.2024.01151","DOIUrl":"10.3345/cep.2024.01151","url":null,"abstract":"<p><strong>Background: </strong>Patients with systemic lupus erythematosus (SLE) are susceptible to infectious diseases owing to various immunosuppressive treatments and disease characteristics. Meningococcal infections progress rapidly with a high incidence of severe complications and mortality; therefore, meningococcal vaccination is needed. However, there is limited evidence regarding the immunity and immunogenicity of patients with SLE.</p><p><strong>Purpose: </strong>This study aimed to analyze the serum bactericidal activity against meningococci in patients with SLE in 2 domestic institutions in Korea.</p><p><strong>Methods: </strong>Serum samples were collected from patients diagnosed with SLE (age <19 years) at Seoul National University Children's Hospital and Ewha Womans University Mokdong Hospital in 2016-2018. Serum bactericidal activity against the 4 meningococcal serogroups was analyzed using a serum bactericidal assay with rabbit serum. The patients' demographic information, diagnostic history, and disease activity status were obtained from electronic medical records.</p><p><strong>Results: </strong>The mean age of the 41 included patients was 20.3±5.4 years (range, 10-35 years). All but one patient received steroids. The sera of most of the patients (34 of 41 [82.9%]) lacked bactericidal activity against serogroup A. Some patients showed bactericidal activity against serogroups C, W-135, and Y (63.4%, 56.1%, and 61.0%, respectively). There were no significant differences in the geometric mean indices based on complement consumption state or anti-double-stranded DNA antibody positivity.</p><p><strong>Conclusion: </strong>Although the sera of some patients exhibited serum bactericidal activity against meningococci, most remained seronegative. It is important that patients with SLE at risk of meningococcal infection receive appropriate vaccinations. Our findings serve as baseline serological data for meningococcal vaccination policies for patients with SLE.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"362-369"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enteric pathogens implicated in acute infectious diarrhea among young children in resource-limited region with rapidly growing population: a hospital-based cross-sectional study.","authors":"Aseel Mahmood Ibrahim Al-Mashahedah, Randa Mohammed Dhahi","doi":"10.3345/cep.2024.01333","DOIUrl":"10.3345/cep.2024.01333","url":null,"abstract":"<p><strong>Background: </strong>Acute infectious diarrhea is among the leading causes of morbidity and mortality worldwide, particularly in developing countries and among children younger than 5 years of age.</p><p><strong>Purpose: </strong>To determine the causative microorganisms in diarrhea and elucidate their epidemiological trajectory among children younger than 5 years of age to establish successful preventive measures.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in Al-Musayyib District, Babil Governorate, Iraq, using data from January 2023 to January 2024 provided by the information system of Ibn Saif Children's Hospital and Al-Musayyib General Hospital. Data from 300 children under 5 years of age with infectious diarrhea were collected to determine the causative pathogens. Patient data including sex, age, treatment, and posttreatment clinical condition, were collected from the hospital archive and analyzed.</p><p><strong>Results: </strong>Overall, 56% of males and 44% of females had diarrhea. The 1-2-year age group was the most susceptible to diarrhea (33.3%). This rate gradually decreased with age, reaching 9.9% in the 4-5-year age group. Furthermore, bacteria were the causative organisms in 43% of cases, followed by viruses, parasites, and fungi at 24.7%, 12%, and 7.7%, respectively. Mixed infections were detected in 12.6%. Posttreatment, 89.7% of patients completely recovered, 8% experienced physiological disorders, and 2.3% died.</p><p><strong>Conclusion: </strong>Bacteria were the most common causative organisms of infectious diarrhea among children younger than 5 years of age. Children in the 1-2-year age group were the most commonly affected. This study highlights that diarrhea continues to threaten the lives and well-being of children.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"379-387"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of serum zinc and selenium levels in etiology of febrile seizures.","authors":"Yavuz Ataş, Hatice Gamze Poyrazoğlu","doi":"10.3345/cep.2024.01410","DOIUrl":"10.3345/cep.2024.01410","url":null,"abstract":"<p><strong>Background: </strong>Febrile seizures (FSs) are the most common form of childhood seizures. Determining the role of trace elements in the pathophysiology of FSs will contribute to the management of FSs by pediatricians.</p><p><strong>Purpose: </strong>This study aimed to investigate the effects of zinc and selenium on the nervous system and how they may influence the risk of FSs.</p><p><strong>Methods: </strong>In this case-control study, there were 60 children in the simple FS group and 40 children in the complex FS group. The control groups comprised 50 children with fever but without seizures and 50 healthy children. Blood samples were collected within the first hour after FS.</p><p><strong>Results: </strong>Zinc and selenium levels were significantly lower in children with fever but without seizures versus healthy children (P<0.001). Serum zinc levels were lower in children with FSs (simple and complex FSs) than in healthy children (P<0.001) but higher than in children with fever but without seizures (P<0.001). Serum selenium levels in children with FSs (simple and complex) were lower than in healthy children but higher than in the children with fever but without seizures. However, these differences were not statistically significant (P>0.05).</p><p><strong>Conclusion: </strong>Serum zinc levels are significantly decreased during infection, whereas they show a statistically significant increase within the first hour after FS activity. This indicates that the body secretes zinc during FSs to restore homeostasis, reduce oxidative stress, and increase the seizure threshold. Therefore, zinc supplementation during febrile periods may effectively prevent FSs in high-risk children.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"388-394"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further research on impact of microplastics on children's health is essential to protecting future generations.","authors":"Jongin Lee, Dong-Wook Lee","doi":"10.3345/cep.2024.01459","DOIUrl":"10.3345/cep.2024.01459","url":null,"abstract":"","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"359-361"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent sigh breaths during high-frequency oscillatory ventilation among newborn infants.","authors":"Ga Won Jeon","doi":"10.3345/cep.2025.00549","DOIUrl":"https://doi.org/10.3345/cep.2025.00549","url":null,"abstract":"","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment and clinical outcomes of pediatric autoimmune hemolytic anemia: real-world single-center data from Korea.","authors":"Young Dai Kwon, Eun Sun Jung, Yeon Jung Lim","doi":"10.3345/cep.2024.02026","DOIUrl":"https://doi.org/10.3345/cep.2024.02026","url":null,"abstract":"<p><strong>Background: </strong>: Autoimmune hemolytic anemia (AIHA) is rare and characterized by hemolytic anemia with a positive direct antiglobulin test result after the exclusion of other causes. While adults often relapse within 1 year of first-line steroid therapy, children generally respond well. However, current treatment approaches lack substantial evidence and are primarily expert opinion-based.</p><p><strong>Purpose: </strong>: This study aimed to contribute our single-center experience to pediatric AIHA treatment guidelines.</p><p><strong>Methods: </strong>: Between January 2012 and June 2024, 475 children were diagnosed with anemia; of them, 18 had immune hemolytic anemia, including six with neonatal alloimmune hemolytic anemia, two who were treated at other centers, and two with transient bone marrow suppression due to a viral infection. Thus, this study retrospectively analyzed the treatment responses of eight patients with AIHA.</p><p><strong>Results: </strong>: The median age at diagnosis was 5.2 (range, 2.3-11.8) years; 62.5% (5/8) were male. Median hemoglobin (Hb) at diagnosis was 6.3 (range, 3.4-9.5) g/dL, median reticulocyte index was 6.53% (range, 1.64-22.07%), median total bilirubin was 2.75 (range, 0.98-7.23) mg/dL, and median lactate dehydrogenase was 1662.0 (range, 790-2921) U/L. All haptoglobin levels were <10 mg/dL. Treatments included steroids (8/8), red blood cell transfusions (5/8), and intravenous immunoglobulins (2/8). Half of the steroid-treated patients received intravenous methylprednisolone for 1-5 days, while half received oral prednisolone (median, 1.78 [range, 0.79-3.39] mg/kg/day). The median time to age-adjusted normal Hb levels was 16.5 (range, 9-22) days. Steroids were administered for a median 37.5 (range, 14-119) days. Excluding one patient later diagnosed with systemic lupus erythematosus, no relapses occurred during the 3-19-month follow-up period.</p><p><strong>Conclusion: </strong>: Patients with pediatric AIHA showed relapse-free rapid hematological improvement and sustained steroid responses within 2 months, suggesting that systematic steroid treatment is feasible and highlighting the need for multicenter trials to establish standardized guidelines.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 vaccine hesitancy among parents of children with systemic lupus erythematosus: a comment.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.3345/cep.2025.00304","DOIUrl":"https://doi.org/10.3345/cep.2025.00304","url":null,"abstract":"","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with thiamin deficiency in pediatric patients with heart disease and receiving diuretics: a single-center study.","authors":"Phakwan Laohathai, Rathaporn Sumboonnanonda, Puthita Saengpanit, Chodchanok Vijarnsorn, Chatchawan Srisawat, Kwanjai Chotipanang, Sarawut Junnu, Supawan Kunnangja, Hathaichanok Rukprayoon, Phakkanan Phuangphan, Sompong Liammongkolkul, Arthima Phaokong, Narumon Densupsoontorn","doi":"10.3345/cep.2024.01893","DOIUrl":"https://doi.org/10.3345/cep.2024.01893","url":null,"abstract":"<p><strong>Background: </strong>: Thiamin deficiency (TD) manifesting clinically as wet beriberi can significantly impair a patient's cardiac function. Children with heart disease who are receiving diuretic treatment may be at increased risk for severe clinical manifestations of TD.</p><p><strong>Purpose: </strong>: This study aimed to determine the prevalence of TD and evaluate the association between various factors with thiamin status in pediatric patients with heart disease undergoing diuretic treatment.</p><p><strong>Methods: </strong>: Children with heart disease aged 1 month to 15 years who exhibited increased pulmonary blood flow or congestive heart failure and had been taking diuretics for at least 1 month were recruited. Data regarding their heart condition, treatment, dietary intake, anthropometry, and symptoms and signs of TD were collected. An erythrocyte transketolase activity assay after the addition of exogenous thiamin pyrophosphate was used to assess thiamin status. Left ventricular ejection fraction and N-terminal pro-brain natriuretic peptide levels were indicators of cardiac function and laboratory evidence of congestive heart failure (CHF), respectively.</p><p><strong>Results: </strong>: A total of 68 participants were recruited, of whom 10 (15%) had TD. TD was not associated with a CHF exacerbation. An adequate dietary thiamin intake was associated with a better thiamin status (β: -0.37, P=0.003), while increasing age was linked to a poorer thiamin status (β: +0.40, P=0.001).</p><p><strong>Conclusion: </strong>: Thiamin deficiency was present in 15% of pediatric patients with heart disease who were receiving diuretic treatment. An adequate dietary thiamin intake appeared to have a protective effect against thiamin deficiency, while increasing age was associated with a poorer thiamin status.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}