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2006 IEEE/NLM Life Science Systems and Applications Workshop最新文献

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A Stochastic Approach to 3-D Image Modeling 三维图像建模的随机方法
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250410
D. Joshi, Jia Li, J.Z. Wang
{"title":"A Stochastic Approach to 3-D Image Modeling","authors":"D. Joshi, Jia Li, J.Z. Wang","doi":"10.1109/LSSA.2006.250410","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250410","url":null,"abstract":"Statistical modeling methods have been successfully used to segment, classify, and annotate digital images, over the years. In this paper, we present a 3-D hidden Markov model (HMM) for volume image modeling. The 3-D HMM is applied to volume image segmentation and tested using synthetic images with ground truth. Potential applications to 3-D biomedical image analysis are also discussed","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126170554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell Clinics Technology Platform for Cell-Based Sensing 基于细胞传感的细胞临床技术平台
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250371
M. Urdaneta, M. Christophersen, E. Smela, S. B. Prakash, N. Nelson, P. Abshire
{"title":"Cell Clinics Technology Platform for Cell-Based Sensing","authors":"M. Urdaneta, M. Christophersen, E. Smela, S. B. Prakash, N. Nelson, P. Abshire","doi":"10.1109/LSSA.2006.250371","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250371","url":null,"abstract":"The cell clinics microsystem is a platform for long-term cell monitoring for such applications as cell-based sensing. This system includes microvials with individually actuated lids, integrated circuits that monitor cells and control the position of the vial hinges, and an automated cell loading mechanism that relies on dielectrophoresis to manipulate individual cells into the vials","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125374242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Continuous Monitoring of Blood Glucose Concentration using a Fully Implantable Wireless Biomedical Microsystem 利用全植入式无线生物医学微系统连续监测血糖浓度
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250419
M. M. Ahmadi, G. Jullien, Peiyu Zhang
{"title":"Continuous Monitoring of Blood Glucose Concentration using a Fully Implantable Wireless Biomedical Microsystem","authors":"M. M. Ahmadi, G. Jullien, Peiyu Zhang","doi":"10.1109/LSSA.2006.250419","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250419","url":null,"abstract":"In this paper, we conceptually describe a new microsystem which we are developing for continuous blood glucose monitoring. The microsystem is intended to be implanted underneath the skin and measure the blood glucose concentration every few minutes. The power to the implant along with data transmission will use a transcutaneous wireless link. The microsystem uses a novel electrochemical glucose sensor which does not require oxygen for reaction with glucose, eliminating the oxygen limitation and the hydrogen peroxide production problems","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"248 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123031652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
BioLabs-On-A-Chip: Monitoring Cells using CMOS Biosensors BioLabs-On-A-Chip:使用CMOS生物传感器监测细胞
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250374
S. B. Prakash, N. Nelson, A. Haas, V. Jeng, P. Abshire, M. Urdaneta, E. Smela
{"title":"BioLabs-On-A-Chip: Monitoring Cells using CMOS Biosensors","authors":"S. B. Prakash, N. Nelson, A. Haas, V. Jeng, P. Abshire, M. Urdaneta, E. Smela","doi":"10.1109/LSSA.2006.250374","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250374","url":null,"abstract":"Cell clinics, CMOS/MEMS hybrid microsystems for capturing and in-situ investigation of living cells, aims at providing high-speed, automated, and economical cell monitoring. Integrated sensors are being developed for extracellular signal amplification, cell-substrate capacitance sensing, contact imaging, and fluorescence detection. We describe the methodology for characterizing the responses of these sensors to biological cells. We also present results obtained from the long-term monitoring of cells cultured on-chip using two of the sensors: (i) a bio-amplifier, used for amplifying weak extracellular potentials from electrically active cells, and (ii) a cell-substrate capacitance sensor, used for tracking cell adhesion and assessing cell viability","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128751580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Chitosan-mediated Patterned Viral Nanotemplate Assembly onto Inorganic Substrates through Nucleic Acid Hybridization 壳聚糖介导的病毒纳米模板在无机底物上的核酸杂交组装
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250423
H. Yi, G. Rubloff, R. Ghodssi, J. Culver
{"title":"Chitosan-mediated Patterned Viral Nanotemplate Assembly onto Inorganic Substrates through Nucleic Acid Hybridization","authors":"H. Yi, G. Rubloff, R. Ghodssi, J. Culver","doi":"10.1109/LSSA.2006.250423","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250423","url":null,"abstract":"We present patterned assembly of tobacco mosaic virus (TMV) through hybridization of its own genomic information with probe DNA assembled onto electrodeposited chitosan scaffold. Chitosan's unique pH-responsive and chemically reactive properties allow facile biomolecule assembly onto conductive surfaces from aqueous environment. Genetically modified TMV serves as a potent nanotemplate for covalent conjugation of fluorescent markers or nanoparticles. This work represents a significant step toward assembling biological components for devices in biomedical applications","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127104338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiscale analysis of heart rate variability 心率变异性的多尺度分析
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250408
Jing Hu, Jianbo Gao, Yinhe Cao
{"title":"Multiscale analysis of heart rate variability","authors":"Jing Hu, Jianbo Gao, Yinhe Cao","doi":"10.1109/LSSA.2006.250408","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250408","url":null,"abstract":"Biological time series are often highly nonlinear and nonstationary. To effectively characterize the complexity of biological signals, we propose a new multiscale analysis method. It has a distinguished feature of scale isolation, and thus can readily deal with nonstationarity in biological signals. By analyzing a number of heart rate variability data, we show that the method can accurately distinguish between healthy subjects and patients with congestive heart failure. Furthermore, our analysis suggests that the dimension of the dynamics of the cardiovascular system is lower under the healthy than under diseased conditions. This is compatible with the observation that a healthy cardiovascular system is a tightly coupled system with coherent functions, while components in a malfunctioning cardiovascular system are somewhat loosely coupled and function incoherently. Therefore, if cardiovascular dynamics could be deterministically chaoslike, it would be more likely to be detected in healthy subjects","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134004515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Extraction of Neurite Structures for High Throughput Imaging Screening of Neuron Based Assays 提取神经突结构用于高通量成像筛选基于神经元的检测
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250391
Yong Zhang, Xiaobo Zhou, Stephen T. C. Wong
{"title":"Extraction of Neurite Structures for High Throughput Imaging Screening of Neuron Based Assays","authors":"Yong Zhang, Xiaobo Zhou, Stephen T. C. Wong","doi":"10.1109/LSSA.2006.250391","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250391","url":null,"abstract":"Neuron image analysis has recently emerged as a critical component for enabling quantitative systems neurobiology and high throughput drug screening. In this paper, we present a new algorithm for fast and automatic extraction of neurite structures in microscopy neuron images. The algorithm is based on novel methods for soma segmentation, seed point detection, recursive center line detection, and 2D curve smoothing. The algorithm is fully automatic without any human interaction while robust enough for processing images of poor quality, e.g., low contrast or low signal-to-noise ratio. It can be used to extract accurately highly complex neurite structures. All these advantages make the proposed algorithm suitable for increasingly demanding and complex image analysis tasks in systems biology and drug screening","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115490601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Looped Actin Structures for Testing Processive Molecular Motors 用于检测遗传分子马达的环状肌动蛋白结构
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250424
M. Riegelman, J. Sellers
{"title":"Looped Actin Structures for Testing Processive Molecular Motors","authors":"M. Riegelman, J. Sellers","doi":"10.1109/LSSA.2006.250424","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250424","url":null,"abstract":"A method is described for constructing looped actin filaments. Circular islands of nitrocellulose were patterned onto a microscope cover slip by micro-contact printing. A flow cell was then constructed over the patterned surface. Skeletal myosin was introduced into the assay which non-specifically attached to the nitrocellulose islands. Labeled actin filaments were added to the assay and self assembled along the perimeter of the islands to form circular loops of around 4-6 mum in diameter. By altering the biochemical conditions in the assay, the bound myosin acted as a linker to hold the assembled filament in this looped configuration. Regions of the loop with enhanced fluorescent intensity suggest \"closed loops\" were formed from single filaments with overlapping ends. Adaptations of this assembly technique can be used for in vitro motility assays with highly processive actin based motor proteins such as myosin V. A more complete understanding of the factors that influence the processivity of myosin V may ultimately assist in efforts to exploit the molecule's unique functionality in engineered micro- and nano-fluidic devices","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128814326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fast Automatic Registration Algorithm for Large Microscopy Images 大型显微镜图像的快速自动配准算法
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250414
Kun Huang, L. Cooper, A. Sharma, T. Pan
{"title":"Fast Automatic Registration Algorithm for Large Microscopy Images","authors":"Kun Huang, L. Cooper, A. Sharma, T. Pan","doi":"10.1109/LSSA.2006.250414","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250414","url":null,"abstract":"In this paper, a framework of fast registration algorithm for large microscopy images is presented. The rationale behind this approach is that the rigid transform gives the global mapping between the two images while the nonrigid components further refines the local matching of the pixels by taking care of local nonrigid distortion and variation. Therefore, to estimate rigid transform, the global features such as specific anatomical structures need to be used instead of point features which does not contain any global information. Then to estimate local nonrigid transform, the local features such as points are used. The algorithm is divided into two stages: the first stage is to find an accurate estimate of the rigid (Euclidean) transform between the two images. To achieve this goal, high level (global) features such as small regions with anatomical meanings such as clusters of cells or blood vessels are exploited for matching purposes. A voting scheme is used to confirm the matching and compute the rigid transformation between two consecutive images. This then transforms the foundation for the second stage of nonrigid registration. Using the accurate estimate of the rigid transform, a large number of point feature correspondence is established and used as control points for the nonrigid transform","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126001342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Various Configurations of Arterial Smooth Muscle Cells Affect Molecular Transport in the Arterial Wall 动脉平滑肌细胞的不同结构影响动脉壁的分子运输
2006 IEEE/NLM Life Science Systems and Applications Workshop Pub Date : 2006-11-30 DOI: 10.1109/LSSA.2006.250399
M. Dabagh, P. Jalali, P. Sarkomaa
{"title":"Various Configurations of Arterial Smooth Muscle Cells Affect Molecular Transport in the Arterial Wall","authors":"M. Dabagh, P. Jalali, P. Sarkomaa","doi":"10.1109/LSSA.2006.250399","DOIUrl":"https://doi.org/10.1109/LSSA.2006.250399","url":null,"abstract":"The shape of smooth muscle cells (SMCs) in an artery wall can considerably affect molecular transport across the media layer. In this work, we present a two dimensional numerical simulation of interstitial fluid diffusing through media layer. It is modeled as a heterogeneous medium composed of smooth muscle cells with elliptic shape. The assumption of elliptic SMCs resembles the spindled shape of SMCs. The interstitial fluid enters from fenestral pores which are assumed to be distributed uniformly over the internal elastic lamina (IEL). Results show the value of ATP concentration is dependent of the shape of SMCs","PeriodicalId":360097,"journal":{"name":"2006 IEEE/NLM Life Science Systems and Applications Workshop","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126875924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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