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2006 IEEE/NLM Life Science Systems and Applications Workshop最新文献

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Integrated Fluorescence Sensing for Lab-on-a-chip Devices 集成荧光传感芯片实验室设备
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250392
Honghao Ji, M. Dandin, P. Abshire, E. Smela
{"title":"Integrated Fluorescence Sensing for Lab-on-a-chip Devices","authors":"Honghao Ji, M. Dandin, P. Abshire, E. Smela","doi":"10.1109/LSSA.2006.250392","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250392","url":null,"abstract":"A low noise optical sensor and biocompatible microscale optical filters for integrated fluorescence sensors were developed and tested. The sensor was fabricated in a 0.5 mum CMOS process. The measured reset noise of the sensor is reduced by a factor of 10 compared to conventional active pixel sensors. The transmission ratio in the pass-band and suppression ratio in the stop-band of the optical filters are comparable to that of macroscopic commercial filters for fluorescence microscopy","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129665611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Inferring the Structure of Genetic Regulatory Networks Using Information Theoretic Tools 利用信息理论工具推断基因调控网络的结构
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250379
Wentao Zhao, E. Serpedina, E. Dougherty
{"title":"Inferring the Structure of Genetic Regulatory Networks Using Information Theoretic Tools","authors":"Wentao Zhao, E. Serpedina, E. Dougherty","doi":"10.1109/LSSA.2006.250379","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250379","url":null,"abstract":"By combining the mutual information and conditional mutual information, a practical metric is proposed to capture the inference confidence of direct connectivity between two genes. This metric helps to avoid the disadvantage of general schemes, i.e., the dichotomy of either being connected or disconnected. Based on data sets generated by synthetic networks, the performance of proposed algorithm is compared favorably with respect to other schemes in the literature. The proposed algorithm is also applied on realistic cutaneous melanoma data set to recover a genetic network containing 470 genes","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132458828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Multiplexed Detection of Anthrax Sequences with Quantum Dot Nanoprobes 利用量子点纳米探针对炭疽菌序列进行多路检测
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250425
Y. Ho, Tza-Huei Wang
{"title":"Multiplexed Detection of Anthrax Sequences with Quantum Dot Nanoprobes","authors":"Y. Ho, Tza-Huei Wang","doi":"10.1109/LSSA.2006.250425","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250425","url":null,"abstract":"We demonstrate a bio-agent detection scheme using colocalization of target-selective quantum dot nanoprobes. The presence of a target is shown through the colocalized emissions of bound events and easily distinguished with colorimetric measurements, negating an additional step for separation of unbound probes. Multiplexed detection can be achieved by multiple quantum dots with spectrally separable emissions. Genetic analysis of anthrax pathogenicity-relevant sequences serves as a multiplexed example of this approach. Furthermore, this method shares characteristics with a homogeneous format which leads to better reaction kinetics and faster detection compared with conventional solid-phase approaches.","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114687616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Quality-based distance measures and applications to clustering 基于质量的距离度量及其在聚类中的应用
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250390
D. Taverna, M. Brun, E. Dougherty, Yidong Chen
{"title":"Quality-based distance measures and applications to clustering","authors":"D. Taverna, M. Brun, E. Dougherty, Yidong Chen","doi":"10.1109/LSSA.2006.250390","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250390","url":null,"abstract":"When analyzing biological data sets, a common approach is to partition the data into clusters. Examples of this include finding a subset of genes with co-regulated expression among experiments, grouping similar disease phenotypes, or implicating regions of genetic variation in disease. The ability to separate the data into subsets depends upon the structure of the distribution of points and the choice of clustering algorithm. Furthermore, the biological relevance of the clustering results is biased by the variation among the data points themselves. We introduce a mathematical quality-based distance metric which will allow all data, regardless of its error, to be included in analysis without the need to introduce a cutoff. This removes the need to exclude points or to change the dimensionality. The advantage of this approach is shown by clustering simulated data with added noise","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128466678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation Methods for Cell Cycle Analysis Algorithms in Confocal Fluorescence Images 共聚焦荧光图像细胞周期分析算法的验证方法
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250406
D. Padfield, J. Rutscher, N. Thomas, B. Roysam
{"title":"Validation Methods for Cell Cycle Analysis Algorithms in Confocal Fluorescence Images","authors":"D. Padfield, J. Rutscher, N. Thomas, B. Roysam","doi":"10.1109/LSSA.2006.250406","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250406","url":null,"abstract":"Automated analysis of live cells over extended time periods requires both novel assays and automated image analysis algorithms. Among other applications, this is necessary for studying the effect of inhibitor compounds that are designed to block the replication of cancerous cells. Due to their toxicity, fluorescent dyes that bind to the nuclear DNA cannot be used to mark nuclei, and traditional non-toxic nuclear markers do not yield information about the cell cycle phases. Instead, a non-toxic cell cycle phase marker can be used. We previously described a set of image analysis methods designed to automatically segment nuclei in such 2D time-lapse images. While the methods show promise, it is necessary to provide a validation framework for these methods. This paper introduces methods for validating the various stages of the algorithm in order to demonstrate their viability for automatic cell cycle analysis","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130825611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
M-Health: The Development of Cuff-less and Wearable Blood Pressure Meters for Use in Body Sensor Networks 移动健康:用于身体传感器网络的无袖带和可穿戴式血压计的发展
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250377
Carmen C. Y. Poon, Y. Wong, Yuan-ting Zhang
{"title":"M-Health: The Development of Cuff-less and Wearable Blood Pressure Meters for Use in Body Sensor Networks","authors":"Carmen C. Y. Poon, Y. Wong, Yuan-ting Zhang","doi":"10.1109/LSSA.2006.250377","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250377","url":null,"abstract":"To meet the needs of the increasingly aging population, development of wearable medical devices and body sensor networks technologies for applications in telemedicine and mobile health are imperative. In this direction, we have developed a cuff-less and noninvasive pulse transit time (PTT)-based approach to overcome the shortcomings of conventional invasive or cuff-based blood pressure (BP) measurement techniques for long-term and continuous measurement of BP and its variability. The technique is useful for designing wearable BP meters, which, if connected with various types of wearable devices by a body sensor network, could form a front-end infrastructure for long-term personal health monitoring. In this paper, we evaluated the PTT-based approach with data collected from two groups of 85 subjects. The results suggested that the PTT-based approach is a promising technique for the noninvasive and cuff-less measurement of BP","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124360532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 62
Body Sensor Networks: Infrastructure for Life Science Sensing Research 身体传感器网络:生命科学传感研究的基础设施
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250376
B. Lo, Guang-Zhong Yang
{"title":"Body Sensor Networks: Infrastructure for Life Science Sensing Research","authors":"B. Lo, Guang-Zhong Yang","doi":"10.1109/LSSA.2006.250376","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250376","url":null,"abstract":"The recent advances in biosensor design, wireless communication and computer architecture have enabled the realization of integrated, miniature wireless biosensors. Based on these technologies, the concept of body sensor network (BSN) has recently been proposed to provide intelligent, context aware sensing. The BSN outlines the basic infrastructure for pervasive sensing. In addition to healthcare applications, it also has important value for life science research and enables large-scale, continuous monitoring of drug response and epidemic studies. This paper introduces the basic concept of BSN, outlines its major components and highlights several key applications for life science research","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"515 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132686665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
Chitosan for Biofunctionalization of Microsystems 壳聚糖用于微系统的生物功能化
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250400
S. Koev, M. Powers, V. Badilita, H. Yi, W. Bentley, G. Payne, G. Rubloff, R. Ghodssi
{"title":"Chitosan for Biofunctionalization of Microsystems","authors":"S. Koev, M. Powers, V. Badilita, H. Yi, W. Bentley, G. Payne, G. Rubloff, R. Ghodssi","doi":"10.1109/LSSA.2006.250400","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250400","url":null,"abstract":"We present the use of the polysaccharide chitosan for immobilizing biomolecules on microfabricated device surfaces. The main advantages of chitosan are its abundance of primary amine groups and its ability to be electrodeposited. Biomolecules are easily attached to chitosan 's amines by standard glutaraldehyde chemistry. The electrodeposition of chitosan allows accurate spatial and temporal control of biomolecule placement. We have demonstrated this biofunctionalization method for two different bioMEMS devices: a biophotonic sensor and a micromechanical biosensor. We have successfully assembled probe DNA on each of them and detected hybridization with target DNA as a demonstration of sensor operation. Here, we briefly present the fabrication procedure and testing results for both of these bioMEMS sensing devices","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"358 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115870080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Economical Multichannel Integrated Receiver/Reconstruction System for MRI 一种经济的MRI多通道集成接收/重构系统
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250417
I. Dalal
{"title":"An Economical Multichannel Integrated Receiver/Reconstruction System for MRI","authors":"I. Dalal","doi":"10.1109/LSSA.2006.250417","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250417","url":null,"abstract":"A design is presented for a multichannel integrated receiver/reconstruction system for MRI that alleviates the concerns associated with commercial solutions regarding cost, scalability and the ability to access intermediate data. Up to 16 MR signals are sampled directly at RF, with digital down-conversion and image reconstruction performed by a single-chip field-programmable gate array (FPGA). Imaging researchers can readily access data from any point in the processing chain over a network, and the design can scale modularly in blocks of 8n or 16n channels","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123868077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wearable Technology in the Rehabilitation Hospital of the Future 未来康复医院的可穿戴技术
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250378
Paolo Bonato
{"title":"Wearable Technology in the Rehabilitation Hospital of the Future","authors":"Paolo Bonato","doi":"10.1109/LSSA.2006.250378","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250378","url":null,"abstract":"Wearable systems for continuous monitoring of patient status could positively affect the quality of patient management in rehabilitation hospitals. Wireless systems are particularly attractive in the context of monitoring patients over periods of a few days to a week. Special garments constitute an appealing solution for monitoring patients over periods of weeks to months. Two main categories of applications are relevant to rehabilitation medicine: 1) monitoring patients in the inpatient units and 2) monitoring patients in an outpatient setting","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121267605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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