{"title":"集成荧光传感芯片实验室设备","authors":"Honghao Ji, M. Dandin, P. Abshire, E. Smela","doi":"10.1109/LSSA.2006.250392","DOIUrl":null,"url":null,"abstract":"A low noise optical sensor and biocompatible microscale optical filters for integrated fluorescence sensors were developed and tested. The sensor was fabricated in a 0.5 mum CMOS process. The measured reset noise of the sensor is reduced by a factor of 10 compared to conventional active pixel sensors. The transmission ratio in the pass-band and suppression ratio in the stop-band of the optical filters are comparable to that of macroscopic commercial filters for fluorescence microscopy","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"3 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"14","resultStr":"{\"title\":\"Integrated Fluorescence Sensing for Lab-on-a-chip Devices\",\"authors\":\"Honghao Ji, M. Dandin, P. Abshire, E. Smela\",\"doi\":\"10.1109/LSSA.2006.250392\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A low noise optical sensor and biocompatible microscale optical filters for integrated fluorescence sensors were developed and tested. The sensor was fabricated in a 0.5 mum CMOS process. The measured reset noise of the sensor is reduced by a factor of 10 compared to conventional active pixel sensors. The transmission ratio in the pass-band and suppression ratio in the stop-band of the optical filters are comparable to that of macroscopic commercial filters for fluorescence microscopy\",\"PeriodicalId\":360097,\"journal\":{\"name\":\"2006 IEEE/NLM Life Science Systems and Applications Workshop\",\"volume\":\"3 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2006-11-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"14\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2006 IEEE/NLM Life Science Systems and Applications Workshop\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/LSSA.2006.250392\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2006 IEEE/NLM Life Science Systems and Applications Workshop","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/LSSA.2006.250392","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 14
摘要
研制并测试了用于集成荧光传感器的低噪声光学传感器和生物相容性微尺度滤光片。该传感器采用0.5 μ m CMOS工艺制造。与传统的有源像素传感器相比,传感器的测量复位噪声降低了10倍。光学滤光片通带的透射比和阻带的抑制比与荧光显微镜的宏观商用滤光片相当
Integrated Fluorescence Sensing for Lab-on-a-chip Devices
A low noise optical sensor and biocompatible microscale optical filters for integrated fluorescence sensors were developed and tested. The sensor was fabricated in a 0.5 mum CMOS process. The measured reset noise of the sensor is reduced by a factor of 10 compared to conventional active pixel sensors. The transmission ratio in the pass-band and suppression ratio in the stop-band of the optical filters are comparable to that of macroscopic commercial filters for fluorescence microscopy