Japanese Journal of Leprosy最新文献_第4页

[Development of a novel recombinant BCG for tuberculosis vaccine]. [一种新型重组卡介苗的研制]。

Japanese Journal of Leprosy Pub Date : 2013-12-01 DOI: 10.5025/hansen.82.107

Masahiko Makino

{"title":"[Development of a novel recombinant BCG for tuberculosis vaccine].","authors":"Masahiko Makino","doi":"10.5025/hansen.82.107","DOIUrl":"https://doi.org/10.5025/hansen.82.107","url":null,"abstract":"A novel recombinant BCG (BCG-DHTM), that was deficient in urease, expressed with gene encoding the fusion of BCG-derived HSP70 and M. tuberculosis-derived major membrane protein (MMP)-II, was constructed for use as a vaccine against tuberculosis. BCG-DHTM efficiently activated dendritic cells (DC) to induce cytokine production, including IL-12, TNFalpha and IL-1beta and phenotypic changes. The DC infected BCG-DHTM was more potent in activation of native T cells of CD4 and CD8 subsets than those infected vector control BCG. The activation of naïve T cells by BCG-DHTM was closely associated with phagomal maturation, and that of naïve CD8+ T cells by BCG-DHTM was induced by the activation of cytosolic cross-presentation pathway. Further, BCG-DHTM seemed to activate native CD4+ T cells and native CD8+ T cells by antigen-specific fashion. The primary infection of BCG-DHTM in C57BL/6 mice for 12 weeks efficiently produced T cells responsive to in vitro secondary stimulation with MMP-II, HSP70 and H37Rv-derived cytosolic protein and inhibited with multiplication of subsequently challenged M. tuberculosis in lungs at least partially. The effect of BCG-DHTM as a vaccine for tuberculosis is not fully convincing and need the improvement, however, our strategy in the development of new recombinant BCG for tuberculosis seems to provide useful tool.","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5025/hansen.82.107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32161935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate and acquired immune responses to mycobacterial infections: involvement of IL-17A/IL-23 axis in protective immunity. 对分枝杆菌感染的先天和获得性免疫反应:IL-17A/IL-23轴参与保护性免疫

Japanese Journal of Leprosy Pub Date : 2013-12-01 DOI: 10.5025/hansen.82.123

Masayuki Umemura, Goro Matsuzaki

引用次数: 5

[Present state of Hansen's disease between 2012 and 2013--weekly epidemiological record, no. 35, 2013, 88, 365-380 (translated by Shuichi Mori)]. [2012年至2013年汉森病现状——每周流行病学记录，编号;[35,2013, 88, 365-380]。

Japanese Journal of Leprosy Pub Date : 2013-12-01

Sumana Barua

引用次数: 0

[Guidelines for the treatment of Hansen's disease in Japan (third edition)]. [日本麻风病治疗指南(第三版)]。

Japanese Journal of Leprosy Pub Date : 2013-12-01 DOI: 10.5025/hansen.82.143

Masamichi Goto, Reiko Nogam, Yoshiko Okano, Masaichi Gidoh, Rie Yotsu, Yutaka Ishida, Shinichi Kitajima, Masanori Kai, Norihisa Ishii, Motoaki Ozaki, Kentaro Hatano

{"title":"[Guidelines for the treatment of Hansen's disease in Japan (third edition)].","authors":"Masamichi Goto, Reiko Nogam, Yoshiko Okano, Masaichi Gidoh, Rie Yotsu, Yutaka Ishida, Shinichi Kitajima, Masanori Kai, Norihisa Ishii, Motoaki Ozaki, Kentaro Hatano","doi":"10.5025/hansen.82.143","DOIUrl":"https://doi.org/10.5025/hansen.82.143","url":null,"abstract":"ad hoc committee of Japanese Leprosy Association recommends revised standard treatment protocol of leprosy in Japan, which is a modification of World Health Organization's multidrug therapy (WHO/MDT, 2010). For paucibacillary (PB) leprosy, 6 months treatment by rifampicin and dapsone (MDT/PB) is enough. However, for high bacterial load multibacillary (MB) leprosy, 12 months treatment seems insufficient. Thus, (A) For MB with bacterial index (BI) > 3 before treatment, 2 years treatment by rifampicin, dapsone and clofazimine (MDT/MB) is necessary. When BI becomes negative and active lesion is lost within 2 years, no maintenance therapy is necessary. When BI is still positive, one year of MDT/MB is added (3 years in total), followed by maintenance therapy by dapsone and clofazimine until BI negativity and loss of active lesions. (B) For MB with BI < 3 or fresh MB (less than 6 months after the onset of the disease) with BI > 3, 1 year treatment by MDT/MB is necessary. When BI becomes negative and active lesion is lost within one year, no maintenance therapy is necessary. When BI is still positive or active lesion is remaining, additional therapy with MDT/MB for one more year is recommended. Brief summary of diagnosis, purpose of therapy, character of drugs, and prevention of deformity is also described.","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5025/hansen.82.143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32161940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

[Quality of life of leprosy patients' group in Vietnam]. [越南麻风病患者群体的生活质量]。

Japanese Journal of Leprosy Pub Date : 2013-12-01 DOI: 10.5025/hansen.82.83

Hiroyuki Watanabe

{"title":"[Quality of life of leprosy patients' group in Vietnam].","authors":"Hiroyuki Watanabe","doi":"10.5025/hansen.82.83","DOIUrl":"https://doi.org/10.5025/hansen.82.83","url":null,"abstract":"Vietnam has achieved WHO's leprosy elimination goal at a national level, but there are a lot ofex-leprosy patients who have severe physical disabilities in the leprosy treatment centers and resettlement villages. The purpose of this study is to analyze the quality of life (QOL) of ex-leprosy patients in Vietnam. The study was conducted in two leprosy treatment centers in Vietnam. The SF-36v2 QOL survey was used to evaluate the leprosy patients' health related conditions, and as a comparison group, SF-36v2 QOL survey was provided to a random group from the general population to measure the general groups' health related conditions. For those participants aged from 10 to 29 years old, the patients' group scored lower than the general group in each of the following categories; Role physical, Bodily pain, General health perceptions, Vitality, Social functioning, Role emotional. On the other hand, middle aged and elderly participants were found to show no significant difference between the patients' group and the general group. In comparing the two leprosy treatment centers, the score of Role physical and Role emotional were significantly higher in the leprosy treatment center where vocational training programs for leprosy patients are offered. From these results, the use of vocational training program is one of the effective methods for improving the QOL of the patients' group.","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5025/hansen.82.83","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32161489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

[Towards novel tuberculosis and leprosy vaccine development: the role of Th1-inducing peptide in cytotoxic T cell differentiation]. [迈向新型结核病和麻风病疫苗的发展:th1诱导肽在细胞毒性T细胞分化中的作用]。

Japanese Journal of Leprosy Pub Date : 2013-12-01 DOI: 10.5025/hansen.82.111

Toshiki Tamura, Yoko Shimohakamada, Masahiko Makino

{"title":"[Towards novel tuberculosis and leprosy vaccine development: the role of Th1-inducing peptide in cytotoxic T cell differentiation].","authors":"Toshiki Tamura, Yoko Shimohakamada, Masahiko Makino","doi":"10.5025/hansen.82.111","DOIUrl":"https://doi.org/10.5025/hansen.82.111","url":null,"abstract":"The effectiveness of a vaccine against tuberculosis and leprosy is mainly judged by its capability to induce memory CD8 cytotoxic T cells (CTL). It has been reported that 'help' from CD4+ T cells is required to induce memory CTL. However, how CD4+ T cells instruct or support memory CTL during priming phase has not been resolved in detail. Therefore, we examined the helper function of CD4+ T cells in CTL differentiation. Peptide-25 is the major T cell epitope of Ag85B of Mycobacterium tuberculosis. We found that this peptide induced the expression of T-bet and TATA box binding protein-associated factor that can induce the chromatin remodeling of ifn-gamma gene, and as a result induced Th1 differentiation even in the absence of IFN-gamma and IL-12. Next, we established an in vitro CTL differentiation system using Peptide-25, Peptide-25 specific CD4+ T cells, OVA specific CD8+ T cells and splenic DC. By using this system, we found that CD4+ T cells activated DC even in the absence of IFN-gamma and CD40 ligand association, and the activated DC induced the functional differentiation of CTL. To identify the regulatory factors for DC activation, we analyzed the gene expression profile of helper CD4 T cells and identified 27 genes. Taken together, these results suggest that the inducing factors for Th1 differentiation are not indispensable to induce the functional differentiation of CTL.","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5025/hansen.82.111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32161936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Molecular mechanisms of dormancy and drug tolerance in mycobacteria]. 分枝杆菌休眠和耐药的分子机制

Japanese Journal of Leprosy Pub Date : 2013-12-01 DOI: 10.5025/hansen.82.119

Sohkichi Matsumoto

引用次数: 0

[International cooperation with the neglected tropical disease Buruli ulcer in Togo]. [与多哥被忽视的热带病布鲁里溃疡的国际合作]。

Japanese Journal of Leprosy Pub Date : 2013-12-01 DOI: 10.5025/hansen.82.99

Tomoki Niiyama

{"title":"[International cooperation with the neglected tropical disease Buruli ulcer in Togo].","authors":"Tomoki Niiyama","doi":"10.5025/hansen.82.99","DOIUrl":"https://doi.org/10.5025/hansen.82.99","url":null,"abstract":"The objectives of this paper are to grasp the current status of an endemic disease, known as Buruli ulcer (BU), in the Republic of Togo and the expansion of international assistance in the field. By adopting the explicit support model, this paper also compares the obtained research results with those of the Republic of Ghana and Benin, to clarify the primary functions played among respective governments, WHO, and NGO. Under the auspices of the WHO Global Buruli Ulcer Initiative (GBUI, 1998-), National Buruli Ulcer Control Programme (NBUCP) in the Togo was initiated in 1999. However, due to the shortage of national budget and politico-economic instabilities of the nation, the actual implementation of NBUCP proved to be problematic. It was after 2007 that the programme began to move forward with the interventions of NGOs like DAHW and Handicap International. Currently, major players involved in the implementation of the policies provided by the GBUI are WHO, NGOs and the targeted governments. In other words, the organizations involved in BU treatment work together by fulfilling their functions. Unlike the neighboring countries, the Togolese government encountered much difficulty in materializing its national programme. Largely due to the political instability and the severe shortage of national budget, stronger assistances from NGOs were required at various levels of the national health measures from formulating to implementing the programme. As the programmes in Togo and Ghana/Benin expanded over the years, the respective support model revealed to be unique and different. In Ghana and Benin, intimate cooperation among WHO, government and NGOs has been established. In Togo, strengthening of collaboration among the three players is expected.","PeriodicalId":35918,"journal":{"name":"Japanese Journal of Leprosy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5025/hansen.82.99","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32161934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[In memoriam: Dr. Kyaw Myint]. [纪念觉敏博士]。

Japanese Journal of Leprosy Pub Date : 2013-04-01

引用次数: 0

[Present leprosy situation in the world in 2012]. [2012年世界麻风病现状]。

Japanese Journal of Leprosy Pub Date : 2013-04-01 DOI: 10.5025/hansen.82.59

Shuichi Mori, Sumana Barua, Koichi Suzuki, Rie Roselyne Yotsu, Norihisa Ishii

引用次数: 1