Global Journal of Pharmacy & Pharmaceutical Sciences最新文献

Review of Pembrolizumab and other Anti PD-1/PD-L1 Antibodies Pembrolizumab和其他抗PD-1/PD-L1抗体的综述

Global Journal of Pharmacy & Pharmaceutical Sciences Pub Date : 2018-12-21 DOI: 10.19080/gjpps.2018.06.555696

Caleb P Gottlich Ms

引用次数: 0

An Overview of Medicine Pricing Policies that May be Applicable to Low-and Middle-Income Countries 可能适用于中低收入国家的药品定价政策概述

Global Journal of Pharmacy & Pharmaceutical Sciences Pub Date : 2018-12-03 DOI: 10.19080/gjpps.2018.06.555694

V. Bangalee

引用次数: 1

A Clinical Review on Huntington Disease 亨廷顿病的临床研究进展

Global Journal of Pharmacy & Pharmaceutical Sciences Pub Date : 2018-11-28 DOI: 10.19080/gjpps.2018.06.555693

P. Malkani

{"title":"A Clinical Review on Huntington Disease","authors":"P. Malkani","doi":"10.19080/gjpps.2018.06.555693","DOIUrl":"https://doi.org/10.19080/gjpps.2018.06.555693","url":null,"abstract":"Huntington disease (HD) is a progressive, fatal, neurodegenerative disorder caused by an expanded (Cytosine, Adenine, Guanine) CAG repeat in the huntingtin gene, which encodes an abnormally long polyglutamine repeat in huntingtin protein. HD is characterised by unwanted choreatic movements, behavioural and psychiatric disturbances and dementia. HD is an autosomal dominant inherited disease caused by an elongated CAG repeat (36 repeats or more) on the short arm of chromosome 4p16.3 in huntingtin gene. The longer the CAG repeat, and then the onset of disease is earlier. The mechanism by which neuronal degeneration and cell death are being generated in HD may include excitotoxicity, energy deficit, oxidative stress, inflammatory process and protein aggregation. In the brain, the basal ganglia are highly affected which organize motor movement. The disease is characterised by a primary progressive loss of medium spiny projection neuron in basal ganglia. When the disease develops before age 20, the condition is called juvenile HD. Management should be versatile and is based on treating symptoms with a view to improving quality of life. Medication and non-medical care for depression and aggressive behavior may be required.","PeriodicalId":359719,"journal":{"name":"Global Journal of Pharmacy & Pharmaceutical Sciences","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122466197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Closer Insight into The Role of Vitamin D in Polycystic Ovary Syndrome (Pcos) 进一步了解维生素D在多囊卵巢综合征(Pcos)中的作用

Global Journal of Pharmacy & Pharmaceutical Sciences Pub Date : 2018-11-19 DOI: 10.19080/gjpps.2018.06.555692

Alshaymaa Amin Zaki El-Bahya

{"title":"A Closer Insight into The Role of Vitamin D in Polycystic Ovary Syndrome (Pcos)","authors":"Alshaymaa Amin Zaki El-Bahya","doi":"10.19080/gjpps.2018.06.555692","DOIUrl":"https://doi.org/10.19080/gjpps.2018.06.555692","url":null,"abstract":"Infertility is a complex disorder with significant medical, psychosocial, and economic aspects [1], affecting about 15% of couples [2]. One major cause of female infertility is polycystic ovary syndrome (PCOS). PCOS is an endocrine disorder characterized by anovulation, menstrual disorder, amenorrhea, hirsutism, and infertility. Women with PCOS have impaired metabolism of androgen and estrogen and they are often obese, insulin resistant, and at risk for type 2 diabetes and cardiovascular disease [3]. PCOS has two definitions, set in1990 by the National Institutes for Health (NIH) and in 2003 by the Rotterdam consensus workshop. The NIH requires the presence of chronic anovulation and clinical or biochemical signs of hyperandrogenism. The Rotterdam consensus requires the presence of two or all of three features: clinical and/or biochemical hyperandrogeneism, chronic anovulation and polycystic ovaries Rotterdam (2004). The Rotterdam criteria added ovarian morphology, expanding the inclusion criteria, and thus increasing the prevalence of PCOS Dewailly, CatteauJonard et al. (2006). As the 2003 Rotterdam consensus included ovarian morphology in PCOS diagnosis, four phenotypes of PCOS are recognized (Table 1). Abstract","PeriodicalId":359719,"journal":{"name":"Global Journal of Pharmacy & Pharmaceutical Sciences","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122957256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Effect of Season on UV Absorbing Property of Syzygium cumini L. Leaves 季节对秋合欢叶片紫外吸收特性的影响

Global Journal of Pharmacy & Pharmaceutical Sciences Pub Date : 2018-10-23 DOI: 10.19080/gjpps.2018.06.555687

P. Mitra

引用次数: 1

An Investigation of the Consciousness Energy Healing Therapy on Physicochemical and Thermal Properties of Silver Sulfadiazine 意识能量治疗对磺胺嘧啶银理化及热性能的影响

Global Journal of Pharmacy & Pharmaceutical Sciences Pub Date : 2018-10-23 DOI: 10.19080/GJPPS.2018.06.555688

Dahryn Trivedi, M. Trivedi, A. Branton, G. Nayak, S. Jana

{"title":"An Investigation of the Consciousness Energy Healing Therapy on Physicochemical and Thermal Properties of Silver Sulfadiazine","authors":"Dahryn Trivedi, M. Trivedi, A. Branton, G. Nayak, S. Jana","doi":"10.19080/GJPPS.2018.06.555688","DOIUrl":"https://doi.org/10.19080/GJPPS.2018.06.555688","url":null,"abstract":"Silver sulfadiazine is a topical sulfa drug antibiotic that is used by burn patients to prevent the bacterial infection. This study was aimed to analyze the impact of the Trivedi Effect® on the physicochemical and thermal properties of silver sulfadiazine with the help of various analytical techniques. The silver sulfadiazine sample was divided into the control and treated parts; where, no Biofield Treatment was provided to the control part, while the treated part received the Biofield Treatment remotely by a renowned Biofield Energy Healer, Dahryn Trivedi. The PXRD peak intensities and the crystallite sizes were significantly altered ranging from -75.25% to 31.21% and -8.80% to 192.76% respectively, along with 64.06% increase in the average crystallite size of the treated sample than the control sample. The particle sizes were decreased by 1.60% (d10), 2.30% (d50), 2.06% (d90), and 4.40% [D (4,3)]; therefore, the surface area was increased by 2.61% in the treated sample in contrast to the control sample. The latent heat of fusion and decomposition of the treated sample were significantly altered by -21.52% and 32.03%, respectively, compared to the control sample. Additionally, the total weight loss was reduced by 1.86%; however, the residue amount was increased by 2.88% in the treated sample compared with the control sample. Hence, the Biofield Treatment might be considered as a novel approach to generate a new polymorph of silver sulfadiazine that is more soluble, bioavailable, and thermally stable, which could be useful in designing a novel pharmaceutical formulation for better therapeutic response against various type of bacterial disease.","PeriodicalId":359719,"journal":{"name":"Global Journal of Pharmacy & Pharmaceutical Sciences","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131322020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recommendations for the Management of Constipation in Cancer Patients 癌症患者便秘处理建议

Global Journal of Pharmacy & Pharmaceutical Sciences Pub Date : 2018-10-22 DOI: 10.19080/gjpps.2018.06.555686

J. Arnall

{"title":"Recommendations for the Management of Constipation in Cancer Patients","authors":"J. Arnall","doi":"10.19080/gjpps.2018.06.555686","DOIUrl":"https://doi.org/10.19080/gjpps.2018.06.555686","url":null,"abstract":"Constipation is a common condition that is often overlooked among cancer patients particularly those with advanced disease. It is often associated with distressing or debilitating symptoms that adversely impact the quality of life of these patients. Hence, it is imperative that practicing clinicians are cognizant of the various etiologies of constipation especially those that are secondary to both cancer therapies and supportive care. Since discontinuation of the offending drug(s) may not be a viable option in the hematology/oncology setting, patient counseling and initiation of preventative measures which include scheduled bowel regimens for therapies known to cause constipation are central to optimal management. As constipation goes unresolved or becomes more severe laxative therapy should be optimized to achieve resolution of symptoms. In severe and refractory cases of constipation consulting a gastrointestinal specialist may be prudent. Herein, we highlight the most common laxative therapies that may be considered in adult cancer patients experiencing initial and refractory constipation as well as provide practical considerations and a management algorithm that can be easily applied or implemented in clinical practice.","PeriodicalId":359719,"journal":{"name":"Global Journal of Pharmacy & Pharmaceutical Sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124981944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perforated Peptic Ulcer: A Post-Operative Case 术后穿孔性消化性溃疡1例

Global Journal of Pharmacy & Pharmaceutical Sciences Pub Date : 2018-10-16 DOI: 10.19080/gjpps.2018.06.555685

Hassam Ali

引用次数: 0

Role of Skills for Clinical, Hospital and Community Pharmacist in Pharmaceutical Care 临床、医院和社区药师技能在药学服务中的作用

Global Journal of Pharmacy & Pharmaceutical Sciences Pub Date : 2018-10-15 DOI: 10.19080/GJPPS.2018.06.555684

A. Nagappa

引用次数: 0

Neuropharmacology of Alzheimer’s Disease and Dementia 阿尔茨海默病和痴呆症的神经药理学

Global Journal of Pharmacy & Pharmaceutical Sciences Pub Date : 2018-10-15 DOI: 10.19080/GJPPS.2018.06.555683

Y. Sattar

引用次数: 0