Global Journal of Pharmacy & Pharmaceutical Sciences最新文献

{"title":"Role of Vitamin D3 on Bone Health in Human Bone Osteosarcoma Cells (MG-63): Influence of Biofield Energy Healing Treatment","authors":"G. Nayak, M. Trivedi, A. Branton, Dahryn Trivedi, S. Jana","doi":"10.19080/GJPPS.2018.06.555681","DOIUrl":"https://doi.org/10.19080/GJPPS.2018.06.555681","url":null,"abstract":"The aim was to evaluate the impact of Biofield Treated vitamin D3 and DMEM on bone health. The test items (TI), were divided into two parts. One part of each sample received Consciousness Energy Treatment by Gopal Nayak and those samples were labeled as Biofield Treated (BT), while other parts of each sample were denoted as untreated test items (UT). MTT data showed test samples were found safe and nontoxic in tested concentrations. ALP was significantly increased by 213.46% and 218.66% in BT-DMEM + UT-TI and BT-DMEM + BT-TI, respectively at 1 µg/mL compared to UT-DMEM + UT-TI. Moreover, ALP was significantly increased by 200.79% and 187.09% in BT-DMEM + UT-TI and BT-DMEM + BT-TI, respectively at 10 µg/mL than untreated. Collagen synthesis was significantly increased by 551.25% and 130.31% in BT-DMEM + UT-TI and BT-DMEM + BT-TI, respectively at 1 µg/mL than untreated. Collagen was significantly increased by 401.97% in BT-DMEM + UT-TI at 10 µg/mL, while increased by 197.57% and 276.82% in UT-DMEM + BT-TI and BT-DMEM + UT-TI, respectively at 50 µg/mL than untreated. Percent bone mineralization was significantly increased by 186.86% and 188.23% in BT-DMEM + UT-TI and BT-DMEM + BT-TI, respectively at 10 µg/mL than untreated. It was further increased significantly by 224.04% and 156.72% in BT-DMEM + UT-TI and BT-DMEM + BT-TI, respectively at 50 µg/mL than untreated. Overall, data suggests that Biofield Treated vitamin D3 could be a potential alternative nutraceutical supplement to combat vitamin D3 deficiency and fight against various bone disorders.","PeriodicalId":359719,"journal":{"name":"Global Journal of Pharmacy & Pharmaceutical Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123368660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Disease Epidemiology Due to FDA Warning on E-Cigarettes","authors":"A. Abdussalam","doi":"10.19080/GJPPS.2018.06.555680","DOIUrl":"https://doi.org/10.19080/GJPPS.2018.06.555680","url":null,"abstract":"","PeriodicalId":359719,"journal":{"name":"Global Journal of Pharmacy & Pharmaceutical Sciences","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122745963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic use Profiles and Microbial Patterns in the Surgery Department of Bangil Regional General Hospital, Pasuruan","authors":"F. Herawati, Beatrix Eyleen Giovanny, R. Yulia, A. Jaelani","doi":"10.19080/gjpps.2018.06.555689","DOIUrl":"https://doi.org/10.19080/gjpps.2018.06.555689","url":null,"abstract":"This study aimed to determine the profile of the use of antibiotics in units of DDD / 100 patient-days, types of bacteria as well as the sensitivity of bacteria in the Surgery Department of Bangil Regional General Hospital, Pasuruan during the period from January to June 2016. The \u0000study was conducted using a descriptive, cross-sectional study design and data collection was done retrospectively. Nineteen percent patients in the surgical ward was given antibiotic. The results showed that the 3 most-used antibiotics are ciprofloxacin (11.8 DDD / 100 patient-days), \u0000ceftazidime (6.7 DDD / 100 patient-days), and cefixime (4.3 DDD / 100 patient-days). Ciprofloxacin became the most widely used antibiotics with DU of 26% from the total antibiotic. Within six months, there are four bacteria identified from the culture test result, i.e.: Staphylococcus aureus, Klebsiella pneumoniae, Stenotrophomonas maltophilia and Acinetobacter sp. Only vancomycin is an antibiotic which has 100% sensitivity to S. \u0000aureus. The DDD / 100 patient-days for 19% patients is 45.83, this result shows that the trend of using antibiotic is more than one DDD antibiotic per day.","PeriodicalId":359719,"journal":{"name":"Global Journal of Pharmacy & Pharmaceutical Sciences","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123113486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytosomes: An Advanced Drug Delivery System for Herbal Drug","authors":"D. Singh","doi":"10.19080/gjpps.2018.06.555679","DOIUrl":"https://doi.org/10.19080/gjpps.2018.06.555679","url":null,"abstract":"reacting phytoconstituents in 1:1 ration in an aprotic solvent. ration selected group study shows that of bonds. Abstract Plant extracts have been proved useful in treatment of various diseases, but their hydrophilic nature and unique chemical structure has imposed major challenges because of their poor bioavailability. Phytosomes, a complex between phytoconstituents and phospholipid improves absorption of phytoconstituents orally as well as topically. Phytosomes technology applied to poorly absorbable phytoconstituents. The bioavailability of phytoconstituents can be improved by the use of drug delivery system which has the capacity to cross the biological membrane. Phytosomes have better pharmacokinetic profile than conventional herbal extracts.","PeriodicalId":359719,"journal":{"name":"Global Journal of Pharmacy & Pharmaceutical Sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132607825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Availability and Utilization of Medicines Used for Preventing and Treating Malaria in Public Health Facilities in Jimma Town, Southwest Ethiopia","authors":"A. Bekele","doi":"10.19080/GJPPS.2018.06.555678","DOIUrl":"https://doi.org/10.19080/GJPPS.2018.06.555678","url":null,"abstract":"Malaria remains a major global public health and development challenge. It caused 216 million cases and 655,000 deaths worldwide in 2010, of which 81% of the cases and 91% of the deaths were from sub-Saharan Africa [1]. In Ethiopia, malaria also remains one of the most public health problems despite considerable effort made to control it [2-4]. Approximately 75% of the land mass where 68% of the total population lives is malarious [2]. The Federal democratic Republic of Ethiopia Ministry of Health estimated that there are more than 5 million clinical cases and thousands of deaths due to malaria each year [2]. However, the epidemiological pattern of the disease varies from place to place and even from time to time [5-7]. About 1 million confirmed clinical cases and 1,581 deaths were officially reported due to malaria in 2010. Malaria poses a significant impediment to social and economic development and the disease was responsible for the greatest economic burden upon most of the countries in the southern part of the Sahara. In 1995, the average gross domestic product (GDP) in malarias countries was five-fold lower compared to non-malaria countries [8]. The economic loss caused by malaria in Africa in 1995 was estimated at 800 million U.S dollars. By 1997 this figure has risen to USD 2 billion, an enormous health and socioeconomic burden to an already poor continent [9]. The burden of malaria has been intensified by the appearance of chloroquine-resistant plasmodium falciparum, which arouse in south East Asia and was first documented in east Africa in 1979. Since then, there have been reports of chloroquine resistance in most countries in Africa, with especially high resistance in east Africa. In addition, Abstract","PeriodicalId":359719,"journal":{"name":"Global Journal of Pharmacy & Pharmaceutical Sciences","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127563385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disorder of Infancy and Childhood: A Review","authors":"V. Ashwlayan","doi":"10.19080/GJPPS.2018.05.555675","DOIUrl":"https://doi.org/10.19080/GJPPS.2018.05.555675","url":null,"abstract":"During the last decade, a substantial scientific base has been established for psychopharmacology of adult patients. Diagnostic precision for treatment has been facilitated by the continuing revision of the American Psychiatric Association’s Diagnostic and Statistical Manual for Mental Disorders. The increasing confidence with the data thus generated regarding psychotropic drugs has also increased attention to child and adolescent psychotropic drugs in child and adolescent population have been conducted despite their frequent use. This review will focus on three diagnostic whose primary treatment is medication-attention deflect hyperactivity disorder, functional enuresis, and Tourette’s disorder. Using psychotropic drugs to treat children and adolescents often requires a very different approach than when the same drugs are used for psychiatric disorders among adults. Most adults given psychotropic drugs suffer from major and major depression. Despite well-defined diagnostic criteria, many children are given psychotropic drugs merely to control a group of symptoms or behavior in order to facilitate the child’s learning and development. The psychiatric assessment of a child requires obtaining information from the child, the parents or caretakers, and teachers. The overall diagnostic impression is formed from psychiatric, social, neuropsychologic, and educational evaluations. Before the initiation of psychotropic drugs, the child and family need to be familiar with the risks and benefits of drug therapy, any alternate therapies, and possible adverse effects including drug withdrawal. In addition, and idiosyncratic effects should be presented. The risks of untreated illness should also be discussed. Pharmacotherapy for children and adolescents is usually administered in conjunction with other therapies (e.g., psychotherapy, family therapy, or behavioral therapy). Medication should not be used in place of other therapies or because other therapies have failed. Careful documentation of baseline symptoms is necessary before initiating drug therapy to identify the responsive symptoms and established a realistic expectation for treatment outcome.","PeriodicalId":359719,"journal":{"name":"Global Journal of Pharmacy & Pharmaceutical Sciences","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128458929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Season on In VitroAnti-Oxidant Activity of SyzygiumCuminiL.Leaves","authors":"P. Mitra","doi":"10.19080/gjpps.2018.05.5556673","DOIUrl":"https://doi.org/10.19080/gjpps.2018.05.5556673","url":null,"abstract":"Syzygiumcumini Linn ( )is a medicinal plant. Anti oxidant activity of S. cuminiL .leaves is known in literature. In the present study we have examined effect of season on in vitroanti oxidant activity of S. cuminiL .leaves. Leaves of S. cuminiL .were collected in different seasons and in vitroanti oxidant activity of the leaves was measured by superoxide anion generation with the help of linoleic acid peroxidation assay, xanthine-xanthine oxidase assay and by DPPH photometric assay. Anti oxidant compounds like total phenol, ascorbic acid, flavonoids and carotenoid present in the leaves of different seasons were also estimated. Results showed that in vitroanti oxidant activity of S. cuminiL .leaves was maximum during summer (March-May). Anti oxidant activity was related with high content of total phenol, ascorbic acid, flavonoid and carotenoids in the leaves. It is therefore concluded that leaves of S. cuminiL .of summer should be used to get maximum anti oxidant activity.","PeriodicalId":359719,"journal":{"name":"Global Journal of Pharmacy & Pharmaceutical Sciences","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116051635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Good Prescribing Interventions, made an Impact in Reduced Coartem Usage – a Retrospective Study at the Copperbelt University Health Facility","authors":"K. Ponshano","doi":"10.19080/GJPPS.2018.05.555672","DOIUrl":"https://doi.org/10.19080/GJPPS.2018.05.555672","url":null,"abstract":"According to the WHO malaria report, 2017, it was reported in 2016 that, 91 countries had a total of 216 million cases of malaria of which malaria deaths globally reached 445,000 [1]. Malaria is the commonest presentation illness in Sub-Sahara Africa, and over diagnosis of malaria in patients presenting with fever in Zambia is a major public health problem [1-3]. Malaria remains an important cause of illness and death in adults and children. It requires an integrated approach, including prevention and prompt treatment with effective antimalarial agents [1-3]. The recommended first line treatment of malaria in Zambia is artemisin based combination (ABC) therapy that is Artemether 20mg+Lumefantrine 120mg (coartem) tablets [2]. Over the past years, the introduction of the relatively expensive artemether plus lumefantrine (Coartem) drug and the subsequent appearance of malaria resistance in our country have driven the need to rationalize the overuse of antimalarial drugs at the Copperbelt University (CBU) health facility [3]. Furthermore, the recent decline in malaria transmission in many areas of Zambia has led to increasing awareness that is often associated with neglect of non-malarial causes of fever [46]. The availability of rapid diagnostic tests for malaria (RDTs) as well as parasitological test (microscopy) has provided a potentially important instrument to address these problems. All suspected cases of fever should have malaria tests to confirm the diagnosis by using both microscopy and RDTs and supported by a quality assurance programme. In 2015 the ‘WHO Guidelines for Malaria Diagnosis and Treatment’ recommended parasitological confirmation in all patients with suspected malaria before treatment and restricting antimalarial treatment to parasite-positive patients [7,8]. This was one of the managerial interventions that were implemented at CBU health facility. The idea was to limit the over use of valuable drug to patients who may not need them but due to the presenting fever, physicians tend to prescribe even when the microscopic examination Abstract","PeriodicalId":359719,"journal":{"name":"Global Journal of Pharmacy & Pharmaceutical Sciences","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131490616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}